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Zegocractin (CM 4620) Calcium Channel inhibitor

Name: Zegocractin (CM 4620)
Brand: Selleck Chemicals
SKU: S6834
Availability: InStock
Rating: 5 (1 reviews)

Cat.No.S6834

Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.

Chemical Structure

Molecular Weight: 421.76

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: Purity: 99.99%

99.99

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Chemical Information, Storage & Stability

Molecular Weight	421.76	Formula	C₁₉H₁₁ClF₃N₃O₃	Storage (From the date of receipt)	3 years -20°C powder
CAS No.	1713240-67-5	--		Storage of Stock Solutions	1 year-80°Cin solvent 1 month-20°Cin solvent
Synonyms	N/A			Smiles	CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (237.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Molarity Calculator

Mass	Concentration	Volume	Molecular Weight
=	×	×

Dilution Calculator Molecular Weight Calculator

In vivo Batch:
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

Dosage: mg/kg Average weight of animals: g Dosing volume per animal:μL Number of animals:

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO + % + % Tween 80 + % ddH₂O

%DMSO+ %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH₂O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC₅₀/Ki	Orai1/STIM1-mediated Ca2+ currents ^[1] (Cell-free assay) 120 nM Orai2/STIM1-mediated currents ^[1] (Cell-free assay) 900 nM
In vitro	CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
References	[1] https://pubmed.ncbi.nlm.nih.gov/31050811/ [2] https://pubmed.ncbi.nlm.nih.gov/31050811/

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2024-05-22)

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
NCT04661540	Completed	Pneumonia	CalciMedica Inc.\|Northwestern University	March 2 2021	Phase 2
NCT04195347	Recruiting	Acute Pancreatitis	St. Jude Children''s Research Hospital\|CalciMedica Inc.	September 4 2020	Phase 1\|Phase 2
NCT04345614	Completed	Pneumonia	CalciMedica Inc.	April 8 2020	Phase 2
NCT03709342	Completed	Acute Pancreatitis	CalciMedica Inc.	January 6 2019	Phase 2

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