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Catalog No. Product Name Information Product Use Citations Product Validations
S1244 Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
mBio, 2021, 12(6):e0322821
Hum Cell, 2021, 34(6):1911-1918
S2871 T0070907 T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.
Redox Biol, 2022, 50:102256
Biomed Pharmacother, 2022, 151:113109
Exp Neurol, 2022, 354:114100
S8077 RI-1 RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.
Clin Exp Pharmacol Physiol, 2022, 10.1111/1440-1681.13646
Elife, 2021, 10e65234
Oncogene, 2021, 10.1038/s41388-021-01932-0
S8234 RS-1 RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.
Int J Biol Sci, 2021, 17(4):1026-1040
Chembiochem, 2021, 22(20):2957-2965
S1244 Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
Hum Cell, 2022, 10.1007/s13577-022-00671-y
mBio, 2021, 12(6):e0322821
Hum Cell, 2021, 34(6):1911-1918
S2871 T0070907 T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.
Redox Biol, 2022, 50:102256
Biomed Pharmacother, 2022, 151:113109
Exp Neurol, 2022, 354:114100
S8077 RI-1 RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.
Clin Exp Pharmacol Physiol, 2022, 10.1111/1440-1681.13646
Elife, 2021, 10e65234
Oncogene, 2021, 10.1038/s41388-021-01932-0
S8234 RS-1 RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.
Int J Biol Sci, 2021, 17(4):1026-1040
Chembiochem, 2021, 22(20):2957-2965
Tags: RAD51 inhibitor | RAD51 activator | RAD51 modulator