G-quadruplex

DNA Damage/DNA Repair

DPP Aminopeptidase Procollagen C Proteinase P450 (e.g. CYP17) Phospholipase (e.g. PLA) Factor Xa PDE DHFR Carbonic Anhydrase Hydroxylase Liver X Receptor FAAH Acyltransferase Dehydrogenase Phosphorylase PPAR CYP17 CETP FXR HMG-CoA Reductase Transferase IDO/TDO Retinoid Receptor Casein Kinase NAMPT phosphatase Lipase Lipoxygenase Thioredoxin Decarboxylase Vitamin Serine/threonin kinase LDL Fatty Acid Synthase FOX Glycogen synthesis PKM Glycolysis HDL Carbohydrate Metabolism ATP-citrate lyase Acetyl-CoA carboxylase CYP450 PCSK9 Leukotriene PDHK PGC-1α ROR FABP Peroxidases Aldose Reductase Xanthine Oxidase THR Epoxide Hydrolase PEP GTPCH FAO PAI-1 LDH SCD PREP CPSase Mannosidase Thioredoxin Reductase SGK FTase γGCS CPT SREBP Mitochondrial Metabolism PARG Glucosylceramide Synthase Catalase 3-MST Serine hydrolase CAR glucocerebrosidase Mitochondrial pyruvate carrier GOT SHIP SOD LCN Endogenous Metabolite ATGL NMT Aconitase AGEs Amino Acids and Derivatives Amylase Drug Metabolite Glucokinase Glucosidase glycosidase GSNOR GST Hexokinase Isocitrate Dehydrogenase (IDH) Liposome LPL Receptor MAGL NEDD4-1 NPC1L1 PGK1 Reductase stilbene oxidase UGT

All (3)
New G-quadruplex Products

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
S7444	Pyridostatin Trifluoroacetate Salt	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with K_d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.	Nucleic Acids Res, 2025, 53(7)gkaf301 Nucleic Acids Res, 2025, 53(12)gkaf543 Cell Rep, 2025, 44(5):115706
E8172	Pyridostatin	Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.
E0853^New	360A	360A stabilizes G-quadruplex structures and inhibits telomerase activity, showing an IC50 of 300 nM in TRAP-G4 assays.
E0853^New	360A	360A stabilizes G-quadruplex structures and inhibits telomerase activity, showing an IC50 of 300 nM in TRAP-G4 assays.