Tizanidine

Catalog No.S5537

Tizanidine Chemical Structure

Molecular Weight(MW): 253.71

Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.

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Biological Activity

Description Tizanidine is an imidazoline derivative and a centrally acting α2 adrenergic agonist used as a muscle relaxant for therapy of acute muscle spasms and chronic spasticity.
Targets
α2 adrenergic receptor [1]
()
In vitro

Like clonidine, it has sedative, anxiolytic, and analgesic properties, but it has a shorter duration of action and less effect on heart rate and blood pressure[1].

In vivo Tizanidine is shown to significantly reduce pain and tissue tenderness and to improve the quality of sleep[1].

Protocol

Solubility (25°C)

In vitro DMSO 50 mg/mL (197.07 mM)
Water 15 mg/mL (59.12 mM)
Ethanol 6 mg/mL (23.64 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 253.71
Formula

C9H8ClN5S

CAS No. 51322-75-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03068897 Completed Low Back Pain Montefiore Medical Center May 3 2017 Phase 4
NCT03068897 Completed Low Back Pain Montefiore Medical Center May 3 2017 Phase 4
NCT02887534 Withdrawn Acute Muscle Pain Sun Pharma Advanced Research Company Limited November 2016 Phase 2
NCT02887534 Withdrawn Acute Muscle Pain Sun Pharma Advanced Research Company Limited November 2016 Phase 2
NCT02725359 Completed Thyroidectomy Ataturk University April 2016 Phase 4
NCT02725359 Completed Thyroidectomy Ataturk University April 2016 Phase 4

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Adrenergic Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID