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MTH1

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis DNA alkylator High-mobility Group CRISPR/Cas9
Cat.No. Product Name Information Product Use Citations Product Validations
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
iScience, 2024, 27(10):110862
Bio Protoc, 2023, 10.21769/BioProtoc.4870
Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC
Verified customer review of (S)-crizotinib
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although this compound showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Adv Healthc Mater, 2024, e2402349.
Colloids Surf B Biointerfaces, 2022, 218:112715
Cell Syst, 2019, 9(1):74-92.e8
Verified customer review of TH588
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Nat Commun, 2024, 15(1):2377
Breast Cancer Res, 2022, 24(1):41
Oncogene, 2021, 10.1038/s41388-021-02105-9