Prazosin

Catalog No.S5780

Prazosin Chemical Structure

Molecular Weight(MW): 383.40

Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.

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Biological Activity

Description Prazosin is an α1-blocker that acts as an inverse agonist at alpha-1 adrenergic receptors. It is used to treat hypertension.
Targets
α1-adrenergic receptor [1]
()

Protocol

Animal Research:

[1]

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  • Animal Models: Sprague-Dawley rats
  • Formulation: 0.9% NaCl saline
  • Dosages: 10 mg/kg/day
  • Administration: via oral gavage
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 77 mg/mL (200.83 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 383.40
Formula

C19H21N5O4

CAS No. 19216-56-9
Storage powder
in solvent
Synonyms N/A

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Clinical Trial Information

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT03710642 Recruiting Alzheimer''s Disease|Disruptive Behavior Alzheimer''s Disease Cooperative Study (ADCS)|National Institute on Aging (NIA)|VA Puget Sound Health Care System March 30 2019 Phase 2
NCT03710642 Recruiting Alzheimer''s Disease|Disruptive Behavior Alzheimer''s Disease Cooperative Study (ADCS)|National Institute on Aging (NIA)|VA Puget Sound Health Care System March 30 2019 Phase 2
NCT03539614 Recruiting Posttraumatic Stress Disorder VA Office of Research and Development June 4 2018 Phase 3
NCT03539614 Recruiting Posttraumatic Stress Disorder VA Office of Research and Development June 4 2018 Phase 3
NCT03010995 Withdrawn Cigarette Smoking Toxicity|Nicotine|Acute Cardiovascular Disease University of Louisville March 13 2018 Phase 1
NCT03416569 Withdrawn no Condition Basic Science University of Maryland March 2018 Not Applicable

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Adrenergic Receptor Signaling Pathway Map

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