Casein Kinase
- Inhibitory Selectivity
- Solubility
| Catalog No. | Product Name | Solubility(25°C) | ||
|---|---|---|---|---|
| Water | DMSO | Alcohol | ||
| S2248 | Silmitasertib (CX-4945) | <1 mg/mL | 16 mg/mL | <1 mg/mL |
| S5265 | TBB | -1 mg/mL | 86 mg/mL | -1 mg/mL |
| S7642 | D 4476 | <1 mg/mL | 79 mg/mL | <1 mg/mL |
| S8237 | IC261 | <1 mg/mL | 62 mg/mL | <1 mg/mL |
| S5516 | Ellagic Acid hydrate | -1 mg/mL | 2 mg/mL | -1 mg/mL |
Isoform-specific Inhibitors
Casein Kinase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2248 |
Silmitasertib (CX-4945)Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2. |
|
|
| S5265New |
TBBTBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively. |
||
| S7642 |
D 4476D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM. |
Western blot of signaling effects. 48 hrs after transfection cells were serum‐starved for 12 h before stimulation with Wnt5a for 30 min or 120 min (200 ng/ml) in the presence or absence of casein kinase inhibitor D4476 (100 μM).
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| S8237 |
IC261IC261 is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM. |
||
| S5516New |
Ellagic Acid hydrateEllagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S2248 |
Silmitasertib (CX-4945)Silmitasertib (CX-4945) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM in a cell-free assay, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2. |
|
|
| S5265New |
TBBTBB (4,5,6,7-tetrabromobenzotriazole) is a selective cell-permeable CK2 inhibitor with IC50 values of 0.9 and 1.6 μM for rat liver and human recombinant CK2 respectively. |
||
| S7642 |
D 4476D 4476 is a potent, selective, and cell-permeant CK1 (casein kinase 1) inhibitor with IC50 of 200 nM and 300 nM in a cell-free assay for CK1 from Schizosaccharomyces pombe and CK1δ, respectively. Also acts as an ALK5 inhibitor with IC50 of 500 nM. |
Western blot of signaling effects. 48 hrs after transfection cells were serum‐starved for 12 h before stimulation with Wnt5a for 30 min or 120 min (200 ng/ml) in the presence or absence of casein kinase inhibitor D4476 (100 μM).
|
|
| S8237 |
IC261IC261 is a novel inhibitor of CK1. The IC50 of IC261 for CK1 is 16 μM and for Cdk5 is 4.5 mM. |
||
| S5516New |
Ellagic Acid hydrateEllagic acid is a potent inhibitor of protein kinase CK2 with IC50s of 0.04, 2.9 and 3.5 μM for CK2, Lyn and PKA respectively. It shows potent antioxidant, anti-mutagenic and antidepressant properties. |
