Thymidylate Synthase

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP

Cat.No.	Product Name	Information	Product Use Citations
S1209	5-Fluorouracil (5-FU)	5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.	Nature, 2025, 10.1038/s41586-025-08974-4 Cancer Cell, 2025, S1535-6108(25)00223-5 Cell Stem Cell, 2025, S1934-5909(25)00265-6
S5971	Pemetrexed	Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):7853 Nat Commun, 2025, 16(1):8476 Sci Adv, 2025, 11(4):eadp4765
S1192	Raltitrexed	Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.	iScience, 2024, 27(10):110862 Mol Ther, 2022, S1525-0016(22)00717-1 ACS Chem Neurosci, 2022, 13(17):2646-2657
S1778	Trifluridine (NSC 75520)	Trifluridine (NSC 75520), also known as NSC 529182, Viroptic, Trifluorothymidine, or TFT, is an anti-herpesvirus antiviral agent that acts by interfering with viral DNA replication and is used primarily on the eye.	Nat Med, 2023, 29(3):605-614 JCI Insight, 2022, 7(22e158060) Biochem Biophys Res Commun, 2022, 610:119-126
S8539	TAS-102 (Trifluridine/Tipiracil Hydrochloride Mixture)	TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.	Cell Death Dis, 2025, 16(1):255 iScience, 2024, 27(10):110862 STAR Protoc, 2024, 5(2):103090
S5790	Folinic acid (Leucovorin)	Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.	Nat Cell Biol, 2024, Nat Commun, 2022, 13(1):6308
E4818	Pemetrexed (disodium heptahydrate)	Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
S3169	2'-Deoxyuridine 5'-monophosphate disodium salt	2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
S1135	Pemetrexed disodium	Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with K_i of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis.	Nat Commun, 2025, 16(1):8932 Cell Death Dis, 2024, 15(8):555 Cell Commun Signal, 2024, 22(1):375
S3731	Tipiracil hydrochloride	Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.	iScience, 2024, 27(10):110862 Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9 JCI Insight, 2022, 7(22e158060)