4-Methylumbelliferone (4-MU)

Catalog No.S2256

For research use only.

4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.

4-Methylumbelliferone (4-MU) Chemical Structure

CAS No. 90-33-5

Selleck's 4-Methylumbelliferone (4-MU) has been cited by 4 Publications

Purity & Quality Control

Related Other Products

Biological Activity

Description 4-Methylumbelliferone is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM.
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
COS1 cells NGjP[YhHfW6ldHnvckBie3OjeR?= M3zP[WFod26rc4TpZ{Bi[3Srdnn0fUB4[XNiZHX0[ZJucW6nZDDpckBEV1NzIHPlcIx{KHS{YX7z[oVkfGWmIIfpeIghT0GOIEStVHBCWiCpYX3tZUBz\WOncITvdkwhTUN3ME2wMlAzOSEQvF2= NEDud48yOjZzN{myOC=>
CV-1 cells M2rr[mZ2dmO2aX;uJIF{e2G7 NXTYdJVoVWG6aX3hcEBz\XCxcoTldkBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIGDldo95cXOxbXWgdJJwdGmoZYLheI9zKGGldHn2ZZRm\CC{ZXPldJRweiCpYX3tZUBI[Wx2IHPobY1memmlIHnuJJRz[W6|aXXueIx6KHS{YX7z[oVkfGWmIFPWMVEh[2WubIOgZpkh\nWwY4Tpc45idCCjc4PhfUwhTUN3ME2wMlA1OyEQvF2= MYmxNVczODh3NB?=
COS-1 cells NEnjZXpHfW6ldHnvckBie3OjeR?= NHn6WVJKdiC4aYTyc{B1emGwc3HjeIl3[XSrb36gc4YhcHWvYX6gdIVzd3irc3;t[UBxem:uaX\ldoF1d3JiYXP0bZZifGWmIILlZ4VxfG:{IHfhcY1iKG2nYYP1doVlKGmwIGDQRXIuT0GONDDjbIlu\XKrYzDDU3MuOSClZXzsd{whTUN3ME2wMlAzKM7:TR?= NEW3ZnkyOjh5M{WxOy=>
CV-1 cells MVHGeY5kfGmxbjDhd5NigQ>? NVjjOYZySWO2aY\heIlwdiCxZjDw[ZJwgGm|b33lJJBzd2yrZnXyZZRweiCjY4TpeoF1\WRicnXj[ZB1d3JiZ3HtcYEhdWWjc4Xy[YQh[nliaX7keYN1cW:wIH;mJFUxLSCxZjDtZZhqdXWvIHHsb4FtcW6nIIDoc5NxcGG2YYPlJIFkfGm4aYT5MEB1emGwc3\lZ5Rqd25iYYPzZZkhcW5iQ2[tNUBk\WyuczygSWM2OD1yLkC4PVE{KM7:TR?= M4\SS|k5OzZ4MkC=
CV-1 cells MYDGeY5kfGmxbjDhd5NigQ>? M{Gxd2lvKH[rdILvJJRz[W6|Y4LpdJRqd26jbDDhZ5RqfmG2aX;uJI9nKFCncn;4bZNwdWVicILvcIln\XKjdH;yJIFkfGm4YYTl[EBz\WOncITvdkBo[W2vYTCoVHBCWiliZYjwdoV{e2WmIHnuJGNXNTFiY3XscJMtKEWFNUC9NE4xPiEQvF2= NGfsUFQ5PTd4OUC3
COS-1 cells Ml3MSpVv[3Srb36gZZN{[Xl? NX\2UWJxUW5idnn0do8h[WexbnnzeEBi[3Srdnn0fUB1\XO2ZXSg[o9zKHS{YX7zZYN1cX[jdHnvckBqdiCqdX3hckBRWEGUIHfhcY1iNUejbESgZ4hqdWW{aXOgR29UNTFiY3XscJMtKEWFNUC9NE4xOiEQvF2= MYKxNlczQTZ4OB?=
CV-1 cells MV3GeY5kfGmxbjDhd5NigQ>? NXfTbVR2UW5idnn0do8h\X[jbIXheIlwdiCjZ3HpcpN1KFK[Uj3hcJBp[S:SUFHSMYdidW2jIHnuJGNXNTFiY3XscJMh[nliY3;0doFve2[nY4Tpc44h[XO|YYmge4F{KGSndHXycYlv\WRuIFXDOVA:OC5|MkWg{txO MYqxNlk2PDB4MR?=
