Hydroxytyrosol Acetate

Catalog No.S3848 Batch:S384801

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Technical Data

Formula

C10H12O4
Molecular Weight 196.20 CAS No. 69039-02-7
Solubility (25°C)* In vitro DMSO 39 mg/mL (198.77 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Hydroxytyrosol acetate (HTy-Ac), an extra virgin olive oil (EVOO) polyphenol, exhibits antioxidant and anti-inflammatory effects.
In vitro Hydroxytyrosol acetate significantly preventes t-BHP-induced OPA1 cleavage as well as the induction of Afg3l2. The significant morphology change in mitochondria induced by t-BHP is also normalized by Hydroxytyrosol acetate. Analysis of mitochondrial function reveals significant protection by hydroxytyrosol acetate on mitochondrial basal, maximal, spare respiration and complex activities. Hydroxytyrosol acetate works as an effective nutrient preventing OPA1 cleavage, mitochondrial dysfunction and muscle cell degeneration[2].
In vivo Hydroxytyrosol acetate administered orally inhibits platelet aggregation in rats and that a decrease in thromboxane synthesis along with an increase in nitric oxide production contribute to this effect[1].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    C2C12 cell

  • Concentrations

    1, 10 and 50 μM

  • Incubation Time

    24 h

  • Method

    C2C12 myotubes are treated with Hydroxytyrosol acetate at doses of 1, 10 and 50 μM for 24 h, followed by 100 μM t-BHP for an additional 24 h. The protective effects of Hydroxytyrosol acetate on mitochondrial membrane potential and cell viability are analyzed.

Animal Study:[1]
  • Animal Models

    Male Wistar rats

  • Dosages

    1, 5, 10, 20, 50, and 100 mg/kg per day

  • Administration

    p.o.

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.