Name: Esmolol HCl
Brand: Selleck Chemicals
SKU: S4100
Availability: InStock
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Batch: S410001 DMSO]66 mg/mL]false]Water]66 mg/mL]false]Ethanol]66 mg/mL]false Purity: 99.43%

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COA
NMR
HPLC
SDS
Datasheet

99.43

Related Targets	AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Adrenergic Receptor Inhibitors	Zenidolol (ICI-118551) Hydrochloride Yohimbine HCl L755507 Atipamezole Higenamine hydrochloride Fenoterol hydrobromide Medetomidine HCl Rauwolscine hydrochloride Deoxycorticosterone acetate Detomidine HCl

Solubility

In vitro
Batch:

DMSO : 66 mg/mL (198.89 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : 66 mg/mL

Ethanol : 66 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Chemical Information, Storage & Stability

Molecular Weight	331.83	Formula	C₁₆H₂₅NO₄.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	81161-17-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	ASL8052			Smiles	CC(C)NCC(COC1=CC=C(C=C1)CCC(=O)OC)O.Cl

Mechanism of Action

Features	The suppressive effects of ONO-1101 on cardiovascular performance are less than those of Esmolol at equipotent beta-blocking doses.
Targets/IC₅₀/Ki	beta-adrenergic receptor
In vitro	Esmolol contains one asymmetric centre and exists as an enantiomeric pair, the (-)-enantiomer is active and the (+)-enantiomer is inactive, which is analogous to other P-blockers that have an oxypropranolamine nucleus. Esmolol has a rapid onset and offset of activity, the primary site of activity of Esmolol is on sinus node and atrioventricular (AV) nodal conduction systems.
In vivo	Esmolol (20 mg/kg) infusion in sepsis improves oxygen utilization of myocardium and preserves myocardial function in septic rats. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in heart rate (HR) in rabbits, with the maximum percent reductions of 13%. Esmolol (5 mg/kg, i.v.) produces a dose-dependent decrease in mean arterial pressure (MAP) in rabbits, with the maximum percent reductions of 38.2%. Esmolol (300 mg/kg) significantly decreases the heart rate, rate-pressure product, left ventricular contraction, cardiac output, and relative refractory period of the right ventricle, suppresses the AV nodal conduction, and increases the effective refractory period of the right ventricle and the preload of the left ventricle in canine. Esmolol (300 mg/kg) significantly reduces the isoproterenol-induced increase in heart rate and ventricular contraction in canine.
References	[1] https://pubmed.ncbi.nlm.nih.gov/7758250/ [2] https://pubmed.ncbi.nlm.nih.gov/16215384/ [3] https://pubmed.ncbi.nlm.nih.gov/11698317/ [4] https://pubmed.ncbi.nlm.nih.gov/10413070/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT06390748	Completed	Sepsis\|Lymphocyte Disorder T\|Immunologic Paralysis\|Catecholamine; Overproduction\|Beta-Blocker\|Cytokine Storm\|Sympathetic Nervous System Diseases	Lin Chen\|Sichuan Provincial People''s Hospital	January 1 2021	Phase 2
NCT04137991	Completed	Nociceptive Pain\|Goal-directed Therapy\|Hemodynamic Instability\|Nol-Index\|Remifentanil\|Cardiac Surgery\|Vascular Surgery\|General Anesthesia	Erasme University Hospital	October 10 2019	Not Applicable

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Esmolol HCl Adrenergic Receptor antagonist

Chemical Structure

Molecular Weight: 331.83