Z-VAD(OH)-FMK (Caspase Inhibitor VI)

Catalog No.S8102

For research use only.

Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

Z-VAD(OH)-FMK (Caspase Inhibitor VI) Chemical Structure

CAS No. 161401-82-7

Selleck's Z-VAD(OH)-FMK (Caspase Inhibitor VI) has been cited by 19 publications

Purity & Quality Control

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Biological Activity

Description Z-VAD(OH)-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Targets
Caspase [1]
In vitro

Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SF188 NV;yXZBUSXCxcITvd4l{KGG|c3H5 NGHUWm9KdmirYnn0bY9vKG:oIEKwV{1xem:2b4DhcoF5[WSrb3ytbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKGOjc4Dhd4V{KGmwIHj1cYFvKFOIMUi4JINmdGy| MlTvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{NkGwOlcoRjF5Mk[xNFY4RC:jPh?=
SF188 NWL2NotZSXCxcITvd4l{KGG|c3H5 M3;iXWlvcGmkaYTpc44hd2ZiVF7GMYFteGijLXnu[JVk\WRiYYDvdJRwe2m|IHnuJIh2dWGwIGPGNVg5KGOnbHzz NU\6U45XRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUeyOlExPjdpPkG3NlYyODZ5PD;hQi=>
SF188 M1XDNGFxd3C2b4Ppd{Bie3OjeR?= M1\ROWlvcGmkaYTpc44hd2ZiY4njcI9p\XirbXnk[U1qdmS3Y3XkJIFxd3C2b4Ppd{BqdiCqdX3hckBUTjF6ODDj[Yxtew>? M3zwXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5Mk[xNFY4Lz5zN{K2NVA3PzxxYU6=

Protocol (from reference)

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 453.46
Formula

C21H28FN3O7

CAS No. 161401-82-7
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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