ZM241385

Catalog No.S8105

ZM241385 Chemical Structure

Molecular Weight(MW): 337.34

ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.

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Cited by 1 Publication

1 Customer Review

  • T cells treated with MTX, astilbin, ZM241385 and SCH772984. The levels of p-ERK1/2, p-P65, p-STAT1 and p-STAT3 were analyzed by western blot.

    Biochem Pharmacol, 2018, doi: 10.1016/j.bcp.2018.01.033. ZM241385 purchased from Selleck.

Purity & Quality Control

Choose Selective Adenosine Receptor Inhibitors

Biological Activity

Description ZM-241385 is a high affinity antagonist ligand selective for the adenosine A2A receptor.
Targets
adenosine A2A receptor [3]
In vitro

ZM 241385 has high affinity for A2a receptors. In rat phaeochromocytoma cell membranes, ZM 241385 displaces binding of tritiated 5'-N-ethylcarboxamidoadenosine (NECA) with a pIC50 of 9.52[3]. ZM241385 delays the appearance of anoxic depolarization (AD), a phenomenon strictly related to cell damage and death, protect from the synaptic activity depression brought about by a severe (7 min) OGD period, and protect CA1 neuron and astrocyte from injury[4].

In vivo ZM-241385 significantly blunts the hypotensive effects of CCPA and NECA without altering the bradycardia induced by these agonists. It blocks the infarct size-reducing effects(cardioprotective effects) of this two distinct adenosine receptor agonists[1].

Protocol

Cell Research:

[2]

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  • Cell lines: PC12 cells
  • Concentrations: 1 μM
  • Incubation Time: 24 h
  • Method:

    Nitric oxide (NO) production is assessed by measuring the amount of nitrite, a stable metabolic product of NO that provides an indirect measurement of NO, by using the Griess diazotization reaction. Briefly, 24 h after incubation with 1.0 µM CG21680 or 1.0 µM ZM241385 or exposure to SMF, samples of medium (150 µl) are collected from cells and mixed with 130 µl dH2O and with 20 µl Griess reagent using instruction supplied by the manufacturer. After a 30 min incubation period at room temperature, the samples are evaluated spectrophotometrically at 548 nm and OD values-in comparison with a standard curve is determined in culture medium by using serial dilutions of sodium nitrite-represented total stable metabolites of NO.


    (Only for Reference)
Animal Research:

[1]

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  • Animal Models: Adult Sprague-Dawley rats 
  • Formulation: 10% DMSO in 1 ml normal saline
  • Dosages: 1.5 mg/kg
  • Administration: i.v.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 67 mg/mL (198.61 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 337.34
Formula

C16H15N7O2

CAS No. 139180-30-6
Storage powder
in solvent
Synonyms N/A

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID