Thymidylate Synthase

Inhibitory Selectivity

Thymidylate Synthase Products

Catalog No. Information Product Use Citations Product Validations
S1209

Fluorouracil (5-Fluorouracil, 5-FU)

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

S1192

Raltitrexed

Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

S1778

Trifluridine

Trifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

S3731

Tipiracil hydrochloride

Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.

S3169New

2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

S8539

TAS-102

TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.

Catalog No. Information Product Use Citations Product Validations
S1209

Fluorouracil (5-Fluorouracil, 5-FU)

Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.

S1192

Raltitrexed

Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.

S1778

Trifluridine

Trifluridine (NSC 529182, NSC 75520) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.

S3731

Tipiracil hydrochloride

Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.

S3169New

2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

S8539

TAS-102

TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.