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Casein Kinase

Other Metabolism Related Inhibitors

Dehydrogenase Transferase DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase Factor Xa PDE DHFR

Isoform-selective Products

CK1 CK2

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7085	IWP-2	IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM in a cell-free assay, selective blockage of Porcn-mediated Wnt palmitoylation, does not affect Wnt/β-catenin in general and displays no effect against Wnt-stimulated cellular responses. IWP-2 specifically inhibits CK1δ.	Cell Metab, 2026, 38(4):673-693.e17 Gut Microbes, 2026, 18(1):2639216 Sci Bull (Beijing), 2025, S2095-9273(25)00472-4
S1105	LY294002	LY294002 (SF 1101, NSC 697286) is the first synthetic molecule known to inhibit PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively; more stable in solution than Wortmannin, and also blocks autophagosome formation. It not only binds to class I PI3Ks and other PI3K-related kinases, but also to novel targets seemingly unrelated to the PI3K family. This compound also inhibits CK2 with IC50 of 98 nM. It is a non-specific DNA-PKcs inhibitor and activates autophagy and apoptosis.	Research (Wash D C), 2026, 9:1190 Cell Prolif, 2026, 59(3):e70108 EMBO Rep, 2026, 27(5):1270-1300
S2248	Silmitasertib (CX-4945)	Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, although it is less potent against Flt3, Pim1 and CDK1 (inactive in cell-based assay). This compound induces autophagy and promotes apoptosis. Phase 1/2.	Theranostics, 2026, 16(7):3648-3664 Nat Cell Biol, 2025, 27(8):1272-1287 Nat Commun, 2025, 16(1):997
S0707	Silmitasertib (CX-4945) sodium salt	Silmitasertib (CX-4945) sodium salt is a potent, orally bioavailable and selective inhibitor of casein kinase 2 (CK2) with IC50 of 1 nM against CK2α and CK2α'.	CNS Neuroscience & Therapeutics, April 14 2022, 28(7):1033-1044 Cancer Research, April 03 2025, 85(7):1253-1269 Diabetologia, 2024, 10.1007/s00125-024-06128-1
S7642	D 4476	D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM.	Neoplasia, 2025, 66:101175 Cell Rep Med, 2023, 4(4):101015 Cell Rep, 2023, 42(9):113035
S5265	TBB	TBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively.	International Journal of Molecular Sciences, November 26, 2019, 5951 International Journal of Molecular Sciences, November 26, 2019, 5951 Nucleic Acids Research, December 2, 2019, 10977-10993
S8237	IC261	IC261 (SU-5607) is a novel inhibitor of CK1. The IC50 of this compound for CK1 is 16 μM and for Cdk5 is 4.5 mM.	Int J Nanomedicine, 2025, 20:9019-9030 Cell Rep, 2023, 42(7):112812 Cell Metab, 2022, S1550-4131(21)00542-8
S6734	PF-670462	PF-670462 is a potent and selective inhibitor of CK1ε and CK1δ with IC50 value of 90 nM and 13 nM, respectively.	NPJ Precis Oncol, 2025, 9(1):274 mSystems, 2025, 10(9):e0043825 J Biomed Sci, 2024, 31(1):72
S2249	PF 4800567	PF 4800567 is a novel and potent inhibitor of casein kinase 1 epsilon (IC50=32 nM) with greater than 20-fold selectivity over casein kinase 1 delta(IC50=711 nM).	Blood Advances, July 14, 2020, 3072-3084 Sci Adv, 2026, 12(17):eadw4136 Blood Advances, 2020, 3072-3084
E2914	5,6-Dichlorobenzimidazole 1-beta-D-ribofuranoside	5,6-Dichlorobenzimidazole riboside(DRB) is a nucleoside analog that inhibits several carboxyl-terminal domain (CTD) kinases including casein kinase II and CDKs. It trigger p53-dependent apoptosis of human colon adenocarcinoma cells without inducing genotoxic stress to healthy cells.	Cell Rep Methods, 2026, S2667-2375(26)00080-9 Cancer Science, 2025, 1952-1962 Cancer Sci, 2025, 10.1111/cas.70081
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