For research use only. Not for use in humans.

Zilovertamab vedotin

Synonyms: VLS-101, MK-2140 Cat.No.D4013 Purity:99%

Zilovertamab vedotin (VLS-101, MK-2140) is an antibody-drug conjugate (ADC) composed of a humanised monoclonal antibody targeting ROR1 and the anti-mitotic cytotoxic agent monomethyl auristatin E (MMAE). It has potential for the treatment of lymphoid malignancies.

Zilovertamab vedotin

CAS No. 2376463-48-6

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Quality Control

Batch: D401301 Purity: 99% Protein concentration: 5.27mg/ml Endotoxin Level: ＜1EU/mg

99

Specificity

Name	Citation	RORγ
S18-000003	0	++
TMP778	0	+++

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1. "+" indicates inhibitory effect. Increased inhibition is marked by a higher "+" designation. 2. "✔" indicates inhibitory effect, but without specific value.

Mechanism of Action

Description	Zilovertamab vedotin (VLS-101, MK-2140) is an antibody-drug conjugate (ADC) composed of a humanised monoclonal antibody targeting ROR1 and the anti-mitotic cytotoxic agent monomethyl auristatin E (MMAE). It has potential for the treatment of lymphoid malignancies.
References	https://pubmed.ncbi.nlm.nih.gov/35561299/

Cell Lines	Assay Type	Concentration	Incubation Time	Formulation	Activity Description	PMID

Product Details

CAS No.	2376463-48-6
ADC antiody	Zilovertamab
ADC cytotoxin	MMAE
Formulation	1xPBS
Storage (From the date of receipt)	Store the undiluted solution at -20°C in the dark to avoid freeze-thaw cycles.

Comparison of Clones for

^*Literature analysis of various clone (for this target) products available on the market shows that Selleck's selected clones are more frequently applied. (data until September 2024)

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