Deoxycorticosterone acetate

Catalog No.S4243 Synonyms: 11-Deoxycorticosterone acetate, DOC acetate, Cortexone acetate

For research use only.

Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.

Deoxycorticosterone acetate Chemical Structure

CAS No. 56-47-3

Selleck's Deoxycorticosterone acetate has been cited by 1 Publication

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Biological Activity

Description Deoxycorticosterone acetate (11-Deoxycorticosterone, DOC, Cortexone) is a steroid hormone used for intramuscular injection for replacement therapy of the adrenocortical steroid.
In vivo Deoxycorticosterone acetate (DOCA) is an agent commonly used to induce hypertension in experimental animals. This form of hypertension is dependent on altered regulation of central pressor mechanisms including the brain renin-angiotensin system.

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 372.5
Formula

C23H32O4

CAS No. 56-47-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(=O)OCC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01331239 Completed Drug: LCI699 Cushings Disease|Cushing Disease Novartis Pharmaceuticals|Novartis March 23 2011 Phase 2
NCT01186484 Completed Drug: JNJ-212082 Prostatic Neoplasms Janssen Pharmaceutical K.K. June 1 2010 Phase 1

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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