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RAD51

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group
Cat.No. Product Name Information Product Use Citations Product Validations
S8434 RAD51 Inhibitor B02 B02 is a small-molecule inhibitor of human RAD51 with an IC50 of 27.4 μM, but does not inhibit its E. coli homologue RecA (IC50 > 250 μM).
Nucleic Acids Res, 2025, 53(18)gkaf961
NPJ Precis Oncol, 2025, 9(1):20
Clin Epigenetics, 2025, 17(1):20
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S8077 RI-1 RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with IC50 ranging from 5 to 30 μM.
Cell Rep Med, 2025, 6(8):102284
MedComm (2020), 2024, 5(8):e690
Cell Death Discov, 2024, 10(1):434
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S8234 RS-1 RS-1 is a RAD51-stimulatory compound, which increases the DNA binding activity of RAD51. It is an HDR(homology-directed repair) enhancer that enhances Cas9- and TALEN-mediated knock-in efficiency in rabbit embryos both in vitro and in vivo.
Sci Bull (Beijing), 2025, S2095-9273(25)00865-5
Functional & Integrative Genomics, 2025, 180
Funct Integr Genomics, 2025, 25(1):180
E0308New RAD51-IN-17 RAD51-IN-1, a B02 derivative, functions as a potent RAD51 inhibitor. This compound is applicable for cancer research investigations.
S9941New Emzadirib Emzadirib, an inhibitor of RAD51, exhibits a reduction in RAD51 foci. This compound displays significant anti-tumor activity with tumor growth inhibition in in vivo and in vitro models.
S2871 T0070907 T0070907 is a potent inhibitor of PPARγ (peroxisome proliferator activator receptor γ ) that induces G2/M arrest and enhances the effect of radiation in human cervical cancer cells through mitotic catastrophe. It also acts as an antagonist of PPARγ that suppresses breast cancer cell proliferation and motility via both PPARgamma-dependent and -independent mechanisms.
Nucleic Acids Res, 2025, 53(14)gkaf669
Cell Rep Med, 2025, 6(10):102373
Apoptosis, 2025, 30(5-6):1391-1409
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S1244 Amuvatinib (MP-470) Amuvatinib (MP-470, HPK 56) is a potent and multi-targeted inhibitor of c-Kit, PDGFRα and Flt3 with IC50 of 10 nM, 40 nM and 81 nM, respectively. It suppresses c-MET and c-RET, and is also active as a DNA repair protein Rad51 inhibitor with antineoplastic activity. Phase 2.
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-2220
Hematol Oncol, 2025, 43(5):e70131
bioRxiv, 2024, 2023.11.21.568071
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