Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1186 BIBR 1532 <1 mg/mL 66 mg/mL 3 mg/mL
S1319 Costunolide <1 mg/mL 47 mg/mL 1 mg/mL
S2250 (-)-Epigallocatechin Gallate 23 mg/mL 72 mg/mL 83 mg/mL
S8118 RHPS 4 methosulfate <1 mg/mL 91 mg/mL <1 mg/mL
S4981 Cyclogalegenol <1 mg/mL 98 mg/mL 19 mg/mL
S3894 Cycloastragenol -1 mg/mL 98 mg/mL -1 mg/mL
Catalog No. Information Product Use Citations Product Validations

BIBR 1532

BIBR 1532 is a potent, selective, non-competitive telomerase inhibitor with IC50 of 100 nM in a cell-free assay. No inhibition of DNA and RNA polymerases, including HIV reverse transcriptase were observed at concentrations vastly exceeding the IC50 for telomerase.



Costunolide, a natural sesquiterpene compound with multiple biological activities; inhibits FPTase with IC50 of 20 μM, also inhibits telomerase with IC50 of 65-90 μM.


(-)-Epigallocatechin Gallate

(-)-Epigallocatechin Gallate(EGCG) is the main catechin extraction of green tea that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.


RHPS 4 methosulfate

RHPS4 is a potent inhibitor of Telomerase at submicromolar.



Cyclogalegenol, the aglycone derivative of astragaloside A, is found in various species of Astragalus and may activate telomerase.



Cycloastragenol is a saponin comprising a group of oil glucosides naturally present in a number of plants. It is a potent telomerase activator in neuronal cells.