Thymidylate Synthase

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Thymidylate Synthase Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S1135 Pemetrexed (LY-231514) disodium Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
J Exp Clin Cancer Res, 2021, 40(1):344
Br J Cancer, 2021, 10.1038/s41416-021-01441-7
Cell Chem Biol, 2021, S2451-9456(21)00442-6
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Cell, 2021, 184(2):334-351.e20
Cancers (Basel), 2021, 13(9)2061
Anal Chem, 2020, 10.1021/acs.analchem.0c02756
S1209 Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Cell, 2021, 184(25):6119-6137.e26
Sci Adv, 2021, 7(36):eabh1684
Nat Commun, 2021, 12(1):4840
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Cell Chem Biol, 2021, S2451-9456(21)00261-0
Sci Adv, 2020, 6(49)eabd9443
Ocul Surf, 2019, 10.1016/j.jtos.2019.11.011
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

S3731 Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
S5790New Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
S5971New Pemetrexed Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
J Exp Clin Cancer Res, 2021, 40(1):344
Br J Cancer, 2021, 10.1038/s41416-021-01441-7
Front Oncol, 2021, 11:711043
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
Adv Sci (Weinh), 2021, e2103360
S1135 Pemetrexed (LY-231514) disodium Pemetrexed (LY-231514) disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
J Exp Clin Cancer Res, 2021, 40(1):344
Br J Cancer, 2021, 10.1038/s41416-021-01441-7
Cell Chem Biol, 2021, S2451-9456(21)00442-6
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
Cell, 2021, 184(2):334-351.e20
Cancers (Basel), 2021, 13(9)2061
Anal Chem, 2020, 10.1021/acs.analchem.0c02756
S1209 Fluorouracil (5-Fluorouracil, 5-FU) Fluorouracil (5-Fluorouracil, 5-FU, NSC 19893) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Cell, 2021, 184(25):6119-6137.e26
Sci Adv, 2021, 7(36):eabh1684
Nat Commun, 2021, 12(1):4840
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 529182, NSC 75520, Viroptic, Trifluorothymidine, TFT) is an anti-herpesvirus antiviral agent by interacting viral DNA replication, used primarily on the eye.
Cell Chem Biol, 2021, S2451-9456(21)00261-0
Sci Adv, 2020, 6(49)eabd9443
Ocul Surf, 2019, 10.1016/j.jtos.2019.11.011
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

S3731 Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
S5790New Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
S5971New Pemetrexed Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
J Exp Clin Cancer Res, 2021, 40(1):344
Br J Cancer, 2021, 10.1038/s41416-021-01441-7
Front Oncol, 2021, 11:711043
S8539 TAS-102 TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
Adv Sci (Weinh), 2021, e2103360
S5790New Folinic acid Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).
S5971New Pemetrexed Pemetrexed (LY231514, Alimta) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
J Exp Clin Cancer Res, 2021, 40(1):344
Br J Cancer, 2021, 10.1038/s41416-021-01441-7
Front Oncol, 2021, 11:711043