Home Transmembrane Transporters Calcium Channel inhibitor Zegocractin (CM-4620)

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Zegocractin (CM-4620) CRAC Channel Inhibitor

Cat.No.S6834

Zegocractin (CM 4620) is an inhibitor of calcium-release activated calcium-channel (CRAC channel). CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
Zegocractin (CM-4620) Calcium Channel inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 421.76

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Quality Control

Batch: Purity: 99.99%
99.99

Solubility

In vitro
Batch:

DMSO : 100 mg/mL (237.1 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

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In vivo
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Chemical Information, Storage & Stability

Molecular Weight 421.76 Formula

C19H11ClF3N3O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1713240-67-5 -- Storage of Stock Solutions

Synonyms N/A SMILES CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F

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Mechanism of Action

Targets/IC50/Ki
Orai1/STIM1-mediated Ca2+ currents
(Cell-free assay)
120 nM
Orai2/STIM1-mediated currents
(Cell-free assay)
900 nM
In vitro

CM4620 inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of near 120 nM and 900 nM, respectively.
References

Clinical Trial Information

(data from https://clinicaltrials.gov, updated on 2026-06-03)

NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT04195347 RECRUITING
Acute Pancreatitis
St. Jude Children's Research Hospital
 2020-09-04 PHASE1; PHASE2
NCT04681066 COMPLETED
Acute Pancreatitis; Systemic Inflammatory Response Syndrome
CalciMedica, Inc.
 2021-03-24 PHASE2
NCT04661540 TERMINATED
Pneumonia
CalciMedica, Inc.
 2021-03-02 PHASE2
NCT04345614 COMPLETED
Pneumonia
CalciMedica, Inc.
 2020-04-08 PHASE2
NCT04661540 Completed
Pneumonia
CalciMedica Inc.|Northwestern University
 2021-03-02 Phase 2
NCT04195347 Recruiting
Acute Pancreatitis
St. Jude Children''s Research Hospital|CalciMedica Inc.
 2020-09-04 Phase 1|Phase 2

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