research use only

Z-FY-CHO

Cat.No.P1157

Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of Cathepsin L (CTSL) that ameliorates cell apoptosis and preserves effective autophagic degradation.

Amino-acid Sequence

CAS No. 167498-29-5

Quality Control

Batch: P115701 DMSO] 89 mg/mL] false] Ethanol] 4 mg/mL] false] Water] Insoluble] false Purity: 99.12%

99.12

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vitro
Batch:

DMSO : 89 mg/mL (199.32 mM)；
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)

Ethanol : 4 mg/mL

Water : Insoluble

Molecular Weight Calculator

In vivo Batch: Add solvents to the product individually and in order.					In vivo Formulation Calculator
	Homogeneous suspension	CMC-NA	≥5mg/ml	Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.	In vivo Formulation Calculator
Clear solution	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O	4.45mg/ml (9.97mM)	Taking the 1 mL working solution as an example, add 50 μL of 89 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results.
Clear solution	5% DMSO 1 95% Corn oil	0.6mg/ml (1.34mM)	Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results.

Biological Activity

Description	Z-FY-CHO (Z-Phe-Tyr-CHO) is a potent and specific inhibitor of Cathepsin L (CTSL) that ameliorates cell apoptosis and preserves effective autophagic degradation.

References
https://pubmed.ncbi.nlm.nih.gov/26797274/

References

https://pubmed.ncbi.nlm.nih.gov/26797274/

Product Information

Molecular Formula	C₂₆H₂₆N₂O₅
Molecular Weight	446.50
CAS No.	167498-29-5
Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)