Catalog No.S5782

Doxazosin Chemical Structure

Molecular Weight(MW): 451.48

Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.

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Biological Activity

Description Doxazosin is a quinazoline-derivative that selectively antagonizes postsynaptic α1-adrenergic receptors.



Solubility (25°C)

In vitro DMSO 31 mg/mL (68.66 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 451.48


CAS No. 74191-85-8
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT01946035 Completed Drug: Doxazosin XL|Other: Placebo Allergic Rhinitis University of Dundee September 2013 Phase 4
NCT01379898 Completed Drug: Phenoxybenzamine|Drug: Doxazosin Pheochromocytoma University Medical Center Groningen|Radboud University|UMC Utrecht|VU University of Amsterdam|Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)|Leiden University Medical Center|Erasmus Medical Center|Maastricht University Medical Center|St. Antonius Hospital|Medisch Spectrum Twente|Maxima Medical Center|Canisius-Wilhelmina Hospital|Onze Lieve Vrouwe Gasthuis|Atrium Medical Center|Isala December 2011 Phase 4
NCT01062945 Completed Drug: Placebo|Drug: Doxazosin Cocaine Addiction|Cocaine Abuse|Cocaine Dependence|Substance Abuse Baylor College of Medicine|National Institute on Drug Abuse (NIDA) January 2010 Phase 1
NCT00646841 Completed Drug: Doxazosin gastrointestinal therapeutic system (GITS) Hypertension Pfizer February 2003 Phase 4
NCT00645034 Completed Drug: placebo|Drug: sildenafil Benign Prostatic Hyperplasia Pfizer November 2002 Phase 2

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Adrenergic Receptor Signaling Pathway Map

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