Zotiraciclib

Synonyms: SB1317 (TG02)

Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.

Zotiraciclib Chemical Structure

Zotiraciclib Chemical Structure

CAS: 937270-47-8

Purity & Quality Control

Batch: S700201 DMSO] 15 mg/mL] false] Water] Insoluble] false] Ethanol] Insoluble] false Purity: 99.98%
99.98

Zotiraciclib Related Products

Signaling Pathway

Choose Selective CDK Inhibitors

Biological Activity

Description Zotiraciclib (SB1317; TG02) is a novel small molecule potent CDK/JAK2/FLT3 inhibitor, emerged with potent CDK (IC50 against CDKs 1, 2 and 9 = 9, 5 and 3 nM, respectively), FLT3 (IC50 = 19 nM) and JAK2 (IC50 = 19 nM) potency.
Features TG02 adopts a slightly different preferred conformation in order to achieve the key interaction with Asp698 when docks into FLT3.
Targets
CDK9 [1] CDK2 [1] CDK1 [1] FLT3 [1] JAK2 [1]
3 nM 5 nM 9 nM 19 nM 19 nM
NCT Number Recruitment Conditions Sponsor/Collaborators Start Date Phases
NCT05588141 Recruiting
Brain Tumor|Cancer
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
May 16 2023 Phase 1|Phase 2
NCT02942264 Completed
Brain Tumor|Astrocytoma|Astroglioma|Glioblastoma|Gliosarcoma
National Cancer Institute (NCI)|National Institutes of Health Clinical Center (CC)
December 14 2016 Phase 1|Phase 2
NCT01204164 Completed
AML|ALL|Blast Crisis|MDS|Multiple Myeloma
Tragara Pharmaceuticals Inc.
August 2010 Phase 1

Chemical Information & Solubility

Molecular Weight 372.46 Formula

C23H24N4O

CAS No. 937270-47-8 SDF --
Smiles CN1C/C=C/CCOC2=CC(=CC=C2)C3=CC=NC(=NC4=CC=CC(=C4)C1)N3
Storage (From the date of receipt) 3 years-21°C powder

In vitro
Batch:

DMSO : 15 mg/mL ( (40.27 mM); Moisture-absorbing DMSO reduces solubility. Please use fresh DMSO.)

Water : Insoluble

Ethanol : Insoluble


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In vivo
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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