DHFR

DHFR Products

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  • DHFR Inhibitors (13)
  • New DHFR Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1210 Methotrexate Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Clin Transl Med, 2024, 14(2):e1586
iScience, 2024, 27(1):108667
EMBO Mol Med, 2023, 15(12):e18199
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Cell, 2022, 40(10):1128-1144.e8
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
S7785 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
J Pers Med, 2022, 12(2)258
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Mol Cancer Res, 2024, 22(1):82-93
Amino Acids, 2024, 56(1):15
Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
S5097 Methotrexate disodium Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816
Pharmaceutics, 2023, 15(2)576
Bioact Mater, 2022, 18:459-470
S1497 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.
Cancer Cell, 2023, 41(4):660-677.e7
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S2006 Pyrimethamine Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
BMC Cancer, 2024, 24(1):116
Pharmaceuticals (Basel), 2023, 16(3)447
Mol Biol Rep, 2022, 10.1007/s11033-022-07262-y
S1236 Leucovorin (Folinic acid) Calcium Pentahydrate Leucovorin (Folinic acid) Calcium Pentahydrate is a derivative of folic acid, which can be used to increase levels of folic acid under conditions favoring folic acid inhibition.Solutions are unstable and should be fresh-prepared.
Cell Rep Med, 2023, 4(10):101200
Cell Rep Med, 2023, S2666-3791(23)00367-1
J Hepatocell Carcinoma, 2023, 10:483-495
S5927 Proguanil Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.
Int J Med Sci, 2022, 19(2):233-241
Sci Adv, 2021, 7(27)eabh3032
S2588 Calcium Levofolinate Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782,L-Leucovorin calcium) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.
Drug Resist Updat, 2023, 71:101005
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
E1003 Aminopterin Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
Mol Cancer Res, 2024, 22(1):82-93
S5200 Diaveridine Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
S5136 Calcium folinate (Leucovorin calcium) Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared.
S1210 Methotrexate Methotrexate, analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Clin Transl Med, 2024, 14(2):e1586
iScience, 2024, 27(1):108667
EMBO Mol Med, 2023, 15(12):e18199
S1135 Pemetrexed disodium Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Cancer Cell, 2022, 40(10):1128-1144.e8
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
S7785 Pemetrexed Disodium Hydrate Pemetrexed Disodium Hydrate (LY-231514) is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Pemetrexed Disodium Hydrate stimulates autophagy and apoptosis.
Cell Rep, 2022, 38(9):110448
Front Pharmacol, 2022, 13:1032975
J Pers Med, 2022, 12(2)258
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Mol Cancer Res, 2024, 22(1):82-93
Amino Acids, 2024, 56(1):15
Cell Death Dis, 2023, 10.1038/s41419-023-06240-x
S5097 Methotrexate disodium Methotrexate sodium, an analog of folic acid, is a nonspecific inhibitor of the dihydrofolate reductase(DHFR) of bacteria and cancerous cells as well as normal cells. It forms an inactive ternary complex with DHFR and NADPH. Methotrexate (MTX) induces apoptosis.
Chin Med J (Engl), 2023, 10.1097/CM9.0000000000002816
Pharmaceutics, 2023, 15(2)576
Bioact Mater, 2022, 18:459-470
S1497 Pralatrexate Pralatrexate is an antifolate, and structurally a folate analog. Its IC50 is < 300 nM in some cell lines. Pralatrexate induces tumor cell apoptosis.
Cancer Cell, 2023, 41(4):660-677.e7
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S2006 Pyrimethamine Pyrimethamine(RP 4753) is a dihydrofolate reductase (DHFR) inhibitor, used as an antimalarial drug.
BMC Cancer, 2024, 24(1):116
Pharmaceuticals (Basel), 2023, 16(3)447
Mol Biol Rep, 2022, 10.1007/s11033-022-07262-y
S5927 Proguanil Proguanil (chlorguanide, chloroguanide) is a prophylactic antimalarial drug. It inhibits the dihydrofolate reductase of plasmodia and thereby blocks the biosynthesis of purines and pyrimidines, which are essential for DNA synthesis and cell multiplication.
Int J Med Sci, 2022, 19(2):233-241
Sci Adv, 2021, 7(27)eabh3032
S2588 Calcium Levofolinate Calcium Levofolinate (Calcium Folinate, Levoleucovorin calcium, CL307782,L-Leucovorin calcium) is a calcium salt of folinic acid that is an adjuvant used in cancer chemotherapy.Solutions are unstable and should be fresh-prepared.
Drug Resist Updat, 2023, 71:101005
S3129 Trimethoprim Trimethoprim (BW 56-72, NIH 204, NSC-106568) is a bacteriostatic antibiotic mainly used in the prophylaxis and treatment of urinary tract infections.
E1003 Aminopterin Aminopterin (4-amino Folic Acid, 4-amino PGA, 4-Aminofolic acid, 4-Aminopteroylglutamic acid, Aminopteroylglutamic acid, APGA, NSC 739), a folic acid antagonist, is a competitive inhibitor of dihydrofolate reductase (DHFR) with Ki of 3.7 pM.
Mol Cancer Res, 2024, 22(1):82-93
S5200 Diaveridine Diaveridine (AI3-23935, CCRIS-3784) is coccidiostat with anti-parasitic activity and also a dihydrofolate reductase (DHFR) inhibitor preventing folic acid synthesis in species of Pneumocystis.
S5136 Calcium folinate (Leucovorin calcium) Calcium folinate (Leucovorin calcium) is a metabolically active, reduced form of folic acid that is rapidly absorbed and extensively metabolized in the liver to other folic acid derivatives.Solutions are unstable and should be fresh-prepared.

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Tags: DHFR inhibitor|DHFR agonist|DHFR activator|DHFR inducer|DHFR antagonist|DHFR signaling pathway|DHFR assay kit