Isoprenaline (NCI-C55630) HCl

Catalog No.S2566

For research use only.

Isoprenaline HCl (NCI-C55630) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.

Isoprenaline (NCI-C55630) HCl Chemical Structure

CAS No. 51-30-9

Selleck's Isoprenaline (NCI-C55630) HCl has been cited by 2 Publications

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Biological Activity

Description Isoprenaline HCl (NCI-C55630) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.
Targets
β-adrenergic receptor [1]
In vitro

Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells. [1] Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity. [2] Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO). [3] Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged. [4] Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells. [5]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 50 mg/mL
(201.84 mM)
Water 50 mg/mL
(201.84 mM)
Ethanol Insoluble

Chemical Information

Molecular Weight 247.72
Formula

C11H17NO3.HCl

CAS No. 51-30-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04303689 Active not recruiting Drug: Colchicine Tablets|Drug: Placebo Essential Hypertension University of Copenhagen|University of Aarhus August 1 2020 Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-01-17)

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