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Telomerase

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group CRISPR/Cas9
Cat.No. Product Name Information Product Use Citations Product Validations
S2250 EGCG ((-)-Epigallocatechin Gallate) EGCG ((-)-Epigallocatechin Gallate) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Clin Mol Hepatol, 2025, 10.3350/cmh.2024.0694
Cell Rep, 2025, 44(6):115799
Front Pharmacol, 2024, 15:1403424
Verified customer review of EGCG ((-)-Epigallocatechin Gallate)
S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. This compound induces apoptosis in cancer cells.
Biogerontology, 2024, 10.1007/s10522-024-10094-x
JCI Insight, 2023, 10.1172/jci.insight.170320
Cancers (Basel), 2023, 15(10)2673
Verified customer review of BIBR 1532
S1319 Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
J Tradit Complement Med, 2023, 13(4):345-357
Pathol Res Pract, 2022, 236:153966
Front Plant Sci, 2021, 12:699068
S8118 RHPS 4 methosulfate RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.
Nucleic Acids Res, 2025, 53(7)gkaf301
Cell Rep, 2025, 44(5):115706
Cancers (Basel), 2022, 14(11)2624
S3894 Cycloastragenol Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Cancer Sci, 2020, 111(8):2789-2802
E4660 TAC (TERT Activator-1) TAC(TERT activator compound) is an activator of TERT, that upregulates TERT transcription via the MEK/ERK/AP-1 cascade. It enhances telomere synthesis, reduces aging markers, inflammation, and senescence, and preserves brain function, highlighting TERT's potential in combating aging and related diseases.
S4981 Cyclogalegenol Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
E1302 Braco-19 trihydrochloride Braco-19 trihydrochloride(BRAC-O19, BRACO19 3HCl) is a G-quadruplex-stabilizing agent and an inhibitor of telomere/telomerase. It establishes antiviral activity against HIV-1 and anticancer effects by inhibiting telomerase capping and catalytic functions.
E4620 L-778123 hydrochloride L-778123 hydrochloride is a potent dual inhibitor of farnesyl protein transferase (FPTase) with an IC50 of 2 nM and geranylgeranyl protein transferase I (GGPTase-I) with an IC50 of 98 nM. It also displays promising anti-leukemia activity.
E1739 MST-312 MST-312(Telomerase Inhibitor IX) is an inhibitor of telomerase. This compound is a chemically modified derivative of green tea epigallocatechin gallate (EGCG). It exhibits high chemical stability, lowers the effective dose in the induction of telomere shortening, and lowers drug resistance. This chemical can be used for the research of cancer. It can also be used as a promising strategy in the treatment of multiple myeloma (MM).

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