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MTH1

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Cat.No. Product Name Information Product Use Citations Product Validations
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
SLAS Discovery, 2026 Feb, 100291
SLAS Discovery, 2025, 100291
iScience, 2024, 27(10):110862
Verified customer review of (S)-crizotinib
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Nucleic Acids Research, May 13, 2024, 6532–6542
Nat Commun, 2024, 15(1):2377
Nucleic Acids Research, 2024, 6532-6542
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although this compound showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Oncology Letters, December 29, 2017, 3240-3244
Adv Healthc Mater, 2024, e2402349.
Advanced Healthcare Materials, 2024, e2402349
Verified customer review of TH588