G-quadruplex

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group

Cat.No.	Product Name	Information	Product Use Citations
S7444	Pyridostatin Trifluoroacetate Salt	Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with K_d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.	Nucleic Acids Res, 2025, 53(7)gkaf301 Nucleic Acids Res, 2025, 53(12)gkaf543 Cell Rep, 2025, 44(5):115706
E8172	Pyridostatin	Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.
E0853^New	360A	360A stabilizes G-quadruplex structures and inhibits telomerase activity, showing an IC50 of 300 nM in TRAP-G4 assays.

Cat.No.

Product Name

Information

Product Use Citations

Product Validations

S7444

Pyridostatin Trifluoroacetate Salt

Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with K_d of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.

Nucleic Acids Res, 2025, 53(7)gkaf301

Nucleic Acids Res, 2025, 53(12)gkaf543

Cell Rep, 2025, 44(5):115706

E8172

Pyridostatin

Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.

E0853^New

360A

360A stabilizes G-quadruplex structures and inhibits telomerase activity, showing an IC50 of 300 nM in TRAP-G4 assays.