Ivabradine HCl

For research use only.

Catalog No.S2086 Synonyms: S 16257-2

1 publication

Ivabradine HCl Chemical Structure

CAS No. 148849-67-6

Ivabradine HCl (S 16257-2), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

Size Price Stock Quantity  
10mM (1mL in DMSO) EUR 216 In stock
EUR 58 In stock
EUR 363 In stock
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Selleck's Ivabradine HCl has been cited by 1 publication

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Biological Activity

Description Ivabradine HCl (S 16257-2), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
Targets
Adrenergic Receptor [1]

Protocol

Solubility (25°C)

In vitro DMSO 101 mg/mL (199.98 mM)
Water 82 mg/mL (162.36 mM)
Ethanol '101 mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 505.05
Formula

C27H36N2O5.HCl

CAS No. 148849-67-6
Storage powder
in solvent
Synonyms S 16257-2
Smiles CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl

In vivo Formulation Calculator (Clear solution)

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Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and MSDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

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* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and MSDS / COA (available online).

The Serial Dilution Calculator Equation

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Molecular Weight Calculator

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Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04436016 Not yet recruiting Drug: Ivabradine|Drug: Placebo Myocardial Injury|Myocardial Ischemia University Hospital Geneva September 2020 Phase 4
NCT04031573 Not yet recruiting Drug: Ivabradine|Drug: Placebo Septic Shock Assistance Publique - Hôpitaux de Paris September 1 2020 Phase 3
NCT04405804 Not yet recruiting Drug: Ivabradine 5Mg Tab Acute Heart Failure|Dilated Cardiomyopathy Bambino Gesù Hospital and Research Institute|Ministero della Salute Italy May 2020 Phase 2
NCT04164004 Not yet recruiting Other: Kansas City Cardiomyopathy Questionnaire-12 Heart Failure Stanford University May 1 2020 Not Applicable
NCT03137537 Recruiting Drug: Ivabradine|Drug: Placebo Oral Tablet Lymphoma|Autonomic Imbalance|Cancer Survivorship Dana-Farber Cancer Institute|Amgen February 27 2018 Phase 2

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Adrenergic Receptor Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID