For research use only.

Catalog No.S3007 Synonyms: GG167

2 publications

Zanamivir Chemical Structure

CAS No. 139110-80-8

Zanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.

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Selleck's Zanamivir has been cited by 2 publications

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  • Dose-response curve of the SH5190, SH5190 R292K and the A(H1N1)pdm09 (2167) viruses in the presence of oseltamivir zanamivir (B) using a chemiluminescent (NA-star) assay. The NA activity of the H7N9 or H1N1 viruses under increasing concentrations (0.03-1000 nM) of the NAIs was determined. Each data point represents the normalized mean ± SEM neuraminidase activity from three replicated wells. The experiments were repeated twice.

    Emerg Microbes Infec, 2014, 3:e78.. Zanamivir purchased from Selleck.

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Biological Activity

Description Zanamivir (GG167) is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.
neuraminidase [1]
In vitro

Zanamivir, a novel neuraminidase inhibitor, is effective at decreasing replication of the virus in vitro. [1] Zanamivir results in reduced sensitivity in influenza A/H1N1 variant His274Asn, as well as His274Gly, His274Ser, and His274Gln. [2] Zanamivir blocks influenza neuraminidase and prevents the cleavage of sialic acid residues, thus interfering with progeny virus dispersement within the mucosal secretions and reducing viral infectivity. [3] Zanamivir prevents hemadsorption and fusion of persistently infected cells with uninfected cells. Zanamivir reduces the number (but not the area) of plaques if present only during the adsorption period and reduces plaque area (but not number) if added only after the 90-min adsorption period in plaque assays. Zanamivir also reduces the area of plaques formed by a neuraminidase-deficient variant, confirming that its interference with cell-cell fusion is unrelated to inhibition of neuraminidase activity. Zanamivir has no effect on hemadsorption but does inhibit HA2b-red blood cell fusion, as judged by both lipid mixing and content mixing. [4]

In vivo Zanamivir reduces lung titers of the virus and decreases morbidity and mortality in a model of lethal challenge in mice. [1]


Solubility (25°C)

In vitro Water 25 mg/mL (75.23 mM)
DMSO 2 mg/mL (6.01 mM)
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 332.31


CAS No. 139110-80-8
Storage powder
in solvent
Synonyms GG167
Smiles CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04494412 Not yet recruiting Drug: Zanamivir Influenza Human GlaxoSmithKline October 20 2020 Phase 2
NCT02377401 Completed Drug: Zanamivir Influenza Human GlaxoSmithKline April 28 2015 Phase 1
NCT01527110 Completed Drug: Intravenous (IV) zanamivir Influenza Human GlaxoSmithKline January 1 2012 Phase 3
NCT01353768 Completed Other: retrospective chart review Infections Respiratory Tract GlaxoSmithKline July 2011 --

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Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID