Z-IETD-FMK

For research use only.

Catalog No.S7314 Synonyms: Caspase-8 Inhibitor

23 publications

Z-IETD-FMK Chemical Structure

CAS No. 210344-98-2

Z-IETD-FMK (Caspase-8 Inhibitor) is a specific Caspase-8 inhibitor.

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Selleck's Z-IETD-FMK has been cited by 23 publications

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Biological Activity

Description Z-IETD-FMK (Caspase-8 Inhibitor) is a specific Caspase-8 inhibitor.
Targets
Caspase-8 [1]
In vitro

Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 NUnBUFFlTnWwY4Tpc44h[XO|YYm= M3mxTnouUUWWRD3GUWsh[WOlZXzldoF1\XNidHjlJHBRUS2rbnT1Z4VlKGOnbHyg[IVifGhib3[gTIVxTzJiY3XscJMv M{TIdlMxPjdzNEW4
HL-60 NGDRcZlHfW6ldHnvckBie3OjeR?= M{CwOFUxKM7:TR?= NVfiVpBDOSCq MVPjc41xdGW2ZXz5JIJtd2OtczD0bIUhOjNvSGXBMYlv\HWlZXSgSG5CKG[{YXft[Y51[XSrb36= NX\kfI83OzB3NUG2NlA>
MG63 NXvpfI1SS3m2b4TvfIlkcXS7IHHzd4F6 NWPySG9nOTBizszN NV\ISYs4eGG{dHnhcIx6KHKndnXyd4VlKE2VUD20MYlv\HWlZXSgUWc3OyClZXzsJIN6fG:2b4jpZ4l1gQ>? NUC0RWVqOjl|MEGzNFg>
HXO-RB44 cells MVnBdI9xfG:|aYOgZZN{[Xl? MVTk[YNz\WG|ZYOgeIhmKGGyb4D0c5Rq[yC{YYTld{BqdmS3Y3XkJIJ6KGK3ZnHsbY4> NEjidoYzPzlyNE[5Oy=>
Jurkat cells M1zHS2Z2dmO2aX;uJIF{e2G7 MoHLOVAh|ryP NV7SPHZ7OSCq MUfhZo9tcXOqZYOgeIhmKGOuZXH2ZYdmKG:oIITCbYQ> M17iN|I2PjN{NECx
DU 145 MUjGeY5kfGmxbjDhd5NigQ>? MYOyNEDPxE1? MYmyOEBp MUXpcpRmenK3cITl[EB1cGViY3zlZZZi\2Vib3[gVGFTWCCrbnT1Z4VlKGK7IHXy[49{fGW{b3ygdIVzd3irZHW= NY\lT2NDOjV3ME[yOlU>

... Click to View More Cell Line Experimental Data

In vivo In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. [3] Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. [4]

Protocol

Animal Research:

[3]

- Collapse
  • Animal Models: T. cruzi-infected mice
  • Dosages: 0.4 mg/3 days
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 91 mg/mL (138.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 654.68
Formula

C30H43FN4O11

CAS No. 210344-98-2
Storage powder
in solvent
Synonyms Caspase-8 Inhibitor
Smiles CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID