Pritelivir (BAY 57-1293)

Catalog No.S7546 Synonyms: AIC316

For research use only.

Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.

Pritelivir (BAY 57-1293) Chemical Structure

CAS No. 348086-71-5

Selleck's Pritelivir (BAY 57-1293) has been cited by 2 Publications

Purity & Quality Control

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Biological Activity

Description Pritelivir (BAY 57-1293, AIC316) is a potent helicase primase inhibitor, exhibiting antiviral effect on herpes simplex virus (HSV) with IC50 of 20 nM for both HSV-1 and HSV-2.
Targets
helicase primase [1]
In vitro

The mechanism of action is that BAY 57-1293 directly inhibits the ATPase activity of the viral helicase-primase enzyme complex in a dose-dependent manner. BAY 57-1293 also shows potent antiviral activity against acyclovir resistant HSV mutants. [1] BAY 57-1293 reduces Aβ and P-tau induced by herpes simplex virus type 1 in vero cells. [3]

In vivo BAY 57-1293 (p.o.) shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes (0.5 mg/kg), in a murine zosteriform spread model of cutaneous disease (15 mg/kg), and in a murine ocular herpes model. [2]

Protocol (from reference)

Animal Research:[2]
  • Animal Models: Murine and rat lethal challenge models of disseminated herpes, a murine zosteriform spread model of cutaneous disease, a murine ocular herpes model.
  • Dosages: Suspended in 0.5% tylose in PBS
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 402.49
Formula

C18 H18 N4 O3 S2

CAS No. 348086-71-5
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles CC1=C(SC(=N1)N(C)C(=O)CC2=CC=C(C=C2)C3=CC=CC=N3)S(=O)(=O)N

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Molarity Calculator

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Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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