Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S2678 NSC 207895 <1 mg/mL 0.4 mg/mL <1 mg/mL
S8059 Nutlin-3a <1 mg/mL 100 mg/mL 100 mg/mL
S7030 RG-7112 <1 mg/mL 100 mg/mL 100 mg/mL
S8606 HDM201 <1 mg/mL 100 mg/mL 3 mg/mL
S7875 NVP-CGM097 <1 mg/mL 65 mg/mL 65 mg/mL
S8403 MX69 <1 mg/mL 95 mg/mL 41 mg/mL
S7205 Idasanutlin (RG-7388) <1 mg/mL 100 mg/mL 8 mg/mL
S2341 (-)-Parthenolide <1 mg/mL 49 mg/mL 49 mg/mL
S1061 Nutlin-3 <1 mg/mL 100 mg/mL 30 mg/mL
S8065 Nutlin-3b <1 mg/mL 100 mg/mL 100 mg/mL
S7649 MI-773 (SAR405838) <1 mg/mL 100 mg/mL 31 mg/mL
S7489 YH239-EE <1 mg/mL 100 mg/mL 18 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

NSC 207895

NSC 207895 suppresses MDMX with IC50 of 2.5 μM, leading to enhanced p53 stabilization/activation and DNA damage, and also regulates MDM2, an E3 ligase.



Nutlin-3a, the active enantiomer of Nutlin-3, inhibits the p53/MDM2 interaction with IC50 of 90 nM in a cell-free assay.



RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor with HTRF IC50 of 18 nM.



HDM201 is a novel, highly potent and selective inhibitor of the p53-Mdm2 interaction with affinity constant for Mdm2 in the picomolar range and a selectivity ratio greater than 10000-fold vs Mdm4.



NVP-CGM097 is a highly potent and selective MDM2 inhibitor with Ki value of 1.3 nM for hMDM2 in TR-FRET assay. It binds to the p53 binding-site of the Mdm2 protein, disrupting the interaction between both proteins, leading to an activation of the p53 pathway.



MX69 is a MDM2/XIAP inhibitor that binds to MDM2 RING protein with binding Kd values of 2.34 μM. It is used for cancer treatment.


Idasanutlin (RG-7388)

Idasanutlin (RG-7388) is a potent and selective p53-MDM2 inhibitor with IC50 of 6 nM showing improved in vitro binding as well as cellular potency/selectivity.



(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, specifically depletes HDAC1 protein without affecting other class I/II HDACs; Also promotes the ubiquitination of MDM2 and activates p53 cellular functions.



Nutlin-3 is a potent and selective Mdm2 (RING finger-dependent ubiquitin protein ligase for itself and p53) antagonist with IC50 of 90 nM in a cell-free assay; stabilizes p73 in p53-deficient cells.



Nutlin-3b is a p53/MDM2 antagonist or inhibitor with IC50 value of 13.6 μM, 150-fold less potent (+)-enantiomer of Nutlin-3 as in comparison with opposite (-)-enantiomer Nutlin-3a.


MI-773 (SAR405838)

MI-773 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.



YH239-EE, the ethyl ester of YH239, is a potent p53-MDM2 antagonist and an apoptosis inducer.