Zoxazolamine

Catalog No.S4233 Synonyms: NSC 24995, Contrazole

For research use only.

Zoxazolamine (NSC 24995, Contrazole) is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric.

Zoxazolamine Chemical Structure

CAS No. 61-80-3

Purity & Quality Control

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Biological Activity

Description Zoxazolamine (NSC 24995, Contrazole) is a centrally acting myorelaxant, which is formerly used as an antispasmodic and uricosuric.
In vitro

Zoxazolamine is in the centrally-acting muscle relaxant class of drugs, which reportedly act by decreasing CNS interneuronal activity. These drugs, but not anxiolytics, decrease dopaminergic turnover and induce a pacemaker-like discharge pattern in dopaminergic neurons.[1] Zoxazolamine is a member of the large class of biologically active 2-amino-2-oxazoles. Zoxazolamine is also used as a tool for assessing hepatic cytochrome P-450 activity.[2]

Protocol (from reference)

Solubility (25°C)

In vitro

DMSO 34 mg/mL
(201.68 mM)
Ethanol 34 mg/mL
(201.68 mM)
Water Insoluble

Chemical Information

Molecular Weight 168.58
Formula

C7H5ClN2O

CAS No. 61-80-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC2=C(C=C1Cl)N=C(O2)N

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