Home Apoptosis Thymidylate Synthase

Thymidylate Synthase

Other Apoptosis Related Inhibitors

Caspase Bcl-2 p53 Ferroptosis PD-1/PD-L1 Survivin TNF-alpha MDM2/MDMX KRas IAP
Cat.No. Product Name Information Product Use Citations Product Validations
S1209 5-Fluorouracil (5-FU) 5-FU (5-Fluorouracil) is a DNA/RNA synthesis inhibitor, which interrupts nucleotide synthetic by inhibiting thymidylate synthase (TS) in tumor cells. Fluorouracil induces apoptosis and can be used in the treatment of HIV.
Adv Sci (Weinh), 2026, 13(19):e11406
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Verified customer review of 5-Fluorouracil (5-FU)
S5971 Pemetrexed Pemetrexed (LY231514) is a novel antifolate and antimetabolite for thymidylate synthase (TS), dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. This compound induces autophagy and apoptosis.
Anticancer Research, 2026, 1323-1335
Nat Commun, 2025, 16(1):7853
Nat Commun, 2025, 16(1):8476
S1192 Raltitrexed Raltitrexed (ZD-1694) is a thymidylate synthase inhibitor with an IC50 of 9 nM for the inhibition of L1210 cell growth.
iScience, 2024, 27(10):110862
Mol Ther, 2022, S1525-0016(22)00717-1
ACS Chem Neurosci, 2022, 13(17):2646-2657
Verified customer review of Raltitrexed
S1778 Trifluridine (NSC 75520) Trifluridine (NSC 75520), also known as NSC 529182, Viroptic, Trifluorothymidine, or TFT, is an anti-herpesvirus antiviral agent that acts by interfering with viral DNA replication and is used primarily on the eye.
Nat Med, 2023, 29(3):605-614
JCI Insight, 2022, 7(22e158060)
Biochem Biophys Res Commun, 2022, 610:119-126
E4818 Pemetrexed (disodium heptahydrate) Pemetrexed (disodium heptahydrate) is a folate antimetabolite that inhibits thymidylate synthase, dihydrofolate reductase and glycinamide ribonucleotide formyltransferase. It also induces apoptosis and cell-cycle arrest in non-small-cell lung cancer carrying an EGFR exon 19 deletion.
Medical Science Monitor, October 31, 2019, 8172-8180
Frontiers in Oncology, May 17, 2021, 668798
Anticancer Research, 2022, 709-722
S8539 TAS-102 (Trifluridine/Tipiracil Hydrochloride Mixture) TAS-102 (Trifluridine-Tipiracil Hydrochloride Mixture) is an orally administered combination of a thymidine-based nucleic acid analogue, trifluridine, and a thymidine phosphorylase inhibitor, tipiracil hydrochloride.
Cell Death Dis, 2025, 16(1):255
iScience, 2024, 27(10):110862
STAR Protoc, 2024, 5(2):103090
S3169 2'-Deoxyuridine 5'-monophosphate disodium salt

2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP). The inhibition of dUMP to dTMP at the methylation step is a key in controlling bacterial and eukaryotic cell growth.
S1135 Pemetrexed Disodium (LY231514) Pemetrexed disodium is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM in cell-free assays, respectively. Pemetrexed induces autophagy and apoptosis.
Frontiers in Pharmacology, September 27, 2021, 718675
Cancer Research, November 2, 2022, 4079-4092
Frontiers in Oncology, August 18, 2021, 711043
Verified customer review of Pemetrexed Disodium (LY231514)
S3731 Tipiracil hydrochloride Tipiracil (MA-1) is an inhibitor of thymidine phosphorylase, the enzyme that degrades trifluridine into trifluorothymidine. Its combination with trifluridine increases the bioavailability of trifluridine.
iScience, 2024, 27(10):110862
Cell Mol Immunol, 2022, 10.1038/s41423-022-00842-9
JCI Insight, 2022, 7(22e158060)
S5790 Folinic acid (Leucovorin) Folinic acid (Leucovorin) is a biological folic acid that increases the level of reduced folates in tissues, which promotes the inhibition of thymidylate synthase (TS).Solutions are unstable and should be fresh-prepared.
Nat Cell Biol, 2024,
Nat Commun, 2022, 13(1):6308