Z-VAD(OH)-FMK (Caspase Inhibitor VI)

For research use only.

Catalog No.S8102

17 publications

Z-VAD(OH)-FMK (Caspase Inhibitor VI) Chemical Structure

CAS No. 161401-82-7

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

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USD 377 In stock
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Selleck's Z-VAD(OH)-FMK (Caspase Inhibitor VI) has been cited by 17 publications

1 Customer Review

  • Effect on the RAS of CFZ, z-VAD-fmk, or CFZ+z-VAD-fmk treatments administered 5 or 12 days after C26 inoculation and control groups. Serum levels of a renin and b ANGII. c The mRNA expression of ATF2. d Western blot analysis of ATF2 and pATF2. e pATF2-to-ATF2 ratio. Significant differences were detected between most of the groups, with the exceptionsof (A and B) CP and UT (D) and ZP and ZT (#); and (C and E) CP and UP (*), CT and UT (#), and HC, ZP, ZT and CC (&). ZP:z-VAD-fmk.

    Med Oncol, 2015, 32(4):100. . Z-VAD(OH)-FMK (Caspase Inhibitor VI) purchased from Selleck.

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Biological Activity

Description Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
Caspase [1]
In vitro

Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
SF188 M4nTWmFxd3C2b4Ppd{Bie3OjeR?= NXf3c2RqUW6qaXLpeIlwdiCxZjCyNHMueHKxdH;wZY5igGGmaX;sMYlv\HWlZXSgZYN1cX[jdHnvckBw\iClYYPwZZNmeyCrbjDoeY1idiCVRkG4PEBk\Wyucx?= MknQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd{NkGwOlcoRjF5Mk[xNFY4RC:jPh?=
SF188 MnezRZBweHSxc3nzJIF{e2G7 NUe3W|Z3UW6qaXLpeIlwdiCxZjDUUmYu[WyyaHGtbY5lfWOnZDDhdI9xfG:|aYOgbY4hcHWvYX6gV2YyQDhiY3XscJM> NFjSTms9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{K2NVA3Pyd-MUeyOlExPjd:L3G+
SF188 M2m0eGFxd3C2b4Ppd{Bie3OjeR?= MlO3TY5pcWKrdHnvckBw\iCleXPsc4hmgGmvaXTlMYlv\HWlZXSgZZBweHSxc3nzJIlvKGi3bXHuJHNHOTh6IHPlcIx{ MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzJ4MUC2O{c,OTd{NkGwOlc9N2F-

... Click to View More Cell Line Experimental Data


Solubility (25°C)

In vitro DMSO 90 mg/mL (198.47 mM)
Ethanol 90 mg/mL (198.47 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 453.46


CAS No. 161401-82-7
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)CF)NC(=O)OCC1=CC=CC=C1

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID