Z-VAD-FMK

Catalog No.S7023 Synonyms: Z-VAD(OMe)-FMK

For research use only.

Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

Z-VAD-FMK Chemical Structure

CAS No. 187389-52-2

Selleck's Z-VAD-FMK has been cited by 747 publications

Purity & Quality Control

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Biological Activity

Description Z-VAD-FMK (Z-VAD(OMe)-FMK) is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 μM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 μM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U937 NIDpT4tCeG:ydH;zbZMhSXO|YYm= NVfzcnRMPTEQvF2= M3jHb|Q5cA>? NX;z[ngyemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCVS1mtTWkhfHKnYYTt[Y51yqB? M4DlXVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK0NFQ{Lz5{NUiyOFA1OzxxYU6=
HL-60 MkTWRZBweHSxc3nzJGF{e2G7 NWe5[JNYPTEQvF2= MYS0PIg> MlrOdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> M2DLW|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEK0NFQ{Lz5{NUiyOFA1OzxxYU6=
DTK-SME MWDBdI9xfG:|aYOgRZN{[Xl? NF;SbYs2OM7:TR?= MVuybC=> NEiy[YJFVVOR Mnu1dIFzfGmjbHz5JIlvcGmkaYTzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDieZBqfmGlYXnu[S=> NXm2cVk6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW4OFM5QTdpPkK1PFQ{QDl5PD;hQi=>
HCT116  NUjzc5B7SXCxcITvd4l{KEG|c3H5 MorIOVDPxE1? NH7mRmgzcA>? MlfobY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDESHZR MnPpQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6Nki4NVgoRjJ3OE[4PFE5RC:jPh?=
SGN NVyyc3dWSXCxcITvd4l{KEG|c3H5 Mo\yNlBuVQ>? M2XLb|Q5cA>? MnjzbIF{KG6xIHnu[ox2\W6lZTDvckBCUUZuIHPhcJBicW5iZYjwdoV{e2mxbjDvdkBk\WyuIHHwc5B1d3Orcx?= MnHFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV6N{S2N|MoRjJ3OEe0OlM{RC:jPh?=
A549/V16 M2\PVWFxd3C2b4Ppd{BCe3OjeR?= MYG1NO69VQ>? NHvrZmQycA>? NFjse2tz\XC{ZYPz[ZMhXEdxVF2tbY5lfWOnZDDhdI9xfG:|aYO= MoS5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV7NE[wN|MoRjJ3OUS2NFM{RC:jPh?=
U1 Mn\5T4lv[XOnIFHzd4F6 M4f0TVExOM7:TR?= MUKybC=> NH;Wbm9qdmirYnn0d{Bk[XOyYYPlMVM> NG\HPZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUm4NFk1Oid-MkW5PFA6PDJ:L3G+
ACH-2 M1u3ZmFxd3C2b4Ppd{BCe3OjeR?= MkHhNE0zODEQvF2= MWOybC=> MnTwdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M3O3V|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
U1 MXTBdI9xfG:|aYOgRZN{[Xl? MVOwMVExOM7:TR?= MWmybC=> MoTGdoVlfWOnczDkdpVoNWmwZIXj[YQh[XCxcITvd4l{KGGwZDDzeYJ{\XG3ZX70JGhKXi1zIILldIxq[2G2aX;uJIlvKGFiZH;z[U1l\XCnbnTlcpQhdWGwbnXy M4L5VlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
HUVEC-2c NE\WR4RCeG:ydH;zbZMhSXO|YYm= MlPBOVDPxE1? NYnWNoFZPmh? MkjK[IVkemWjc3XkJJRp\SCxeD3MSGwucW6mdXPl[EBifXSxcHjh[5k> NVTtWIhzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNlE4OjlpPkK2NFIyPzJ7PD;hQi=>
SP2/0 M3yyWmFxd3C2b4Ppd{BCe3OjeR?= MVmxNFDPxE1? NInGSVMycA>? NYDXfFF[TE2VTx?= NXjEOJJ[[myxY3vzJJRp\SCjcH;weI9{cXNib3[gV3AzNzBiY3XscJM> NIThem89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC3OFc{Oid-Mk[wO|Q4OzJ:L3G+
CEF MkjwT4lv[XOnIFHzd4F6 NY\rXoRlOCx|Mzy2O{wyODEQvF2= MUWxOY1qdg>? NX\2OI1t\G:5bj3y[Yd2dGG2ZYOgVHIh\W68eX3lJIFkfGm4aYT5JJRwKDRy78{FJIF1KDFyMN88US=> MnjZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzMEKzN|koRjJ4MUCyN|M6RC:jPh?=
BEL-7402 MoTwRZBweHSxc3nzJGF{e2G7 M{\RUFIx|ryP NXnwTIJwOWh? M1fuZYF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> NW\1W402RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xOlQ4QTVpPkK2NVY1Pzl3PD;hQi=>
HepG2 NWTIUoVZSXCxcITvd4l{KEG|c3H5 MlXINlDPxE1? NVHiV4ZMOWh? M{\PTIF1fGWwdXH0[YQhfGinIHHwc5B1d3SrYzDpcoR2[3Srb36gc4YhUUmLLUGwxsA> MmnJQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzNkS3PVUoRjJ4MU[0O|k2RC:jPh?=
HGL5 NUnSb5lVSXCxcITvd4l{KEG|c3H5 MmmyOVDPxE1? NWW0S2dPOjSq MWfpcoRq[2G2ZYOgZUBxem:2ZXP0bZZmKGWoZnXjeEBi\2GrboP0JIV1d3Cxc3nk[S=> Mo\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzNkmwO|UoRjJ4MU[5NFc2RC:jPh?=
GC1a MWnBdI9xfG:|aYOgRZN{[Xl? MmfjOVDPxE1? MnPWNlRp Mn\JbY5lcWOjdHXzJIEheHKxdHXjeIl3\SCnZn\lZ5Qh[WejaX7zeEBmfG:yb4Pp[IU> Mo\YQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjZzNkmwO|UoRjJ4MU[5NFc2RC:jPh?=
A549 MXLBdI9xfG:|aYOgRZN{[Xl? MlnKNlAh|ryP Mk\MNlRp NUj1W2tFemWmdXPld{Bk\WyuIHTlZZRpKGOjdYPl[EBjgSCKRlPQJJRz\WG2bXXueC=> MonaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV5OUSxOFkoRjJ3N{m0NVQ6RC:jPh?=
HeLa MmWwRZBweHSxc3nzJGF{e2G7 MlH1NVDPxE1? Ml\IOFhp MlzL[IVkdGmwZYOgeIhmKHKjdHWgc4Yh[XCxcITvd4l{KGS{YX3heIlk[WyueR?= NID3U2s9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe3NlU1PSd-MkW3O|I2PDV:L3G+
SGC-7901 M13Yb2Fxd3C2b4Ppd{BCe3OjeR?= MUeyNOKh|ryP MY[xbC=> NXP4NnZ5cW6qaXLpeJMhfGinIHPlcIwh\GWjdHigbY5lfWOnZDDifUBwgGGuaYDsZZRqdg>? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTd4N{C3Okc,OjV5NkewO|Y9N2F-
MCF-7 MWTBdI9xfG:|aYOgRZN{[Xl? NFTxTlUyOM7:TR?= MlLDNog> MXrpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC M{frVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{KyNVE1Lz5{NUeyNlEyPDxxYU6=
A549 NYDnNJpOSXCxcITvd4l{KEG|c3H5 NXLEb4lROTBizszN Mkf5NlRp NWXSbFc2TE2VTx?= NWLuTnZOeHKxbX;0[ZMhUEKFLYTy[YF1\WRiQUW0PUBk\WyuIIP1dpZqfmGuID[gZZR1\W63YYTld{B1cGViY3zlZZZm\CCSQWLQJIV5eHKnc4Ppc44> NHnQR|A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4N|U3QCd-MkW2PFM2Pjh:L3G+
U87 NWS4d|duT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= MU[1NO69VQ>? NWXib|VZOWh? NUCxUoU1emWlb4\ldpMh[2WubDDndo94fGhiZoLvcUBVVVpidILlZZRu\W62 M2\MWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkixOlY5Lz5{NU[4NVY3QDxxYU6=
Neocortical Neuron MYTO[ZVzd3SxeHnjbZR6KEG|c3H5 MUCxNFDPxE1? MojmNYg> MYHhcpRi\2:waYrld{BJd2mjbXnk[UBCNUmwZIXj[YQhVmW3cn;0c5hq[2m2eR?= MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ5NUCwNUc,OjV4N{WwNFE9N2F-
Primary human placental cytotrophoblasts M{LzVmFxd3C2b4Ppd{BCe3OjeR?= NYnRPZBXOzEQvF2= MkDLNlRp NHzMOFBFVVOR MmDQdoV3\XK|ZYOgeIhmKGmwaHnibZRqd25ib3[gNVHPui2KU1SyJIJ6KHS{aXPsc5NidsLi MlzLQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NEK1PVIoRjJ3NkSyOVkzRC:jPh?=
MM NEmyWVRCeG:ydH;zbZMhSXO|YYm= NIe0VFA2OM7:TR?= NYHuW2J5OjCvaX6= M3;WO5BienSueTDpcohq[mm2czDTTGsucW6mdXPl[EAh[2WubDDk[YF1cA>? Ml\kQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3M{CwPVgoRjJ3NUOwNFk5RC:jPh?=
DLD1 NWS3WYtTSXCxcITvd4l{KEG|c3H5 NVy0SVdnOjEEoN88US=> Mlj0NYg> NFL1UpVx[XK2bImgdoV3\XK|ZYOgZ4VtdCCjcH;weI9{cXNiY3H1d4VlKGK7IGfTVFE> NXzNNnhURGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlQzPDZpPkK1OVI1OjR4PD;hQi=>
MDA-MB-231 NVrO[ZNuS3m2b4TvfIlkcXS7IFHzd4F6 MXOxNO69VQ>? MX:xbC=> NEjLVXlifWevZX70d{Bk\WyuIHTlZZRpKGGodHXyJGNJXUFidILlZZRu\W62 NUDneXpkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NlE2ODFpPkK1OVIyPTBzPD;hQi=>
MKN28 MXjBdI9xfG:|aYOgRZN{[Xl? NWLKWYtROTEQvF2= M13CU|MxdWmw M3;FVWROW09? NFKzfnlqdmirYnn0d{BVVkZvzsGgdIx2eyCFSGitbY5lfWOnZDDhdI9xfG:|aYO= NWLQbGpJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NVM6PjBpPkK1OVE{QTZyPD;hQi=>
HL-60 M2XOb2N6fG:2b4jpZ4l1gSCDc4PhfS=> NFLKd|YyODEQvF2= NYTkXlJqOWh? M4XibmROW09? MXpCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| MnfnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MEK5N|IoRjJ3NUCyPVMzRC:jPh?=
AGS M3u5ZWFxd3C2b4Ppd{BCe3OjeR?= M3qyRVEx|ryP NF62[WsycA>? MXHwdoV3\W62czDjeZJkfW2rbj3pcoR2[2WmIHPs[YF3[WenIH;mJINie3Cjc3WtN{whNThuIHHu[EAuQSCycn;0[Ylvew>? M3z2b|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEmyNlE1Lz5{NUS5NlIyPDxxYU6=
A549  M4\2emFxd3C2b4Ppd{BCe3OjeR?= MXSxNO69VQ>? Ml62NlRp Moj2Zoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp M4DNflxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEO0PVg6Lz5{NUSzOFk5QTxxYU6=
INS-1 M374VmFxd3C2b4Ppd{BCe3OjeR?= MnTuOVDPxE1? NUW2UJA3Pmh? NEjyPXFFVVOR M1nSPYRm[3KnYYPld{B1cGVicILvdI9zfGmxbjDv[kBm[XKueTDhdI9xfG:2aXOgZ4VtdHQEoB?= NWTsdnBHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW0N|A5QTdpPkK1OFMxQDl5PD;hQi=>
Primary hepatocytes  Mo\ERZBweHSxc3nzJGF{e2G7 NEHjXZA2OM7:TR?= NWjadnF{OTiq M1nHd4lvcGmkaYTzJIFxd3C2b4Ppd{Bw\iCqZYDheI9kgXSnczDpcoR2[2WmIHL5JGFkfCCGIHHu[EBVVkZvzsG= MlLtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2MEe1N|goRjJ3NEC3OVM5RC:jPh?=
L929-A  MXnDfZRwfG:6aXPpeJkhSXO|YYm= M3\EZlIxyqEQvF2= MmKwNlRp MYPpcohq[mm2czDUUmbPuS2rbnT1Z4VlKGOnbHyg[IVifGh? MnO2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OUi1OFAoRjJ3M{m4OVQxRC:jPh?=
L929-N MXnDfZRwfG:6aXPpeJkhSXO|YYm= NV;uTZBMOjEEoN88US=> MlK1NlRp MWTlcohidmOnczDk[YF1cCC4aXGgZZV1d2O{aX7lJHRPTs7zIIDyc4R2[3Srb36= NI\QW249[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5PFU1OCd-MkWzPVg2PDB:L3G+
Cytotoxicity Assay MlG5R4VtdCCYaXHibYxqfHliQYPzZZk> M3rueVIx|ryP M3GyO|Q5cA>? MUHwdoV3\W62IF3IUWQucW6mdXPl[EBk\WyuIHTlZZRp MUW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTN7MkGxOkc,OjV|OUKxNVY9N2F-
COS7 NVX0cHpjU2mwYYPlJGF{e2G7 Mo\CNVDPxE1? NXrVS2VlOjSq MkXlbY5kemWjc3XzJINie3Cjc3WgN{84KGGldHn2bZRq\XN? NHPRbIs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO4OFAzPSd-MkWzPFQxOjV:L3G+
COS7 NFf1VIxCeG:ydH;zbZMhSXO|YYm= NVnIOpNSOTEQvF2= NGLLWGE1QGh? MlHBdIFzfGmjbHz5JJBz\X[nboTl[EBHSzFyMT3pcoR2[2WmIHPlcIwh\GWjdHi= MlXiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|OESwNlUoRjJ3M{i0NFI2RC:jPh?=
A375 NFSxfVJCeG:ydH;zbZMhSXO|YYm= M4f1SVMx|ryP NXy4S|lIOmh? NGS5XGRxemW4ZX70d{B1cGViZIL1[{1qdmS3Y3XkJHBCWlBiY3zlZZZi\2V? NFvLWnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO3OlEyPSd-MkWzO|YyOTV:L3G+
A549 NFfHNZRCeG:ydH;zbZMhSXO|YYm= M1\3ZVUx|ryP NV7OeFg5OjSq M17kb5JmfmW{c3XzJJJq[m:|b33lJIJqd2enbnXzbZMh[W6mIHHwc5B1d3OrczDjZZV{\WRiYomgJGNpcWqxbnfkZY4> NUfsVVlqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzOFk4QDFpPkK1N|Q6PzhzPD;hQi=>
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HCT116 M1;YdGFxd3C2b4Ppd{BCe3OjeR?= MUKyNO69VQ>? M3vZSFI1cA>? NFHKR5lqdmirYnn0d{B1cGViY3XscEBieG:ydH;0bYMhcW6mdXPl[EBjgSC\TGSyNFU> M3\LTVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2N{GzPFEzLz5{NEexN|gyOjxxYU6=
L02 M{HEWWFxd3C2b4Ppd{BCe3OjeR?= MlfmNlDPxE1? MVyxbC=> NYXSS5pReHKndnXueJMhfGinIHPlcIwh[XCxcITvd4l{KGmwZIXj[YQh[nliTVXIVC=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDdyNkS2NUc,OjR5ME[0OlE9N2F-
A375 MW\BdI9xfG:|aYOgRZN{[Xl? Mnm0NlDPxE1? MoLtNlRp M3TtfZJmfmW{c3XzJIRq[2m2cnnuc45mKEJvaX7keYNm\CCjcH;weI9{cXN? NYO0eI95RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS2PVkyOTFpPkK0Olk6OTFzPD;hQi=>
HDPC MliwRZBweHSxc3nzJGF{e2G7 NYfI[4pvPTEEtV2= NXnBdm9uOjSq MmnPbY5pcWKrdIOgUm8ucW6mdXPl[EBieG:ydH;zbZM> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDZ|NEW5N{c,OjR4M{S1PVM9N2F-
A549 M1;K[mFxd3C2b4Ppd{BCe3OjeR?= MWK1NOK2VQ>? M1H3NVJp NGDMV41FVVOR NYrTS3ZWeHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV6OEGzOUc,OjR3OEixN|U9N2F-
 BV-2 NH7R[YlCeG:ydH;zbZMhSXO|YYm= MUCyNO69VQ>? MnTKNog> M13S[ZN2eHC{ZYPz[ZMhXVZvaX7keYNm\CClaILvcYF1cW5iZYj0dpV{cW:wIHHu[EBlcWyjdHnvckBw\iC2aHWgcpVkdGWjcjDlcpZmdG:yZR?= M1Swd|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUW4NVE5Lz5{NEW1PFEyQDxxYU6=
HT-29  Mmi1RZBweHSxc3nzJGF{e2G7 M2Hu[FUx|ryP NGTNe4w1QGh? NH\sfodjdG:la4OgeIhmKGGyb4D0c5NqeyCrbnT1Z4VlKGK7IHvh[Y1x\mW{b3y= MnX4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NEmxO|UoRjJ2NUS5NVc2RC:jPh?=
A549 MUTBdI9xfG:|aYOgRZN{[Xl? MXK1{txO MnjNNlRp NG\Ud5d{fXCycnXzd4V{KD[nwrCoRmsyODB2MDmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> NVf3e2M3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1Nlk5PzFpPkK0OVI6QDdzPD;hQi=>
MIA-PaCa-2 MYfBdI9xfG:|aYOgRZN{[Xl? NHr1UoQzPGh? NUjKWHc{[myxY3vzJINt\WG4YXflJI9nKGOjc4Dhd4UuOyCrbnT1Z4VlKGK7IHLveIghSS12NEO2OVQh[W6mIIDhZ4xqfGG6ZXy= NUPrZVBVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NVA6QTJpPkK0OVExQTl{PD;hQi=>
Caki-1 NFnmSVVCeG:ydH;zbZMhSXO|YYm= MV:yNO69VQ>? NWfKW4htOWh? M{DLZ4lvcGmkaYTzJHNEWC2rbnT1Z4VlKGGyb4D0c5Nqew>? NGe3WHM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEWwOFY5OSd-MkS1NFQ3QDF:L3G+
CLL MXTBdI9xfG:|aYOgRZN{[Xl? MVqyOe69VQ>? M1Pib|Fp NYLE[YZ2eGG{dHnhcIx6KGKub3Prd{BOVE5{MkO4MYlv\HWlZXSgZ4VtdCCjcH;weI9{cXN? NFjiTlg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES2O|Y{PCd-MkS0Olc3OzR:L3G+
SGC-7901 MW\BdI9xfG:|aYOgRZN{[Xl? MUWxNO69VQ>? NGL6OIgzPGh? MmrpdJJwdW:2ZYOgeIhmKEOJSVmtbY5pcWKrdHXkJINmdGxiZ4Lve5RpKGmwIGPHR{04QTBzIHPlcIx{ NF65Wlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NES1OFQ5QCd-MkS0OVQ1QDh:L3G+
k1735 M2n2UmFxd3C2b4Ppd{BCe3OjeR?= NFH6OpczOOLCid88cS=> M4H2U|Rp NEf2emRqdmirYnn0d:KhW2GubX;u[Yxt[S2rbnT1Z4VlKGGyb4D0c5Nqew>? MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDR3MUGxOkc,OjR2NUGxNVY9N2F-
HaCaT  NGftR|VCeG:ydH;zbZMhSXO|YYm= NWHrTIc4OTByzszN Mon5NYg> MUHicJVvfHNiVW\CMYlv\HWlZXSgZZBweHSxc3nzJIlvKEijQ3HUJINmdGy| MlLOQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|NU[5PVcoRjJ2M{W2PVk4RC:jPh?=