HepG2 cells MX\GeY5kfGmxbjDhd5NigQ>? Ml;oSYZn\WO2aY\lJINwdmOnboTyZZRqd25iYXfhbY5{fCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIFjldGczKGOnbHzzMEBGSzVyPUCuNFM6KM7:TR?= MV:xOlExPzF3MB?=
Huh7 cells MXPGeY5kfGmxbjDhd5NigQ>? MmDCSpVv[3Srb37hcEBi[3Srdnn0fUBifCCqdX3hckBRWEGUIHfhcY1iKGmwIFj1bFch[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMkKg{txO NFn2WmEyPjN4Nk[wNS=>
Huh7 cells M33yOmZ2dmO2aX;uJIF{e2G7 MYrF[oZm[3Rib36gVHBCWiCpYX3tZUB1emGwc3HjeIl3[XSrb36gZYN1cX[rdImgbY4hUHWqNzDj[YxteyxiRVO1NF0xNjJ{IN88US=> MYexOlQ2OTB6Nx?=
U2OS cells M4XMTGZ2dmO2aX;uJIF{e2G7 MWHF[oZm[3Rib36gVHBCWmejbX3hJJRz[W6|YXP0bZZifGmxbjDhZ5Rqfmm2eTDpckBWOk:VIHPlcIx{NCCHQ{WwQVAvODNizszN NFq5R2kyPjNyMEm0OC=>
CV1 cells M2Ple2Z2dmO2aX;uJIF{e2G7 M4\oenRz[W6|YXP0bZZifGmxbjDv[kBRWEGUZ3HtcYEhcW5iQ2[xJINmdGy|LDDFR|UxRTBwMEe2JO69VQ>? NX;HOJNOOTZ6MkG3Olk>
human keratinocytes M3H1VnBzd2yrZnXyZZRqd25iYYPzZZk> M4K1XmFvfGmycn;sbYZmemG2aY\lJIFkfGm4aYT5JIFo[Wmwc4SgbJVu[W5ia3XyZZRqdm:leYTld{whTUN3ME24JO69VQ>? NUDFdlM{OTZ6MkG3Olk>
HT29 cell NIHOOG5Rem:uaX\ldoF1cW:wIHHzd4F6 NHzhSplCdnSrcILvcIln\XKjdHn2[UBi[3Srdnn0fUBi\2GrboP0JIh2dWGwIFjUNlkh[2WubDDsbY5mNCCHQ{WwQVQ2KM7:TR?= NHjscpgyPjh{MUe2PS=>
NIH3T3 cells NWrJN2ZJTnWwY4Tpc44h[XO|YYm= NHnnVohC[3Srdnn0fUBifCCqdX3hckBRWEGUIHfhcY1iKHS{YX7z[oVkfGWmIHnuJG5KUDOWMzDj[YxteyCkeTDseYNq\mW{YYPlJIFkfGm4aYT5JIF{e2G7LDDFR|UxRTBwM{Kg{txO M4flWFE3QDV2MEi1
CV1 cells NUm5SFB3TnWwY4Tpc44h[XO|YYm= NHHTTo5VemGwc3HjeIl3[XSrb36gc4YhcHWvYX6gVHBCWmejbX3hJIlvKEOYMTDj[YxteyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4{ODhizszN MUSxOlk4ODN7MR?=
Huh7 cells M4XjXGZ2dmO2aX;uJIF{e2G7 NFvmdllC[3Srdnn0fUBifCCqdX3hckBRWEGUIHfhcY1iKGmwIFj1bFch[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMkKg{txO NHq3cJkyPzB|NEG0PS=>
HepG2 cells MmnMSpVv[3Srb36gZZN{[Xl? Ml7WRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFTKGejbX3hJIlvKGFiSHXwS|Ih[2WubIOgZpkhWFCDUj3HRWw1KHS{YX7zZYN1cX[jdHnvckBie3OjeTygSWM2OD1yLkG1PEDPxE1? NFvHd5oyPjl5M{O1PC=>
HepG2 cells NVjnOYZXTnWwY4Tpc44h[XO|YYm= M1nhUWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWiCpYX3tZUBqdiCKZYDHNkBk\WyuczDifUBRWEGULVfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMUW4{txO NEHnRVUyPjl5OUO0NS=>
CV1 cells NX3kW3ZKTnWwY4Tpc44h[XO|YYm= MmraRYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIlvKEOYMTDj[YxteyxiRVO1NF0xNjNyODFOwG0> M{TYW|E4ODB3M{m0
HEK293 cells MlzhSpVv[3Srb36gZZN{[Xl? MkWwRYN1cX[rdImgZZQhcHWvYX6gZYRqeG:|ZTD0bZN{fWViUGDBVkBo[W2vYTDlfJBz\XO|ZXSgbY4hUEWNMkmzJINmdGy|IHL5JHBRSVJvR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5|MTFOwG0> NFfPeJAyPzN2M{O3NS=>
rat L6 cells NXOxOXJSTnWwY4Tpc44h[XO|YYm= MVLF[oZm[3Rib36g[oF1fHliYXPp[EBwgGmmYYTpc44hcW5icnH0JGw3KGOnbHzzMEBGSzVyPUWg{txO Mlq3NVc{PDN|N{G=
HepG2 cells MofLSpVv[3Srb36gZZN{[Xl? M3zTfmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIlvKEincFeyJINmdGy|IHL5JHBRSVJvR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5yOEKg{txO MlS4NVcyPTdyMUm=
CV1 cells MWPGeY5kfGmxbjDhd5NigQ>? MV\B[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIGDQRXJidHCqYTDpckBEXjFiY3XscJMh[nliR1HMOEB1emGwc3HjeIl3[XSrb36gZZN{[XliYX\0[ZIhOjRiaILzMEBGSzVyPUOuOFYh|ryP M1\3[FE4PTB5MkK1
CV1 cells MVfGeY5kfGmxbjDhd5NigQ>? M13VWmFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJIlvKEOYMTDj[YxteyCkeTDHRWw1KHS{YX7zZYN1cX[jdHnvckBie3OjeTDh[pRmeiB{NDDodpMtKEWFNUC9NE4xOyEQvF2= MXOxO|UxPzJ{NR?=
CV1 cells NETkXVdHfW6ldHnvckBie3OjeR?= NI[1S3RC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iQ2[xJINmdGy|IHL5JJJm[2WydH;yJJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjNyODFOwG0> M322eFE5ODJ7MUe4
CV1 cells M4[yXmZ2dmO2aX;uJIF{e2G7 Mo\JRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhcW5iQ2[xJINmdGy|IHL5JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjNyODFOwG0> NXTkSIIyOTdzMkm3NlU>
HEK293 cells NVTXdWJqTnWwY4Tpc44h[XO|YYm= NIPPXnBC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SC{ZXPldJRweiCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IFfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMEO1JO69VQ>? M{G4S|E4Ojl{NkC2
NIH3T3 cells MVzGeY5kfGmxbjDhd5NigQ>? NXPjc3FjSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIF7JTFNVOyClZXzsd{BjgSCJQVy0JJRz[W6|YXP0bZZifGmxbjDhd5NigSxiRVO1NF0xNjN{IN88US=> MX:xO|YzPDd5Nx?=
HEK293 cells M33tV2Z2dmO2aX;uJIF{e2G7 NGi2PGVC\2:waYP0JIFkfGm4aYT5JIF1KFCSQWLnZY1u[SCneIDy[ZN{\WRiaX6gTGVMOjl|IHPlcIx{KGK7IFfBUFQhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMUmg{txO M4nvc|E5ODJ7MUe2
HEK293 cells MXLGeY5kfGmxbjDhd5NigQ>? NWjB[|lDSWexbnnzeEBi[3Srdnn0fUBifCCSUFHS[4FudWFiZYjwdoV{e2WmIHnuJGhGUzJ7MzDj[YxteyCjc4Pld5Nm\CCjczDhVFIh\2WwZTDpcoR2[3Srb36sJGVEPTB;MD6xNkDPxE1? MlrINVgxOjlzN{[=
HEK293 cells MYDGeY5kfGmxbjDhd5NigQ>? MVTB[49vcXO2IHHjeIl3cXS7IHH0JHBRSVKpYX3tZUBqdiCKRVuyPVMh[2WubIOgZpkhT0GONDD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xPDVizszN NI\kS2kyQDJ7MU[0OS=>
HepG2 cells MVjGeY5kfGmxbjDhd5NigQ>? MmfCRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT[WyyaHGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDjc{11emGwc3\lZ5Rm\CC5aYToJGdidDRiYomgcJVkcW[ncnHz[UBz\XCxcoTldkBo\W6nIHHzd4F6NCCHQ{WwQVAvODN7IN88US=> MkC4NVg5OzV5MUm=
RAW264.7 cells M{\LRWZ2dmO2aX;uJIF{e2G7 M1zFbnN2eHC{ZYPzbY9vKG:oIFzQV{9KTk5vZ3HtcYEue3SrbYXsZZRm\CCQTzDwdo9lfWO2aX;uJIlvKG2xdYPlJHJCXzJ4ND63JINmdGy|LDDFR|UxRTF5LkWg{txO NFfCWFUyQDhyOUOyOS=>
BL21 cells NFiwfmlHfW6ldHnvckBie3OjeR?= M3S2SGRqe3CuYXPlcYVvfCCxZjDyZYRqdyCuYXLlcIVlKDJqUzmtLFIu[mWwen;5cE1xcGWweXzhcYlvdylvMz37OE1cOSxzLXTpeJJqfGmxLUKtLFUudWW2aInsMVIueGinbonsMY95[XqxbD20MZltMS2ndHjvfJleNXCqZX75cJ0ueHKxcHnvcolkKGGlaXSg[pJwdSCJU2St[pV{\WRiaIXtZY4hWFCDUnfhcY1iKGW6cILld5Nm\CCrbjDFd4Np\XKrY3jpZUBkd2yrIFLMNlEh[2WubIOgZpkhe2OrboTpcIxifGmxbjDwdo95cW2rdImgZZN{[XluIFXDOVA:OC52NTFOwG0> NHzYd5IyQTN2OUG3Oi=>
BHK21 cells NFS4TGFHfW6ldHnvckBie3OjeR?= MlzERYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEKKS{KxJINmdGy|IHHzd4V{e2WmIHHzJHNGSVBiYXP0bZZqfHliYomgcJVkcW[ncnHz[UBz\XCxcoTldkB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC52NTFOwG0> MWGxPVM1QTF5Nh?=
HepG2/C3A cells NHTQdXBHfW6ldHnvckBie3OjeR?= NVTRUnRJSWO2aY\heIlwdiCxZjDoeY1idiCSUFHS[4FudWFibHnnZY5lKGKrbnTpcoch\G:vYXnuMY1m\GmjdHXkJJRz[W6|Y4LpdJRqd26jbDDhZ5Rqfmm2eTDpckBpfW2jbjDI[ZBIOi:FM1GgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDmeZNm\CCJYXy0MWxDTCCkeTDjc5Rz[W6|ZnXjeIlwdiCjc4PhfUwhTUN3ME2wMlAxOzhizszN M3LH[lE4PDB|Nki4
HepG2 cells MmCzSpVv[3Srb36gZZN{[Xl? MoKxRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIHj1cYFvKEincFeyJINmdGy|IHHzd4V{e2WmIHHzJIlv\HWldHnvckBw\iC{ZXPldJRweiC2cnHud4FkfGm4YYTpc44h[nlicnXwc5J1\XJiZ3Xu[UBie3OjeTDy[YxifGm4ZTD0c{Bkd262cn;sMEBGSzVyPUCuNFUh|ryP MlvVNVg3OjV3NUm=
COS1 cells MorVSpVv[3Srb36gZZN{[Xl? MWPB[49vcXO2IHHjeIl3cXS7IHH0JIh2dWGwIILlZ49u[mmwYX70JHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iQ1;TNUBk\WyuczDjc{1mgHC{ZYPzbY5oKEeDTESgZZN{\XO|ZXSgZZMhfHKjboPjdolxfGmxbnHsJIFkfGm4aYT5JIFnfGW{IES4JIhzeyCkeTDseYNq\mW{YYPlJJJmeG:{dHXyJIdmdmViYYPzZZktKEWFNUC9NE4xOiEQvF2= NX;YSZExOTl3MEe4OlE>
HepG2 cells NGrCOlZHfW6ldHnvckBie3OjeR?= MljLRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEincFeyJINmdGy|IHL5JGdCVDRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUCuNlI{KM7:TR?= NHjOdlkyQDN7NEmwOy=>
CV1 cells NFnCUm5HfW6ldHnvckBie3OjeR?= NHfub5dC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJIFnemmlYX6g[5Jm\W5ibX;ub4V6KEOYMTDj[YxteyClbz30doFve2[nY4Tl[EB4cXSqIH\1d4VlKEejbEStSGJFKGK7IITyZY5{[WO2aY\heIlwdiCjc4PhfUwhTUN3ME2wMlA{OyEQvF2= M4HkVlE5QDJ4MkC1
CV1 cells M4q0[WZ2dmO2aX;uJIF{e2G7 NYPDNlZlSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUYXzwbIEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBi\nKrY3HuJIdz\WWwIH3vcotmgSCFVkGgZ4VtdHNiY3:teJJidnOoZXP0[YQhf2m2aDDmeZNm\CCJYXy0MWRDTCCkeTD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9N{41PiEQvF2= M1KxSVE5QDJ4MkC1
U2OS cells M{eycWZ2dmO2aX;uJIF{e2G7 MknORYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGgbY4hXTKRUzDj[YxteyCkeTD0doFve2GldHn2ZZRqd25iYYPzZZktKEWFNUC9NE4xOiEQvF2= NITHfVUyQDN{OUe1NS=>
Hep G2 cells M1TKVWZ2dmO2aX;uJIF{e2G7 MkTMRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGgcIlo[W6mIHLpcoRqdmdiZH;tZYlvKGW6cILld5Nm\CCrbjDoeY1idiCKZYCgS|Ih[2WubIOgZ48ufHKjboPm[YN1\WRid3n0bEBI[Wx2LVTCSEBjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wOEDPxE1? NF2xR3EyQTB3M{e3Oi=>
HeLa cells M174cWZ2dmO2aX;uJIF{e2G7 M3fJVmFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKGyrZ3Hu[EBjcW6maX7nJIRwdWGrbjDlfJBz\XO|ZXSgbY4hcHWvYX6gTIVN[SClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbEStSGJFKGG|c3Xzd4VlKGG|IITyZY5{[3KrcITpc45idCCjY4TpeoF1cW:wIHL5JGdidDRicnXzdI9ve2ViZXzlcYVvfC2mcnn2[Y4hdHWlaX\ldoF{\SC{ZYDvdpRmeiCpZX7lJIF{e2G7LDDFR|UxRTBwMEG1JO69VQ>? MmK2NVkzPzV7NkO=
COS1 cells NGLJeI9HfW6ldHnvckBie3OjeR?= M1XCRWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gVHBCWmejbX3hJJJm[2WydH;yJIV5eHKnc4Pl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3MyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIgh\nW|ZXSgfYVie3RiR3HsOE1FSkRiYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvODJizszN NHjaNW4yQTV|ME[4NS=>
U2OS cells NELHdHZHfW6ldHnvckBie3OjeR?= NYSz[3lVSWexbnnzeEBi[3Srdnn0fUBifCCqdX3hckBRWEGUZ3HtcYEh\XiycnXzd4VlKGmwIGWyU3Mh[2WubIOgZpkhdHWlaX\ldoF{\SC2cnHud4FkfGm4YYTpc44h[XO|YYmsJGVEPTB;MD6wOUDPxE1? MkeyNVk2PzRyNU[=
HepG2 cells M1vqWmZ2dmO2aX;uJIF{e2G7 Mne3RYdwdmm|dDDhZ5Rqfmm2eTDheEBISUx2LYTh[4dm\CCqdX3hckBRWEGUZ3HtcYEhdGmpYX7kJIJqdmSrbneg[I9u[WmwIHX4dJJme3OnZDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bie3Onc4Pl[EBieyC{ZXPldJRweiC2cnHud4FkfGm4YYTpc44h[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5MEBGSzVyPUCuNFM6KM7:TR?= NUfJcpd3OTl5N{WxOlk>
HepG2 cells NYTJbGVbTnWwY4Tpc44h[XO|YYm= MnvFRYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGg[ZhxemW|c3XkJIlvKEincFeyJINmdGy|IHL5JGdCVDRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUCuNlI{KM7:TR?= MkDINVk4QDN2NES=
COS7 cells MojMSpVv[3Srb36gZZN{[Xl? NETPSoZC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KFCSQWLnZY1u[TJiTFLEJIV5eHKnc4Pl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3M4KGOnbHzzJINw\XiycnXzd4lv\yCJQVy0JIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5zIN88US=> M17YR|IxOTN6N{[y
COS7 cells NFXUbHlHfW6ldHnvckBie3OjeR?= NEHHfI5C\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJJJm[2:vYnnuZY51KFCSQWLnZY1u[TFiTFLEJIV5eHKnc4Pl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3M4KGOnbHzzJINw\XiycnXzd4lv\yCJQVy0JIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UB1emGwc3HjeIl3[XSrb36gZZN{[XluIFXDOVA:OC5yMzFOwG0> M{nHbVIxOTN6N{[y
HEK cells MVrGeY5kfGmxbjDhd5NigQ>? M1zuSWFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gS2FNPC22YXfn[YQhWFCDUnHsdIhiKGOqaX3ldolkKHKnY3XweI9zKGW6cILld5Nm\CCrbjDISWsh[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTFyLkW4JO69VQ>? Mn6xNlAzQTl{MUS=
HEK cells M4TNUmZ2dmO2aX;uJIF{e2G7 M2TuTGFod26rc4SgZYN1cX[rdImgZZQhcHWvYX6gS2FNPC22YXfn[YQhWFCDUnfhcY1iKGOqaX3ldolkKHKnY3XweI9zKGW6cILld5Nm\CCrbjDISWsh[2WubIOgZpkhfHKjboPhZ5RqfmG2aX;uJIF{e2G7LDDFR|UxRTBwMEO1JO69VQ>? MmrRNlAzQTl{MUS=
3T3L1 cells MVnGeY5kfGmxbjDhd5NigQ>? MYC3JIRigXN? MXfJcoR2[3Srb36gc4Yh[WSrcH;n[Y5me2m|IHnuJI1wfXOnIEPUN2wyKGOnbHzzJIF{e2W|c3XkJIF{KGmwY4LlZZNmKGmwIHzpdIllKGGlY4XteYxifGmxbjDh[pRmeiB5IHThfZMh[nliT3nsJJJm\CCRIIP0ZYlvcW6p M4[2U|IxPTJ5OU[5
CHO-K1 cells M1fBRWZ2dmO2aX;uJIF{e2G7 M1fPdXBienSrYXygZYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGtUGJFKGW6cILld5Nm\CCrbjDDTG8uUzFiY3XscJMh[29vdILhcpNn\WO2ZXSge4l1cCCJQVy0JIF{e2W|c3XkJIF{KGy3Y3nm[ZJie2ViYXP0bZZqfHliYomgeJJidnOjY4TpeoF1cW:wIHHzd4F6NCCHQ{WwQVAvOSEQvF2= Mo\nNlA2Ojd7Nkm=
HEK293T cells NW\pepdmTnWwY4Tpc44h[XO|YYm= MUexJO69VQ>? MnzQNlQhcHK| M{DWeXBienSrYXygZYdwdmm|dDDhZ5Rqfmm2eTDheEBpfW2jbjDQVGFT\2GvbXGtUGJFKGW6cILld5Nm\CCrbjDISWszQTOWIHPlcIx{KGG|c3Xzd4VlKGG|IHnu[JVkfGmxbjDv[kBz\WOncITvdkB1emGwc3HjeIl3[XSrb36gZZQhOSC3TTDh[pRmeiB{NDDodpMh[nlibIXjbYZmemG|ZTDy[ZBwenSncjDn[Y5mKGG|c3H5 NIrweZAzOTB|MEK2Ny=>
CV1 cells MnnOSpVv[3Srb36gZZN{[Xl? MkP6WJJidnOjY4TpeoF1cW:wIH;mJGdidDRvZoXz[YQhcHWvYX6gVHBCWmejbX3hJGRPSSCkaX7kbY5oKGSxbXHpckBmgHC{ZYPz[YQhcW5iYX\ybYNidiCpcnXlckBud26tZYmgR3YyKGOnbHzzJIJ6KGy3Y3nm[ZJie2VicnXwc5J1\XJiZ3Xu[UBie3OjeTygSWM2OD1yLkGg{txO MWqyNVEyOjd6NB?=
HEK293 cells Ml7OSpVv[3Srb36gZZN{[Xl? MXyxOkB1dyB{MDDodpM> M{jWWHRz[W6|YXP0bZZifGmxbjDv[kBI[Wx2LX\1d4VlKGi3bXHuJHBRSVKpYX3tZUBmgHC{ZYPz[YQhcW5iSFXLNlk{KGOnbHzzJIFnfGW{IEG2JJRwKDJyIHjyd{BjgSCudXPp[oVz[XOnIILldI9zfGW{IHflcoUh[XO|YYmsJGVEPTB;MD6wOFMh|ryP NXT3T2FDOjFzMki2NFA>
HepG2 cells M{\WN2Z2dmO2aX;uJIF{e2G7 MUGxNEB2dW:uL1y= M{fHV|I1KGi{cx?= MVnJcoNz\WG|ZTDpckBodHWlb4PlJINwdnO3bYD0bY9vKGmwIHj1cYFvKEincFeyJINmdGy|IHH0JFExKHWvb3yvUEBi\nSncjCyOEBpenNicnXsZZRqfmVidH:gZ49vfHKxbB?= NVnqeWI{OjF{NU[3OFg>
3T3L1 cell M1PR[2Z2dmO2aX;uJIF{e2G7 NVfobYRoOSC3TR?= NUPZPGp3UW6mdXP0bY9vKG:oIH3veZNmKDOWM1yxJINmdGxiZHnm[oVz\W62aXH0bY9vKGG|c3Xzd4VlKGG|IHnuZ5Jm[XOnIHnuJIFk[3WvdXzheIlwdiCxZjDpcpRz[WOnbHz1cIFzKGyrcHnkJIRzd3CuZYSgZZQhOSC3TTDifUBQcWxicnXkJG8he3SjaX7pcoc> NUXZb2VsOjF2MEGxNVg>
CV1 cells NHHhWHJHfW6ldHnvckBie3OjeR?= NVT6NlAxPDBiaB?= NHPa[JRC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZU1NSkRiZYjwdoV{e2WmIHnuJGNXOSClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKEejbESgZYZ1\XJiNECgbJJ{KGK7IHz1Z4ln\XKjc3WgZoF{\WRidILhcpNi[3SrdnH0bY9vKGG|c3H5MEBGSzVyPUCuNUDPxE1? Ml\YNlE2OTVyNkO=
HepG2 cells MkfoSpVv[3Srb36gZZN{[Xl? M2PlVmFod26rc4SgZYN1cX[rdImgZZQhWFCDUnfhcY1iKHKnY3XweI9zKGW6cILld5Nm\CCrbjDoeY1idiCKZYDHNkBk\WyuczDifUBRWFKHLXz1Z4ln\XKjc3WgdoVxd3K2ZYKg[4Vv\SCjc4PhfUwhTUN3ME2wMlAyKM7:TR?= MWOyNVQ5OjR2Nh?=
HepG2 cells M1XPbWZ2dmO2aX;uJIF{e2G7 MUfUdoFve2GldHn2ZZRqd25ib3[gbJVu[W5iUGDBVodidW2jIHX4dJJme3OnZDDpckBpfW2jbjDI[ZBIOiClZXzsd{Bkdy22cnHud4Zm[3SnZDD3bZRpKFCSUlWzMXRMNUy3YzDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWgZZN{[XluIFXDOVA:OC5yNTFOwG0> M1ntNVIyPDVyNE[4
COS7 cells MonJSpVv[3Srb36gZZN{[Xl? NUDxXXJvVW:mdXzheIlwdiCxZjDoeY1idiCSUFHS[4FudWFvTFLEJIV5eHKnc4Pl[EBqdiCjZoLpZ4FvKGe{ZXXuJI1wdmuneTDDU3M4KGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghT2GuNDDhd5Nme3OnZDDhd{Bi[3SrdnH0bY9vKG:oIITyZY5{[WO2aY\heIlwdiCjY4Tpeol1gSCkeTDseYNq\mW{YYPlJIF{e2G7LDDFR|UxRTBwMESzJO69VQ>? NXr5dVhwOjF6N{OwO|A>
COS-1 cells M2rNOmZ2dmO2aX;uJIF{e2G7 NX;PU3VxOjRiaILz NFq1RVRC\2:waYP0JIFkfGm4aYT5JIF1KGi3bXHuJHBRSVKpYX3tZUBtcWejbnSgZolv\GmwZzDkc41icW5iZYjwdoV{e2WmIHnuJGNQWy1zIHPlcIx{KGGodHXyJFI1KGi{czDifUBtfWOrZnXyZZNmKHKncH;yeIVzKGenbnWtZoF{\WRibIXtbY5wdWW2cnnjJIFv[Wy7c3nzMEBGSzVyPUCuNFQ5KM7:TR?= NWfZUIp7OjJyNUGwOVQ>
COS1 cells MkjOSpVv[3Srb36gZZN{[Xl? NIXzcZozPCCqcoO= NFfLeHNVemGwc3HjeIl3[XSrb36gc4YhcHWvYX6g[pVtdCCuZX7neIghWFCDUnfhcY1iKGW6cILld5Nm\CCrbjDDU3MyKGOnbHzzJINwNXS{YX7z[oVkfGWmIIfpeIghWliUYXzwbIEh[W[2ZYKgNlQhcHK|IHL5JIx2[2moZYLhd4UhemWyb4L0[ZIh\2WwZTDhd5NigSxiRVO1NF0xNjF{IN88US=> M1raRlIzOTl5M{m2
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COS1 cells NH7XW4xHfW6ldHnvckBie3OjeR?= NXGxb|JpSmmwZHnu[{Bi\m[rbnn0fUB1dyCqdX3hckB4cWymIIT5dIUhWFCDUnfhcY1iKEyERDDlfJBz\XO|ZXSgbY4hS0:VMTDj[YxteyClbz3lfJBz\XO|aX7nJGdCVDRiYomgd4NqdnSrbHzheIlwdiCycn;4bY1qfHliYYPzZZk> MWqyNlA4ODZyNB?=
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Ac2F cells MoroSpVv[3Srb36gZZN{[Xl? NGDMVGUxNjFidH:gNVAh|ryP MmG3OkBpenN? MkS5RYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhcW5icnH0JGFkOkZiY3XscJMh[XO|ZYPz[YQh[XNibIXjbYZmemG|ZTDhZ5Rqfmm2eTDheEAxNjFidH:gNVAhfU1iYX\0[ZIhPiCqcoOgZpkhemWyb4L0[ZIh\2WwZTDhd5NigQ>? NF7vUY8zOjhzOUG5NC=>
293H DA cells MljDSpVv[3Srb36gZZN{[Xl? MmHFNVYhcA>? MnfaRYdwdmm|dDDhZ5Rqfmm2eTDheEBRWEGUZ3HtcYEhVEKGIHnuJIh2dWGwIEK5N2ghTEFiY3XscJMh[W[2ZYKgNVYhcHK|IHL5JHRTNU[URWSgZYN1cX[jdHnvckBz\XCxcoTldkBie3OjeTygSWM2OD1yLkCwNlQh|ryP Ml\jNlI2QDJ7N{O=
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HepG2 cells M1fQS2Z2dmO2aX;uJIF{e2G7 NX7pV21UOTBidV2= NFe3SmczPCCq MmLJVoVlfWO2aX;uJI9nKGeudXPvd4Uh[2:wc4XtdJRqd25iaX6gbY5{fWyrbj3y[ZNqe3SjboSgbJVu[W5iSHXwS|Ih[2WubIOgZZQhOTBidV2gZYZ1\XJiMkSgbJJ{KGK7IHfseYNwe2Vib4jp[IF{\SCvZYToc4QhcW5icILld4Vv[2Vib3[gNlIvOiCvTTDv[kBodHWlb4Pl MnT0NlMxOjV{NES=
HepG2 cells NY\D[mZRTnWwY4Tpc44h[XO|YYm= NVvTbIVjOTBidV2= NV2yTGl7OjRiaB?= NYGz[lBSWmWmdXP0bY9vKG:oIHfseYNwe2ViY3;ud5VueHSrb36gbY4hcW6|dXzpck1z\XOrc4ThcpQhcHWvYX6gTIVxTzJiY3XscJMh[XRiMUCgeW0h[W[2ZYKgNlQhcHK|IHL5JIdtfWOxc3Wgc5hq\GG|ZTDt[ZRpd2RiaX6gdJJme2WwY3Wgc4YhOC5zIIXNJI9nKGmwc4XsbY4> MV6yN|AzPTJ2NB?=
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Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 35 mg/mL
(198.67 mM)
Ethanol 35 mg/mL
(198.67 mM)
Water Insoluble

Chemical Information

Molecular Weight 176.17
Formula

C10H8O3

CAS No. 90-33-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=CC(=O)OC2=C1C=CC(=C2)O

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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