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Z-VAD-FMK

For research use only.

Catalog No.S7023

622 publications

Z-VAD-FMK Chemical Structure

CAS No. 187389-52-2

Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.

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10mM (1mL in DMSO) USD 849 In stock
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Selleck's Z-VAD-FMK has been cited by 622 publications

Purity & Quality Control

Choose Selective Caspase Inhibitors

Biological Activity

Description Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor, blocks all features of apoptosis in THP.1 and Jurkat T-cells.
Features A key compound for apoptosis studies.
Targets
Pan-caspase [1]
(THP.1, Jurkat T-cells)
In vitro

Z-VAD-FMK (10 mM) inhibits apoptosis in THP.1 cells. Z-VAD-FMK (10 μM) inhibits activation of PARP protease activity in control THP.1 cell lysates. Z-VAD-FMK (10 mM) inhibits the processing of CPP32 in intact THP.1 and Jurkat cells. [1] Z-VAD-FMK (50 μM) cotreatment abolishes the apoptotic morphology of camptothecin-treated HL60 cells. Z-VAD-FMK (50 μM) blocks camptothecin-induced DNA fragmentation in HL60 cells. [2] Z-VAD-FMK (50 μM) inhibits cell death following dSMN dsRNA-induced apoptosis in S2 cells. Z-VAD-FMK (50 μM) increases the percentage of transfected cells surviving from 26% to 63% in S2 cells. [3] Z-VAD-FMK (> 100 μM) enhances TNFα-induced neutrophil apoptosis, lower concentrations (1-30 μM) completely blocks TNFα-stimulated apoptosis in human neutrophils. [4] Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes. Z-VAD-FMK (10 mM) inhibits apoptosis in anterior stromal keratocytes detected with the TUNEL assay. [5]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
U937 NH:1SGxCeG:ydH;zbZMhSXO|YYm= MnjoOVDPxE1? NYi0TIVuPDiq MlfDdoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBUU0lvSVmgeJJm[XSvZX70xsA> MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NEC0N{c,OjV6MkSwOFM9N2F-
HL-60 MUnBdI9xfG:|aYOgRZN{[Xl? M2n3flUx|ryP NYrzVFc1PDiq MWfy[YR2[2W|IHPlcIwh\GWjdHigZ4F2e2WmIHL5JHNMUS2LSTD0doVifG2nboVCpC=> MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTh{NEC0N{c,OjV6MkSwOFM9N2F-
DTK-SME NH7ZZ3pCeG:ydH;zbZMhSXO|YYm= MWK1NO69VQ>? M1PMfVJp NUHHVXlLTE2VTx?= NFT0OHBx[XK2aXHscJkhcW6qaXLpeJMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JIJ2eGm4YXPhbY5m M3\QU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OESzPFk4Lz5{NUi0N|g6PzxxYU6=
HCT116  NE\3cFVCeG:ydH;zbZMhSXO|YYm= NXTIZ3N1PTEQvF2= NV70[oFGOmh? M2OzT4lvcGmkaYTzJJRp\SClZXzsJIRm[XSqIHnu[JVk\WRiYomgSGRXWA>? NF;TTGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUi2PFgyQCd-MkW4Olg5OTh:L3G+
SGN MU\BdI9xfG:|aYOgRZN{[Xl? M3jvNVIxdU1? Mof0OFhp NW\oT3BRcGG|IH7vJIlv\my3ZX7j[UBwdiCDSV[sJINidHCjaX6g[ZhxemW|c3nvckBweiClZXzsJIFxd3C2b4Ppdy=> M{K1bVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OEe0OlM{Lz5{NUi3OFY{OzxxYU6=
A549/V16 MkXiRZBweHSxc3nzJGF{e2G7 NYH4TopnPTEQvF2= NGLmVYgycA>? M1z1epJmeHKnc4Pld{BVTy:WTT3pcoR2[2WmIHHwc5B1d3Orcx?= M4DRU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUS2NFM{Lz5{NUm0OlA{OzxxYU6=
U1 M4HzOWtqdmG|ZTDBd5NigQ>? NGDN[3oyODEQvF2= MojuNog> MUPpcohq[mm2czDjZZNx[XOnLUO= MXW8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTl6MEm0Nkc,OjV7OEC5OFI9N2F-
ACH-2 NVm3eWV6SXCxcITvd4l{KEG|c3H5 NYjkN2V7OC1{MEFOwG0> NHe2[oMzcA>? NHzLZ|hz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> M{XhWFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3OUiwPVQzLz5{NUm4NFk1OjxxYU6=
U1 M1fhTmFxd3C2b4Ppd{BCe3OjeR?= MWWwMVExOM7:TR?= M1\HVVJp NFW3[mNz\WS3Y3XzJIRzfWdvaX7keYNm\CCjcH;weI9{cXNiYX7kJJN2[nOncYXlcpQhUEmYLUGgdoVxdGmlYYTpc44hcW5iYTDkc5NmNWSncHXu[IVvfCCvYX7u[ZI> NXjlV|BmRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW5PFA6PDJpPkK1PVgxQTR{PD;hQi=>
HUVEC-2c MUHBdI9xfG:|aYOgRZN{[Xl? NG\2bW82OM7:TR?= NXjmd2JHPmh? NWKz[FB5\GWlcnXhd4VlKHSqZTDvfE1NTExvaX7keYNm\CCjdYTvdIhi\3l? NYrTSoVkRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[wNlE4OjlpPkK2NFIyPzJ7PD;hQi=>
SP2/0 M1OyW2Fxd3C2b4Ppd{BCe3OjeR?= NF7kV2QyODEQvF2= Mn3WNYg> Mm\BSG1UVw>? MnfwZoxw[2u|IITo[UBieG:ydH;zbZMhd2ZiU2CyM|Ah[2WubIO= NGHKd2Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkC3OFc{Oid-Mk[wO|Q4OzJ:L3G+
CEF NYrlSY5kU2mwYYPlJGF{e2G7 NYLCXpBkOCx|Mzy2O{wyODEQvF2= NV3hR3ZXOTWvaX6= MlrL[I94di2{ZXf1cIF1\XNiUGKg[Y57gW2nIHHjeIl3cXS7IITvJFQx97zHIHH0JFExOM7:TR?= NF2xOlE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkGwNlM{QSd-Mk[xNFI{Ozl:L3G+
BEL-7402 Mn6yRZBweHSxc3nzJGF{e2G7 NE\oXlYzOM7:TR?= NVL5ZoUyOWh? MWnheJRmdnWjdHXkJJRp\SCjcH;weI91cWNiaX7keYN1cW:wIH;mJGlKUS1zMNMg M4D4XFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ4MU[0O|k2Lz5{NkG2OFc6PTxxYU6=
HepG2 NYi2c3FPSXCxcITvd4l{KEG|c3H5 NFXGXpAzOM7:TR?= NEnwTlIycA>? MmfOZZR1\W63YYTl[EB1cGViYYDvdJRwfGmlIHnu[JVkfGmxbjDv[kBKUUlvMUFCpC=> NHH6c2w9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NkG2OFc6PSd-Mk[xOlQ4QTV:L3G+
HGL5 MUTBdI9xfG:|aYOgRZN{[Xl? MX:1NO69VQ>? NGe0WXEzPGh? NVO0eHp{cW6maXPheIV{KGFicILveIVkfGm4ZTDl[oZm[3RiYXfhbY5{fCCndH;wc5Nq\GV? MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4OUC3OUc,OjZzNkmwO|U9N2F-
GC1a MmrzRZBweHSxc3nzJGF{e2G7 NF7Ib|I2OM7:TR?= M1\XdFI1cA>? M1LDR4lv\GmlYYTld{BiKHC{b4TlZ5RqfmViZX\m[YN1KGGpYXnud5Qh\XSxcH;zbYRm MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjF4OUC3OUc,OjZzNkmwO|U9N2F-
A549 NVT6dnhlSXCxcITvd4l{KEG|c3H5 M4fCXVIxKM7:TR?= MVSyOIg> MlvadoVlfWOnczDj[YxtKGSnYYToJINifXOnZDDifUBJTkOSIITy[YF1dWWwdB?= NV;WU4prRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3PVQyPDlpPkK1O|k1OTR7PD;hQi=>
HeLa MXjBdI9xfG:|aYOgRZN{[Xl? Mo\uNVDPxE1? NWPXXHdSPDiq NYnoZ2hF\GWlbHnu[ZMhfGinIILheIUhd2ZiYYDvdJRwe2m|IHTyZY1ifGmlYXzsfS=> M3O3XlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3N{eyOVQ2Lz5{NUe3NlU1PTxxYU6=
SGC-7901 MmPXRZBweHSxc3nzJGF{e2G7 NGfXeYMzOMLizszN MnfPNYg> MlrxbY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiaX7keYNm\CCkeTDvfIFtcXCuYYTpci=> NEDEWFU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUe2O|A4Pid-MkW3OlcxPzZ:L3G+
MCF-7 NXv5Z5pNSXCxcITvd4l{KEG|c3H5 M12xfFEx|ryP NYHpZWFOOmh? MYrpcohq[mm2czD0bIUh[2WubDDk[YF1cCCrbnT1Z4VlKGK7IEPC NVm5[HVVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW3NlIyOTRpPkK1O|IzOTF2PD;hQi=>
A549 M4DVc2Fxd3C2b4Ppd{BCe3OjeR?= NIHBOnIyOCEQvF2= MmjQNlRp NUPUN4F2TE2VTx?= NXrNV5hteHKxbX;0[ZMhUEKFLYTy[YF1\WRiQUW0PUBk\WyuIIP1dpZqfmGuID[gZZR1\W63YYTld{B1cGViY3zlZZZm\CCSQWLQJIV5eHKnc4Ppc44> M{PheVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NkizOVY5Lz5{NU[4N|U3QDxxYU6=
U87 NHjufHRIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= MUO1NO69VQ>? MWmxbC=> MmLZdoVkd3[ncoOgZ4VtdCCpcn;3eIgh\nKxbTDUUXohfHKnYYTt[Y51 NFHsVYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NU[4NVY3QCd-MkW2PFE3Pjh:L3G+
Neocortical Neuron MknSUoV2em:2b4jpZ4l1gSCDc4PhfS=> NXXNPYZSOTByzszN MX:xbC=> M4XzNYFvfGGpb37pfoV{KEixaXHtbYRmKEFvSX7keYNm\CCQZYXyc5RwgGmlaYT5 Ml7sQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4N{WwNFEoRjJ3Nke1NFAyRC:jPh?=
Primary human placental cytotrophoblasts NHHGR5BCeG:ydH;zbZMhSXO|YYm= MX2zNO69VQ>? Ml3wNlRp M2jzS2ROW09? M1XBWpJmfmW{c3XzJJRp\SCrbnjpZol1cW:wIH;mJFEy|rJvSGPENkBjgSC2cnnjcI9{[W8EoB?= MnPqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV4NEK1PVIoRjJ3NkSyOVkzRC:jPh?=
