Anti-Aging

Tool Compounds

Modeling Agent: D-Galactose; DL-Homocysteine

Detection Reagent: Thiobarbituric acid; 2,6-Dihydroxypurine; 2,2-Diphenyl-1-picrylhydrazyl; ABTS

Antioxidant

Anti-Inflammatory

Metformin Hydrochloride

Dexamethasone Acetate

Glucosamine hydrochloride

Proteostasis Regulation ^[1]

Autophagy Inducers & Proteasome Activators: LY294002; Wortmannin; Trichostatin A; Spermidine; Rapamycin; RAD001; Metformin; Resveratrol; Acetylcorynoline

Anti-glycation Agents: Ferulic Acid; Rosmarinic acid; Carnosic acid; Piceatannol; Ethylenediaminetetraacetic acid; (+)-α-Lipoic acid

Stimulators of extracellular matrix turnover: Minoxidil

Activating Autophagy (A)

Activating Mitophagy: Rapamycin; Melatonin; Resveratrol; Doxorubicin (Adriamycin) Hydrochloride; Urolithin A; Rotenone; Quercetin; Metformin

AMPK Activators ^[2]: Metformin; Resveratrol; Aspirin; MOTS-c; AICAR; Nilotinib

Combating NAD+ Depletion: Nicotinamide Riboside Chloride; β-nicotinamide mononucleotide; Nicotinic Acid; Luteolin

Activating Autophagy (B)

Longevity Protein SIRTs Activators: SRT1720 HCl; Fisetin; Resveratrol; Quercetin; SRT2104; SRT2183; SRT3025 HCl

mTOR Inhibitors: Rapamycin; RAD001; Dactolisib; AZD8055; Torkinib; Temsirolimus; Vistusertib; KU-0063794

ULK1 Activators: LYN-1604; BL-918; Ginkgolide K

Senolytics ^[3]

BCL-2 Inhibitors: Dasatinib; Quercetin; ABT-737; Navitoclax; A-1331852; A-1155463

HSP90 Inhibitors: Alvespimycin (17-DMAG) Hydrochloride; Geldanamycin; Tanespimycin; Ganetespib

Targeting p53: RG-7112; P5091; P22077

Natural Products: Fisetin; Curcumin

Cardiac Glycosides: Ouabain; Digoxin; Bufalin

PROTACs: ARV-825

Miscellaneous: Fenofibrate; Azithromycin; Roxithromycin; R406; Panobinostat; Xevinapant

Senomorphics ^[3]

NF-κB Inhibitors: Rapamycin; Metformin

p38MAPK Inhibitors: SB203580; Doramapimod; PF-3644022

JAK/STAT Inhibitors: Ruxolitinib

ATM Inhibitors: KU-55933; KU-60019

Statins: Atorvastatin; Pravastatin; Pitavastatin (NK-104) Calcium; Simvastatin

Natural Products: Apigenin; Kaempferol; Quercetin; EGCG; Genistein; Oleuropein; Hydroxytyrosol

Glucoregulatory Control

AMPK Activators: Metformin; Resveratrol; Aspirin; MOTS-c; AICAR; Nilotinib

Alpha-Glucosidase Inhibitors ^[4]: Acarbose; 1-Deoxynojirimycin; 4',7-Dimethoxy-5-Hydroxyflavone; N-Caffeoyl O-methyltyramine

Alpha-Amylase Inhibitors ^[4]: 4',7-Dimethoxy-5-Hydroxyflavone; trans-Chalcone; Andrographis Herba Extract

GLP-1R Agonists ^[5]: Exenatide Acetate; Liraglutide; Lixisenatide; Semaglutide; Dulaglutide peptide

Immunosenescence Regulation

Immunomodulating Molecules: Avadomide; Iberdomide; Teriflunomide; Thalidomide; Amlexanox; Fingolimod; Prednisolone; Ossirene; Methylprednisolone; Laquinimod

Immunomodulating Biomacromolecules: LL37; Polzastobart; Bexmarilimab; Mupadolimab; Tesnatilimab; Imalumab; Narsoplimab; Falbikitug; Lacutamab; Enokizumab; Tildrakizumab; Carotuximab

Suppression of Genomic Instability ^[1]

Retrotransposition Inhibitors: Lamivudine; Abacavir; Zidovudine; Emtricitabine; Tenofovir

Telomere Stabilizers: Nicotinamide Riboside Chloride; β-nicotinamide mononucleotide; Nicotinic Acid

Hormetins ^[1]

Intestinal Microorganism Related

Prebiotics: Inulin; Lactulose; 1-Kestose; 1F-Fructofuranosylnystose; 1,1,1,1-Kestohexaose

Metabiotics: Urolithin A; Spermidine; Vitamin K2; Sodium propionate; Sodium butyrate; 2-Methylpentanoic acid

Compound Library

Anti-Aging Compound Library

Flavonoid Compound Library

Natural Phenol Compound Library

Natural Terpenoid Compound Library

Mitochondria-Targeted Compound Library

Gut Microbial Metabolite Library

Anti-alzheimer Disease Compound Library

Anti-diabetic Compound Library

Oxidative Stress Compound Library

DNA Damage/DNA Repair compound Library

References

https://pubmed.ncbi.nlm.nih.gov/35183431/
https://pubmed.ncbi.nlm.nih.gov/34838647/
https://pubmed.ncbi.nlm.nih.gov/35015337/
https://content.iospress.com/articles/nutrition-and-healthy-aging/nha160007
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8947838/