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Inulin

Cat.No.S2609

Inulin(Inulin and sodium chloride), a starch found in the tubers and roots of many plants. Since it is hydrolyzable to fructose, this compound is classified as a fructosan.
Inulin Chemical Structure

Chemical Structure

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Chemical Information, Storage & Stability

Molecular Weight Formula

C6nH10n+2O5n+1

 Storage (From the date of receipt)
CAS No. 9005-80-5 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles OCC1OC(OC2(CO)OC(CO)C(O)C2O)C(O)C(O)C1O

Mechanism of Action

In vitro
Inulin causes (20 g/d and 40 g/d) a significant increase in bifidobacterial counts in feces. This compound exerts a preferential stimulatory effect on numbers of the health-promoting genus Bifidobacterium, whilst maintaining populations of potential pathogens (Escherichia coli, Clostridium) at relatively low levels. It combined with Bifidobacterium results in more potent inhibition of aberrant crypt foci (ACF) than administration of the two separately, achieving 80% inhibition of small ACF. This substance is made by a set of linear chains of fructose molecules, with a degree of polymerization (DP) ranging between 3 and 65, it can be fractionated into a slowly fermentable long-chain fraction (DP ranging from 10 to 65, average 25) or in a rapidly fermentable fraction made of oligofructose (DP ranging from 3 to 8, average 4). Long-chain inulin combined with short-chain oligofructose results in larger numbers of caecal, colonic and faecal bacteria of the Clostridium coccoides-Eubacterium rectale cluster than Control in rats, whereas OF alone does not affect this bacterial group in caecum, colon or faeces.
In vivo
Inulin results in an increase in caecal wt and beta-glucosidase activity and a decrease in caecal pH were observed in rats given this compound-containing diets (with or without B. longum).
References
  • [4] https://pubmed.ncbi.nlm.nih.gov/12419846/
  • [5] https://pubmed.ncbi.nlm.nih.gov/11502244/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05254340 Active not recruiting
Healthy
Indiana University|National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
 August 1 2021 Not Applicable

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