Home Neuronal Signaling Calcium Channel antagonist Z944

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Z944 Calcium Channel antagonist

Cat.No.E0777

Z944 is a highly selective antagonist for T-type calcium channel with IC50s of 50, 160, 110 nM for hCaV3.1, hCaV3.2, and hCaV3.3.
Z944 Calcium Channel antagonist Chemical Structure

Chemical Structure

Molecular Weight: 383.89

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Quality Control

Batch: E077701 DMSO]50 mg/mL]true]Ethanol]19 mg/mL]false]Water]Insoluble]false Purity: 98.51%
98.51

Solubility

In vitro
Batch:

DMSO : 50 mg/mL (130.24 mM) Warmed with 50°C water bath; Ultrasonicated;
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 19 mg/mL

Water : Insoluble

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Mass Concentration Volume Molecular Weight
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In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Chemical Information, Storage & Stability

Molecular Weight 383.89 Formula

C19H27ClFN3O2

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1199236-64-0 -- Storage of Stock Solutions

Mechanism of Action

Targets/IC50/Ki
hCaV3.1
(in FLIPR assay)
50 nM
hCaV3.3
(in FLIPR assay)
110 nM
hCaV3.2
(in FLIPR assay)
160 nM
References

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