Z-JIB-04 (NSC 693627)

Catalog No.S0201 Synonyms: JIB-04 Z-isomer, (Z)-JIB-04

For research use only.

Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.

Z-JIB-04 (NSC 693627) Chemical Structure

CAS No. 199596-24-2

Purity & Quality Control

Choose Selective Histone Demethylase Inhibitors

Biological Activity

Description Z-JIB-04 (NSC 693627, JIB-04 Z-isomer) is an isomer of JIB-04. JIB-04 is a pan-selective Jumonji histone demethylase inihibitor with IC50 of 230 nM, 340 nM, 855 nM, 445 nM, 435 nM, 1100 nM and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.
Targets
JARID1A [1]
(Cell-free assay)
JMJD2D [1]
(Cell-free assay)
JMJD2E [1]
(Cell-free assay)
JMJD2B [1]
(Cell-free assay)
JMJD2A [1]
(Cell-free assay)
Click to View More Targets
230 nM 290 nM 340 nM 435 nM 445 nM

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 308.76
Formula

C17H13ClN4

CAS No. 199596-24-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3
If you have any other enquiries, please leave a message.

* Indicates a Required Field

Please enter your name.
Please enter your email. Please enter a valid email address.
Please write something to us.
Tags: buy Z-JIB-04 (NSC 693627) | Z-JIB-04 (NSC 693627) supplier | purchase Z-JIB-04 (NSC 693627) | Z-JIB-04 (NSC 693627) cost | Z-JIB-04 (NSC 693627) manufacturer | order Z-JIB-04 (NSC 693627) | Z-JIB-04 (NSC 693627) distributor