MM Mn72RZBweHSxc3nzJGF{e2G7 M133N|Ux|ryP M3;zW|IxdWmw NFq1fIxx[XK2bImgbY5pcWKrdIOgV2hMNWmwZIXj[YQhKGOnbHyg[IVifGh? MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTV|MEC5PEc,OjV3M{CwPVg9N2F-
DLD1 NWCyZ3pySXCxcITvd4l{KEG|c3H5 MWWyNOKh|ryP MmDPNYg> M4Pib5BienSueTDy[ZZmenOnczDj[YxtKGGyb4D0c5NqeyClYYXz[YQh[nliV2PQNS=> MmfGQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkSyOFYoRjJ3NUK0NlQ3RC:jPh?=
MDA-MB-231 NF\FcXVEgXSxdH;4bYNqfHliQYPzZZk> NHnxTHEyOM7:TR?= M3fpSlFp MlHBZZVodWWwdIOgZ4VtdCCmZXH0bEBi\nSncjDDTHVCKHS{ZXH0cYVvfA>? MkDSQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV3MkG1NFEoRjJ3NUKxOVAyRC:jPh?=
MKN28 NXi5UWQ{SXCxcITvd4l{KEG|c3H5 Mo\oNVDPxE1? M2C1[FMxdWmw M4HR[2ROW09? M{PFfolvcGmkaYTzJHRPTi4QsTDwcJV{KEOKWD3pcoR2[2WmIHHwc5B1d3Orcx?= M3;BblxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NUGzPVYxLz5{NUWxN|k3ODxxYU6=
HL-60 MVnDfZRwfG:6aXPpeJkhSXO|YYm= Mn20NVAx|ryP NH;tfJUycA>? NF3sXIVFVVOR MWFCpIlueHKxdnXzJJZq[WKrbHn0fUBw\iCWQ17Bd{11emWjdHXkJINmdGy| NXPuSGNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkW1NFI6OzJpPkK1OVAzQTN{PD;hQi=>
AGS NILVO3FCeG:ydH;zbZMhSXO|YYm= NU\G[lR2OTEQvF2= MYKxbC=> Mon0dJJmfmWwdIOgZ5Vz[3WvaX6tbY5lfWOnZDDjcIVifmGpZTDv[kBk[XOyYYPlMVMtKC16LDDhcoQhNTlicILveIVqdnN? MmPXQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2OUKyNVQoRjJ3NEmyNlE1RC:jPh?=
A549  MkHURZBweHSxc3nzJGF{e2G7 MkS4NVDPxE1? MUWyOIg> Mm\uZoxw[2u|IFTNRXMucW6mdXPl[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiYX7kJIFxd3C2b4TpZ{Bk\WyuIHTlZZRp MlLqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2M{S5PFkoRjJ3NEO0PVg6RC:jPh?=
INS-1 M2nIbGFxd3C2b4Ppd{BCe3OjeR?= NGPYRpY2OM7:TR?= NEP5e4E3cA>? NGDrbFJFVVOR MoXU[IVkemWjc3XzJJRp\SCycn;wc5J1cW:wIH;mJIViemy7IHHwc5B1d3SrYzDj[Yxte8Li M{P0dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3NEOwPFk4Lz5{NUSzNFg6PzxxYU6=
Primary hepatocytes  M4rHVmFxd3C2b4Ppd{BCe3OjeR?= M3LRXVUx|ryP Mo\DNVhp NWriZ5N2cW6qaXLpeJMh[XCxcITvd4l{KG:oIHjldIF1d2O7dHXzJIlv\HWlZXSgZpkhSWO2IFSgZY5lKFSQRj5OtS=> MnXnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV2MEe1N|goRjJ3NEC3OVM5RC:jPh?=
L929-A  NUPEblFVS3m2b4TvfIlkcXS7IFHzd4F6 NW\FeG9lOjEEoN88US=> MXSyOIg> Mkm0bY5pcWKrdIOgWG5H|rFvaX7keYNm\CClZXzsJIRm[XSq NVXPPHB{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPVg2PDBpPkK1N|k5PTRyPD;hQi=>
L929-N NHX6VGREgXSxdH;4bYNqfHliQYPzZZk> M33QZVIxyqEQvF2= M3rwbVI1cA>? MlLR[Y5p[W6lZYOg[IVifGhidnnhJIF2fG:lcnnu[UBVVkcQsTDwdo9lfWO2aX;u NYjOOmJxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPVg2PDBpPkK1N|k5PTRyPD;hQi=>
Cytotoxicity Assay MkDUR4VtdCCYaXHibYxqfHliQYPzZZk> MVeyNO69VQ>? MmT6OFhp M2rOUJBz\X[nboSgUWhOTC2rbnT1Z4VlKGOnbHyg[IVifGh? NHrWXGc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NUO5NlEyPid-MkWzPVIyOTZ:L3G+
COS7 NHX1VG5McW6jc3WgRZN{[Xl? M1TZXVEx|ryP NVq1TFNWOjSq M2W3fYlv[3KnYYPld{Bk[XOyYYPlJFMwPyCjY4Tpeol1cWW| M4ntc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ3M{i0NFI2Lz5{NUO4OFAzPTxxYU6=
COS7 M1;rTWFxd3C2b4Ppd{BCe3OjeR?= NX22NFlFOTEQvF2= MYm0PIg> NESzWmFx[XK2aXHscJkheHKndnXueIVlKE[FMUCxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NXTVSIl7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkWzPFQxOjVpPkK1N|g1ODJ3PD;hQi=>
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A375 MnnpRZBweHSxc3nzJGF{e2G7 MWWyNO69VQ>? M2rRdlI1cA>? NX7Ud4RremW4ZYLz[ZMh\GmlaYTybY5wdmViQj3pcoR2[2WmIHHwc5B1d3Orcx?= Mln0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR4OUmxNVEoRjJ2Nkm5NVEyRC:jPh?=
HDPC M{HPRWFxd3C2b4Ppd{BCe3OjeR?= M2PrfVUxyrWP NWWzU2loOjSq NVLye5k{cW6qaXLpeJMhVk9vaX7keYNm\CCjcH;weI9{cXN? M2\FNFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NkO0OVk{Lz5{NE[zOFU6OzxxYU6=
A549 NF\NVopCeG:ydH;zbZMhSXO|YYm= NILpVVA2OML3TR?= MkfwNog> MoDtSG1UVw>? NVnzc2lzeHKndnXueJMhfGinIHj5dI9lcXCub3nkJGRPSSClb370[Y51KHCqYYPlJIlv\HWlZXSgZpkh[2WyaHHsc4Npem:vaX6= M4XOdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUi4NVM2Lz5{NEW4PFE{PTxxYU6=
 BV-2 NWHqTGtrSXCxcITvd4l{KEG|c3H5 MV6yNO69VQ>? NUfCdIJKOmh? NEX4c5l{fXCycnXzd4V{KFWYLXnu[JVk\WRiY3jyc41ifGmwIHX4eJJ2e2mxbjDhcoQh\GmuYYTpc44hd2ZidHjlJI52[2ynYYKg[Y53\WyxcHW= MkDnQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR3NUixNVgoRjJ2NUW4NVE5RC:jPh?=
HT-29  MVjBdI9xfG:|aYOgRZN{[Xl? M4LFTFUx|ryP MVK0PIg> MoXWZoxw[2u|IITo[UBieG:ydH;zbZMhcW6mdXPl[EBjgSCtYXXtdIZmem:u MXq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV2OUG3OUc,OjR3NEmxO|U9N2F-
A549 M3i0SmFxd3C2b4Ppd{BCe3OjeR?= MoDUOe69VQ>? M4XSd|I1cA>? M{XJfZN2eHC{ZYPz[ZMhPmYEoDjCT|ExODRyKT3pcoR2[2WmIHHwc5B1d3Orc9Mg MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDV{OUi3NUc,OjR3Mkm4O|E9N2F-
MIA-PaCa-2 MkXMRZBweHSxc3nzJGF{e2G7 M3z0cFI1cA>? MVzicI9kc3NiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIlv\HWlZXSgZpkh[m:2aDDBMVQ1OzZ3NDDhcoQheGGlbHn0ZZhmdA>? M1Ww[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NUGwPVkzLz5{NEWxNFk6OjxxYU6=
Caki-1 M3XscmFxd3C2b4Ppd{BCe3OjeR?= NFO5coIzOM7:TR?= NHXT[GUycA>? MoeybY5pcWKrdIOgV2NRNWmwZIXj[YQh[XCxcITvd4l{ NXHG[HdZRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS1NFQ3QDFpPkK0OVA1PjhzPD;hQi=>
CLL MWnBdI9xfG:|aYOgRZN{[Xl? M1n4XlI2|ryP NV;YfnpWOWh? Moe3dIFzfGmjbHz5JIJtd2OtczDNUG4zOjN6LXnu[JVk\WRiY3XscEBieG:ydH;zbZM> NYjaeIFpRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkS0Olc3OzRpPkK0OFY4PjN2PD;hQi=>
SGC-7901 M4q0cGFxd3C2b4Ppd{BCe3OjeR?= Ml7hNVDPxE1? MmTFNlRp NXOzZXhteHKxbX;0[ZMhfGinIFPHTWkucW6qaXLpeIVlKGOnbHyg[5Jwf3SqIHnuJHNISy15OUCxJINmdGy| M3HRS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2NEW0OFg5Lz5{NES1OFQ5QDxxYU6=
k1735 MXXBdI9xfG:|aYOgRZN{[Xl? MYWyNQKBkc7:bR?= M1:1ZVRp M4HxW4lvcGmkaYTzxsBU[Wyvb37lcIxiNWmwZIXj[YQh[XCxcITvd4l{ Ml\zQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR2NUGxNVYoRjJ2NEWxNVE3RC:jPh?=
HaCaT  MYrBdI9xfG:|aYOgRZN{[Xl? MUWxNFDPxE1? MV:xbC=> NYXZPXA1[my3boTzJHVXSi2rbnT1Z4VlKGGyb4D0c5NqeyCrbjDIZWNiXCClZXzsdy=> NX;5WFl1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzOVY6QTdpPkK0N|U3QTl5PD;hQi=>
podocytes NVuzbGo4SXCxcITvd4l{KEG|c3H5 MlvYNlAx|ryP NWPGNFNIPmh? NXizWG9bcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nliMzy0MWRITQ>? NWX6ZodtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|c4PzdpPkK0N|M4Pzd5PD;hQi=>
 KB NWLDdlc5SXCxcITvd4l{KEG|c3H5 MlTPOVDPxE1? MmHINlRp Mn;nbY5pcWKrdIOgUIlkdy2DLXnu[JVk\WRiY3HzdIF{\S1|IHHu[EBRSVKSIHHjeIl3[XSrb36= NX7w[ZNJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzN|c1QTJpPkK0N|M4PDl{PD;hQi=>
 HepG2  MlTsRZBweHSxc3nzJGF{e2G7 M4jZZlEx|ryP NUXtNVBYOjSq NGHZOmxz\WS3Y3XzJJZqdWWwdHnuJINt\WG4YXflJINifXOnZDDifUBNWFN? MXO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDN{NUixOkc,OjR|MkW4NVY9N2F-
fetal rat lung fibroblasts  MX3LbY5ie2ViQYPzZZk> MVi4NO69VcLi NVHJeoN{OWh? MnTDbY5pcWKrdIOgR4F{eGG|ZT2zJIFkfGm4aYT5xsA> MYO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDNzNEGzOUc,OjR|MUSxN|U9N2F-
PDL fibroblasts MX3LbY5ie2ViQYPzZZk> MWe4NO69VcLi NXuyNHk1OWh? M{\wSIlvcGmkaYTzJGNie3Cjc3WtN{Bi[3Srdnn0feKh NYHwbYRbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSzNVQyOzVpPkK0N|E1OTN3PD;hQi=>
MB49 M4\0R2Fxd3C2b4Ppd{BCe3OjeR?= MWSyNO69VQ>? MkTFNYg> MWPy[ZZmenOnczDDUU1qdmS3Y3XkJINmdGxiZHXheIg> NUP1bIhWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFI1OzNpPkK0NlgzPDN|PD;hQi=>
