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Tetrahydrozoline HCl Adrenergic Receptor agonist

Name: Tetrahydrozoline HCl
Brand: Selleck Chemicals
SKU: S4043
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S4043

Tetrahydrozoline (Tetryzoline) HCl is an imidazoline derivative with alpha receptor agonist activity.

Chemical Structure

Molecular Weight: 236.74

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Quality Control

Batch: S404301 Water]47 mg/mL]false]Ethanol]26 mg/mL]false]DMSO]12 mg/mL]false Purity: 99.96%

Cited in Nature Medicine for its top-tier quality
COA
NMR
SDS
Datasheet

99.96

Related Targets	AChR 5-HT Receptor COX Calcium Channel Histamine Receptor Dopamine Receptor GABA Receptor TRP Channel Cholinesterase (ChE) GluR
Other Adrenergic Receptor Inhibitors	Zenidolol (ICI-118551) Hydrochloride Yohimbine HCl L755507 Atipamezole Higenamine hydrochloride Fenoterol hydrobromide Medetomidine HCl Rauwolscine hydrochloride Deoxycorticosterone acetate Detomidine HCl

Solubility

In vitro
Batch:

Water : 47 mg/mL

Ethanol : 26 mg/mL

DMSO : 12 mg/mL (50.68 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
Mass value Mass unit	Concentration value Concentration unit	Volume value Volume unit	Molecular weight (g/mol)

Dilution Calculator Molecular Weight Calculator

In vivo batch selection In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg

Average weight of animals: g

Dosing volume per animal: μL

Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO

% Tween 80

% ddH₂O

% DMSO

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight	236.74	Formula	C₁₃H₁₆N₂.HCl	Storage (From the date of receipt)	3 years-20°Cpowder
CAS No.	522-48-5	Download SDF		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	Tetryzoline HCl			Smiles	C1CC(C2=CC=CC=C2C1)C3=NCCN3.Cl

Mechanism of Action

Features	Tetrahydrozoline HCl is an alpha receptor agonist.
Targets/IC₅₀/Ki	α-adrenergic receptor
In vitro	Tetrahydrozoline HCl is an imidazoline derivative with alpha receptor agonist activity. Its main mechanism of action is the constriction of conjunctival blood vessels.
In vivo	Tetrahydrozoline HCl inhibits settlement of the Barnacle Balanus improvisus at 1μM.
References	[1] http://www.ncbi.nlm.nih.gov/pubmed/?term=18259967 [2] http://www.ncbi.nlm.nih.gov/pubmed/?term=15945078

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