Gliomas

Tool Compounds

Modeling Agent: N-Nitroso-N-methylurea

Photosensitizer: 5-Aminolevulinic acid HCl; Verteporfin

Drugs Approved

Eflornithine (DFMO) Hydrochloride Hydrate

Lomustine

Trametinib DMSO solvate

TMZ

Chemotherapy

Single Drug: TMZ; Carmustine

PVC: Procarbazine HCl; Lomustine; Vincristine

Targeted Therapy (A)

DNA/RNA Synthesis: TMZ; Cisplatin; Carmustine; Lomustine; Cyclophosphamide; Procarbazine HCl; Nimustine Hydrochloride

IDH1/2: AG-120; AG-221; Vorasidenib; Olutasidenib; IDH-305; AGI-5198; BAY 1436032; DS-1001b

EGFR: Afatinib; Gefitinib; Lapatinib; Erlotinib; Dacomitinib; AEE788; BDTX-1535; Cetuximab; Nimotuzumab; Panitumumab

VEGF: BIBF 1120; Axitinib; Tivozanib; Vandetanib; Cediranib; Pazopanib; Vatalanib (PTK787) 2HCl; Bevacizumab; Ramucirumab

mTOR: Rapamycin; RAD001; Temsirolimus; Paxalisib; Ridaforolimus

Targeted Therapy (B)

MEK1/2: PD0325901; Cobimetinib; AZD6244; MEK162; Trametinib DMSO solvate

PARP1/2: AZD2281; Niraparib; Niraparib tosylate; Veliparib; Pamiparib

HDAC: Romidepsin; Panobinostat; Belinostat; Abexinostat

Tubulin: Docetaxel; Vincristine; Cabazitaxel; Vinblastine sulfate; Ixabepilone; Patupilone; ABT-751; Fosbretabulin (Combretastatin A4 Phosphate) Disodium; Verubulin hydrochloride

PDGFR: Sunitinib; Crenolanib; Imatinib; Olaratumab

CDK4/6: Palbociclib; Flavopiridol; Ribociclib succinate

CD276: Enoblituzumab; Mirzotamab; Omburtamab

TOP1: Topotecan HCl; Irinotecan Hydrochloride

Recently Active Compounds

5-Aminolevulinic acid HCl

GSCs

PLK1 ^[1]: SBE 13 HCl

PIN1 ^[1]: Sulfopin

BRG1/BRM ^[2]: BRM/BRG1 ATP Inhibitor-1; PFI-3; AU-15330

CARM1 ^[2]: TP-064

BRD9 ^[2]: I-BRD9; dBRD9

METTL3 ^[3]: UZH2

ADAM10 ^[4]: GI254023X

ADAM17 ^[4]: TAPI-1; Batimastat; KP-457; GI254023X

Malignant Synapse ^[5]

Pan-TrK Inhibitor: Entrectinib; Larotrectinib

AMAPR Inhibitor: NBQX; Kynurenic acid; DNQX; Capric acid

Compound Library

FDA-approved Anticancer Drug Library

Anti-cancer Compound Library

Anti-cancer Compound Library-Ⅱ

Anti-cancer Metabolism Compound Library

Cambridge Cancer Compound Library

Small Molecule Immuno-Oncology Compound Library

Tyrosine Kinase Inhibitor Library

Angiogenesis Related compound Library

MAPK Inhibitor Library

PI3K/Akt Inhibitor Library

References

https://doi.org/10.1038/s41467-023-44349-x
https://pubmed.ncbi.nlm.nih.gov/36305736/
https://pubmed.ncbi.nlm.nih.gov/35659339/
https://pubmed.ncbi.nlm.nih.gov/27541285/
https://doi.org/10.1038/s41586-023-06678-1