Home Epigenetics Histone Demethylase inhibitor - JMJD inhibitor Z-JIB-04 (NSC 693627)

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Z-JIB-04 (NSC 693627) Histone Demethylase inhibitor

Cat.No.S0201

Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
Z-JIB-04 (NSC 693627) Histone Demethylase inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 308.76

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S020101 DMSO]8 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false Purity: 99.84%
99.84

Chemical Information, Storage & Stability

Molecular Weight 308.76 Formula

C17H13ClN4

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 199596-24-2 -- Storage of Stock Solutions

Synonyms JIB-04 Z-isomer, (Z)-JIB-04 Smiles C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3

Solubility

In vitro
Batch:

DMSO : 8 mg/mL (25.91 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Water : Insoluble

Ethanol : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
JARID1A [1]
(Cell-free assay)
230 nM
JMJD2D [1]
(Cell-free assay)
290 nM
JMJD2E [1]
(Cell-free assay)
340 nM
JMJD2B [1]
(Cell-free assay)
435 nM
JMJD2A [1]
(Cell-free assay)
445 nM
JMJD3 [1]
(Cell-free assay)
855 nM
JMJD2C [1]
(Cell-free assay)
1100 nM
References

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