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RAD51

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RAD51 Products

All (4)
RAD51 Inhibitors (3)
RAD51 Activators (1)
New RAD51 Products

Catalog No.	Product Name	Information	Product Use Citations	Product Validations
S1244	Amuvatinib (MP-470)	Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.	Hum Cell, 2021, 10.1007/s13577-021-00579-z Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2871	T0070907	T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.	J Inflamm Res, 2021, 14:395-411 Radiother Oncol, 2021, 155:293-303 J Nutr Biochem, 2021, S0955-2863(21)00303-X
S8077	RI-1	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.	Elife, 2021, 10e65234 Oncogene, 2021, 10.1038/s41388-021-01932-0 Front Oncol, 2021, 11:646256
S8234	RS-1	RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.	Int J Biol Sci, 2021, 17(4):1026-1040
S1244	Amuvatinib (MP-470)	Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. Amuvatinib suppresses c-MET and c-RET. Amuvatinib is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.	Hum Cell, 2021, 10.1007/s13577-021-00579-z Hum Cell, 2021, 10.1007/s13577-021-00639-4 Hum Cell, 2020, 10.1007/s13577-020-00420-z
S2871	T0070907	T0070907 is a potent and selective PPARγ inhibitor with IC50 of 1 nM in a cell-free assay, with a >800-fold selectivity over PPARα and PPARδ. T0070907 significantly decreases the levels of DNA-PKcs and RAD51 proteins in ME-180 and SiHa cells.	J Inflamm Res, 2021, 14:395-411 Radiother Oncol, 2021, 155:293-303 J Nutr Biochem, 2021, S0955-2863(21)00303-X
S8077	RI-1	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.	Elife, 2021, 10e65234 Oncogene, 2021, 10.1038/s41388-021-01932-0 Front Oncol, 2021, 11:646256
S8234	RS-1	RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.	Int J Biol Sci, 2021, 17(4):1026-1040

Tags: RAD51 inhibitor | RAD51 activator | RAD51 modulator