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Guanfacine Hydrochloride Adrenergic Receptor agonist

Name: Guanfacine Hydrochloride
Brand: Selleck Chemicals
SKU: S4693
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4693

Guanfacine Hydrochloride (Tenex, Intuniv) is a selective α2A-adrenoceptor agonist with anti-hypertensive effect.

Chemical Structure

Molecular Weight: 282.55

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S469301 DMSO]56 mg/mL]false]Ethanol]56 mg/mL]false]Water]30 mg/mL]false Purity: 99.98%

99.98

Related Targets	AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel GluR MAO Beta Amyloid NMDAR P2 Receptor Trk receptor Serotonin Transporter Notch Cannabinoid Receptor P-gp CaMK Opioid Receptor BACE Sigma Receptor FAAH Neurokinin Receptor OX Receptor CGRP Receptor BChE Adenosine Deaminase CCK receptor MT Receptor
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Chemical Information, Storage & Stability

Molecular Weight	282.55	Formula	C₉H₉Cl₂N₃O.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	29110-48-3	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Guanfacine, Tenex, Intuniv			Smiles	C1=CC(=C(C(=C1)Cl)CC(=O)N=C(N)N)Cl.Cl

Solubility

In vitro
Batch:

DMSO : 56 mg/mL (198.19 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 56 mg/mL

Water : 30 mg/mL

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	α2A-adrenoceptor ^[1]
References	[1] https://pubmed.ncbi.nlm.nih.gov/17173664/ [2] https://pubmed.ncbi.nlm.nih.gov/21931492/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04866030	Completed	Attention Deficit Hyperactivity Disorder (ADHD)	Shire\|Takeda	March 11 2019	--
NCT05870605	Completed	Attention Deficit Hyperactivity Disorder (ADHD)	Shire\|Takeda	November 15 2018	--
NCT01904526	Completed	Smoking	Yale University\|National Institute on Drug Abuse (NIDA)	July 2013	Phase 2

Tech Support

Handling Instructions

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