podocytes MXPBdI9xfG:|aYOgRZN{[Xl? NV3mSVlkOjByzszN MU[2bC=> M2H4OolvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDNuND3ES2U> MmnMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR|M{e3O|coRjJ2M{O3O|c4RC:jPh?=
 KB MVjBdI9xfG:|aYOgRZN{[Xl? MkTZOVDPxE1? M1W2WlI1cA>? MkXYbY5pcWKrdIOgUIlkdy2DLXnu[JVk\WRiY3HzdIF{\S1|IHHu[EBRSVKSIHHjeIl3[XSrb36= NXLVbYExRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|c1QTJpPkK0N|M4PDl{PD;hQi=>
 HepG2  NWjkSohYSXCxcITvd4l{KEG|c3H5 M2fVWlEx|ryP MnzENlRp MYjy[YR2[2W|II\pcYVvfGmwIHPs[YF3[WenIHPheZNm\CCkeTDMVHM> NXHkV3I1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNlU5OTZpPkK0N|I2QDF4PD;hQi=>
fetal rat lung fibroblasts  NF7K[GpMcW6jc3WgRZN{[Xl? NFyxZ5Y5OM7:TdMg M1\kflFp NX;NUYY3cW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? NYXSXXlLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVQyOzVpPkK0N|E1OTN3PD;hQi=>
PDL fibroblasts M2jz[2tqdmG|ZTDBd5NigQ>? M3K2e|gx|ryPwrC= NVPPboFNOWh? NXvDWodkcW6qaXLpeJMhS2G|cHHz[U0{KGGldHn2bZR6yqB? M{HwNlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2M{G0NVM2Lz5{NEOxOFE{PTxxYU6=
MB49 NVHrNnRlSXCxcITvd4l{KEG|c3H5 NEPDV3QzOM7:TR?= NVrRV5pMOWh? MVPy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJ6MkSzN{c,OjR{OEK0N|M9N2F-
5637 MUfBdI9xfG:|aYOgRZN{[Xl? MWOyNO69VQ>? Mn7iNYg> NYXOZpByemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq NFL0bog9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK4NlQ{Oyd-MkSyPFI1OzN:L3G+
A549  NH6xdppCeG:ydH;zbZMhSXO|YYm= MlPhNVAx|ryP MlvaOFhp MnrDd5VxeHKnc4Pld{B1cGViYYDvdJRwe2m|IHPheZNm\CCkeTDwbZBmemmwZdMg NF3CcmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK3NlIxOSd-MkSyO|IzODF:L3G+
MCC-2 MVLBdI9xfG:|aYOgRZN{[Xl? NHztdGszOCEQvF2= NFHHSno3cA>? MWDEUXNQ MojKZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= MmP1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{NkK2OVgoRjJ2Mk[yOlU5RC:jPh?=
ADF NHuwR|RCeG:ydH;zbZMhSXO|YYm= NGHiboI1OM7:TR?= M2\6S|Zp MUfpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NV\nVVdlRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNlgzOzJpPkK0NlI5OjN{PD;hQi=>
 U373  M3vTT2Fxd3C2b4Ppd{BCe3OjeR?= NUSwNVM1PDEQvF2= NY\GNFhCPmh? MXHpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= M1LnfVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkK4NlMzLz5{NEKyPFI{OjxxYU6=
RKO-HIPK2i MVjBdI9xfG:|aYOgRZN{[Xl? M1fFcVQx|ryP M4e3XVZp NE\KWJVqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NHLRPJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKyPFI{Oid-MkSyNlgzOzJ:L3G+
HEC-1B MYTBdI9xfG:|aYOgRZN{[Xl? MnLtNlDPxE1? NF7ieW4ycA>? NHzHVlNz\WS3Y3XzJHRRNWmwZIXj[YQh[XCxcITvd4l{yqClYYPwZZNmNTNiYX7kJINie3Cjc3WtPS=> NWjVepRYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyNVM{PThpPkK0NlE{OzV6PD;hQi=>
4T1 M2POV2NmdGxiVnnhZoltcXS7IFHzd4F6 NXXpXVk2Oi53LUGw{txO MXi0bC=> M4focmROW09? NWCzT4I{emW|Y4Xld{B1cGViY4n0c5RwgGmlaYT5JI9nKDSWMTDj[YxteyCrbnT1Z4VlKGK7IGPQSHQhcW5iYTDjc45k\W62cnH0bY9vKGSncHXu[IVvfCCvYX7u[ZI> Mn3UQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{ME[xOlEoRjJ2MkC2NVYyRC:jPh?=
OS  NWSwOZR5SXCxcITvd4l{KEG|c3H5 NIPVNpMzOM7:TR?= M3\ySVRp NV7tbpJxcW6qaXLpeJMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JHBFXA>? MlPZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MES5N|coRjJ2MkC0PVM4RC:jPh?=
RPE NGm3c3lCeG:ydH;zbZMhSXO|YYm= MmDFNVAx|ryP Moj4OFhp NEXZV49x[XK2aXHscJkhcW6qaXLpeJMhfGinIHPhcJBicW5vMTDhcoQhNTJiYXP0bZZifGmxbjDhd{B4\WyuIHHzJJRp\SClYYPwZZNmKGGldHn2ZZRqd25? M2PP[|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkCyNFUzLz5{NEKwNlA2OjxxYU6=
UD29a MmrTRZBweHSxc3nzJGF{e2G7 NX3jVIlkPTEQvF2= MXmyOIg> MWrpcohq[mm2czD0bIUh[2WubDDk[YF1cCClYYXz[YQh[nliTmXUNy=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDF7MEW3OEc,OjRzOUC1O|Q9N2F-
SH-SY5Y  NIHv[JdCeG:ydH;zbZMhSXO|YYm= NEXHU|AyOM7:TR?= M3HHdVI1cA>? MkHaZZR1\W63YYTld{Bk[XOyYYPlJIFkfGm4YYTpc44h[W6mIHPlcIwh\GWjdHigbY5lfWOnZDDifUBJVkVvMlTH NWO3UlhMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxOFU1PjNpPkK0NVQ2PDZ|PD;hQi=>
HeLa  MkDoRZBweHSxc3nzJGF{e2G7 M2DVW|ExNzJyzszN MmW0NlRp Mn3MbY5pcWKrdIOgeIhmKGGldHn2bZR6KG:oIITo[UBu[Wqxcnn0fUBw\iC2aHWgcYVu[mW{czDv[kB1cGViY3HzdIF{\S2oYX3pcJk> NYL2dJdLRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSxN|czPjZpPkK0NVM4OjZ4PD;hQi=>
SCCVII  NXLiXVdkSXCxcITvd4l{KEG|c3H5 MlvDNlXPxE1? NGjFU|kycA>? MVPpcohq[mm2czD0bIUh[2WubDDrbYxtcW6pIHHmeIVzKGSjc3H0bY5q[g>? Mm[5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMk[0OlQoRjJ2MUK2OFY1RC:jPh?=
RAW 264.7 NIHMTplCeG:ydH;zbZMhSXO|YYm= NE\LU4gzOM7:TR?= M1ftTVE5cA>? NIfwcFNqdmO{ZXHz[ZMhVEN|LVnJM:6zNWGldHnuJJJifGmxIHPvcZBiemWmIITvJGVEXFZvTV;TJJRz\WG2bXXueEBwdmy7 MmDFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzMU[3NFcoRjJ2MUG2O|A4RC:jPh?=
A549  NWDJd41KSXCxcITvd4l{KEG|c3H5 M4n6SVIvPc7:TR?= NVXJN3gyOjSq MUHk[YNz\WG|ZYOgc5Jq\G:waX6tbY5lfWOnZDDheZRweGijZ4mgZZMhf2WubDDhcoQhVG:|czDv[kDPnM,KbTDhcJNwKG:lY4XydoVlKGS3cnnu[{BifXSxcHjh[4lkKHC{b3Pld5M> MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDFyMkWyNkc,OjRzMEK1NlI9N2F-
UM-SCC-10A  NVG5bGdbSXCxcITvd4l{KEG|c3H5 NIC4dmU2OML3TR?= Mo\PNog> M4LkWJJm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhcGmpaD3kc5NmKGm|b3HsZY51d2yjY4TvcoU> NF3FZmM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEC5PFc2Oyd-MkSwPVg4PTN:L3G+
BGC-823 NG\NdFVCeG:ydH;zbZMhSXO|YYm= M2S4XFExKM7:TR?= NHnSbmgzPGh? NYLqS2p7emWmdXPld{B1\XS{YX7kdolv\S2rbnT1Z4VlKGGyb4D0c5Nqe8Li M2LaZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm4OVEyLz5{NEC5PFUyOTxxYU6=
Nalm-6  MmX4RZBweHSxc3nzJGF{e2G7 MmjqNlDPxE1? M3n6XFRp NWjqZZVIcW6qaXLpeJMh[2G|cHHz[U05KGGwZDDjZZNx[XOnLUOgZYN1cX[jdHnvckBidmRiUFHSVE0yKGOuZXH2ZYdm NEXOSJU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzPVk3Pyd-MkSwN|k6Pjd:L3G+
KHOS  NFvuTmhCeG:ydH;zbZMhSXO|YYm= NHHreoQ1OM7:TR?= MXeyOIg> Ml7YZoxw[2u|IITo[UBqdmO{ZXHz[YQh[2ynYY\h[4Uhd2ZiY3HzdIF{\S1|IHHu[EBRSVKSIHnu[JVk\WRiYomgRmJOTDQEoB?= MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDB{NUO2NUc,OjRyMkWzOlE9N2F-
G292 MV;BdI9xfG:|aYOgRZN{[Xl? NH;TcGY1OM7:TR?= MV6yOIg> M1vNWYJtd2OtczD0bIUhcW6lcnXhd4VlKGOuZXH2ZYdmKG:oIHPhd5Bie2VvMzDhcoQhWEGUUDDpcoR2[2WmIHL5JGJDVUR|wrC= NHSyZlc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECyOVM3OSd-MkSwNlU{PjF:L3G+
MG-63 Mlj5RZBweHSxc3nzJGF{e2G7 M1LmUFQx|ryP NV\Jc5FTOjSq NHLwSFhjdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg M{fTWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEK1N|YyLz5{NECyOVM3OTxxYU6=
EBV-transformed B cells MWPBdI9xfG:|aYOgRZN{[Xl? NHTVdFAzOM7:TR?= NIjrSWUzcA>? MoPsSG1UVw>? M37OeoJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? M4T5ZVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEC4OlI5Lz5{NECwPFYzQDxxYU6=
IM-9 B MojLRZBweHSxc3nzJGF{e2G7 NWTJ[3lzOjEQvF2= NYfzW4NvOmh? NIDiTHhFVVOR MoDVZoxw[2u|IHHueIkuS0R6MDDhcoQh[W62aT3DSFg3KGGwdHnic4R6NWmwZIXj[YQh[XCxcITvd4l{ MlHDQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMEi2NlgoRjJ2MEC4OlI5RC:jPh?=
CNE1 NUnJOWJjSXCxcITvd4l{KEG|c3H5 M{THXVIx|ryP M1jPS|Q5cA>? MWnicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> M1XSWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUi1NFI6Lz5{M{m4OVAzQTxxYU6=
CNE2 NFTURXFCeG:ydH;zbZMhSXO|YYm= NXHwc4JKOjEQvF2= MWe0PIg> MWLicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NFHj[Ic9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m4OVAzQSd-MkO5PFUxOjl:L3G+
HL-60 M2PRd2Fxd3C2b4Ppd{BCe3OjeR?= NEK0cYw2OML3TR?= NGSzcoUycA>? M3f2TGROW09? MnTFbY5pcWKrdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkhSkFzNEW= NHGwVoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m0PFc2OSd-MkO5OFg4PTF:L3G+
L929 MnTtRZBweHSxc3nzJGF{e2G7 NF;HTI8yNjJ34pETOeKh|ryPwrC= MYOyOIg> M3f0VIF2\22nboTzJHRPTs7zLXnu[JVk\WRibnXjdo9xfG:|aYOgZY5lKGG3dH;wbIFogQ>? NFvyOXM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{m0NVc3QSd-MkO5OFE4Pjl:L3G+
Jurkat NIDIcWZE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M4Thc|LPxE1? MWm0bC=> NVXRWpM1emW4ZYLz[ZMh\3Kxd4ToJIlvcGmkaYTpc44h[W6mIN8yMYNifGWwaX6g[IVkemWjc3WgZpkhUFNvQWPB MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzh7NkC2NUc,OjN6OU[wOlE9N2F-
RAW264.7  NVPKVo9tSXCxcITvd4l{KEG|c3H5 MoLoNVAh|ryP NIjhVpkzPGh? MkDQ[IVkemWjc3XzJJRp\SCjcH;weI9{cXNiaX7keYNm\CCkeTDHRS=> NWrqSJZKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4NlAzODNpPkKzPFIxOjB|PD;hQi=>
A431  NV:3SZdmU2mwYYPlJGF{e2G7 MVy0NO69VQ>? NH3DeZUzcA>? MnKyZoxw[2u|IH\pd4V1cW5vaX7keYNm\CClbHXheoFo\SCxZjDjZZNx[XOnczDhcoQhWEGUUB?= MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyMEC1PEc,OjN6MECwOVg9N2F-
Jurkat M4jUR2NmdGxiVnnhZoltcXS7IFHzd4F6 MWeyOU0yODEQvF2= NILlU2M3cA>? MkPLbY5pcWKrdIOgfk1HSS2FTVutbY5lfWOnZDDj[YxtKGSnYYTo M{X5WVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUOzOVMzLz5{M{mzN|U{OjxxYU6=
COS-7  M3nqT2Z2dmO2aX;uJGF{e2G7 MmCxOVDDvU1? NVu1e5lzOjSq MVHh[oZm[3S|IITo[UBxem:lZYPzbY5oKG:oIFHUUlF{KHerdHigdI9tgVFidILhZ5R{ NG\CWnI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{mzN|IxQCd-MkO5N|MzODh:L3G+
CAL27 NF7PW|FCeG:ydH;zbZMhSXO|YYm= NXfuUFRpOTBizszN MUWybC=> NVq0Rplxe3WycILld5NmeyCFdYKtUnB{NXKnZIXj[YQhfmmjYnnsbZR6KGK7IIXwJJRwKDlyJR?= NWrN[ZEyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVc{QTZpPkKzPVE4Ozl4PD;hQi=>
THP-1  MV3BdI9xfG:|aYOgRZN{[Xl? M3znV|ExNTVyzszN MVWybC=> NIHCNpRqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSC2cnnweI9tcWSn NYTGXmNRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NFAzQTlpPkKzPVAxOjl7PD;hQi=>
K562 NGfpUXZCeG:ydH;zbZMhSXO|YYm= NUDXfnVOOjEQvF2= MVW0PIg> M2mzOYlvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KDRvTWW= MoXrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6N{[4NlYoRjJ|OEe2PFI3RC:jPh?=
HL-60 NEf2T2xCeG:ydH;zbZMhSXO|YYm= NYrFO41GOTByzszN M1nKc|I1cA>? NX73RVk3cW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliYXLp[ZRidmViZHn0[ZJx\W6nc9Mg NIL0VW89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i2OVc4QCd-MkO4OlU4Pzh:L3G+
HeLa  M2XjTmFxd3C2b4Ppd{BCe3OjeR?= M2X2VVIx|ryP MonaNog> MXrpcohq[mm2czDEUW1RKGmwZIXj[YQh[XCxcITvd4l{ NV3pUGV7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlM6PjZpPkKzPFY{QTZ4PD;hQi=>
U251 M376eGFxd3C2b4Ppd{BCe3OjeR?= MlfWNlDPxE1? MYKyOIg> NX7vbphLcW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzNkixOkc,OjN6MU[4NVY9N2F-
HL-60 MX7BdI9xfG:|aYOgRZN{[Xl? MknQOVDDvU1? NY[4bFViPGh? NWnCeHRs[myxY3vzJJRp\SClbHXheoFo\SCxZjDjZZNx[XOnLUOsJE06NCCjbnSgVGFTWCCrbnT1Z4VlKGK7IE\z MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhyNEewOkc,OjN6MES3NFY9N2F-
Ec-109 M{TmXWFxd3C2b4Ppd{BCe3OjeR?= M2fSc|ExKM7:TR?= MlO2OFhp MlvVdoVxemW|c3XzJHBGNW2nZHnheIVlKEWlLUGwPUBk\WyuIHHwc5B1d3Orcx?= M{nPVFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{iyOlQyLz5{M{e4NlY1OTxxYU6=
RKO M33YNGNmdGxiVnnhZoltcXS7IFHzd4F6 MnfZNVAh|ryP NXjC[lRDOjSq NWLqfINEcW6qaXLpeJMhfGinIHTlZ5Jm[XOnIH;mJINmdGxidnnhZoltcXS7IHPheZNm\CCkeTDERWI> NXHwU41yRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OVgxPjRpPkKzO|U5ODZ2PD;hQi=>
T98G M3LUeGNmdGxiVnnhZoltcXS7IFHzd4F6 M{i1N|EuOTByzszN MVSyOIg> M1\qWolueHKxdnXzJINmdGxidnnhZoltcXS7IHPveJJm[XSvZX70JJdqfGhiVGO= NHLOOXc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e2PVI4PSd-MkO3OlkzPzV:L3G+
Jurkat MWjD[YxtKF[rYXLpcIl1gSCDc4PhfS=> M2jmdVExOC1{MEFOwG0> MYeyOIg> M4nldIlvcGmkaYTzJGhiSTRiaX7keYNmeyCjcH;weI9{cXNiZHXw[Y5l\W62IH;mJINwdmOnboTyZZRqd28EoB?= NIKzXFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ezNlQ5OSd-MkO3N|I1QDF:L3G+
Molt-3  M3nuWmFxd3C2b4Ppd{BCe3OjeR?= MmXUOVDPxE1? NVX4TYFKOmh? NYnYW21GemWmdXPld{Bu\WyjdH;ubY4ucW6mdXPl[EBieG:ydH;zbZM> MkPGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5MkWwNVMoRjJ|N{K1NFE{RC:jPh?=
hMSC12 M{PrW2Fxd3C2b4Ppd{BCe3OjeR?= MmTxNVAx|ryP MWW0[C=> MYXpcohq[mm2czDvd5Rmd2enbnnjJIN2dHS3cnWtbY5lfWOnZDDj[YxtKGSnYYToJIFv\CClYXzjbYZq[2G2aX;u NV;NdIJuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2OVc5OjJpPkKzOlU4QDJ{PD;hQi=>
HM7  NV64NVZJSXCxcITvd4l{KEG|c3H5 MkPCNlDPxE4EoB?= MUixbC=> M2P3XYJtd2OtczDhdIlkfWyjcnXuJGEh[WOndHH0[U1qdmS3Y3XkJINie3Cjc3WtN{Bi[3SrdnH0bY9vKGGwZDDQRXJRKGOuZXH2ZYdm NXPUU3A2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PFM1OTJpPkKzOVg{PDF{PD;hQi=>
Hep-2  M3m3bmFxd3C2b4Ppd{BCe3OjeR?= MVOyNO69VcLi NIfZRmgzPGh? NXnTTm1lTE2VTx?= NEjZNIJidGyndnnheIV{KHSqZTDk[YNz\WG|ZTDv[kBk\WyuII\pZYJqdGm2eTDpcoR2[2WmIHL5JJNqdGmkaX7pci=> MmqxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN3OECwN|IoRjJ|NUiwNFMzRC:jPh?=
HSCs MmPYRZBweHSxc3nzJGF{e2G7 MkTuOVDPxE1? M1LFWFI1cA>? MXzEUXNQ NXvlUVBqcW6qaXLpeJMhdmmub4TpcoljNWmwZIXj[YQhTE6DIHThcYFo\SCrbnTpZ4F1\WRiYomgVGFTWCClbHXheoFo\Q>? NXuyepVCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVk5PzRpPkKzOFk6QDd2PD;hQi=>
