Dimesna

Catalog No.S1201 Synonyms: BNP-7787

For research use only.

Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.

Dimesna Chemical Structure

CAS No. 16208-51-8

Purity & Quality Control

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Biological Activity

Description Dimesna (BNP-7787) is an uroprotective agent used to decrease urotoxicity.
In vitro

Dimesna modulates paclitaxel-induced hyperpolymerization of MTP in a dose-dependent manner, and mesna, an in vivo metabolite of Dimesna, protects against time-dependent cisplatin-induced inactivation of MTP. [1] Dimesna -mediated prevention or mitigation of cisplatin-induced nephrotoxicity may involve aminopeptidase N (APN) inhibition by certain Dimesna -derived esna-disulfide heteroconjugates and appears correlated to the presence of a glycinate moiety and/or an anionic group. Two general mechanisms for Dimesna -mediated nephroprotection of cisplatin-induced nephrotoxicity involving the gamma-glutamyl transpeptidase (GGT), APN and cysteine-conjugated-β-lyase (CCBL) nephrotoxigenic pathway are proposed which acting in a concerted and/or synergistic manner, and thereby prevent or mitigate cisplatin-induced renal toxicity. [2] Mesna and its dimer, Dimesna, are coadministered for mitigation of ifosfamide- and cisplatin-induced toxicities, respectively. Dimesna is selectively reduced to mesna in the kidney, producing its protective effects. In vitro screens of uptake and efflux transporters reveal renal organic anion transporters OAT1, OAT3, and OAT4 are responsible for kidney-specific uptake of Dimesna. Uptake of Dimesna by OAT1, OAT3, and OAT4 is determined to be saturable with KM of 636 μM, 390 μM and 590 μM, respectively. [3]

In vivo Tumors of urinary bladder induced by cyclophosphamide (CP) in rats can be significantly reduced by Dimesna administration in a dose-related manner. [4]

Protocol (from reference)

Animal Research:[4]
  • Animal Models: CP treated Sprague-Dawley rats
  • Dosages: 12 or 35 mg/kg
  • Administration: Orally five times a week

Solubility (25°C)

In vitro

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
Saline
For best results, use promptly after mixing.

30 mg/mL

Chemical Information

Molecular Weight 326.34
Formula

C4H8Na2O6S4

CAS No. 16208-51-8
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C(CS(=O)(=O)[O-])SSCCS(=O)(=O)[O-].[Na+].[Na+]

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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