Telomerase

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Telomerase Signaling Pathways

Telomerase Products

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  • Telomerase Inhibitors (6)
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Catalog No. Product Name Information Product Use Citations Product Validations
P1202 TMPyP4 tosylate

TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.

S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
Nucleic Acids Res, 2022, gkac179
Med Oncol, 2021, 39(1):12
Neuro Oncol, 2020, noaa207
S1319 Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
Front Oncol, 2020, 10:582273
Clin Sci (Lond), 2020, 10.1042/CS20190890
Cell Rep, 2020, 32(2):107897
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Cell Res, 2022, 411(1):113000
Int J Mol Med, 2022, 49(1)11
EMBO Rep, 2021, e53166
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
S8118 RHPS 4 methosulfate RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.
J Am Chem Soc, 2021, 143(49):20779-20791
Elife, 2021, 10e65184
J Inflamm Res, 2021, 14:6799-6812
S3894 Cycloastragenol Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Cancer Sci, 2020, 111(8):2789-2802
S4981 Cyclogalegenol Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.
P1202 TMPyP4 tosylate

TMPyP4 tosylate (TMP 1363), a quadruplex-specific ligand, inhibits the interaction between G-quadruplex (G4) and IGF-1 (Insulin-like growth factor type I). TMPyP4 tosylate is also a telomerase inhibitor with antitumor effects.

S1186 BIBR 1532 BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase are observed at concentrations vastly exceeding the IC50 for telomerase. BIBR 1532 induces apoptosis in cancer cells.
Nucleic Acids Res, 2022, gkac179
Med Oncol, 2021, 39(1):12
Neuro Oncol, 2020, noaa207
S1319 Costunolide Costunolide (NSC 106404), a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.
Front Oncol, 2020, 10:582273
Clin Sci (Lond), 2020, 10.1042/CS20190890
Cell Rep, 2020, 32(2):107897
S2250 (-)-Epigallocatechin Gallate (-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Exp Cell Res, 2022, 411(1):113000
Int J Mol Med, 2022, 49(1)11
EMBO Rep, 2021, e53166
S3273 Hypericin Hypericin (Hyp, HY) is a naturally occurring substance found in the common St. John's Wort (Hypericum species) with antidepressive, antineoplastic and antiviral (human immunodeficiency and hepatitis C virus) activities. Hypericin has inhibitory effects on MAO (monoaminoxidase), PKC (protein kinase C), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450).
Eur J Pharmacol, 2021, 900:174071
S8118 RHPS 4 methosulfate RHPS4 (NSC714187) is a potent inhibitor of Telomerase at submicromolar.
J Am Chem Soc, 2021, 143(49):20779-20791
Elife, 2021, 10e65184
J Inflamm Res, 2021, 14:6799-6812
S3894 Cycloastragenol Cycloastragenol (CAG, TA-65, Cyclogalegigenin, Astramembrangenin) is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.
Cancer Sci, 2020, 111(8):2789-2802
S4981 Cyclogalegenol Cyclogalegenol (Astramembrangenin, Cyclosieversigenin), the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.