Gastric Cancer

Tool Compounds

Modeling Agent

1-Methyl-3-nitro-1-nitrosoguanidine

N-Nitroso-N-methylurea

Dyes

Indocyanine green

Toluidine Blue O

Isosulfan Blue

Anti-Infection

Anti-Helicobacter pylori

Clarithromycin

Amoxicillin

Vonoprazan Fumarate

Auranofin

Auraptene

Fucoidan

Anti-EBV

NIBR189

Paederoside

Drugs Approved

Chemotherapy

Monotherapy

Tegafur

FP

5-Fluorouracil

Cisplatin

XP

Capecitabine

Cisplatin

FOLFOX

5-Fluorouracil

Oxaliplatin

XELOX

Capecitabine

Oxaliplatin

SOX

Tegafur

Oxaliplatin

DCF

Docetaxel

Cisplatin

5-Fluorouracil

DOS

Tegafur

Oxaliplatin

Docetaxel

CSCO Guidelines Recommendations ^[1]

First-Line Treatment

Trastuzumab

Pembrolizumab

Oxaliplatin

Capecitabine

Cisplatin

5-Fluorouracil

Tegafur

Leucovorin (Folinic acid) Calcium Pentahydrate

Calcium Folinate

Nivolumab

Sintilimab

Tislelizumab

Docetaxel

Second-Line Treatment

Docetaxel

Paclitaxel

Irinotecan

Nab-Paclitaxel

Ramucirumab

Pembrolizumab

Nivolumab

Disitamab

Apatinib (YN968D1) mesylate

ICIs

PD-1

Nivolumab

Pembrolizumab

Camrelizumab

Spartalizumab

Cemiplimab

Sintilimab

Zimberelimab

Retifanlimab

Sasanlimab

Tislelizumab

Balstilimab

PD-L1

Avelumab

Atezolizumab

Durvalumab

Adebrelimab

Sugemalimab

Cosibelimab

CTLA-4

Ipilimumab

Tremelimumab

Recently Active Compounds

GCSCs ^[2]

GC Stemness-Targeted

Apatinib

Retinoic acid

Trastuzumab

Cisplatin

Amlodipine

Verapamil HCl

Verteporfin

Ibuprofen

Metformin

Pantoprazole

Quercetin

Sulforaphane

Evodiamine

DAPT

Atractylenolide I

Genistein

CSCs-Targeted

Vantictumab

MK-0752

Vismodegib

Amcasertib

HER2-Targeted

Inhibitor

Lapatinib

Afatinib

Neratinib

Sapitinib

Poziotinib

Tucatinib

mAb

Trastuzumab

Pertuzumab

ADC

Trastuzumab deruxtecan

Trastuzumab Emtansine（T-DM1）

Disitamab vedotin

Trastuzumab MMAE

Targeted Therapy (A) ^[3]

Claudin18.2

Zolbetuximab

TYMS

5-Fluorouracil

Trifluridine

TAS-102

Folinic acid

Tubulin

Combretastatin A4

Ixabepilone

Vincristine (Leurocristine) Sulfate

c-Met

Savolitinib

AMG 337

Onartuzumab

Tivantinib

DNA

Lurbinectedin

Oxaliplatin

Nimustine Hydrochloride

Cisplatin

Lomustine

Thiotepa

Proflavine

Topoisomerase

Irinotecan Hydrochloride Trihydrate

Doxorubicin

Topotecan HCl

Epirubicin HCl

Dxd

VEGFR

Apatinib (YN968D1) mesylate

Ramucirumab

Foretinib

Pazopanib

Sorafenib

Regorafenib

Fruquintinib

Targeted Therapy (B)

EGFR

Nimotuzumab

Pimurutamab

Matuzumab

FGFR

Pemigatinib

Derazantinib

Bemarituzumab

Lirafugratinib

PARP1/2

Pamiparib

Niraparib tosylate

Veliparib

Venadaparib

NF-kB ^[4]

Bortezomib

Curcumin

DHA

(±)-Shikonin

Sulfasalazine

Zeaxanthin

WNT ^[5]

CHIR-99021

XAV-939

RCM-1

SKL2001

NOTCH ^[5]

DAPT

Crenigacestat

Hedgehog ^[5]

Itraconazole

PAK4 ^[6]

LCH-7749944

Padnarsertib

PF-3758309

FRAX486

FRAX1036

Targeted Therapy (C)

HIPPO ^[7]

Verteporfin

Simvastatin

Metformin

Defactinib

PF-573228

Dasatinib

mTOR ^[8]

RAD001

Vistusertib

GSK1059615

Rapamycin

AKT ^[8]

MK-2206 Dihydrochloride

AZD5363

Ipatasertib

Osthole

PI3K ^[8]

Alpelisib

GSK2636771

PI3K/AKT/mTOR ^[8]

Pectolinarigenin

Thymoquinone

ABBV-744

Dactolisib

GSK1059615

Calycosin

HSP90 ^[8]

Luminespib

MMP ^[8]

Astaxanthin

Compound Library