Z-IETD-FMK

For research use only.

Catalog No.S7314 Synonyms: Caspase-8 Inhibitor

21 publications

Z-IETD-FMK Chemical Structure

Molecular Weight(MW): 654.68

Z-IETD-FMK is a specific Caspase-8 inhibitor.

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EUR 1248 In stock
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Selleck's Z-IETD-FMK has been cited by 21 publications

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Biological Activity

Description Z-IETD-FMK is a specific Caspase-8 inhibitor.
Targets
Caspase-8 [1]
In vitro

Z-IETD-FMK, which inhibits the cleavage of caspase-8 and partially inhibits the cleavage of caspase-3 and PARP, prevents the execution of apoptosis in retinal cells exposed to different apoptotic stimuli. [1] Z-IETD-FMK (50 μM) reduces ceramide-induced cardiomyocyte death and significantly inhibits the activation of caspase 3. [2] Inhibition of caspase-8 by Z-IETD-FMK affects the generation of activated/memory T cells and T cell cytokine production, and decreases NF-kappaB responses to TCR:CD3 engagement in T cell cultures. [3]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
HepG2 MXHGeY5kfGmxbjDhd5NigQ>? M1r2OnouUUWWRD3GUWsh[WOlZXzldoF1\XNidHjlJHBRUS2rbnT1Z4VlKGOnbHyg[IVifGhib3[gTIVxTzJiY3XscJMv MoD3N|A3PzF2NUi=
HL-60 MoHFSpVv[3Srb36gZZN{[Xl? MV:1NEDPxE1? NV7Od2k6OSCq MkjJZ49ueGyndHXsfUBjdG:la4OgeIhmKDJ|LVjVRU1qdmS3Y3XkJGRPSSCocnHncYVvfGG2aX;u MkfQN|A2PTF4MkC=
MG63 NHfD[m5EgXSxdH;4bYNqfHliYYPzZZk> NHK0TG0yOCEQvF2= M1;5T5BienSrYXzsfUBz\X[ncoPl[EBOW1BvND3pcoR2[2WmIF3HOlMh[2WubDDjfZRwfG:6aXPpeJk> NHHLWVczQTNyMUOwPC=>
HXO-RB44 cells M4rx[2Fxd3C2b4Ppd{Bie3OjeR?= NWjDTXZM\GWlcnXhd4V{KHSqZTDhdI9xfG:2aXOgdoF1\XNiaX7keYNm\CCkeTDieYZidGmw MXWyO|kxPDZ7Nx?=
Jurkat cells NEXtbopHfW6ldHnvckBie3OjeR?= MmKzOVAh|ryP MVOxJIg> NUPuc3RE[WKxbHnzbIV{KHSqZTDjcIVifmGpZTDv[kB1Smmm MoXVNlU3OzJ2MEG=
DU 145 MW\GeY5kfGmxbjDhd5NigQ>? M2T0T|IxKM7:TR?= NHTLSFAzPCCq NYG1WmRqcW62ZYLyeZB1\WRidHjlJINt\WG4YXflJI9nKFCDUmCgbY5lfWOnZDDifUBmemexc4Tldo9tKHCncn;4bYRm MmXvNlU2ODZ{NkW=

... Click to View More Cell Line Experimental Data

In vivo In vivo, inhibition of caspase-8 by Z-IETD-FMK reduces memory/activated CD4 and CD8 T cells, and increases susceptibility to T. cruzi infection. [3] Z-IETD-FMK promotes neuronal survival and regeneration of injured retinal ganglion cells after CNS injuries. [4]

Protocol

Animal Research:

[3]

- Collapse
  • Animal Models: T. cruzi-infected mice
  • Dosages: 0.4 mg/3 days
  • Administration: --
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 91 mg/mL (138.99 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 654.68
Formula

C30H43FN4O11

CAS No. 210344-98-2
Storage powder
in solvent
Synonyms Caspase-8 Inhibitor
Smiles CCC(C)C(C(=O)NC(CCC(=O)OC)C(=O)NC(C(C)O)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID