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Gadodiamide Hydrate

Cat.No.S1751

Gadodiamide Hydrate, a nonionic Gd3+ chelate, is frequently injected i.v. into magnetic resonance imaging (MRI) to enhance contrast.
Gadodiamide Hydrate Chemical Structure

Chemical Structure

Molecular Weight: 591.67

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Chemical Information, Storage & Stability

Molecular Weight 591.67 Formula

C16H28GdN5O9C16H28GdN5O9.xH2O

 Storage (From the date of receipt)
CAS No. 122795-43-1 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles CNC(=O)CN(CCN(CCN(CC(=O)NC)CC(=O)[O-])CC(=O)[O-])CC(=O)[O-].O.[Gd+3]

Solubility

In vitro
Batch:

Water : 100 mg/mL

DMSO : Insoluble
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

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% DMSO
%
% Tween 80
% ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

In vivo
Gadodiamide results in half-life of 18, 38, and 75 minutes in rats, rabbits, and monkeys, respectively. Gadodiamide is shown to be excreted rapidly, primarily through the kidneys. [1] Gadodiamide, when administered i.v. as gadodiamide injection at a dosage of 0.3 mmol/kg, is stable in vivo and that the very major part of the dose (> 99%) is excreted in urine as an unchanged complex. [2] Gadodiamide produces focal and generalized myoclonus over several hours. Gadodiamide itself produces lesions in the central cerebellar regions resembling in character and severity those produced by the gadodiamide formulation, but not others. [3] Gadodiamide travels quickly throughout the ventricular system from the lateral ventricular site of injection to the fourth ventricle and foramina of Luschka and Magendie within 2 min. [4] Gadodiamide results in transient but statistically significant decreases in aortic pressure, left ventricular pressure, indices of left ventricular contractility and relaxation, and systemic and pulmonary vascular resistance, and increases in aortic blood flow in anesthetized dogs. Gadodiamide injection produces less severe alterations in hemodynamics than gadopentetate dimeglumine. [5]
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/10218810/
  • [5] https://pubmed.ncbi.nlm.nih.gov/8369191/

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