HL-60  MX3DfZRwfG:6aXPpeJkhSXO|YYm= MVKyNO69VcLi MVGyOIg> Mk[zdoVlfWOnczD0bIUh[3m2b4TvfIlkKGWoZnXjeEBw\iCHcom1 NVPaWWxoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0PVQ1QDBpPkKzOFk1PDhyPD;hQi=>
HA MVvBdI9xfG:|aYOgRZN{[Xl? M1O3e|Ux|ryP NYXnTHl1OjSq NWHsNFJWe3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD M1LieVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEe1PVU3Lz5{M{S3OVk2PjxxYU6=
C666-1 NXThOJhqSXCxcITvd4l{KEG|c3H5 MlzjOVDPxE1? MU[yOIg> M{fKSJN2eHC{ZYPz[ZMhfGinIHPs[YF3[WenIH;mJHBCWlBiYX7kJINie3Cjc3WtN{whNTduIHHu[EAuQSCrbnT1Z4VlKGK7IHLvdpRmgm:vaXKvV2FJSQ>? NGiyTYw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S3OVk2Pid-MkO0O|U6PTZ:L3G+
Hepa1-6 MnXmRZBweHSxc3nzJGF{e2G7 MoK2OVDPxE1? M4fJPVJp M2XNVIlvcGmkaYTzJIN2emO3bXnuJIFv\CC{ZYP2[ZJifHKxbD3pcoR2[2WmIHHwc5B1d3Orcx?= NWPjeZFWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFY4PTNpPkKzOFQ3PzV|PD;hQi=>
PLC/PRF/5c M4nOUWFxd3C2b4Ppd{BCe3OjeR?= NVq5cWdWPTEQvF2= NHK3Zo0ycA>? M17yO5Bz\X[nboTzJIFxd3C2b4Ppd{B1emmpZ3Xy[YQh[nliQ1nO Mlq3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2M{i4NlQoRjJ|NEO4PFI1RC:jPh?=
HCT116 MV7BdI9xfG:|aYOgRZN{[Xl? MVuxNFDPxE1? MYCxMlVp M3ezeYlvcGmkaYTzJG9{NWmwZIXj[YQh[2WubDDk[YF1cA>? M1LpVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{S0N|U{Lz5{M{e0OFM2OzxxYU6=
HCEC NEfKZZZHfW6ldHnvckBCe3OjeR?= NVv2PXltPTEQvF2= NV3xb3JCPzKq NHjocmxFVVOR MYTy[ZN1d3KnczDv[kB1cGVibn;ycYFtKEiFRVOgdIhmdm:2eYDl MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd2MkCxNUc,OjN5NEKwNVE9N2F-
Primary rat cerebral cortical neurons M2qxUmFxd3C2b4Ppd{BCe3OjeR?= MnrkNVAx|ryP NUHwSGZDOWh? MUHwdoV3\W62czDD[E1qdmS3Y3XkJIFxd3C2b4Ppd{BidmRiY3XscEBl\WG2aB?= M1PMe|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{SxN|E4Lz5{M{e0NVMyPzxxYU6=
MDA-MB-231  NGTaWIpCeG:ydH;zbZMhSXO|YYm= NGHZb4UzPc7:TR?= MXyyOIg> MnKwZYJzd2ejdHXzJIN6fG:2b4jpZ4l1gSCjbnSgZ4xm[X[jZ3Wgc4Yh[2G|cHHz[U0{KGGwZDDQRXJRKGmwZIXj[YQh[nliUnez NV7yemtpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzN|c2PDRpPkK1N|M4PTR2PD;hQi=>
NLRP3-Tet-on-MC/9  NFeyem9CeG:ydH;zbZMhSXO|YYm= Ml;6NVAuPDEQvF2= M2XUbVEzcA>? M4TmVoF1fGWwdXH0[ZMhfGinIHPlcIwh\GWjdHigZ4F2e2WmIHL5JGNCWFNvYYPzc4Nq[XSnZDDOUHJROyCvdYThcpR{KGmwIITo[UBV\XRvb36gd5l{fGWv NGTib5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{ewN|M5QSd-MkO3NFM{QDl:L3G+
KNS42  NFH2WoRCeG:ydH;zbZMhSXO|YYm= NWfQU|R7PTEQvF2= MmXNNYg> M1HybZJm\HWlZYOgZ4VtdCCmZXH0bEBidmRiY3;tdIxmfGWueTDhZo9tcXOqZXSgZ4F{eGG|ZTCzM|ch[WO2aY\peJkhcW5icnXzdI9ve2VidH:gRWJVNTJ4Mz:ySGcwdWW2Zn;ycYlvKGOxbXLpcoF1cW:w NXG0TWR[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO2PVEyPDVpPkKzOlkyOTR3PD;hQi=>
MCF-7  M4K5[2Fxd3C2b4Ppd{BCe3OjeR?= NVPlSZl2OjEQvF5CpC=> NXnVVYRxPzKq M4nuT4lvcGmkaYTzJIVyfW:uLTDhcoQhPC2RSGStcYVlcWG2ZXSgZZBweHSxc3nz NGXJW2o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{[3OVY1Oyd-MkO2O|U3PDN:L3G+
hCMEC/D3  NH6wT3FCeG:ydH;zbZMhSXO|YYm= NIDwbGEzPc7:TR?= NXTqT2pNPzKq Ml\pdoVlfWOnczDMeJhCKGmwZIXj[YQh[XCxcITvd4l{ M32x[FxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nk[1NVk5Lz5{M{[2OVE6QDxxYU6=
Jurkat NWO4e292SXCxcITvd4l{KEG|c3H5 M4HxN|EzNjVvNUFOwG0> NWPJN2IzOWh? MXvkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> Ml;CQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2NEK5O|YoRjJ|NESyPVc3RC:jPh?=
CNE-1 NF:5WpVCeG:ydH;zbZMhSXO|YYm= M4e1[lIx|ryPwrC= Mn;ENlRp NYrTW4F6cW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR{Nki1NEc,OjN2Mk[4OVA9N2F-
HONE-1 NGDsS4tCeG:ydH;zbZMhSXO|YYm= MUKyNO69VcLi MnXpNlRp Ml;TbY5pcWKrdIOgVmFFODBzLXnu[JVk\WRiY3XscEBl\WG2aB?= MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR{Nki1NEc,OjN2Mk[4OVA9N2F-
astrocytes cell NU\GPWZOSXCxcITvd4l{KEG|c3H5 MmXPOFDPxE1? NXL0XYlQPmh? NHPYOZZz\WS3Y3XzJIViemy7IHHwc5B1d3OrczDpcoR2[2WmIHL5JJN1[XW{b4Pwc5JqdmV? MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzMUe3PEc,OjN2MUG3O|g9N2F-
U-937 MWPBdI9xfG:|aYOgRZN{[Xl? NYL5UIZqOTEQvF2= NHzJbG8{OG2rbh?= NYDrNGRKeHKndnXueJMhXE6ILXnu[JVk\WRibnXjdo9xfG:|aYO= M3HTT|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEGwO|Q5Lz5{M{SxNFc1QDxxYU6=
MDA-MB-231 NF:ze3FCeG:ydH;zbZMhSXO|YYm= NHnHdmkyODEQvF2= NIm0XIoycA>? M{fwOolvcGmkaYTzJJNmdnOrdHn6ZZRqd25idH:gWHJCUUxidYDvckBOXESKIHTve44uemWpdXzheIlwdg>? M4frTlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEC4OFI6Lz5{M{SwPFQzQTxxYU6=
HeLa  Mo\XRZBweHSxc3nzJGF{e2G7 M4\sfVExOM7:TR?= MYGybC=> NXvKTmhY[myxY3vzJGpTWy1zNTDJcoR2[2W|IFHwc5B1d3SrYzDD[YxtKESnYYTo NE\zV2c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{O0OFA1PSd-MkOzOFQxPDV:L3G+
Ec109 M2Pl[2Fxd3C2b4Ppd{BCe3OjeR?= NFzWdngyOM7:TR?= M17tc|Zp Mm\tZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> NIfFTFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OzPFU3QCd-MkOzN|g2Pjh:L3G+
H460  MYfBdI9xfG:|aYOgRZN{[Xl? MXGxNO69VQ>? MnXYOog> M2rSPIJtd2OtczDhdI9xfG:2aXOgZ49u[mmwYYTpc44hd2ZiVHH0MXNu[WOQNzDhcoQhemGmaXH0bY9v Ml3tQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|M{i1OlgoRjJ|M{O4OVY5RC:jPh?=
HeLa  MWfBdI9xfG:|aYOgRZN{[Xl? NGPWXoE2OM7:TR?= M4Hzc|EvPWh? NGTaT5Fi[nKxZ3H0[ZPDqEOqbHHtfYRq[S2rbnT1Z4VlKGGyb4D0c5Nqew>? M4nRclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|M{CzPFA1Lz5{M{OwN|gxPDxxYU6=
SK-HEP1 NHj4ZnNCeG:ydH;zbZMhSXO|YYm= NH6xRW0yODEQvF2= NV;uclN1OWh? NWHjS|FXcW6qaXLpeJMhS3KWMTDhZ5RqfmG2ZXSgZ4F{eGG|ZT2zMEAuPyxiLUisJE06NCCjbnSgdI9tgSiDRGCtdoljd3OnKTDwc4x6dWW{YYPl Ml;NQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|MEK2OVAoRjJ|M{CyOlUxRC:jPh?=
QGY7701 NF;ZenZCeG:ydH;zbZMhSXO|YYm= Mn:2NlXPxE1? MXSxMlVp MV7pcohq[mm2czDhZ4N2dXWuYYTpc44hd2Zic4XiMWcyKHCqYYPlJIlv\HWlZXSgZpkhTE:[IDugdZVmemOndHnu NIjXTYk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{K0NFA3OSd-MkOyOFAxPjF:L3G+
HepG2 MV\BdI9xfG:|aYOgRZN{[Xl? NILPOWUzOM7:TR?= MY[zNI1qdg>? MoXhbY5pcWKrdIOgeIhmKGWwaHHuZ4VlKGOnbHyg[IVifGhiYomgZ49u[mmwZXSgeJJm[XSvZX70JI9nKGGyaXflcolvKGGwZDDUVmFKVA>? MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ{NEKzPUc,OjN{MkSyN|k9N2F-
U87  MkXURZBweHSxc3nzJGF{e2G7 MX:yOe69VQ>? M3Lz[FJp NXTsbVR7\GWlcnXhd4V{KGm|b3zpdZVqemm2aXflcolvKCiLU1ypMYlv\HWlZXSgZZBweHSxdHnjJINmdGxiZHXheIgtKGK3dDDuc5QhdmWlcn;0bYMh[2WubDDk[YF1cA>? MkK1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{Mkm2NlYoRjJ|MkK5OlI3RC:jPh?=
HSC-2 NF3zTGZCeG:ydH;zbZMhSXO|YYm= M4rwclI2NzVyzszN M3XDe|Fp NF3LVYVqdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3NUK0PEc,OjNzNUWyOFg9N2F-
