For research use only.

Catalog No.S7314 Synonyms: Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK

32 publications

Z-IETD-FMK Chemical Structure

CAS No. 210344-98-2

Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific Caspase-8 inhibitor.

Selleck's Z-IETD-FMK has been cited by 32 publications

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Biological Activity

Description Z-IETD-FMK (Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK) is a specific Caspase-8 inhibitor.
Caspase-8 [1]
In vitro

Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 M2DCcGZ2dmO2aX;uJIF{e2G7 NFfOVFRbNUmHVFStSm1MKGGlY3Xs[ZJifGW|IITo[UBRWElvaX7keYNm\CClZXzsJIRm[XSqIH;mJGhmeEd{IHPlcIx{Ng>? MUe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8{ODZ5MUS1PEc,OzB4N{G0OVg9N2F-
HL-60 NE[zNllHfW6ldHnvckBie3OjeR?= MVW1NEDPxE1? Mnm5NUBp NFHJXJJkd22ybHX0[Yx6KGKub3Prd{B1cGViMkOtTHVCNWmwZIXj[YQhTE6DIH\yZYdu\W62YYTpc44> MormQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOzB3NUG2NlAoRjNyNUWxOlIxRC:jPh?=
MG63 MX\DfZRwfG:6aXPpeJkh[XO|YYm= NF2wZokyOCEQvF2= MlPsdIFzfGmjbHz5JJJmfmW{c3XkJG1UWC12LXnu[JVk\WRiTVe2N{Bk\WyuIHP5eI91d3irY3n0fS=> Ml\RQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjl|MEGzNFgoRjJ7M{CxN|A5RC:jPh?=
HXO-RB44 cells MXvBdI9xfG:|aYOgZZN{[Xl? M3fyS4Rm[3KnYYPld{B1cGViYYDvdJRwfGmlIILheIV{KGmwZIXj[YQh[nliYoXmZYxqdg>? NEK0T|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{N{mwOFY6Pyd-Mke5NFQ3QTd:L3G+
Jurkat cells NVriVW9HTnWwY4Tpc44h[XO|YYm= M1HxOlUxKM7:TR?= NHW5ZZIyKGh? MYPhZo9tcXOqZYOgeIhmKGOuZXH2ZYdmKG:oIITCbYQ> MV68ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTZ|MkSwNUc,OjV4M{K0NFE9N2F-
DU 145 M2rSXGZ2dmO2aX;uJIF{e2G7 MVKyNEDPxE1? NVr6fXZKOjRiaB?= NX3JU4NncW62ZYLyeZB1\WRidHjlJINt\WG4YXflJI9nKFCDUmCgbY5lfWOnZDDifUBmemexc4Tldo9tKHCncn;4bYRm MVO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zPTVyNkK2OUc,OjV3ME[yOlU9N2F-

... Click to View More Cell Line Experimental Data

In vivo In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. [3] Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. [4]


Animal Research:


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  • Animal Models: T. cruzi-infected mice
  • Dosages: 0.4 mg/3 days
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 91 mg/mL (138.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 654.68


CAS No. 210344-98-2
Storage powder
in solvent
Synonyms Caspase-8 Inhibitor, Z-IE(OMe)TD(OMe)-FMK

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID