MTH1

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Catalog No. Product Name Information Product Use Citations Product Validations
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC
Sci Adv, 2020, 22;6(21):eaaz8521
Cancers (Basel), 2020, 27;12(5)pii: E1087
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Oncogene, 2021, 10.1038/s41388-021-02105-9
Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507
Cancer Biother Radiopharm, 2020, 10.1089/cbr.2019.3031
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Cell Syst, 2019, 9(1):74-92.e8
Oncol Lett, 2018, 15(3):3240-3244
Oncol Lett, 2017, 13(4):2161-2168
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC
Sci Adv, 2020, 22;6(21):eaaz8521
Cancers (Basel), 2020, 27;12(5)pii: E1087
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Oncogene, 2021, 10.1038/s41388-021-02105-9
Mol Cancer Res, 2020, 10.1158/1541-7786.MCR-19-0507
Cancer Biother Radiopharm, 2020, 10.1089/cbr.2019.3031
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Cell Syst, 2019, 9(1):74-92.e8
Oncol Lett, 2018, 15(3):3240-3244
Oncol Lett, 2017, 13(4):2161-2168
Tags: MTH1 inhibitor|MTH1 agonist|MTH1 activator|MTH1 inducer|MTH1 antagonist|MTH1 signaling pathway|MTH1 assay kit