Catalog No.S5787 Synonyms: SR33589
Molecular Weight(MW): 556.76
Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).
Purity & Quality Control
|Description||Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).|
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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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Clinical Trial Information
|NCT Number||Recruitment||interventions||Conditions||Sponsor/Collaborators||Start Date||Phases|
|NCT01430806||Unknown status||Drug: Dronedarone arm|Drug: Dronedarone||ICD|ICD SHOCKS|DRONEDARONE||Rabin Medical Center||October 2011||Not Applicable|
|NCT01266681||Unknown status||Drug: amiodarone|Drug: Dronedarone||Atrial Fibrillation||Eastbourne General Hospital||March 2011||Not Applicable|
|NCT01199081||Completed||Drug: Dronedarone||Atrial Fibrillation||Sanofi||October 2010||Phase 4|
|NCT01213368||Completed||Drug: DRONEDARONE (SR33589)|Drug: placebo||Atrial Fibrillation||Sanofi||September 2010||Phase 2|
|NCT01140581||Completed||Drug: DRONEDARONE||Atrial Fibrillation||Sanofi||September 2010||Phase 4|
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