ZLN005

For research use only.

Catalog No.S7447

6 publications

ZLN005 Chemical Structure

CAS No. 49671-76-3

ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.

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Selleck's ZLN005 has been cited by 6 publications

2 Customer Reviews

  • ZLN005 increased Sirt1 protein expression in cardiomyocytes.

    Exp Cell Res, 2016, 345(1):25-36.. ZLN005 purchased from Selleck.

    Caco2 cells were treated with different concentrations (10 or 20 lg/ml) of a PGC-1a agonist (ZLN005) (c) for 6 h without UA stimulation. SIRT1, PGC-1, PPARc and ABCG2 were measured, and quantitative analyses of the results are shown. The data are presented as the mean ± SEM. *p<0.05 and **p<0.01 compared with the control group.

    Endocrine, 2016, 53(2):443-52. ZLN005 purchased from Selleck.

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Choose Selective PGC-1α Inhibitors

Biological Activity

Description ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.
Targets
PGC-1α [1]
In vitro

In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1]

In vivo ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1]

Protocol

Animal Research:[1]
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  • Animal Models: Male C57BKS db/db and lean littermate C57BKS mice.
  • Dosages: ~15 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 37 mg/mL (147.79 mM)
Ethanol 2 mg/mL (7.98 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 250.34
Formula

C17H18N2

CAS No. 49671-76-3
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID