Home Transmembrane Transporters Aquaporin inhibitor Z433927330

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Z433927330 Aquaporin inhibitor

Cat.No.S3585

Z433927330 is a potent and efficacious inhibitor of mouse AQP7 (Aquaporin-7) with an IC50 of ~0.2 µM. This compound also inhibits mouse AQP3 (Aquaporin-3) and mouse AQP9 (Aquaporin-9) with IC50s of ~0.7 µM and ~1.1 µM, respectively.
Z433927330 Aquaporin inhibitor Chemical Structure

Chemical Structure

Molecular Weight: 364.40

Jump to Mechanism of Action Solubility Chemical Information, Storage & Stability Specificity

Quality Control

Batch: S358501 DMSO]73 mg/mL]false]Ethanol]2 mg/mL]false]Water]Insoluble]false Purity: 99.86%
99.86

Chemical Information, Storage & Stability

Molecular Weight 364.40 Formula

C20H20N4O3

 Storage (From the date of receipt) 3 years -20°C powder
CAS No. 1005883-72-6 -- Storage of Stock Solutions

Synonyms N/A Smiles CCOC(=O)C1=CC=C(NC(=O)NCC2=CC=C(C=C2)[N]3C=CC=N3)C=C1

Solubility

In vitro
Batch:

DMSO : 73 mg/mL (200.32 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 2 mg/mL

Water : Insoluble

Molarity Calculator

Mass Concentration Volume Molecular Weight

In vivo
Batch:

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg
g
μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO
%
% Tween 80
% ddH2O
% DMSO
+
%

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Mechanism of Action

Targets/IC50/Ki
AQP7 [1]
0.2 μM
AQP3 [1]
0.7 μM
AQP9 [1]
1.1 μM
References

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