HSC-4 M1XXNWFxd3C2b4Ppd{BCe3OjeR?= M4SycFI2NzVyzszN MmS3NYg> Ml3XbY5pcWKrdIOgV24uOzhvaX7keYNm\CCleYTveI95cWOrdIm= MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3NUK0PEc,OjNzNUWyOFg9N2F-
CL-1 NU\KUZBpSXCxcITvd4l{KEG|c3H5 NVq4UIZqOjEQvF2= MYqxbC=> NGrlW4hjdG:la4OgU3A1PDliaX7keYNm\CClZXzsJIRm[XSq NGT3SFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{GzNVc5Oid-MkOxN|E4QDJ:L3G+
MEL MYLBdI9xfG:|aYOgRZN{[Xl? MXmyNO69VQ>? NEDFe2ozPGh? M1T6emROW09? NYHHPXRscW2yYXny[ZMhWDK[Nz3pcoR2[2WmIF3FUEBk\WyuIHHwc5B1d3Orcx?= MX:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzBzNEi4O{c,OjNyMUS4PFc9N2F-
Bel-7402  Mki5R4F{eGG|ZTDBZ5RqfmG2aX;uJGF{e2G7 MVO1NO69VQ>? NHzyTYszcA>? M33WTIlvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> MoLQQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjNyMEi3OFIoRjJ|MEC4O|QzRC:jPh?=
Eca-109 MYPBdI9xfG:|aYOgRZN{[Xl? MVSyOe69VQ>? NEjIcFc{OG2rbh?= NWHVW5gzcW6qaXLpeJMhSkpvQkGxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NIHq[W49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{C3Olk3Pyd-MkOwO|Y6Pjd:L3G+
MEL MWTBdI9xfG:|aYOgRZN{[Xl? MU[yNO69VQ>? MXOxbC=> M2DSTGROW09? NF;m[XdqdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NHH3PFA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxOFg5Pyd-MkOwNVQ5QDd:L3G+
Bel-7402  NGntN2dCeG:ydH;zbZMhSXO|YYm= NHHJbnM2OM7:TR?= MW[ybC=> M4TnO4lvcGmkaYTzJHBETS2rbnT1Z4VlKGGwb3nrbZM> NVnRTXlSRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNFg4PDJpPkKzNFA5PzR{PD;hQi=>
L929 MVTGeY5kfGmxbjDBd5NigQ>? Mmr4Nk42|ryP NED5OFAycA>? NFKxOFZqdmO{ZXHz[ZMhWkmSMTDlfJBz\XO|aX;uJIFv\CCneHHj[ZJj[XSnZDDUUmbPuS2rbnT1Z4VlKG2rdH;jbI9v\HKrYXyg[Jl{\nWwY4Tpc44h[W6mIGLPV{Bxem:mdXP0bY9v NUnybYFuRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNFA2OThpPkKzNFAxPTF6PD;hQi=>
RCC  NYfPTpU6S2WubDDWbYFjcWyrdImgRZN{[Xl? NWS1VGRNOTByzszN MVeyOIg> MUfy[YNwfmW{ZYOgeIhmKH[rYXLpcIl1gSCxZjDj[YxteyCneIDvd4VlKHSxIEG1[E1RT0p{ NIntTpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm5NVQ6PCd-MkK5PVE1QTR:L3G+
NB2a/d1 M{XFRWFxd3C2b4Ppd{BCe3OjeR?= NWLzW4R2OTByzszN MYm3Nog> MUTheJRmdnWjdHXzJJN1[XW{b4Pwc5JqdmVvaX7keYNm\CClYYPwZZNmKGGldHn2bZR6NCCSQWLQMEBidmRidHH1JINt\WG4YXfl M3[yWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUi4OVQyLz5{Mkm4PFU1OTxxYU6=
T cell MVHHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MYKyOU0yODEQvF2= MkfQNlRp NXHoT|N1\G:|ZT3k[ZBmdmSnboTsfUBqdmirYnn0[YQhXCClZXzsJJBzd2yrZnXyZZRqd25ibXXkbYF1\WRidHjyc5VocCC2aHWgZ48ue3SrbYXsZZRqd25id3n0bEBidnSrLVPEN{BidmRiYX70bU1ETDJ6 MkK2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7OEK1N|goRjJ{OUiyOVM5RC:jPh?=
K562 MmnXRZBweHSxc3nzJGF{e2G7 M1rtSlExOM7:TR?= MW[xbC=> M{jF[4Jtd2OtczDBZo5w[mG4aYPjeY3DqEZvaX7keYNm\CCjcH;weI9{cXN? MlfNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7N{KzO|IoRjJ{OUeyN|czRC:jPh?=
Jurkat  NVjKZVZrSXCxcITvd4l{KEG|c3H5 NESzfJo1OM7:TR?= MVGxbC=> NUjHU5g3[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? M3;YV|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OUSyO|M5Lz5{Mkm0Nlc{QDxxYU6=
BGC-823 MmDCRZBweHSxc3nzJGF{e2G7 MnnGNVAx|ryP NGnmbpQycA>? MUjwZZJ1cWGubImgdoV{[3WnczDj[YxteyCjZ3HpcpN1KGSjbXHn[UBw\iCmYXnkfoVqdg>? MonZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ7Mk[1OFUoRjJ{OUK2OVQ2RC:jPh?=
Hep3B NYXBSWZpSXCxcITvd4l{KEG|c3H5 NESyXZU2OM7:TR?= NFK5boIycA>? M1\DcoJtd2OtczDhdI9xfG:|aYOgbY5lfWOnZDDifUBJTUeFcx?= NYjOW283RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK5NlMyPTRpPkKyPVI{OTV2PD;hQi=>
LLC-PK1 MX7BdI9xfG:|aYOgRZN{[Xl? MUKyNO69VQ>? M{TiT|Fp MVjwdoV3\W62czDjbZNxdGG2aX6tbY5lfWOnZDDk[Ydz[WSjdHnvckBw\iCDdHe1MEBj\WOuaX6tNUwh[W6mIFH0[|EzKHC{b4TlbY5{ NHrwSmI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki5OlA{Pyd-MkK4PVYxOzd:L3G+
A549 Mnf2RZBweHSxc3nzJGF{e2G7 M4fBZVUx|ryP MYexbC=> NYXmOWJk[myxY3vzJJRp\SCEQVmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh6N{KxOUc,OjJ6OEeyNVU9N2F-
SGC-7901  M3Toc2Fxd3C2b4Ppd{BCe3OjeR?= NUTEOXJqOTEQvF2= NFz5PIozPGh? NGrUeINqdmirYnn0d{DPui{Qsj3kbY1mfGi7bHHjdplte2ira3;ubY4ucW6mdXPl[EBieG:ydH;zbZPDqA>? NHztVZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mki0PFU6Pyd-MkK4OFg2QTd:L3G+
DM6 M3XafGFxd3C2b4Ppd{BCe3OjeR?= M2\ERlExOM7:TR?= MYe3Nog> NV[1R5NK[myxY3vzJIJwfGhiRULGMVEh[W6mIFWySpRzNW2nZHnheIVlKGO7dH;0c5hq[2m2eR?= MnrKQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6MkWzNlgoRjJ{OEK1N|I5RC:jPh?=
MCF-7, MDA-MB-468, Caco-2 NWrPVWNQT3Kxd4ToJGlvcGmkaYTpc44hSXO|YYm= NVjGS2U2PTEQvF2= M3ryblQ5cA>? MonvbY5pcWKrdIOgeIhmKGOnbHyg[5Jwf3SqIHnubIljcXSrb36gbY5lfWOnZDDifUB{[XCxbnnu NHuyT|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkiwNFk3QCd-MkK4NFA6Pjh:L3G+
A2750  M{PtVmFxd3C2b4Ppd{BCe3OjeR?= NF61UVkzOM7:TR?= NUCyWWcyOmh? M{H6RWROW09? M{PDWIJtd2OtczDjZZNx[XOnIHPs[YF3[WenIHT1dolv\yCqZXzlcoFtcW5idILlZZRu\W62IHHu[EBz\WS3Y3XzJIF2fG:yaHHnbYMh[2WubDDk[YF1cA>? M2C5PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{i0N|Y{Lz5{Mke4OFM3OzxxYU6=
U87  NH;k[oZCeG:ydH;zbZMhSXO|YYm= M1j5RVIx|ryP MnrhNlRp M2XzNpJm\HWlZYOgeIhmKGGyb4D0c5NqeyC{YYTlJIlv\HWlZXSgZpkhWEyDQh?= MnXaQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5N{i3PFAoRjJ{N{e4O|gxRC:jPh?=
HT1080 NIrFU2VIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M1LxW|Ux|ryP MnjjO4Q> NFLIb|RqdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBk[XW|ZXSgZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIFTDRUBidmRiT13Q MlTmQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5NEC5PFQoRjJ{N{SwPVg1RC:jPh?=
A549  MVfBdI9xfG:|aYOgRZN{[Xl? NHrZfWY2OM7:TR?= MlT0Nog> M2DZPJBienSrYXzsfUBl\WO{ZXHz[ZMhe2:maYXtJJNmdGWwaYTlMYlv\HWlZXSgZZBweHSxc3nz MUO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{MUiwOEc,OjJ5MkG4NFQ9N2F-
Primary OPC M2ryb2Fxd3C2b4Ppd{BCe3OjeR?= MnrONe69VQ>? M2fZc|ZpNzJ2aB?= M2KyZ5Jm\HWlZYOgeIhmKHCncnPlcpRi\2Vib3[gZ4VtdHNiaX6g[YFzdHlvIHHu[EBt[XSnLXHwc5B1d3Orcz;u[YNzd3Orcx?= MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjdyN{O4OUc,OjJ5MEezPFU9N2F-
PMNs MX7BdI9xfG:|aYOgRZN{[Xl? NGe5V4M1OM7:TR?= NVz6UFhYPmh? MnnoSG1UVw>? NV3xWHRIemW4ZYLz[YQhfGinIHHtc5VvfCCxZjDjcIVifmWmIHPhd5Bie2VvMzD0c{Bv\WG{II\lbIlkdGVibHX2[Yx{ MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ7MkW3O{c,OjJ4OUK1O|c9N2F-
