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Doxazosin Adrenergic Receptor antagonist

Name: Doxazosin
Brand: Selleck Chemicals
SKU: S5782
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S5782

Doxazosin(UK 33274) is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

Chemical Structure

Molecular Weight: 451.48

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S578201 DMSO]31 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.95%

99.95

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Chemical Information, Storage & Stability

Molecular Weight	451.48	Formula	C₂₃H₂₅N₅O₅	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	74191-85-8	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	UK 33274			Smiles	COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC

Solubility

In vitro
Batch:

DMSO : 31 mg/mL ( (68.66 mM) Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	1.55mg/ml (3.43mM)	Taking the 1 mL working solution as an example, add 50 μL of 31 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.	0.22mg/ml (0.49mM)	Taking the 1 mL working solution as an example, add 50 μL of 4.4 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT01946035	Completed	Allergic Rhinitis	University of Dundee	September 2013	Phase 4
NCT01379898	Completed	Pheochromocytoma	University Medical Center Groningen\|Radboud University Medical Center\|UMC Utrecht\|VU University of Amsterdam\|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)\|Leiden University Medical Center\|Erasmus Medical Center\|Maastricht University Medical Center\|St. Antonius Hospital\|Medisch Spectrum Twente\|Maxima Medical Center\|Canisius-Wilhelmina Hospital\|Onze Lieve Vrouwe Gasthuis\|Atrium Medical Center\|Isala	December 2011	Phase 4
NCT01062945	Completed	Cocaine Addiction\|Cocaine Abuse\|Cocaine Dependence\|Substance Abuse	Baylor College of Medicine\|National Institute on Drug Abuse (NIDA)	January 2010	Phase 1
NCT00646841	Completed	Hypertension	Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	February 2003	Phase 4
NCT00645034	Completed	Benign Prostatic Hyperplasia	Pfizer''s Upjohn has merged with Mylan to form Viatris Inc.\|Pfizer	November 2002	Phase 2

Tech Support

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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