Home Epigenetics Histone Demethylase inhibitor - JMJD inhibitor Z-JIB-04 (NSC 693627) For research use only.

Z-JIB-04 (NSC 693627)

Synonyms: JIB-04 Z-isomer, (Z)-JIB-04

Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

Z-JIB-04 (NSC 693627) Chemical Structure

Z-JIB-04 (NSC 693627) Chemical Structure

CAS: 199596-24-2

Purity & Quality Control

Batch: S020101 DMSO] 8 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.84%
99.84

Z-JIB-04 (NSC 693627) Related Products

Signaling Pathway

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Histone Demethylase Signaling Pathway

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Biological Activity

Description Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
Targets
JARID1A [1]
(Cell-free assay)		 JMJD2D [1]
(Cell-free assay)		 JMJD2E [1]
(Cell-free assay)		 JMJD2B [1]
(Cell-free assay)		 JMJD2A [1]
(Cell-free assay)		 Click to View More Targets
230 nM 290 nM 340 nM 435 nM 445 nM

Chemical Information & Solubility

Molecular Weight 308.76 Formula

C17H13ClN4
CAS No. 199596-24-2 SDF --
Smiles C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3
Storage (From the date of receipt) 3 years -20°C powder

In vitro
Batch:

DMSO : 8 mg/mL ( (25.91 mM)； Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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