Isoprenaline HCl
Catalog No.S2566 Synonyms: NCI-c55630
Molecular Weight(MW): 247.72
Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
Purity & Quality Control
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Biological Activity
| Description | Isoprenaline is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block. | |
|---|---|---|
| Targets |
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| In vitro |
Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells. [1] Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity. [2] Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO). [3] Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged. [4] Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells. [5] |
Protocol
Solubility (25°C)
| In vitro | DMSO | 50 mg/mL (201.84 mM) |
|---|---|---|
| Water | 50 mg/mL (201.84 mM) | |
| Ethanol | Insoluble |
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Chemical Information
| Molecular Weight | 247.72 |
|---|---|
| Formula | C11H17NO3.HCl |
| CAS No. | 51-30-9 |
| Storage | powder |
| in solvent | |
| Synonyms | NCI-c55630 |
Bio Calculators
Molarity Calculator
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Dilution Calculator
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This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )
* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).
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