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Potassium Iodide

Cat.No.S1897

Potassium Iodide is used to treat overactive thyroid and to protect the thyroid gland from the effects of radiation from inhaled or swallowed radioactive iodine.
Potassium Iodide Chemical Structure

Chemical Structure

Molecular Weight: 166

Jump to Mechanism of Action Chemical Information, Storage & Stability

Chemical Information, Storage & Stability

Molecular Weight 166 Formula

K+I-

 Storage (From the date of receipt)
CAS No. 7681-11-0 Download SDF Storage of Stock Solutions

Synonyms N/A Smiles [K+].[I-]

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
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Mechanism of Action

In vitro
Iodine induces abnormal morphologic changes of cells, inhibited cell proliferation, and increases apoptosis rate in rat aorta endothelial cells. Iodine also reduces the activity of SOD, GSH-Px, and concentrations of GSH and increases the concentrations of MDA and protein carbonyl in a dose-dependent manner. Excess iodine decreased the activity of eNOS and increased the activity of iNOS and the expression of ICAM-1 and VCAM-1 in culture medium. Excess iodine exposure increases oxidative stress, causes damage of vascular endothelial cells, and altered the expression of adhesion factors and the activity of NOS. [1] Potassium iodide increases avidity of some immune reactions including C-mediated cell lysis mediated by altered access of C-binding receptors. [2] Potassium iodide (≥50 mM) increases lipid peroxidation in concentration-dependent manner. Potassium iodide (25 mM) reduces Fenton reaction-induced lipid peroxidation. [3] Potassium iodide is able to eliminate E faecalis from bovine root dentin when used with a 15-minute contact time. [4]
In vivo
Potassium Iodide decreases Schiff's bases (SB) concentrations in liver and lung homogenates after the administration of PTU but, unexpectedly, the level of SB increases in kidney homogenates of Wistar rats. [5]
References
  • https://pubmed.ncbi.nlm.nih.gov/15356477/
  • https://pubmed.ncbi.nlm.nih.gov/17159816/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT01301768 Withdrawn
Dietary Intervention|Pregnancy Jail|Iodine Deficiency
Fundacio d''Investigacio en Atencio Primaria Jordi Gol i Gurina
 November 2008 Not Applicable
NCT00379535 Terminated
Pregnancy
University Hospital Toulouse|Ministry of Health France
 December 2006 Phase 3

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