Telomerase
Signaling Pathway Map
Research Area
Inhibitory Selectivity
Telomerase Products
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1186 |
BIBR 1532BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells. |
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| S1319 |
CostunolideCostunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM. |
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| S3273New |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
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| S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
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| S8118 |
RHPS 4 methosulfateRHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar. |
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| S4981 |
CyclogalegenolCyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase. |
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| S3894 |
CycloastragenolCycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S1186 |
BIBR 1532BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells. |
|
|
| S1319 |
CostunolideCostunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM. |
||
| S3273New |
HypericinHypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). |
||
| S2250 |
(-)-Epigallocatechin Gallate(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity. |
|
|
| S8118 |
RHPS 4 methosulfateRHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar. |
| Catalog No. | Information | Product Use Citations | Product Validations |
|---|---|---|---|
| S4981 |
CyclogalegenolCyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase. |
||
| S3894 |
CycloastragenolCycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells. |
