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Isoprenaline (NCI-C55630) HCl

Name: Isoprenaline (NCI-C55630) HCl
Brand: Selleck Chemicals
SKU: S2566
Rating: 5 (3 reviews)

Catalog No.S2566 Synonyms: NCI-c55630,Isoproterenol hydrochloride

For research use only.

Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.

Isoprenaline (NCI-C55630) HCl Chemical Structure

CAS No. 51-30-9

Selleck's Isoprenaline (NCI-C55630) HCl has been cited by 3 Publications

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Biological Activity

Description

Isoprenaline HCl (NCI-c55630,Isoproterenol hydrochloride) is a non-selective beta-adrenergic receptor agonist, used for the treatment of bradycardia and heart block.

Targets

β-adrenergic receptor ^[1]

In vitro

Isoprenaline (300 nM, 3 min) increases particulate cGMP- and cilostamide-inhibited, low-Km cAMP phosphodiesterase (cAMP-PDE) activity by about 100% in intact rat fat cells. ^[1] Isoprenaline inhibits insulin-stimulated glucose transport activity in rat adipocytes. Isoprenaline, in the absence of adenosine, promotes a time-dependent (t1/2 approximately 2 min) decrease in the accessibility of insulin-stimulated cell surface GLUT4 of > 50%, which directly correlated with the observed inhibition of transport activity. ^[2] Isoprenaline (5 nM and 10 mM) increases cyclic AMP levels and this effect is potentiated by cilostamide (10 mM), by rolipram, a cyclic AMP-specific PDE (PDE 4) inhibitor (10 mM) and by cyclic GMP-elevating agents (50 nM ANF or 30 nM SNP plus 100 nM DMPPO). ^[3] Isoprenaline increases the transcriptional activity of Gi alpha-2 gene to 140% of the control value, whereas gene specific hybridization for Gs alpha remains unchanged. ^[4] Isoprenaline (20 nM) increases the amplitude of total iK and causes a negative shift of approximately 10 mV in the activation curve for iK, both in the absence and in the presence of 300 nM nisoldipine to block the L-type Ca2+ current. Isoprenaline (20 nM) increases the spontaneous pacemaker rate of sino-atrial node pacemaker cells by 16% in rabbit isolated pacemaker cells. ^[5]

Protocol (from reference)

References

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Solubility (25°C)

In vitro

Chemical Information

Molecular Weight	247.72
Formula	C₁₁H₁₇NO₃.HCl
CAS No.	51-30-9
Storage	3 years	-20°C	powder
Storage	2 years	-80°C	in solvent
Smiles	CC(C)NCC(C1=CC(=C(C=C1)O)O)O.Cl

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Clinical Trial Information

NCT Number	Recruitment	Interventions	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04303689	Active not recruiting	Drug: Colchicine Tablets\|Drug: Placebo	Essential Hypertension	University of Copenhagen\|University of Aarhus	August 1 2020	Not Applicable

(data from https://clinicaltrials.gov, updated on 2022-08-01)

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