Dronedarone

Catalog No.S5787 Synonyms: SR33589

Dronedarone Chemical Structure

Molecular Weight(MW): 556.76

Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).

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Biological Activity

Description Dronedarone is a derivative of amiodarone which is classified as a Class III antiarrhythmic agent. It shows rate-dependent inhibition of the rapid Na+ current, inhibits α and β-adrenergic receptors like Class II agents, exhibits blockade of K+ outward currents as the main mechanism of action of Class III, and effectively block slow Ca2+ inward currents (Class IV).

Protocol

References

Solubility (25°C)

Chemical Information

Molecular Weight 556.76
Formula

C31H44N2O5S

CAS No. 141626-36-0
Storage powder
in solvent
Synonyms SR33589

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01522651 Completed Atrial Fibrillation Gilead Sciences January 2012 Phase 2
NCT01522651 Completed Atrial Fibrillation Gilead Sciences January 2012 Phase 2
NCT01430806 Unknown status ICD|ICD SHOCKS|DRONEDARONE Rabin Medical Center October 2011 Not Applicable
NCT01430806 Unknown status ICD|ICD SHOCKS|DRONEDARONE Rabin Medical Center October 2011 Not Applicable
NCT01991119 Completed Atrial Fibrillation Samsung Medical Center May 2011 Not Applicable
NCT01991119 Completed Atrial Fibrillation Samsung Medical Center May 2011 Not Applicable

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID