For research use only.

Catalog No.S7447

6 publications

ZLN005 Chemical Structure

CAS No. 49671-76-3

ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.

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Selleck's ZLN005 has been cited by 6 publications

2 Customer Reviews

  • ZLN005 increased Sirt1 protein expression in cardiomyocytes.

    Exp Cell Res, 2016, 345(1):25-36.. ZLN005 purchased from Selleck.

    Caco2 cells were treated with different concentrations (10 or 20 lg/ml) of a PGC-1a agonist (ZLN005) (c) for 6 h without UA stimulation. SIRT1, PGC-1, PPARc and ABCG2 were measured, and quantitative analyses of the results are shown. The data are presented as the mean ± SEM. *p<0.05 and **p<0.01 compared with the control group.

    Endocrine, 2016, 53(2):443-52. ZLN005 purchased from Selleck.

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Biological Activity

Description ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.
PGC-1α [1]
In vitro

In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1]

In vivo ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1]


Animal Research:[1]
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  • Animal Models: Male C57BKS db/db and lean littermate C57BKS mice.
  • Dosages: ~15 mg/kg
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 37 mg/mL (147.79 mM)
Ethanol 2 mg/mL (7.98 mM)
Water Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 250.34


CAS No. 49671-76-3
Storage powder
in solvent
Synonyms N/A
Smiles CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID