Telomerase

Signaling Pathway Map

Research Area

Inhibitory Selectivity

Telomerase Products

Catalog No. Information Product Use Citations Product Validations
S1186

BIBR 1532

BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase were observed at concentrations vastly exceeding the IC50 for telomerase.
Cancer Res, 2017, 77(20):5530-5542
Oncotarget, 2017, 8(1):179-190
Biosens Bioelectron, 2016, 87:600-606
S1319

Costunolide

Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
J Agric Food Chem, 2013, 61(44):10481-7
S2250

(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Ther Med, 2018, 15(5):4284-4290
J Cell Mol Med, 2017, 10.1111/jcmm.13169
Front Pharmacol, 2017, 8:325
S8118

RHPS 4 methosulfate

RHPS4 is a potent inhibitor of Telomerase at submicromolar.
S4981

Cyclogalegenol

Cyclogalegenol, the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
S3894

Cycloastragenol

Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Catalog No. Information Product Use Citations Product Validations
S1186

BIBR 1532

BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase were observed at concentrations vastly exceeding the IC50 for telomerase.
Cancer Res, 2017, 77(20):5530-5542
Oncotarget, 2017, 8(1):179-190
Biosens Bioelectron, 2016, 87:600-606
S1319

Costunolide

Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
J Agric Food Chem, 2013, 61(44):10481-7
S2250

(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Ther Med, 2018, 15(5):4284-4290
J Cell Mol Med, 2017, 10.1111/jcmm.13169
Front Pharmacol, 2017, 8:325
S8118

RHPS 4 methosulfate

RHPS4 is a potent inhibitor of Telomerase at submicromolar.
Catalog No. Information Product Use Citations Product Validations
S4981

Cyclogalegenol

Cyclogalegenol, the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
S3894

Cycloastragenol

Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.