ZLN005

Catalog No.S7447

For research use only.

ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.

ZLN005 Chemical Structure

CAS No. 49671-76-3

Selleck's ZLN005 has been cited by 10 Publications

2 Customer Reviews

Purity & Quality Control

Choose Selective PGC-1α Inhibitors

Biological Activity

Description ZLN005 is a potent and tissue-specific PGC-1α transcriptional activator.
Targets
PGC-1α [1]
In vitro

In L6 myotubes, ZLN005 increases expression of the PGC-1α gene and downstream genes by activation of AMP-activated protein kinase, and improves glucose uptake and fatty acid oxidation without obvious cytotoxicity. While ZLN005 does not has the same effects in rat primary hepatocytes, which suggests cell type–specificity. [1]

In vivo ZLN005 (15 mg/kg, p.o.) produces antihyperglycemia and antihyperlipidemia effects and increases insulin sensitivity in db/db mice but not lean mice. [1]

Protocol (from reference)

Animal Research:[1]
  • Animal Models: Male C57BKS db/db and lean littermate C57BKS mice.
  • Dosages: ~15 mg/kg
  • Administration: p.o.

Solubility (25°C)

In vitro

DMSO 37 mg/mL
(147.79 mM)
Ethanol 2 mg/mL
(7.98 mM)
Water Insoluble

Chemical Information

Molecular Weight 250.34
Formula

C17H18N2

CAS No. 49671-76-3
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC(C)(C)C1=CC=C(C=C1)C2=NC3=CC=CC=C3N2

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
as vortex, ultrasound or hot water bath can be used to aid dissolving.

Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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