Home DNA Damage/DNA Repair G-quadruplex

G-quadruplex

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group
Cat.No. Product Name Information Product Use Citations Product Validations
S7444 Pyridostatin Trifluoroacetate Salt Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.
Nucleic Acids Res, 2025, 53(7)gkaf301
Nucleic Acids Res, 2025, 53(12)gkaf543
Cell Rep, 2025, 44(5):115706
E8172 Pyridostatin Pyridostatin (RR82) is a highly selective small molecule that stabilizes telomeric DNA G-quadruplex with a Kd of 490 nM, promoting their folding and inducing dysfunctional telomeres by uncapping POT1 and activating DNA damage signaling. It also modulates gene expression, reducing SRC protein levels and SRC-dependent motility in breast cancer cells, contributing to its anti-proliferative effects.
Nucleic Acids Research, 2025 Jun 20, gkaf543
Nucleic Acids Research, 2024 Oct 28, 11785-11805
RNA, 2019 Dec, 1731-1750
E0853New 360A 360A stabilizes G-quadruplex structures and inhibits telomerase activity, showing an IC50 of 300 nM in TRAP-G4 assays.