5637 NIfCNplCeG:ydH;zbZMhSXO|YYm= Mn;SNlDPxE1? M{DaRlFp NWnzO4xLemW4ZYLz[ZMhS01vaX7keYNm\CClZXzsJIRm[XSq NYLW[VViRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSyPFI1OzNpPkK0NlgzPDN|PD;hQi=>
A549  MWHBdI9xfG:|aYOgRZN{[Xl? MUSxNFDPxE1? M3G4UlQ5cA>? MWrzeZBxemW|c3XzJJRp\SCjcH;weI9{cXNiY3H1d4VlKGK7IIDpdIVzcW6nwrC= NGXVXIc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK3NlIxOSd-MkSyO|IzODF:L3G+
MCC-2 NHvZOpZCeG:ydH;zbZMhSXO|YYm= MlHDNlAh|ryP NFzNVm03cA>? NXrhWJI4TE2VTx?= MknwZoxw[2u|IHnu[JVk\WRiYomgd5RifXKxc4Dvdolv\SCjcH;weI9{cXNiY3XscEBl\WG2aB?= NFrlRoI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEK2NlY2QCd-MkSyOlI3PTh:L3G+
ADF NFH3VXdCeG:ydH;zbZMhSXO|YYm= M1rnRlQx|ryP NXnQSZJYPmh? NHX5XJlqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> Mmi5QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjR{MkiyN|IoRjJ2MkK4NlMzRC:jPh?=
 U373  MUfBdI9xfG:|aYOgRZN{[Xl? NV\OW4lvPDEQvF2= NHnyVZE3cA>? MXvpcohq[mm2czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkcGWvb4To[ZJieHlicHz1d{BbdkOuMh?= NILSUoE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKyPFI{Oid-MkSyNlgzOzJ:L3G+
RKO-HIPK2i MUTBdI9xfG:|aYOgRZN{[Xl? M1u2OFQx|ryP MVG2bC=> NG\MW2pqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSClaHXtc5Rp\XKjcImgdIx2eyCcblPsNi=> NHXYSZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEKyPFI{Oid-MkSyNlgzOzJ:L3G+
HEC-1B M1Tlc2Fxd3C2b4Ppd{BCe3OjeR?= NYXiboV7OjEQvF2= M3S0OFFp MYPy[YR2[2W|IGTQMYlv\HWlZXSgZZBweHSxc3nzxsBk[XOyYYPlMVMh[W6mIHPhd5Bie2VvOR?= M{DH[lxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MkGzN|U5Lz5{NEKxN|M2QDxxYU6=
4T1 MkHZR4VtdCCYaXHibYxqfHliQYPzZZk> NHrvbHczNjVvMUFOwG0> MWK0bC=> M{W2eGROW09? NYe4SlF6emW|Y4Xld{B1cGViY4n0c5RwgGmlaYT5JI9nKDSWMTDj[YxteyCrbnT1Z4VlKGK7IGPQSHQhcW5iYTDjc45k\W62cnH0bY9vKGSncHXu[IVvfCCvYX7u[ZI> MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNkG2NUc,OjR{ME[xOlE9N2F-
OS  M{fv[WFxd3C2b4Ppd{BCe3OjeR?= MmraNlDPxE1? MmDxOIg> NGrweHlqdmirYnn0d{B1cGViY3XscEBl\WG2aDDjZZV{\WRiYomgVGRV MWm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyNEmzO{c,OjR{MES5N|c9N2F-
RPE NHPLV2FCeG:ydH;zbZMhSXO|YYm= MV:xNFDPxE1? M2LaVVQ5cA>? MXfwZZJ1cWGubImgbY5pcWKrdIOgeIhmKGOjbIDhbY4uOSCjbnSgMVIh[WO2aY\heIlwdiCjczD3[YxtKGG|IITo[UBk[XOyYYPlJIFkfGm4YYTpc44> MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPDJyMkC1Nkc,OjR{MEKwOVI9N2F-
UD29a NF72N4lCeG:ydH;zbZMhSXO|YYm= Mo\oOVDPxE1? NYXvV2pYOjSq MoW5bY5pcWKrdIOgeIhmKGOnbHyg[IVifGhiY3H1d4VlKGK7IF7VWFM> M2\rbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MUmwOVc1Lz5{NEG5NFU4PDxxYU6=
SH-SY5Y  NGTw[WJCeG:ydH;zbZMhSXO|YYm= MmrWNVDPxE1? NH3NU4kzPGh? NX3QPWlX[XS2ZX71ZZRmeyClYYPwZZNmKGGldHn2ZZRqd25iYX7kJINmdGxiZHXheIghcW6mdXPl[EBjgSCKTlWtNmRI MlnrQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzNEW0OlMoRjJ2MUS1OFY{RC:jPh?=
HeLa  MXPBdI9xfG:|aYOgRZN{[Xl? MUCxNE8zOM7:TR?= MV6yOIg> Mmj1bY5pcWKrdIOgeIhmKGGldHn2bZR6KG:oIITo[UBu[Wqxcnn0fUBw\iC2aHWgcYVu[mW{czDv[kB1cGViY3HzdIF{\S2oYX3pcJk> MofqQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRzM{eyOlYoRjJ2MUO3NlY3RC:jPh?=
SCCVII  NUPEUpFtSXCxcITvd4l{KEG|c3H5 NXLQc45HOjYQvF2= M4nrZVFp M4La[olvcGmkaYTzJJRp\SClZXzsJItqdGyrbnegZYZ1\XJiZHHzZZRqdmmk NGXUZ489[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGyOlQ3PCd-MkSxNlY1PjR:L3G+
RAW 264.7 NHzFWVJCeG:ydH;zbZMhSXO|YYm= M4TTS|Ix|ryP MWWxPIg> NEXtPWtqdmO{ZXHz[ZMhVEN|LVnJM:6zNWGldHnuJJJifGmxIHPvcZBiemWmIITvJGVEXFZvTV;TJJRz\WG2bXXueEBwdmy7 NH71emI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGxOlcxPyd-MkSxNVY4ODd:L3G+
A549  NVHKeGM2SXCxcITvd4l{KEG|c3H5 NGfHfo0zNjYQvF2= MXmyOIg> MoDK[IVkemWjc3XzJI9zcWSxbnnuMYlv\HWlZXSgZZV1d3CqYXf5JIF{KHenbHygZY5lKEyxc4Ogc4Yh|pURiH2gZYx{dyCxY3P1dpJm\CCmdYLpcoch[XW2b4DoZYdq[yCycn;j[ZN{ NHLqXYs9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NEGwNlUzOid-MkSxNFI2OjJ:L3G+
UM-SCC-10A  NEfMVnpCeG:ydH;zbZMhSXO|YYm= NI[wW2k2OML3TR?= MYGybC=> M1PIRpJm\HWlZYOgZZBweHSxc3nzJIlv\HWlZXSgZpkhcGmpaD3kc5NmKGm|b3HsZY51d2yjY4TvcoU> M{fpOFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ2MEm4O|U{Lz5{NEC5PFc2OzxxYU6=
BGC-823 MX7BdI9xfG:|aYOgRZN{[Xl? MnrTNVAh|ryP NHvLVnUzPGh? MmntdoVlfWOnczD0[ZRz[W6mcnnu[U1qdmS3Y3XkJIFxd3C2b4Ppd:Kh NYLiXm85RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwPVg2OTFpPkK0NFk5PTFzPD;hQi=>
Nalm-6  M1H4OmFxd3C2b4Ppd{BCe3OjeR?= M1i3b|Ix|ryP Mn3VOIg> NH7vb4pqdmirYnn0d{Bk[XOyYYPlMVgh[W6mIHPhd5Bie2VvMzDhZ5RqfmG2aX;uJIFv\CCSQWLQMVEh[2ynYY\h[4U> NI\NNZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECzPVk3Pyd-MkSwN|k6Pjd:L3G+
KHOS  MYjBdI9xfG:|aYOgRZN{[Xl? M4m2WFQx|ryP MoTrNlRp NXnXTolj[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NXGwSI1LRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNlU{PjFpPkK0NFI2OzZzPD;hQi=>
G292 MmjBRZBweHSxc3nzJGF{e2G7 NX20O|hGPDEQvF2= NVX0doE2OjSq NGXkWHljdG:la4OgeIhmKGmwY4LlZZNm\CClbHXheoFo\SCxZjDjZZNx[XOnLUOgZY5lKFCDUmCgbY5lfWOnZDDifUBDSk2GM9Mg NXTvXFJoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNlU{PjFpPkK0NFI2OzZzPD;hQi=>
MG-63 MWDBdI9xfG:|aYOgRZN{[Xl? NU\Jbmd5PDEQvF2= MlP2NlRp NU\kUm1V[myxY3vzJJRp\SCrbnPy[YF{\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZT2zJIFv\CCSQWLQJIlv\HWlZXSgZpkhSkKPRERCpC=> NFzTVoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{NECyOVM3OSd-MkSwNlU{PjF:L3G+
EBV-transformed B cells MWPBdI9xfG:|aYOgRZN{[Xl? NWr3cWt2OjEQvF2= M2XtWlJp NWnwOGg{TE2VTx?= M3;6bIJtd2OtczDhcpRqNUOGOECgZY5lKGGwdHmtR2Q5PiCjboTpZo9lgS2rbnT1Z4VlKGGyb4D0c5Nqew>? MljWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjRyMEi2NlgoRjJ2MEC4OlI5RC:jPh?=
IM-9 B MnP0RZBweHSxc3nzJGF{e2G7 MoDWNlDPxE1? MVWybC=> NWjrbXM1TE2VTx?= MXficI9kc3NiYX70bU1ETDhyIHHu[EBidnSrLVPEPFYh[W62aXLv[JkucW6mdXPl[EBieG:ydH;zbZM> NX7HWJBRRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkSwNFg3OjhpPkK0NFA5PjJ6PD;hQi=>
CNE1 MnvkRZBweHSxc3nzJGF{e2G7 MUiyNO69VQ>? Ml3aOFhp M1TWVoJtd2OtczDMT{1CNWmwZIXj[YQh[XCxcITvd4l{ M{PCdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUi1NFI6Lz5{M{m4OVAzQTxxYU6=
CNE2 NXGw[VFOSXCxcITvd4l{KEG|c3H5 Mk[0NlDPxE1? NH7uOHo1QGh? MWXicI9kc3NiTFutRU1qdmS3Y3XkJIFxd3C2b4Ppdy=> MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzl6NUCyPUc,OjN7OEWwNlk9N2F-
HL-60 NEPSdFhCeG:ydH;zbZMhSXO|YYm= MX[1NOK2VQ>? MYmxbC=> MnfNSG1UVw>? NF[xOGVqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCEQUG0OS=> MorvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NEi3OVEoRjJ|OUS4O|UyRC:jPh?=
L929 NVnpWpJ3SXCxcITvd4l{KEG|c3H5 MoK4NU4zPeLCk{ZCpO69VcLi MmfBNlRp MmntZZVodWWwdIOgWG5H|rFvaX7keYNm\CCwZXPyc5B1d3OrczDhcoQh[XW2b4DoZYd6 MkfTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN7NEG3OlkoRjJ|OUSxO|Y6RC:jPh?=
Jurkat NHTTOpFE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M4jk[VLPxE1? MYK0bC=> NHHtepVz\X[ncoPld{Boem:5dHigbY5pcWKrdHnvckBidmRizsKtZ4F1\W6rbjDk[YNz\WG|ZTDifUBJWy2DU1G= NFLSVpA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{i5OlA3OSd-MkO4PVYxPjF:L3G+
RAW264.7  M33PcmFxd3C2b4Ppd{BCe3OjeR?= NYXBS|BzOTBizszN M2fwNVI1cA>? NHTJWFhl\WO{ZXHz[ZMhfGinIHHwc5B1d3OrczDpcoR2[2WmIHL5JGdC NFjkZZo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iyNFIxOyd-MkO4NlAzODN:L3G+
A431  MkPsT4lv[XOnIFHzd4F6 MU[0NO69VQ>? MkHvNog> M{Dyc4Jtd2OtczDmbZNmfGmwLXnu[JVk\WRiY3zlZZZi\2Vib3[gZ4F{eGG|ZYOgZY5lKFCDUmC= M3PGb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OECwNFU5Lz5{M{iwNFA2QDxxYU6=
Jurkat MULD[YxtKF[rYXLpcIl1gSCDc4PhfS=> MXyyOU0yODEQvF2= NVnwbnhsPmh? MWrpcohq[mm2czD6MWZCNUOPSz3pcoR2[2WmIHPlcIwh\GWjdHi= NXTHdGJDRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|M2OzJpPkKzPVM{PTN{PD;hQi=>
COS-7  MlzvSpVv[3Srb36gRZN{[Xl? MmLIOVDDvU1? MlvrNlRp NXzScG5N[W[oZXP0d{B1cGVicILvZ4V{e2mwZzDv[kBCXE5zczD3bZRpKHCxbInRJJRz[WO2cx?= NVTYZVB7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5N|MzODhpPkKzPVM{OjB6PD;hQi=>
CAL27 MUfBdI9xfG:|aYOgRZN{[Xl? MV6xNEDPxE1? NHH1e|QzcA>? M3LPdJN2eHC{ZYPz[ZMhS3W{LV7Qd{1z\WS3Y3XkJJZq[WKrbHn0fUBjgSC3cDD0c{A6OCV? NV:0eVlHRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO5NVc{QTZpPkKzPVE4Ozl4PD;hQi=>
THP-1  MmHPRZBweHSxc3nzJGF{e2G7 NX7ET2JCOTBvNUFOwG0> NVLtS|hkOmh? NX7i[41wcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidILpdJRwdGmmZR?= M3XtS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|OUCwNlk6Lz5{M{mwNFI6QTxxYU6=
K562 M3vTWGFxd3C2b4Ppd{BCe3OjeR?= MXeyNO69VQ>? MmjWOFhp NHTtdoZqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSB2LV3V NYDoN2FoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4O|Y5OjZpPkKzPFc3QDJ4PD;hQi=>
HL-60 M1zsOWFxd3C2b4Ppd{BCe3OjeR?= MorMNVAx|ryP MUeyOIg> NIrF[3pqdmirYnn0d{BieG:ydH;zbZMhcW6mdXPl[EBjgSCjYnnleIFv\SCmaYTldpBmdmW|wrC= MknWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN6NkW3O|goRjJ|OE[1O|c5RC:jPh?=
HeLa  MnPmRZBweHSxc3nzJGF{e2G7 NVq4WnJQOjEQvF2= M2PFd|Jp M2LIOIlvcGmkaYTzJGROVVBiaX7keYNm\CCjcH;weI9{cXN? NVrsVIpMRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO4OlM6PjZpPkKzPFY{QTZ4PD;hQi=>
U251 Mn3yRZBweHSxc3nzJGF{e2G7 MY[yNO69VQ>? NHr2dI0zPGh? NXHYNIlxcW6qaXLpeJMh[2G|dHnjbY4hcW6mdXPl[EBIOi:PIIDoZZNmKGG{cnXzeEBidmRiYYDvdJRwe2m| MUG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzhzNkixOkc,OjN6MU[4NVY9N2F-
HL-60 NF\0VGFCeG:ydH;zbZMhSXO|YYm= NUjtO4ttPTEEtV2= M3\VOFRp MkjCZoxw[2u|IITo[UBkdGWjdnHn[UBw\iClYYPwZZNmNTNuID25MEBidmRiUFHSVEBqdmS3Y3XkJIJ6KD[| NH3KN|M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{iwOFcxPid-MkO4NFQ4ODZ:L3G+
Ec-109 M3nWeGFxd3C2b4Ppd{BCe3OjeR?= M4\MNFExKM7:TR?= NUexR255PDiq M3L4NJJmeHKnc4Pld{BRTS2vZXTpZZRm\CCHYz2xNFkh[2WubDDhdI9xfG:|aYO= NFzaNoQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e4NlY1OSd-MkO3PFI3PDF:L3G+
RKO M1LZOGNmdGxiVnnhZoltcXS7IFHzd4F6 M3GwcFExKM7:TR?= MnraNlRp MVvpcohq[mm2czD0bIUh\GWlcnXhd4Uhd2ZiY3XscEB3cWGkaXzpeJkh[2G3c3XkJIJ6KESDQh?= M1POeFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|N{W4NFY1Lz5{M{e1PFA3PDxxYU6=
T98G MX;D[YxtKF[rYXLpcIl1gSCDc4PhfS=> MVqxMVExOM7:TR?= NVTEc5hjOjSq MljEbY1xem:4ZYOgZ4VtdCC4aXHibYxqfHliY3;0doVifG2nboSge4l1cCCWUx?= MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd4OUK3OUc,OjN5NkmyO|U9N2F-
Jurkat NIriN|NE\WyuIG\pZYJqdGm2eTDBd5NigQ>? M1TtZlExOC1{MEFOwG0> MW[yOIg> M1;HZYlvcGmkaYTzJGhiSTRiaX7keYNmeyCjcH;weI9{cXNiZHXw[Y5l\W62IH;mJINwdmOnboTyZZRqd28EoB?= MVu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd|MkS4NUc,OjN5M{K0PFE9N2F-
Molt-3  M4[xU2Fxd3C2b4Ppd{BCe3OjeR?= NEjaVGk2OM7:TR?= MUSybC=> NWO2[GNSemWmdXPld{Bu\WyjdH;ubY4ucW6mdXPl[EBieG:ydH;zbZM> MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzd{NUCxN{c,OjN5MkWwNVM9N2F-
hMSC12 MXHBdI9xfG:|aYOgRZN{[Xl? M4fUTlExOM7:TR?= NYrDbpZ3PGR? NGLqb5NqdmirYnn0d{Bwe3Snb3flcolkKGO3bIT1doUucW6mdXPl[EBk\WyuIHTlZZRpKGGwZDDjZYxkcW[rY3H0bY9v MnrBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4NUe4NlIoRjJ|NkW3PFIzRC:jPh?=
HM7  Mnq2RZBweHSxc3nzJGF{e2G7 MoO4NlDPxE4EoB?= MUmxbC=> NEjIdWZjdG:la4OgZZBq[3WuYYLlckBCKGGlZYTheIUucW6mdXPl[EBk[XOyYYPlMVMh[WO2aY\heIlwdiCjbnSgVGFTWCClbHXheoFo\Q>? NX:2cJBYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PFM1OTJpPkKzOVg{PDF{PD;hQi=>
Hep-2  NFrJOotCeG:ydH;zbZMhSXO|YYm= NXK3ZnQyOjEQvF5CpC=> MnjCNlRp NUPVN2ozTE2VTx?= MmfBZYxt\X[rYYTld{B1cGViZHXjdoVie2Vib3[gZ4VtdCC4aXHibYxqfHliaX7keYNm\CCkeTDzbYxq[mmwaX6= NYPoRoU{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO1PFAxOzJpPkKzOVgxODN{PD;hQi=>
HSCs NWraOGNMSXCxcITvd4l{KEG|c3H5 M4PGWVUx|ryP M3XMN|I1cA>? NHzuZoxFVVOR M33PO4lvcGmkaYTzJI5qdG:2aX7pZk1qdmS3Y3XkJGRPSSCmYX3h[4UhcW6maXPheIVlKGK7IGDBVnAh[2ynYY\h[4U> NH;NT|c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5PVg4PCd-MkO0PVk5PzR:L3G+
HL-60  MojNR5l1d3SxeHnjbZR6KEG|c3H5 Moe2NlDPxE4EoB?= MV[yOIg> NVW0ZnNxemWmdXPld{B1cGViY4n0c5RwgGmlIHXm[oVkfCCxZjDFdpk2 NHOzTYY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S5OFQ5OCd-MkO0PVQ1QDB:L3G+
HA MnTtRZBweHSxc3nzJGF{e2G7 MorlOVDPxE1? NYLBSYhPOjSq MnPVd5VxeHKnc4Pld{B1cGViY3zlZZZi\2Vib3[gVGFTWCCjbnSgZ4F{eGG|ZT2zMEAuPyxiYX7kJE06KGmwZIXj[YQh[nliYn;yeIV7d22rYj;TRWhC MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR5NUm1Okc,OjN2N{W5OVY9N2F-
C666-1 NGXwSGJCeG:ydH;zbZMhSXO|YYm= MnPGOVDPxE1? NXvDU2QyOjSq NVnMenUze3WycILld5NmeyC2aHWgZ4xm[X[jZ3Wgc4YhWEGUUDDhcoQh[2G|cHHz[U0{NCBvNzygZY5lKC17IHnu[JVk\WRiYomgZo9zfGW8b33pZk9USUiD MlOzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN2N{W5OVYoRjJ|NEe1PVU3RC:jPh?=
Hepa1-6 NYPV[4U6SXCxcITvd4l{KEG|c3H5 NIi0Rlc2OM7:TR?= NGnUZ2szcA>? MoKzbY5pcWKrdIOgZ5Vz[3WvaX6gZY5lKHKnc4\ldoF1em:uLXnu[JVk\WRiYYDvdJRwe2m| NXLub2FERGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0OFY4PTNpPkKzOFQ3PzV|PD;hQi=>
PLC/PRF/5c MYDBdI9xfG:|aYOgRZN{[Xl? NXGycm57PTEQvF2= MnLqNYg> NWrYb241eHKndnXueJMh[XCxcITvd4l{KHS{aXfn[ZJm\CCkeTDDTW4> MXK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR|OEiyOEc,OjN2M{i4NlQ9N2F-
HCT116 NHXkcVBCeG:ydH;zbZMhSXO|YYm= NXvmN2FWOTByzszN NEHZdI0yNjWq MkP0bY5pcWKrdIOgU5MucW6mdXPl[EBk\WyuIHTlZZRp Mmn2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5NESzOVMoRjJ|N{S0N|U{RC:jPh?=
HCEC MnnjSpVv[3Srb36gRZN{[Xl? Mmn5OVDPxE1? Mn24O|Jp NF;WTmJFVVOR MmXidoV{fG:{ZYOgc4YhfGinIH7vdo1idCCKQ1XDJJBp\W6xdInw[S=> NGnNSlU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{e0NlAyOSd-MkO3OFIxOTF:L3G+
Primary rat cerebral cortical neurons MV7BdI9xfG:|aYOgRZN{[Xl? NH3ObnIyODEQvF2= NWPoVIVOOWh? NW[3emlPeHKndnXueJMhS2RvaX7keYNm\CCjcH;weI9{cXNiYX7kJINmdGxiZHXheIg> NX3tUIxCRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO3OFE{OTdpPkKzO|QyOzF5PD;hQi=>
MDA-MB-231  NUHWdnBsSXCxcITvd4l{KEG|c3H5 M3TpeVI2|ryP NHzOenczPGh? NETl[nRi[nKxZ3H0[ZMh[3m2b4TvfIlkcXS7IHHu[EBkdGWjdnHn[UBw\iClYYPwZZNmNTNiYX7kJHBCWlBiaX7keYNm\CCkeTDS[|M> MnvMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjV|M{e1OFQoRjJ3M{O3OVQ1RC:jPh?=
NLRP3-Tet-on-MC/9  NIfUV3lCeG:ydH;zbZMhSXO|YYm= M2fYdFExNTRyzszN NHrEToIyOmh? NUjSXmt{[XS2ZX71ZZRmeyC2aHWgZ4VtdCCmZXH0bEBk[XW|ZXSgZpkhS0GSUz3hd5Nw[2mjdHXkJG5NWlB|IH31eIFvfHNiaX6geIhmKFSndD3vckB{gXO2ZX2= MkHZQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN5MEOzPFkoRjJ|N{CzN|g6RC:jPh?=
KNS42  MnvhRZBweHSxc3nzJGF{e2G7 M2iyZVUx|ryP M3\ES|Fp NUX4cFlFemWmdXPld{Bk\WyuIHTlZZRpKGGwZDDjc41xdGW2ZXz5JIFjd2yrc3jl[EBk[XOyYYPlJFMwPyCjY4Tpeol1gSCrbjDy[ZNxd26|ZTD0c{BCSlRvMk[zM|JFTy:vZYTmc5JucW5iY3;tZolv[XSrb36= Mn30QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN4OUGxOFUoRjJ|NkmxNVQ2RC:jPh?=
MCF-7  MkWwRZBweHSxc3nzJGF{e2G7 NIjOTogzOM7:TdMg NEDX[VA4Omh? NIfGOWxqdmirYnn0d{BmeXWxbD2gZY5lKDRvT1jUMY1m\GmjdHXkJIFxd3C2b4Ppdy=> M3fnU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|Nke1OlQ{Lz5{M{[3OVY1OzxxYU6=
hCMEC/D3  Ml20RZBweHSxc3nzJGF{e2G7 NF\4Z3UzPc7:TR?= NYD6UZRvPzKq NYTad40{emWmdXPld{BNfHiDIHnu[JVk\WRiYYDvdJRwe2m| MX68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzZ4NUG5PEc,OjN4NkWxPVg9N2F-
Jurkat MlW3RZBweHSxc3nzJGF{e2G7 M3XMUlEzNjVvNUFOwG0> NFjPZWUycA>? MYfkc5NmKGSncHXu[IVvfGy7IIP1dJBz\XO|ZYOgV3BJNWmwZIXj[YQhWGG{LUSgZ4xm[X[jZ3WsJHBCWlBiY3zlZZZi\2VuIFTORUBnemGpbXXueIF1cW:wLDDhcoQhdG:|czDv[kB3cWGkaXzpeJk> NIr6R3o9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{S0Nlk4Pid-MkO0OFI6PzZ:L3G+
CNE-1 M1rCUGFxd3C2b4Ppd{BCe3OjeR?= MV6yNO69VcLi NXX2fW5COjSq NVzSbVZ1cW6qaXLpeJMhWkGGMECxMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NILOeI49[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SyOlg2OCd-MkO0NlY5PTB:L3G+
HONE-1 MnTkRZBweHSxc3nzJGF{e2G7 NV70VohmOjEQvF5CpC=> MUCyOIg> M3PQU4lvcGmkaYTzJHJCTDByMT3pcoR2[2WmIHPlcIwh\GWjdHi= MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzR{Nki1NEc,OjN2Mk[4OVA9N2F-
astrocytes cell NInae|VCeG:ydH;zbZMhSXO|YYm= M3jwbFQx|ryP M1q2RlZp MofMdoVlfWOnczDlZZJtgSCjcH;weI9{cXNiaX7keYNm\CCkeTDzeIF2em:|cH;ybY5m M2DEZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEGxO|c5Lz5{M{SxNVc4QDxxYU6=
U-937 M{\OWmFxd3C2b4Ppd{BCe3OjeR?= NXjLeldqOTEQvF2= M2DyNVMxdWmw Mo\VdJJmfmWwdIOgWG5HNWmwZIXj[YQhdmWlcn;weI9{cXN? M{\DUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEGwO|Q5Lz5{M{SxNFc1QDxxYU6=
MDA-MB-231 NGP2cmNCeG:ydH;zbZMhSXO|YYm= M3HVeFExOM7:TR?= MWixbC=> M2LoeIlvcGmkaYTzJJNmdnOrdHn6ZZRqd25idH:gWHJCUUxidYDvckBOXESKIHTve44uemWpdXzheIlwdg>? MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRyOESyPUc,OjN2MEi0Nlk9N2F-
HeLa  NFjEflRCeG:ydH;zbZMhSXO|YYm= MlvXNVAx|ryP NXe3XXJKOmh? M1;HN4Jtd2OtczDKVnMuOTViSX7keYNmeyCDcH;weI91cWNiQ3XscEBF\WG2aB?= MoXwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN|NESwOFUoRjJ|M{S0NFQ2RC:jPh?=
Ec109 M{nJZWFxd3C2b4Ppd{BCe3OjeR?= MW[xNO69VQ>? NGO4cVA3cA>? MlnkZoxw[2u|IHHwc5B1d3SrYzDjc41jcW6jdHnvckBw\iCWYYStV41i[055IHHu[EBz[WSrYYTpc44> MWe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzN|OEW2PEc,OjN|M{i1Olg9N2F-
H460  MXHBdI9xfG:|aYOgRZN{[Xl? NIL5WGkyOM7:TR?= MoX3Oog> NXjWO4VC[myxY3vzJIFxd3C2b4TpZ{Bkd22kaX7heIlwdiCxZjDUZZQuW22jY163JIFv\CC{YXTpZZRqd25? NECzSZQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{OzPFU3QCd-MkOzN|g2Pjh:L3G+
HeLa  M1rrdWFxd3C2b4Ppd{BCe3OjeR?= NVLpd2ZGPTEQvF2= NX62c4JqOS53aB?= MYrhZpJw\2G2ZYRCpGNpdGGveXTpZU1qdmS3Y3XkJIFxd3C2b4Ppdy=> NWi3copbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOzNFM5ODRpPkKzN|A{QDB2PD;hQi=>
SK-HEP1 NYrDRm9jSXCxcITvd4l{KEG|c3H5 MUSxNFDPxE1? MnLRNYg> MlixbY5pcWKrdIOgR5JVOSCjY4TpeoF1\WRiY3HzdIF{\S1|LDCtO{whNThuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzNyMk[1NEc,OjN|MEK2OVA9N2F-
QGY7701 M{PHb2Fxd3C2b4Ppd{BCe3OjeR?= MlrxNlXPxE1? NIHx[YgyNjWq M1TLUIlvcGmkaYTzJIFk[3WvdXzheIlwdiCxZjDzeYIuTzFicHjhd4UhcW6mdXPl[EBjgSCGT2igL{ByfWW{Y3X0bY4> NYTvfZN7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOyOFAxPjFpPkKzNlQxODZzPD;hQi=>
HepG2 NYDTUotzSXCxcITvd4l{KEG|c3H5 MnrTNlDPxE1? Mkj1N|BucW5? M1fyTYlvcGmkaYTzJJRp\SCnbnjhcoNm\CClZXzsJIRm[XSqIHL5JINwdWKrbnXkJJRz\WG2bXXueEBw\iCjcHnn[Y5qdiCjbnSgWHJCUUx? MkfiQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjN{MkSyN|koRjJ|MkK0NlM6RC:jPh?=
U87  MUXBdI9xfG:|aYOgRZN{[Xl? NXOycFlGOjYQvF2= NH6w[XkzcA>? NFj6T21l\WO{ZXHz[ZMhcXOxbHnxeYlzcXSrZ3XubY4hMEmVTDmtbY5lfWOnZDDhdI9xfG:2aXOgZ4VtdCCmZXH0bEwh[nW2IH7veEBv\WO{b4TpZ{Bk\WyuIHTlZZRp MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzJ{OU[yOkc,OjN{Mkm2NlY9N2F-
HSC-2 MX3BdI9xfG:|aYOgRZN{[Xl? MlnYNlUwPTEQvF2= MnO3NYg> NFnhOlFqdmirYnn0d{BUVi1|OD3pcoR2[2WmIHP5eI91d3irY3n0fS=> MVe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzF3NUK0PEc,OjNzNUWyOFg9N2F-
HSC-4 NXzTfnVGSXCxcITvd4l{KEG|c3H5 NFHLcVEzPS93MN88US=> MXSxbC=> NYDOcmc5cW6qaXLpeJMhW05vM{itbY5lfWOnZDDjfZRwfG:6aXPpeJk> M131PVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUW1NlQ5Lz5{M{G1OVI1QDxxYU6=
CL-1 MULBdI9xfG:|aYOgRZN{[Xl? NXXqVXNnOjEQvF2= NIC4UmQycA>? MorIZoxw[2u|IF;QOFQ6KGmwZIXj[YQh[2WubDDk[YF1cA>? M1nJU|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MUOxO|gzLz5{M{GzNVc5OjxxYU6=
MEL NVXheXhlSXCxcITvd4l{KEG|c3H5 Ml7YNlDPxE1? M1\iSFI1cA>? M4W5SmROW09? NGDDPY1qdXCjaYLld{BROlh5LXnu[JVk\WRiTVXMJINmdGxiYYDvdJRwe2m| NFTzU3U9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{CxOFg5Pyd-MkOwNVQ5QDd:L3G+
Bel-7402  MlzYR4F{eGG|ZTDBZ5RqfmG2aX;uJGF{e2G7 MnXaOVDPxE1? MWSybC=> NU\K[oFvcW6qaXLpeJMhWEOHLXnu[JVk\WRiYX7vbYtqew>? MVq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzByOEe0Nkc,OjNyMEi3OFI9N2F-
Eca-109 NIXEOVlCeG:ydH;zbZMhSXO|YYm= Mn;uNlXPxE1? MnXKN|BucW5? M33XdolvcGmkaYTzJGJLNUJzMT3pcoR2[2WmIHPlcIwh\GWjdHi= MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzB5Nkm2O{c,OjNyN{[5Olc9N2F-
MEL NH;R[IxCeG:ydH;zbZMhSXO|YYm= MXWyNO69VQ>? M3ficFFp NG[1R4NFVVOR MkjhbY1x[Wm{ZYOgVFJZPy2rbnT1Z4VlKE2HTDDj[YxtKGGyb4D0c5Nqew>? M{X2e|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|MEG0PFg4Lz5{M{CxOFg5PzxxYU6=
Bel-7402  NVu1e293SXCxcITvd4l{KEG|c3H5 NHzmWHo2OM7:TR?= NG\mfZozcA>? MoXybY5pcWKrdIOgVGNGNWmwZIXj[YQh[W6xaXvpdy=> NXjqNJZJRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNFg4PDJpPkKzNFA5PzR{PD;hQi=>
L929 Mn;ISpVv[3Srb36gRZN{[Xl? NEHGVm4zNjYQvF2= NWfScWw3OWh? M1vze4lv[3KnYYPld{BTUVBzIHX4dJJme3Orb36gZY5lKGW6YXPldoJifGWmIGTOSu6yNWmwZIXj[YQhdWm2b3Poc45lemmjbDDkfZNnfW6ldHnvckBidmRiUl;TJJBzd2S3Y4Tpc44> NYLEe|E1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkOwNFA2OThpPkKzNFAxPTF6PD;hQi=>
RCC  MlTqR4VtdCCYaXHibYxqfHliQYPzZZk> MVqxNFDPxE1? MkfWNlRp NIfhXIJz\WOxdnXy[ZMhfGinII\pZYJqdGm2eTDv[kBk\WyuczDlfJBwe2WmIITvJFE2\C2SR1qy MXS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl7MUS5OEc,OjJ7OUG0PVQ9N2F-
NB2a/d1 M3y4XmFxd3C2b4Ppd{BCe3OjeR?= M3rBSFExOM7:TR?= M3HvNFczcA>? MnTHZZR1\W63YYTld{B{fGG3cn;zdI9zcW6nLXnu[JVk\WRiY3HzdIF{\SCjY4Tpeol1gSxiUFHSVEwh[W6mIITheUBkdGWjdnHn[S=> NEPr[Is9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm4PFU1OSd-MkK5PFg2PDF:L3G+
T cell NH\NZ29Iem:5dHigTY5pcWKrdHnvckBCe3OjeR?= NF[yXJYzPS1zMEFOwG0> NInIelUzPGh? NXzySGdY\G:|ZT3k[ZBmdmSnboTsfUBqdmirYnn0[YQhXCClZXzsJJBzd2yrZnXyZZRqd25ibXXkbYF1\WRidHjyc5VocCC2aHWgZ48ue3SrbYXsZZRqd25id3n0bEBidnSrLVPEN{BidmRiYX70bU1ETDJ6 MWG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjl6MkWzPEc,OjJ7OEK1N|g9N2F-
K562 NXHzS4hbSXCxcITvd4l{KEG|c3H5 NGO1PGIyODEQvF2= M2\lcVFp M2CwcoJtd2OtczDBZo5w[mG4aYPjeY3DqEZvaX7keYNm\CCjcH;weI9{cXN? NFXqNZM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm3NlM4Oid-MkK5O|I{PzJ:L3G+
Jurkat  M{\jO2Fxd3C2b4Ppd{BCe3OjeR?= NHjudlM1OM7:TR?= NWDISIZUOWh? NULweph1[WKxbHnzbIV{KE[jc1ytbY5lfWOnZDDjZZNx[XOnIHHjeIl3[XSrb36gZY5lKGOnbHyg[IVifGh? NGX5d409[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mkm0Nlc{QCd-MkK5OFI4Ozh:L3G+
BGC-823 NFTueIVCeG:ydH;zbZMhSXO|YYm= NVj4WpBWOTByzszN MXuxbC=> NIHTdm9x[XK2aXHscJkhemW|Y4Xld{Bk\WyuczDh[4FqdnO2IHThcYFo\SCxZjDkZYllgmWrbh?= NIPGVpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyOlU1PSd-MkK5NlY2PDV:L3G+
Hep3B M33CUWFxd3C2b4Ppd{BCe3OjeR?= NE\Se5A2OM7:TR?= NF\kfXIycA>? MmLwZoxw[2u|IHHwc5B1d3OrczDpcoR2[2WmIHL5JGhGT0O| NGnrWFk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkmyN|E2PCd-MkK5NlMyPTR:L3G+
LLC-PK1 M{f4dmFxd3C2b4Ppd{BCe3OjeR?= NV3XVm9MOjEQvF2= M{GzSFFp MWXwdoV3\W62czDjbZNxdGG2aX6tbY5lfWOnZDDk[Ydz[WSjdHnvckBw\iCDdHe1MEBj\WOuaX6tNUwh[W6mIFH0[|EzKHC{b4TlbY5{ MXe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh7NkCzO{c,OjJ6OU[wN|c9N2F-
A549 MlrLRZBweHSxc3nzJGF{e2G7 MnHhOVDPxE1? NIK4XFMycA>? NXK1d25V[myxY3vzJJRp\SCEQVmtbY5lfWOnZDDhdI9xfG:|aYRCpC=> Mmf6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6OEeyNVUoRjJ{OEi3NlE2RC:jPh?=
SGC-7901  MknPRZBweHSxc3nzJGF{e2G7 NV\WZWhuOTEQvF2= NF7le4szPGh? NXWyUIxncW6qaXLpeJMh|rJuzsKt[Ilu\XSqeXzhZ5J6dHOqaXvvcolvNWmwZIXj[YQh[XCxcITvd4l{yqB? Ml64QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ6NEi1PVcoRjJ{OES4OVk4RC:jPh?=
DM6 MkPyRZBweHSxc3nzJGF{e2G7 MljUNVAx|ryP MXO3Nog> NVS1dplU[myxY3vzJIJwfGhiRULGMVEh[W6mIFWySpRzNW2nZHnheIVlKGO7dH;0c5hq[2m2eR?= MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjh{NUOyPEc,OjJ6MkWzNlg9N2F-
MCF-7, MDA-MB-468, Caco-2 MlPvS5Jwf3SqIFnubIljcXSrb36gRZN{[Xl? NFLQW4E2OM7:TR?= M4W2RlQ5cA>? M{fQU4lvcGmkaYTzJJRp\SClZXzsJIdzd3e2aDDpcohq[mm2aX;uJIlv\HWlZXSgZpkhe2Gyb37pci=> M{f6OFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{OECwPVY5Lz5{MkiwNFk3QDxxYU6=
A2750  NWW2TnBGSXCxcITvd4l{KEG|c3H5 MXiyNO69VQ>? M4XSS|Jp M1m5WGROW09? NGf4U|FjdG:la4OgZ4F{eGG|ZTDjcIVifmGpZTDkeZJqdmdiaHXs[Y5idGmwIITy[YF1dWWwdDDhcoQhemWmdXPld{BifXSxcHjh[4lkKGOnbHyg[IVifGh? MWC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd6NEO2N{c,OjJ5OESzOlM9N2F-
U87  MV;BdI9xfG:|aYOgRZN{[Xl? MX[yNO69VQ>? MUCyOIg> Mmf2doVlfWOnczD0bIUh[XCxcITvd4l{KHKjdHWgbY5lfWOnZDDifUBRVEGE MnrNQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ5N{i3PFAoRjJ{N{e4O|gxRC:jPh?=
HT1080 NF7BNoNIem:5dHigTY5pcWKrdHnvckBCe3OjeR?= M33DclUx|ryP NUnFSFlbP2R? NFHIXo9qdmirYnn0d{B1cGViY3XscEBoem:5dHigbY5pcWKrdHnvckBk[XW|ZXSgZpkh[2:vYnnu[YQhfHKnYYTt[Y51KG:oIFTDRUBidmRiT13Q M2HmS|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{N{SwPVg1Lz5{Mke0NFk5PDxxYU6=
A549  Mm[yRZBweHSxc3nzJGF{e2G7 M13TelUx|ryP NWjqbm9nOmh? M2nkUpBienSrYXzsfUBl\WO{ZXHz[ZMhe2:maYXtJJNmdGWwaYTlMYlv\HWlZXSgZZBweHSxc3nz MWS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjd{MUiwOEc,OjJ5MkG4NFQ9N2F-
Primary OPC Mo\PRZBweHSxc3nzJGF{e2G7 MVSx{txO MUm2bE8zPGh? MknPdoVlfWOnczD0bIUheGW{Y3XueIFo\SCxZjDj[YxteyCrbjDlZZJtgS1iYX7kJIxifGVvYYDvdJRwe2m|L37lZ5Jwe2m| NHrtSpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkewO|M5PSd-MkK3NFc{QDV:L3G+
PMNs MorqRZBweHSxc3nzJGF{e2G7 MoXrOFDPxE1? MWO2bC=> MknJSG1UVw>? MYPy[ZZmenOnZDD0bIUh[W2xdX70JI9nKGOuZXH2[YQh[2G|cHHz[U0{KHSxIH7lZZIhfmWqaXPs[UBt\X[nbIO= MYm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ7MkW3O{c,OjJ4OUK1O|c9N2F-
A549  M{f6S2Fxd3C2b4Ppd{BCe3OjeR?= NYW0S5BWPTEQvF2= NWmzWnJXOWh? MYDwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBD[W:qdX;zbYRmKEl? NGfiZpo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[4O|Y{PSd-MkK2PFc3OzV:L3G+
AGS NXLodpZxSXCxcITvd4l{KEG|c3H5 NX:3fGc3OjEQvF2= NILQZlgyOmh? MUnpcohq[mm2czD0bIUh[WO2aY\heIlwdiCxZjDwdo8u[2G|cHHz[U0{KGmwIILld5BwdnOnIITvJJRp\SCHdF;BZ{BnemGldHnvci=> MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZ6N{O5PEc,OjJ4OEezPVg9N2F-
shC9  MVnBdI9xfG:|aYOgRZN{[Xl? MXixNO69VQ>? MVWxOog> NXvie2pD[my3boTzJHNJUCCneIDy[ZN{cW:wIHnuJJNpSzliY3XscJMh\Xiyb4Pl[EB1dyCnaYTo[ZIhWEFib4KgUHBE NI\GPY09[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{Mk[0NVA6PCd-MkK2OFExQTR:L3G+
primary MEFs M1LkcmZ2dmO2aX;uJGF{e2G7 MoPXNVJp NEXsbZLDqGmwY4LlZZNmeyCndH;wc5Nq\GVvaX7keYNm\CCvaYTvZ4hwdmS{aXHsJI1mdWK{YX7lJIRmeG:uYYLpfoF1cW:w NVG3e2oyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVM4PjdpPkKyOlE{PzZ5PD;hQi=>
3T9 MEFs NXfYU5hFTnWwY4Tpc44hSXO|YYm= M4S4eFE3cA>? NYCwWYFRcW6lcnXhd4V{KGO7dH;jbJJwdWViYzDy[Yxm[XOnIHHmeIVzKGW2b4Dvd4ll\S22cnXheI1mdnR? NX20V41YRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK2NVM4PjdpPkKyOlE{PzZ5PD;hQi=>
3T9 MEFs MYjGeY5kfGmxbjDBd5NigQ>? MoTaNVhp NULBR5k3fXC{ZXf1cIF1\XNiaX7peIlifG:{IHPhd5Bie2VvOTDieZQh\G:5boLl[5Vt[XSnczDl[oZm[3SxcjDjZZNx[XOnczDh[pRmeiCndH;wc5Nq\GVidILlZZRu\W62 MUS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjZzM{e2O{c,OjJ4MUO3Olc9N2F-
MDA-MB-231  NXf2Z25ESXCxcITvd4l{KEG|c3H5 MXSyNO69VQ>? NF7GT5o1\A>? M1q2SpJm\HWlZYOgeIhmKGOnbHygZZBweHSxc3nzJIlv\HWlZXSgZpkhdWW2Zn;ycYlvKHS{ZXH0cYVvfCC5YYOgd4lodmmoaXPhcpRtgQ>? M2TtSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUmzOFQyLz5{MkW5N|Q1OTxxYU6=
C6  MU\BdI9xfG:|aYOgRZN{[Xl? M1fUd|Ex|ryP M1:wcFI1cA>? NYG2OXQy[myxY3vzJJRp\SC|dYDwdoV{e2m4ZTDl[oZm[3Rib3[geIhmKHCncITp[IUhd25idnnhZoltcXS7 MnXhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3OEi5PFAoRjJ{NUi4PVgxRC:jPh?=
HL-60  M2fzUWFxd3C2b4Ppd{BCe3OjeR?= NIjwUIcyODEQvF2= NXq1[lVoOjSq NWHydpZrcW6qaXLpeJMhfGinIHPlcIwh[XCxcITvd4l{KHOnbHXjeIVlKChtKT3t[Y51cHmuIN8yMUgy6obUNjmt[IlodHWlb4D5doFvd3OrZHZCpFU> MnjBQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ3NE[2OlkoRjJ{NUS2OlY6RC:jPh?=
HL-60 M3;pfmFxd3C2b4Ppd{BCe3OjeR?= MlLQNVAuQDEQvF2= MmS4OIg> NVjZcm8xcW6qaXLpeJMhXEeKUT3pcoR2[2WmIHPlcIwh[XCxcITvd4l{yqB? M2LIWVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUKzNlI6Lz5{MkWyN|IzQTxxYU6=
BCC MnPZRZBweHSxc3nzJGF{e2G7 M{fkdlUx|ryP MmjVNYg> NWDEcJdLcW6qaXLpeJMhTEGWUz3t[YRq[XSnZDDndo94fGhiaX7obYJqfGmxbh?= M4\3NFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{NUG5OFM3Lz5{MkWxPVQ{PjxxYU6=
RAW 264.7 NYrmO2hySXCxcITvd4l{KEG|c3H5 MXW1NE8yODEQvF2= NXjoT4JYOWh? NF;QOFhkd26lZX70doF1cW:wLXTldIVv\GWwdDDpcohq[mm2czDEU24ucW6mdXPl[EBzWk6DIHPs[YF3[Wen NXPvTFY1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PVE1OjZpPkKyOFkyPDJ4PD;hQi=>
K562 M4DlS2Fxd3C2b4Ppd{BCe3OjeR?= MoLwNlXPxE1? MYOybC=> MYPwdoV3\W62czDhdI9xfG:|aYOgbY5lfWOnZDDifUBkdy22cnXheI1mdnRid3n0bEBidXW{ZX7zbY4hTyCjbnSgWHJCUUx? NVn0ZYFbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0PFM4PzdpPkKyOFg{Pzd5PD;hQi=>
SGC-7901 MX7BdI9xfG:|aYOgRZN{[Xl? NX;MXVFpOjBizszNxsA> MX[ybC=> NXrFVm1x[XS2ZX71ZZRmeyCKMl:yxsBweiCWTl[g{tEucW6mdXPl[EBk\WyuIHHwc5B1d3OrczDhd{B4\WyuIHHzJINie3Cjc3WtN{Bi[3Srdnn0feKh MlvvQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2N{G1PFkoRjJ{NEexOVg6RC:jPh?=
PC3 M1G5OmFxd3C2b4Ppd{BCe3OjeR?= MXixNO69VQ>? NXzCTnFbPGh? M1rSd4NwfW62ZYLzJIZt[X[xY3;4bYQucW6mdXPl[EBk[XOyYYPlMZJmdGG2ZXSgZZBweHSxc3nz MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR5MUm3OEc,OjJ2N{G5O|Q9N2F-
SMMC-7721 MnvrRZBweHSxc3nzJGF{e2G7 MXq1NO69VQ>? MmfTOFhp MVPheJRmdnWjdHXzJI9VWi2rbnT1Z4VlKGGyb4D0c5Nqew>? MnT6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NkW4N|MoRjJ{NE[1PFM{RC:jPh?=
HeLa  M3TDPWFxd3C2b4Ppd{BCe3OjeR?= M{PC[|UxyqEQvF2= NX3GTHRUPC96aB?= M{PtRolvcGmkaYTzJHNVWy2rbnT1Z4VlKGyjdHWtdIhie2ViYYDvdJRwfGmlIHX2[Y51ew>? MkXFQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ2NkC1NFQoRjJ{NE[wOVA1RC:jPh?=
HeLa  Mn;tRZBweHSxc3nzJGF{e2G7 MorSOVDDqM7:TR?= M1TtSlFp NUTnfIV[e3WycILld5NmeyC2aHWgSnJCWC2rbnT1Z4VlKGGlY4XteYxifGmxbjDv[kBidm6neHnuJHYheG:|aYTpeoUh[2WubIO= MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjR2OUS0NEc,OjJ2NEm0OFA9N2F-
T47D  Mn7SRZBweHSxc3nzJGF{e2G7 NFTMbmQyODEQvF2= M4HVclFp M3HBS4Jtd2OtczD0bIUh\2WwZYLheIlwdiCxZjDFMYNi\C:FVF[yJIJ6KFOWUx?= NXXrcGR6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkK0NFEyPjhpPkKyOFAyOTZ6PD;hQi=>
HeLa  NH3nXWVCeG:ydH;zbZMhSXO|YYm= MnLoN|DPxE1? MXe0bC=> NV\tR3Z5yqCrbnPy[YF{\XNidHjlJIdmdmW{YXygZ4VtdCC4aXHibYxqfHliNEigbEBi\nSncjDwbI91d2S7bnHtbYMhfHKnYYTt[Y51yqB? MYq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjN7NEK0PEc,OjJ|OUSyOFg9N2F-
HCC NXSwcYpuSXCxcITvd4l{KEG|c3H5 MnHTNlAh|ryPwrC= M3\jUFJp MYHheJRmdnWjdHXzJJRp\SCGSFGgbY5lfWOnZDDhZ5RqfmG2aX;uJI9nKFCDUmC= M4\xPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{M{SyO|MzLz5{MkO0Nlc{OjxxYU6=
mESCs NV3rZnRxSXCxcITvd4l{KEG|c3H5 M2[3[VIvPc7:TR?= MmPONog> MkG0bY5pcWKrdIOgeIhmKE6jRj3t[YRq[XSnZDDjZZNx[XOnIHHjeIl3[XSrb36= M{XnSVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{Mki1Nlc1Lz5{MkK4OVI4PDxxYU6=
EMT-6  NF;Ed3BEgXSxdH;4bYNqfHliQYPzZZk> NFr0epUyODEQvF2= NHjn[mcycA>? M1HWeZBienSrYXzsfUBjdG:la3XkJINmdGxiZHXheIghcW6mdXPl[EBjgSC|aYLhcYV{cW6n MlnzQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJ{NUG5NlEoRjJ{MkWxPVIyRC:jPh?=
MCF7 M37VcmFxd3C2b4Ppd{BCe3OjeR?= NF7ROVY2OMLizszN MlzWNYg> M2r4WolvcGmkaYTzJHBCKGGldHn2ZZRm\CClYYPwZZNmNTNuID25MEBidmRicH;sfUhCTFBvcnnic5NmMSCyb3z5cYVz[XOn NXradYs3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKyNlM{PDVpPkKyNlI{OzR3PD;hQi=>
K562 MnKxRZBweHSxc3nzJGF{e2G7 NH24UFIzOCEQvF5CpC=> MnS3OFhp MVnEUXNQ MkGzZoxw[2u|IHzhdIF1cW6rYj3pcoR2[2WmIHnubIljcXSrb36gc4YhfmmjYnnsbZR6KGGwZDDhdI9xfG:|aYOgbY5lfWO2aX;u MYS8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjJzNkG1PEc,OjJ{MU[xOVg9N2F-
Molt4-hyg MXPBdI9xfG:|aYOgRZN{[Xl? MYGxNO69VQ>? NXzNZZZ3OC53aB?= M1e0fYJtd2OtczDmZZJv\XOxbD3pcoR2[2WmIHPhd5Bie2VvMz3sbYtmKGGldHn2bZR6 MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPjJ5NUixNUc,OjZ{N{W4NVE9N2F-
HeLa MXnBdI9xfG:|aYOgRZN{[Xl? NUPCNJV6OTEQvF2= NX\xNZdDOC53aB?= NWHLTndZcW6qaXLpeJMh[XCxcITvd4l{KGmwZIXj[YQh[nlidHjlJINwdWKrbnXkJJRz\WG2bXXueEB4cXSqIHfvcYl{cW5iTjDhcoQhXFKDSVy= M3fQPFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MUe5OlYyLz5{MkG3PVY3OTxxYU6=
Jurkat T NV\hXnkzSXCxcITvd4l{KEG|c3H5 MXqzNO69VQ>? M3T3OFAvPWh? MYPEUXNQ M2XwT4Jtd2OtczD0bIUhgmm{YX2tbY5lfWOnZDDhdI9xfG:|aYO= MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjF3OUi5PEc,OjJzNUm4PVg9N2F-
Neutrophil M4L3NmFxd3C2b4Ppd{BCe3OjeR?= NVXxOIpHOjEQvF2= MoDxNE42cA>? NXi4VYtE[XS2ZX71ZZRmeyC2aHWgdJJwNWGyb4D0c5Rq[yCnZn\lZ5Qhd2ZiTXHSNS=> NXnwVI9uRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMk[xPVY5PDRpPkK2NVk3QDR2PD;hQi=>
HCT116 NGDjcVJCeG:ydH;zbZMhSXO|YYm= M37ESFUxyqEQvF2= M3LsdVJp MYLy[ZZmenOnczDzfY5memerc4TpZ{BieG:ydH;zbZMh\W[oZXP0d{Bw\iClZXzlZ495cWJiYX7kJG5RSy1zNtMg NIjMcoo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkG1PVc2Oid-MkKxOVk4PTJ:L3G+
MDA-MB-231  M4ruNWFxd3C2b4Ppd{BCe3OjeR?= NHi2clYzNjVvNz61{txO NUTlfnpvOmh? M1KwWYlvcGmkaYTzJJRp\SClZXzsJIRm[XSqIH;mJG1FSS2PQj2yN|Eh[2WubIOgbY5lfWOnZDDifUBUTFRiaX6gZUBkd26lZX70doF1cW:wIHTldIVv\GWwdDDtZY5v\XJ? NEXhTHk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGxOVUzPid-MkKxNVU2OjZ:L3G+
LNCaP M2PwSWFxd3C2b4Ppd{BCe3OjeR?= NU\pXJN5PDEQvF2= MWCybC=> MWXpcohq[mm2czDieZRmcW5iaX7keYNm\CClZXzsJIFxd3C2b4Ppdy=> NWXZfWF2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNVQ4PjRpPkKyNVE1PzZ2PD;hQi=>
MB231 MYnBdI9xfG:|aYOgRZN{[Xl? M3TIZVExOM7:TR?= M1XxbFFp NInBOZhFVVOR Ml\vZYJzd2ejdHXzJJRp\SCrbnT1Z5Rqd25ib3[gZ4VtdCCmZXH0bEBjgSCZRVWxJIlvcGmkaYTpc44tKFSUQVnMJJRz\WG2bXXueEwh[W6mIITo[UBkd22kaX7heIlwdg>? MmnIQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJzMUK5OFAoRjJ{MUGyPVQxRC:jPh?=
HCC38  M4f2cGFxd3C2b4Ppd{BCe3OjeR?= M3X1Z|ExOM7:TR?= MmnLNYg> M4jycmROW09? NIrFV3Zi[nKxZ3H0[ZMhfGinIHnu[JVkfGmxbjDv[kBk\WyuIHTlZZRpKGK7IGfFSVEhcW6qaXLpeIlwdixiVGLBTWwhfHKnYYTt[Y51NCCjbnSgeIhmKGOxbXLpcoF1cW:w MX28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOjFzMkm0NEc,OjJzMUK5OFA9N2F-
MDA-MB231 M1S0R2Fxd3C2b4Ppd{BCe3OjeR?= NHXnTFE2OMLizszN MnLONlRp NYn6Xm9{TE2VTx?= M2PadYFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> NGPY[Ho9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkGwNVM{PSd-MkKxNFE{OzV:L3G+
LNCaP MnnSRZBweHSxc3nzJGF{e2G7 NHX5eHg2OMLizszN NV76VpVuOjSq MXrEUXNQ MnPrZYJzd2ejdHXzJIN2emO3bXnuMYlv\HWlZXSgZ4VtdCCmZXH0bC=> NXHyd4dyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFE{OzVpPkKyNVAyOzN3PD;hQi=>
HCT116 M2e5cGFxd3C2b4Ppd{BCe3OjeR?= NHXoOY42OMLizszN NH70NmUzPGh? Mmr6SG1UVw>? M361RoFjem:pYYTld{BkfXKldX3pck1qdmS3Y3XkJINmdGxiZHXheIg> NWS4cXBKRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkKxNFE{OzVpPkKyNVAyOzN3PD;hQi=>
Ishikawa  NHrC[2RCeG:ydH;zbZMhSXO|YYm= NIjMSYwzPc7:TR?= MoHmNlRp M{DwT5Jm\HWlZYOgZ4VtdCCmZXH0bEBidmRiYYDvdJRwe2m|IHnu[JVk\WRiYomgRoFnKEFz MkHTQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOEi5NVgoRjJ{MEi4PVE5RC:jPh?=
 YD-8  NVTCTG1GSXCxcITvd4l{KEG|c3H5 NH7yWJgyODEQvF2= NIXqXFYycA>? MlPlbY5pcWKrdIOgVGxGVy2rbnT1Z4VlKGGyb4D0c5Nqew>? MnyyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyOE[xPFMoRjJ{MEi2NVg{RC:jPh?=
eosinophil  NFHMe45CeG:ydH;zbZMhSXO|YYm= NWW3RYJCQTEQvF2= NUn5UYl[OjSq M{KzN4lvcGmkaYTzJIFxd3C2b4Ppd{BqdmS3Y3XkJIJ6KE[jczDhcpRq[m:medMg Mn\MQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjJyN{mzN|QoRjJ{MEe5N|M1RC:jPh?=
L929 M4izdWdzd3e2aDDJcohq[mm2aX;uJGF{e2G7 MofiNk42|ryP NG\v[YIzPGh? M2K2VolvcGmkaYTzJJRp\SCneIDy[ZN{cW:wIH;mJJAueDN6IHHu[EBPTi4QulKgeI8h[XWpbXXueEBVVkcQsT3pcoR2[2WmIH7lZ5JweHSxc3nzJIFv\CCjdYTvdIhi\3l? NHftcHY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCyO|A6Pyd-MkKwNlcxQTd:L3G+
YD-8  NF\jV5RCeG:ydH;zbZMhSXO|YYm= M4T6XFExOM7:TR?= NV;v[GFpOWh? NGfrb4ljdG:la4OgeIhmKEeVLVjDcE1qdmS3Y3XkJIFxd3C2b4Ppdy=> NIjsTIo9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MkCyNFA4QCd-MkKwNlAxPzh:L3G+
HBx NEXNdXRCeG:ydH;zbZMhSXO|YYm= NV;BSFRVOjYQvF2= M1LQZVQ5cA>? NWi2U4x5TE2VTx?= NEXETHJz\WS3Y3XkJINmdGxiZHXheIghcW6mdXPl[EBjgSB|LV3B M1f4dlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ{MEKwNFc5Lz5{MkCyNFA4QDxxYU6=
U937  NUXSPJBRSXCxcITvd4l{KEG|c3H5 M{P6OlUxyqEQvF2= Mmf1NYg> NHnYTVlqdmirYnn0d{BJTi2rbnT1Z4VlKGGyb4D0c5Nqe8Li M3jDN|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJzOUm4O|MyLz5{MUm5PFc{OTxxYU6=
HL60 M1zSdWFxd3C2b4Ppd{BCe3OjeR?= MYW0NO69VQ>? MUG0NI1qdg>? MnHhSG1UVw>? Ml3nZoxw[2u|IFLOSGMh[2:vcH;1coR{KGmwZIXj[UBmgHCxc4Xy[UBw\iCyaH;zdIhifGmmeXzz[ZJqdmViYX7kJGRPSSCocnHncYVvfGG2aX;u NFzXcWU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUm4N|I6Pid-MkG5PFMzQTZ:L3G+
M-14 M4mwSmFxd3C2b4Ppd{BCe3OjeR?= MnTDNlXPxE1? M{\EOVAvPWh? NH\ZTnjDqGmwaHnibZR{KGKxdHigeIhmKGO{dXTlJIV5fHKjY4StJIFv\CClb33wc5Vv\C2rbnT1Z4VlKGGyb4D0c5Nqew>? NUD2dJl{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5OVQ6PTlpPkKxPVU1QTV7PD;hQi=>
SK-BR-3 M4jHcWFxd3C2b4Ppd{BCe3OjeR?= MUG1NOKh|ryP MlfENog> MUPicI9kc3NiYYDvdJRwfGmlIFTORUBnemGpbXXueIF1cW:wIHnu[JVk\WRiYomgZ49u[mmwYYTpc44hd2ZiU12tNVY1KGGwZDDyZYRq[XSrb36= NYDFZpIyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkG5NFE{QDZpPkKxPVAyOzh4PD;hQi=>
MDA-MB-468 NVjR[4o{SXCxcITvd4l{KEG|c3H5 NYrN[I8yPTEEoN88US=> MX2ybC=> MXvicI9kc3NiYYDvdJRwfGmlIFTORUBnemGpbXXueIF1cW:wIHnu[JVk\WRiYomgZ49u[mmwYYTpc44hd2ZiU12tNVY1KGGwZDDyZYRq[XSrb36= NEHNfZI9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MUmwNVM5Pid-MkG5NFE{QDZ:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Western blot
IRF-1 / p-STAT1 / cleaved PARP1 / cleaved-caspase3; 

PubMed: 27191889     


With the addition of Z-VAD-FMK, levels of cleaved Caspase-3 and PARP1 were decreased.

Beclin1 / Atg5 / Atg7 / LC-3I / LC-3II; 

PubMed: 27191889     


Levels of Beclin1, Atg5, Atg7 and LC3-II were decreased after IFN-γ stimulation. However, when IFN-γ was combined with the caspase inhibitor, levels of Beclin1, Atg5, Atg7 and LC3-II were not decreased as determined by the Western Blot test. 

p23 / Hsp90 / hTRET / MMP2; 

PubMed: 19740745     


Expression of Hsp90 client proteins during cell death. HeLa cells were preincubated with z-VAD-fmk (100 μM) for 1 h and exposed to various concentrations of tunicamycin (Tu, in μM) for 24 h. Cell extracts were prepared and analyzed by Western blotting. β-Actin was used as the loading control.

cyto C; 

PubMed: 17301139     


z-VAD-fmk did not inhibit cytochrome c release in RRV-infected MA104 cells (RRV: rhesus rotavirus). Mock- and RRV-infected MA104 cells either were not pretreated or were pretreated with 100 μM z-VAD-fmk for 2 h before RRV infection, and treatment was continued during infection. Fourteen hours after RRV infection, the cytosolic and heavy-membrane fractions were assayed for cytochrome c by Western blotting. Mock-infected MA104 cells were used as negative controls. Cox IV and tubulin were used as protein loading controls for the heavy-membrane and cytosolic fractions, respectively. Positions of molecular weight markers are indicated on the left.

27191889 19740745 17301139
Growth inhibition assay
Cell viability; 

PubMed: 12522090     


Inhibition of magnolol-induced apoptotic cell death by z-VAD-fmk. CH27 cells were treated with cell permeable broad-spectrum caspase inhibitor (z-VAD-fmk) 2 h prior to 80 μm magnolol treatment. Cell viability was estimated. ***P<0.001, compared with the 80 μM magnolol-treated group. 

12522090
Immunofluorescence
cytochrome c ; 

PubMed: 11726499     


Immunolocalization of Smac/DIABLO and cytochrome c in HeLa cells. (A-C) Viable (non-apoptotic) HeLa cells were stained with antibodies to cytochrome c (green) and Smac/DIABLO (red) as indicated. Note that both proteins clearly co-localize within punctate, mitochondrial structures. (D–F) HeLa cells, pre-incubated with z-VAD-fmk (100 µM), were UV-irradiated followed by further incubation for 8 h. Note the cells where cytochrome c has exited mitochondria and can be seen in a diffuse pattern throughout the cell, including the nucleus (white arrows). In the latter case, note the retention of Smac/DIABLO in punctate mitochondrial structures within the cytoplasm. (G-I) HeLa cells, pre-incubated with z-VAD-fmk (100 µM), were then treated with 10 µM actinomycin D for 8 h. Once again note the retention of Smac/DIABLO in mitochondrial structures. (J-L) HeLa cells were treated as described in (G-I). A close-up of a single cell that has undergone mitochondrial cytochrome c release, but where Smac/DIABLO is retained within mitochondria, is shown.

Smac/DIABLO; 

PubMed: 11726499     


Immunolocalization of Smac/DIABLO and cytochrome c in HeLa cells. (A-C) Viable (non-apoptotic) HeLa cells were stained with antibodies to cytochrome c (green) and Smac/DIABLO (red) as indicated. Note that both proteins clearly co-localize within punctate, mitochondrial structures. (D–F) HeLa cells, pre-incubated with z-VAD-fmk (100 µM), were UV-irradiated followed by further incubation for 8 h. Note the cells where cytochrome c has exited mitochondria and can be seen in a diffuse pattern throughout the cell, including the nucleus (white arrows). In the latter case, note the retention of Smac/DIABLO in punctate mitochondrial structures within the cytoplasm. (G-I) HeLa cells, pre-incubated with z-VAD-fmk (100 µM), were then treated with 10 µM actinomycin D for 8 h. Once again note the retention of Smac/DIABLO in mitochondrial structures. (J-L) HeLa cells were treated as described in (G-I). A close-up of a single cell that has undergone mitochondrial cytochrome c release, but where Smac/DIABLO is retained within mitochondria, is shown.

Endo G; 

PubMed: 12941691     


GFP-Bax expression and immunostaining of EndoG together with nuclear Hoechst staining in HeLa cells 18 h after transient transfection with a vector encoding GFP-Bax in the absence or in the presence of the caspase inhibitor z-VAD-fmk (100 μM). 

AIF; 

PubMed: 12941691     


GFP-Bax expression and immunostaining of AIF together with nuclear Hoechst staining in HeLa cells 18 h after transient transfection with a vector encoding GFP-Bax in the absence or in the presence of the caspase inhibitor z-VAD-fmk (100 μM). 

11726499 12941691
ELISA
IL-1β; 

PubMed: 26254306     


Cell-free medium supernatants were harvested at 5 h. IL-1β levels were measured by ELISA. Z-VAD-FMK was used as a positive control. Bars represent means ± sem of pooled results from 3 experiments performed in triplicate at different times.

26254306
In vivo In vivo Z-VAD-FMK administration has been shown previously to be nontoxic and to prevent apoptosis in animal models. Intraperitoneal HK-GBS injection leads to preterm delivery, and pretreatment with Z-VAD-FMK delays preterm delivery in mice. In OVA-sensitized mice,treatment of z-VAD-fmk inhibits allergen-induced leukocyte infiltration. Systemic injection of the pan-caspase inhibitor z-VAD-fmk immediately before OVA challenge reduced inflammatory cell accumulation, mucus hypersecretion, and Th2 cytokine release in OVA-sensitized/challenged mice. Treatment with z-VAD-fmk blocked terminal differentiation of lens epithelial cells and keratinocytes, the differentiation of monocytes into macrophages, and the differentiation of erythroid progenitors. z-VAD-fmk attenuated allergen-induced airway inflammation and hyperreactivity. Treatment with z-VAD-fmk in vivo also prevented subsequent T cell activation ex vivo[7].

Protocol

Cell Research:

[6]

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  • Cell lines: human granulosa cell lines (GC1a, HGL5, COV434)
  • Concentrations: 50 μM
  • Incubation Time: 48 h
  • Method:

    To validate the efficacy of Z-VAD-FMK, three human granulosa cell lines (GC1a, HGL5, COV434) were treated for 48 h with etoposide (50 μg/ml) and/or Z-VAD-FMK (50 μM) under normoxic conditions. To mimic the ischemic phase that occurs after ovarian fragment transplantation, cells were cultured without serum under hypoxia (1 % O2) and treated with Z-VAD-FMK. The metabolic activity of the cells was evaluated by WST-1 assay. Cell viability was determined by FACS analyses. The expression of apoptosis-related molecules was assessed by RT-qPCR and Western blot analyses.


    (Only for Reference)
Animal Research:

[7]

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  • Animal Models: CD1 mice
  • Dosages: 10 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 93 mg/mL (198.93 mM)
Water Insoluble
Ethanol Insoluble
In vivo Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):
2% DMSO+35 %PEG 300+2%Tween 80+ddH2O
For best results, use promptly after mixing.
6mg/mL

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 467.49
Formula

C22H30FN3O7

CAS No. 187389-52-2
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

In vivo Formulation Calculator (Clear solution)

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

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Frequently Asked Questions

  • Question 1:

    Can you suggest an in vivo formulation of S7023 for animal studies?

  • Answer:

    For in vivo study of S7023, The IP formulation is 2% DMSO+35 % PEG 300+2% Tween 80+ddH2O up to 6 mg/ml. The gavage formula is 1%CMC-Na up to 30 mg/ml (suspensions).

  • Question 2:

    What is difference between S7023 & S8102?

  • Answer:

    Unlike S7023, S8102 does not require pretreatment with esterase for in vitro studies. This information was cited from the article: https://www.ncbi.nlm.nih.gov/pubmed/16973565.

Caspase Signaling Pathway Map

Related Caspase Products

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID