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Zegocractin (CM 4620)
Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
Zegocractin (CM 4620) Chemical Structure
CAS: 1713240-67-5
Selleck's Zegocractin (CM 4620) has been cited by 1 publication
Purity & Quality Control
Batch:
Purity:
99.99%
99.99
Zegocractin (CM 4620) Related Products
| Related Targets | Cav 2.2 | Click to Expand |
|---|---|---|
| Related Compound Libraries | FDA-approved Drug Library Natural Product Library Ion Channel Ligand Library Exosome Secretion Related Compound Library Calcium Channel Blocker Library | Click to Expand |
Signaling Pathway
Choose Selective Calcium Channel Inhibitors
Biological Activity
| Description | Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively. | ||||
|---|---|---|---|---|---|
| Targets |
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| In vitro | ||||
| In vitro | CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively. |
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|---|---|---|---|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT04661540 | Completed | Pneumonia |
CalciMedica Inc.|Northwestern University |
March 2 2021 | Phase 2 |
| NCT04195347 | Recruiting | Acute Pancreatitis |
St. Jude Children''s Research Hospital|CalciMedica Inc. |
September 4 2020 | Phase 1|Phase 2 |
| NCT04345614 | Completed | Pneumonia |
CalciMedica Inc. |
April 8 2020 | Phase 2 |
| NCT03709342 | Completed | Acute Pancreatitis |
CalciMedica Inc. |
January 6 2019 | Phase 2 |
Chemical Information & Solubility
| Molecular Weight | 421.76 | Formula | C19H11ClF3N3O3 |
| CAS No. | 1713240-67-5 | SDF | -- |
| Smiles | CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F | ||
| Storage (From the date of receipt) | 3 years -20°C powder | ||
|
In vitro |
DMSO : 100 mg/mL ( (237.1 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.) |
Molecular Weight Calculator |
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In vivo Add solvents to the product individually and in order. |
In vivo Formulation Calculator |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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Tech Support
Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.
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