For research use only.

Catalog No.S2086 Synonyms: S 16257-2

1 publication

CAS No. 148849-67-6

Ivabradine HCl (S 16257-2), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

### Biological Activity

Description Ivabradine HCl (S 16257-2), a new If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
Targets

### Solubility (25°C)

 In vitro DMSO 101 mg/mL (199.98 mM) Ethanol 101 mg/mL (199.98 mM) Water 82 mg/mL (162.36 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Molecular Weight 505.05 C27H36N2O5.HCl 148849-67-6 3 years-20°C powder 2 years-80°C in solvent S 16257-2 CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)CC3CC4=CC(=C(C=C34)OC)OC.Cl

### In vivo Formulation Calculator (Clear solution)

 Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.) % DMSO+ % PEG300 Corn oil + % Tween 80+ % ddH2O CalculateReset

### Bio Calculators

Molarity Calculator

## Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

### Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

• Mass
Concentration
Volume
Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

## Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

### Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

• C1
V1
C2
V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

## The Serial Dilution Calculator Equation

• ### Computed Result

• C1=C0/X C2=C1/X C1: LOG(C1): C2: LOG(C2): C3: LOG(C3): C4: LOG(C4): C5: LOG(C5): C6: LOG(C6): C7: LOG(C7): C8: LOG(C8):
Molecular Weight Calculator

## Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

### Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

#### Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

#### Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

#### Molarity Calculator

 Mass Concentration Volume Molecular Weight pg ng μg mg g kg = fM pM nM μM mM M × nL μL mL L ×

### Clinical Trial Information(data from https://clinicaltrials.gov, updated on 2021-09-06)

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04031573 Recruiting Drug: Ivabradine|Drug: Placebo Septic Shock Assistance Publique - Hôpitaux de Paris February 24 2021 Phase 3
NCT04436016 Recruiting Drug: Ivabradine|Drug: Placebo Myocardial Injury|Myocardial Ischemia University Hospital Geneva October 5 2020 Phase 4
NCT04405804 Enrolling by invitation Drug: Ivabradine 5Mg Tab Acute Heart Failure|Dilated Cardiomyopathy Bambino Gesù Hospital and Research Institute|Ministero della Salute Italy June 20 2020 Phase 2
NCT04164004 Not yet recruiting Other: Kansas City Cardiomyopathy Questionnaire-12 Heart Failure Stanford University May 1 2020 Not Applicable
NCT03137537 Terminated Drug: Ivabradine|Drug: Placebo Oral Tablet Lymphoma|Autonomic Imbalance|Cancer Survivorship Dana-Farber Cancer Institute|Amgen February 27 2018 Phase 2

### Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Tel: +1-832-582-8158 Ext:3