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NUDIX

Isoform-selective Products

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Catalog No. Product Name Information Product Use Citations Product Validations
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
Bio Protoc, 2023, 10.21769/BioProtoc.4870
Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC
Antiviral Res, 2020, 178:104790
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Colloids Surf B Biointerfaces, 2022, 218:112715
Cell Syst, 2019, 9(1):74-92.e8
Oncol Lett, 2018, 15(3):3240-3244
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Nat Commun, 2024, 15(1):2377
Breast Cancer Res, 2022, 24(1):41
Oncogene, 2021, 10.1038/s41388-021-02105-9
E1274 TH1760 TH1760 (Compound 18) is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.
E2849 TH5427 TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems.
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
Bio Protoc, 2023, 10.21769/BioProtoc.4870
Am J Respir Crit Care Med, 2020, 10.1164/rccm.202003-0627OC
Antiviral Res, 2020, 178:104790
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although TH588 showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Colloids Surf B Biointerfaces, 2022, 218:112715
Cell Syst, 2019, 9(1):74-92.e8
Oncol Lett, 2018, 15(3):3240-3244
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Nat Commun, 2024, 15(1):2377
Breast Cancer Res, 2022, 24(1):41
Oncogene, 2021, 10.1038/s41388-021-02105-9
E1274 TH1760 TH1760 (Compound 18) is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.
E2849 TH5427 TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems.

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