A549  MX7BdI9xfG:|aYOgRZN{[Xl? MojUOVDPxE1? MV:xbC=> MUHwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? NYe2WWx[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2PFc3OzVpPkKyOlg4PjN3PD;hQi=>
AGS NFTmeYVCeG:ydH;zbZMhSXO|YYm= M3LWSlIx|ryP NFeyeZIyOmh? MnPNbY5pcWKrdIOgeIhmKGGldHn2ZZRqd25ib3[gdJJwNWOjc4Dhd4UuOyCrbjDy[ZNxd26|ZTD0c{B1cGViRYTPRYMh\nKjY4Tpc44> MonTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ4OEezPVgoRjJ{Nki3N|k5RC:jPh?=
shC9  MUnBdI9xfG:|aYOgRZN{[Xl? NHzKWGMyOM7:TR?= NFjXcIQyPmh? NIPIeXpjdHWwdIOgV2hJKGW6cILld5Nqd25iaX6gd4hEQSClZXzsd{BmgHCxc3XkJJRwKGWrdHjldkBRSSCxcjDMVGM> NHLvTIg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[0NVA6PCd-MkK2OFExQTR:L3G+
primary MEFs M1zjXWZ2dmO2aX;uJGF{e2G7 MVexNog> NH\PZ3TDqGmwY4LlZZNmeyCndH;wc5Nq\GVvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJIRmeG:uYYLpfoF1cW:w NF;kVo09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[xN|c3Pyd-MkK2NVM4Pjd:L3G+
3T9 MEFs M3TtS2Z2dmO2aX;uJGF{e2G7 NFf2dFkyPmh? M2WxZolv[3KnYYPld{BkgXSxY3jyc41mKGNicnXs[YF{\SCjZoTldkBmfG:yb4Pp[IUufHKnYYTt[Y51 NVvwUI84RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVM4PjdpPkKyOlE{PzZ5PD;hQi=>
3T9 MEFs NHvCOFRHfW6ldHnvckBCe3OjeR?= M2HnVlE5cA>? NV[5VmM4fXC{ZXf1cIF1\XNiaX7peIlifG:{IHPhd5Bie2VvOTDieZQh\G:5boLl[5Vt[XSnczDl[oZm[3SxcjDjZZNx[XOnczDh[pRmeiCndH;wc5Nq\GVidILlZZRu\W62 M{\RclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NkGzO|Y4Lz5{Mk[xN|c3PzxxYU6=
MDA-MB-231  M{DlOWFxd3C2b4Ppd{BCe3OjeR?= NUj2bpJwOjEQvF2= M4LJRlRl MWry[YR2[2W|IITo[UBk\WyuIHHwc5B1d3OrczDpcoR2[2WmIHL5JI1mfG[xcn3pckB1emWjdH3lcpQhf2G|IIPp[45q\mmlYX70cJk> MV[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjV7M{S0NUc,OjJ3OUO0OFE9N2F-
C6  NFftR5lCeG:ydH;zbZMhSXO|YYm= MkO3NVDPxE1? NYnXZ4RUOjSq NX[5[4Rs[myxY3vzJJRp\SC|dYDwdoV{e2m4ZTDl[oZm[3Rib3[geIhmKHCncITp[IUhd25idnnhZoltcXS7 NUPWNot{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK1PFg6QDBpPkKyOVg5QThyPD;hQi=>
HL-60  MmPwRZBweHSxc3nzJGF{e2G7 MmTMNVAx|ryP NV\ZfVRvOjSq MonYbY5pcWKrdIOgeIhmKGOnbHygZZBweHSxc3nzJJNmdGWldHXkJEgsMS2vZX70bJltKM7{LTix5qaTPilvZHnncJVkd3C7cnHuc5Nq\GYEoEW= M3zNNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUS2OlY6Lz5{MkW0OlY3QTxxYU6=
HL-60 M3;JWWFxd3C2b4Ppd{BCe3OjeR?= NHfxN|kyOC16MN88US=> NXG1VohGPGh? NXfnVlFEcW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? NH;UPHU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWyN|IzQSd-MkK1NlMzOjl:L3G+
BCC MWrBdI9xfG:|aYOgRZN{[Xl? MV[1NO69VQ>? NFPLSoYycA>? MoLtbY5pcWKrdIOgSGFVWy2vZXTpZZRm\CCpcn;3eIghcW6qaXLpeIlwdg>? NILESFE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkWxPVQ{Pid-MkK1NVk1OzZ:L3G+
RAW 264.7 MVvBdI9xfG:|aYOgRZN{[Xl? M3zjfFUxNzFyMN88US=> NHfX[GEycA>? NHrDWHNkd26lZX70doF1cW:wLXTldIVv\GWwdDDpcohq[mm2czDEU24ucW6mdXPl[EBzWk6DIHPs[YF3[Wen M{nsfFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NEmxOFI3Lz5{MkS5NVQzPjxxYU6=
K562 Mle5RZBweHSxc3nzJGF{e2G7 MWSyOe69VQ>? MVKybC=> Mom3dJJmfmWwdIOgZZBweHSxc3nzJIlv\HWlZXSgZpkh[29vdILlZZRu\W62IIfpeIgh[W23cnXud4lvKEdiYX7kJHRTSUmO NIXudJo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS4N|c4Pyd-MkK0PFM4Pzd:L3G+
SGC-7901 M3fMOmFxd3C2b4Ppd{BCe3OjeR?= MVWyNEDPxE4EoB?= MnX2Nog> MUXheJRmdnWjdHXzJGgzVzMEoH;yJHRPTiEQsT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{KGG|IIflcIwh[XNiY3HzdIF{\S1|IHHjeIl3cXS7wrC= NHjWUVM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS3NVU5QSd-MkK0O|E2QDl:L3G+
PC3 NHK0N2dCeG:ydH;zbZMhSXO|YYm= M4jCVlEx|ryP NHfpUnA1cA>? MlW5Z492dnSncoOg[oxifm:lb4jp[E1qdmS3Y3XkJINie3Cjc3WtdoVt[XSnZDDhdI9xfG:|aYO= NIjkT5g9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS3NVk4PCd-MkK0O|E6PzR:L3G+
SMMC-7721 NWfQemhkSXCxcITvd4l{KEG|c3H5 NXLjZ|JMPTEQvF2= MYC0PIg> M3u2ZYF1fGWwdXH0[ZMhd1SULXnu[JVk\WRiYYDvdJRwe2m| NFO4TGQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkS2OVg{Oyd-MkK0OlU5OzN:L3G+
HeLa  NVXyT|A1SXCxcITvd4l{KEG|c3H5 M{Tre|UxyqEQvF2= NV7Ic4dQPC96aB?= NIPiXItqdmirYnn0d{BUXFNvaX7keYNm\CCuYYTlMZBp[XOnIHHwc5B1d3SrYzDleoVvfHN? NU\nUllDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OlA2ODRpPkKyOFYxPTB2PD;hQi=>
HeLa  NF\OWVJCeG:ydH;zbZMhSXO|YYm= NY\ucWZsPTEEoN88US=> NI[4dlMycA>? M1vGZZN2eHC{ZYPz[ZMhfGinIF\SRXAucW6mdXPl[EBi[2O3bYXsZZRqd25ib3[gZY5v\XirbjDWJJBwe2m2aY\lJINmdGy| NVHLVVIxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0OFk1PDBpPkKyOFQ6PDRyPD;hQi=>
T47D  MlvGRZBweHSxc3nzJGF{e2G7 M1fW[|ExOM7:TR?= Mm[0NYg> MXficI9kc3NidHjlJIdmdmW{YYTpc44hd2ZiRT3jZYQwS1SIMjDifUBUXFN? NF;pb4c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkSwNVE3QCd-MkK0NFEyPjh:L3G+
HeLa  MnuxRZBweHSxc3nzJGF{e2G7 MVqzNO69VQ>? M{PMdFRp NHv2SGLDqGmwY4LlZZNmeyC2aHWg[4Vv\XKjbDDj[YxtKH[rYXLpcIl1gSB2ODDoJIFnfGW{IIDoc5Rw\HmwYX3pZ{B1emWjdH3lcpTDqA>? MnfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|OUSyOFgoRjJ{M{m0NlQ5RC:jPh?=
HCC NGGzd5hCeG:ydH;zbZMhSXO|YYm= MmPjNlAh|ryPwrC= M37NSFJp MnnPZZR1\W63YYTld{B1cGViRFjBJIlv\HWlZXSgZYN1cX[jdHnvckBw\iCSQWLQ MlK4QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ|NEK3N|IoRjJ{M{SyO|MzRC:jPh?=
mESCs MkjtRZBweHSxc3nzJGF{e2G7 NEDkOngzNjYQvF2= NWnWWJNSOmh? MmLnbY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= NXHrVm42RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyPFUzPzRpPkKyNlg2Ojd2PD;hQi=>
EMT-6  MW\DfZRwfG:6aXPpeJkhSXO|YYm= M2H6N|ExOM7:TR?= Ml6xNYg> NGq5WIpx[XK2aXHscJkh[myxY3vl[EBk\WyuIHTlZZRpKGmwZIXj[YQh[nlic3nyZY1me2mwZR?= M4[5blxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MkWxPVIyLz5{MkK1NVkzOTxxYU6=
MCF7 MoLxRZBweHSxc3nzJGF{e2G7 NUnQSIRjPTEEoN88US=> NEDOOGIycA>? NWLDc3R4cW6qaXLpeJMhWEFiYXP0bZZifGWmIHPhd5Bie2VvMzygMVktKGGwZDDwc4x6MEGGUD3ybYJwe2VrIIDvcJlu\XKjc3W= NUfxNnVqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlM{PDVpPkKyNlI{OzR3PD;hQi=>
K562 NFW2VZlCeG:ydH;zbZMhSXO|YYm= NHy5NlIzOCEQvF5CpC=> MWS0PIg> MmXPSG1UVw>? MYPicI9kc3NibHHwZZRqdmmkLXnu[JVk\WRiaX7obYJqfGmxbjDv[kB3cWGkaXzpeJkh[W6mIHHwc5B1d3OrczDpcoR2[3Srb36= NHv4NVQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkKxOlE2QCd-MkKyNVYyPTh:L3G+
Molt4-hyg MlvzRZBweHSxc3nzJGF{e2G7 MnvuNVDPxE1? NHnvV3QxNjWq MYXicI9kc3NiZnHycoV{d2xvaX7keYNm\CClYYPwZZNmNTNvbHnr[UBi[3Srdnn0fS=> NEXYOm89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkK3OVgyOSd-Mk[yO|U5OTF:L3G+
HeLa MVjBdI9xfG:|aYOgRZN{[Xl? MlzhNVDPxE1? MVKwMlVp NVnTfZZMcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidHjlJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIHfvcYl{cW5iTjDhcoQhXFKDSVy= NU\3Z4F[RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxO|k3PjFpPkKyNVc6PjZzPD;hQi=>
Jurkat T MV3BdI9xfG:|aYOgRZN{[Xl? MorKN|DPxE1? NUDzcG9pOC53aB?= NHP1d|VFVVOR M4XiWoJtd2OtczD0bIUhgmm{YX2tbY5lfWOnZDDhdI9xfG:|aYO= MnnxQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzNUm4PVgoRjJ{MUW5PFk5RC:jPh?=
Neutrophil Ml20RZBweHSxc3nzJGF{e2G7 MoXGNlDPxE1? MWKwMlVp M2T5VYF1fGWwdXH0[ZMhfGinIIDyc{1ieG:ydH;0bYMh\W[oZXP0JI9nKE2jUkG= M1f0WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MUm2PFQ1Lz5{NkG5Olg1PDxxYU6=
HCT116 NFvo[ZJCeG:ydH;zbZMhSXO|YYm= MkTrOVDDqM7:TR?= NIewS3ozcA>? NGnISZdz\X[ncoPld{B{gW6ncnfpd5Rq[yCjcH;weI9{cXNiZX\m[YN1eyCxZjDj[Yxm[2:6aXKgZY5lKE6SQz2xOuKh NWDve|c2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxOVk4PTJpPkKyNVU6PzV{PD;hQi=>
MDA-MB-231  NFvlbnVCeG:ydH;zbZMhSXO|YYm= Mk\UNk42NTdwNd88US=> M3npc|Jp MofCbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhib3[gUWRCNU2ELUKzNUBk\WyuczDpcoR2[2WmIHL5JHNFXCCrbjDhJINwdmOnboTyZZRqd25iZHXw[Y5l\W62IH3hco5meg>? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzNUWyOkc,OjJzMUW1NlY9N2F-
LNCaP NVq1bHZ7SXCxcITvd4l{KEG|c3H5 MXS0NO69VQ>? MkDGNog> MWnpcohq[mm2czDieZRmcW5iaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> MWW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzNEe2OEc,OjJzMUS3OlQ9N2F-
MB231 NYm1RWJ7SXCxcITvd4l{KEG|c3H5 MoHjNVAx|ryP M{DRV|Fp M2G1bmROW09? MlrUZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? NHmwXZA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxNlk1OCd-MkKxNVI6PDB:L3G+
HCC38  MXjBdI9xfG:|aYOgRZN{[Xl? NEfZdJMyODEQvF2= MV[xbC=> M3TpOmROW09? MkPRZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? MlrwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUK5OFAoRjJ{MUGyPVQxRC:jPh?=
MDA-MB231 M{Hke2Fxd3C2b4Ppd{BCe3OjeR?= NWG5ellIPTEEoN88US=> NIm0b2QzPGh? NXr5d482TE2VTx?= MWPhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M{XPcFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUCxN|M2Lz5{MkGwNVM{PTxxYU6=
LNCaP M2LwSWFxd3C2b4Ppd{BCe3OjeR?= NHW0WmM2OMLizszN M4W1e|I1cA>? NXT5fJhOTE2VTx?= NXPCVJBM[WK{b3fheIV{KGO3cnP1cYlvNWmwZIXj[YQh[2WubDDk[YF1cA>? NHruRno9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNVM{PSd-MkKxNFE{OzV:L3G+
HCT116 MWDBdI9xfG:|aYOgRZN{[Xl? NH;JSm02OMLizszN MVOyOIg> MX3EUXNQ MYnhZpJw\2G2ZYOgZ5Vz[3WvaX6tbY5lfWOnZDDj[YxtKGSnYYTo M2XTUFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUCxN|M2Lz5{MkGwNVM{PTxxYU6=
Ishikawa  M1vUfGFxd3C2b4Ppd{BCe3OjeR?= MWeyOe69VQ>? NETwVHYzPGh? MnvKdoVlfWOnczDj[YxtKGSnYYToJIFv\CCjcH;weI9{cXNiaX7keYNm\CCkeTDCZYYhSTF? NWLJe3JQRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPFg6OThpPkKyNFg5QTF6PD;hQi=>
 YD-8  M3vGd2Fxd3C2b4Ppd{BCe3OjeR?= Ml\TNVAx|ryP NHHoU4oycA>? Mln0bY5pcWKrdIOgVGxGVy2rbnT1Z4VlKGGyb4D0c5Nqew>? NXvtV|g4RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwPFYyQDNpPkKyNFg3OTh|PD;hQi=>
eosinophil  MUjBdI9xfG:|aYOgRZN{[Xl? MkDOPVDPxE1? MoXnNlRp MYXpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBH[XNiYX70bYJw\HoEoB?= MljoQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzN|QoRjJ{MEe5N|M1RC:jPh?=
L929 MXLHdo94fGhiSX7obYJqfGmxbjDBd5NigQ>? MWGyMlXPxE1? NVrnXYxNOjSq NFHJNndqdmirYnn0d{B1cGViZYjwdoV{e2mxbjDv[kBxNXB|ODDhcoQhVkZvzsrCJJRwKGG3Z33lcpQhXE6IzsGtbY5lfWOnZDDu[YNzd3C2b4Ppd{BidmRiYYX0c5Bp[We7 MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB{N{C5O{c,OjJyMkewPVc9N2F-
YD-8  MnLkRZBweHSxc3nzJGF{e2G7 M1LBS|ExOM7:TR?= NXjvSY9lOWh? MVjicI9kc3NidHjlJGdUNUiFbD3pcoR2[2WmIHHwc5B1d3Orcx?= NXW0e|BzRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKwNlAxPzhpPkKyNFIxODd6PD;hQi=>
HBx NFvwVGFCeG:ydH;zbZMhSXO|YYm= M2PFb|I2|ryP MVu0PIg> NX;wcFFFTE2VTx?= M2DDZ5Jm\HWlZXSgZ4VtdCCmZXH0bEBqdmS3Y3XkJIJ6KDNvTVG= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjB{MEC3PEc,OjJyMkCwO|g9N2F-
U937  Mn61RZBweHSxc3nzJGF{e2G7 MkfROVDDqM7:TR?= MnXsNYg> MWLpcohq[mm2czDISk1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NYPkPVJTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5PVg4OzFpPkKxPVk5PzNzPD;hQi=>
HL60 M4n4TWFxd3C2b4Ppd{BCe3OjeR?= NHvyWFU1OM7:TR?= NGC2[o81OG2rbh?= MnHCSG1UVw>? M4XFZYJtd2OtczDCUmREKGOxbYDveY5leyCrbnT1Z4Uh\Xiyb4P1doUhd2ZicHjvd5Bp[XSrZInsd4VzcW6nIHHu[EBFVkFiZoLh[41mdnSjdHnvci=> NEfDOFI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4N|I6Pid-MkG5PFMzQTZ:L3G+
M-14 NGTLRnlCeG:ydH;zbZMhSXO|YYm= NW\kSoRROjYQvF2= NYDZS49wOC53aB?= MX|CpIlvcGmkaYTzJIJwfGhidHjlJINzfWSnIHX4eJJi[3RvIHHu[EBkd22yb4Xu[E1qdmS3Y3XkJIFxd3C2b4Ppdy=> MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTl3NEm1PUc,OjF7NUS5OVk9N2F-
SK-BR-3 NUHMUHlGSXCxcITvd4l{KEG|c3H5 MlLROVDDqM7:TR?= MkPUNog> MojxZoxw[2u|IHHwc5B1d3SrYzDEUmEh\nKjZ33lcpRifGmxbjDpcoR2[2WmIHL5JINwdWKrbnH0bY9vKG:oIGPNMVE3PCCjbnSgdoFlcWG2aX;u MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOTlyMUO4Okc,OjF7MEGzPFY9N2F-
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Assay
Methods Test Index PMID
Western blot IRF-1 / p-STAT1 / cleaved PARP1 / cleaved-caspase3 ; Beclin1 / Atg5 / Atg7 / LC-3I / LC-3II ; p23 / Hsp90 / hTRET / MMP2 ; cyto C 27191889 19740745 17301139
Growth inhibition assay Cell viability 12522090
Immunofluorescence cytochrome c ; Smac/DIABLO ; Endo G ; AIF 11726499 12941691
ELISA IL-1β 26254306
In vivo

In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol (from reference)

Cell Research:

[6]

  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.

  • (Only for Reference)
Animal Research:

[7]

  • Animal Models: CD1 mice
  • Dosages: 10 mg/kg
  • Administration: i.p.
  • (Only for Reference)

Solubility (25°C)

In vitro

DMSO 93 mg/mL
(198.93 mM)
Water Insoluble
Ethanol Insoluble

In vivo

Add solvents to the product individually and in order
(Data is from Selleck tests instead of citations):
2% DMSO+35 %PEG 300+2%Tween 80+ddH2O
For best results, use promptly after mixing.

6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Frequently Asked Questions

Question 1:
Can you suggest an in vivo formulation of S7023 for animal studies?

Answer:
For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

Question 2:
What is difference between S7023 & S8102?

Answer:
Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

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