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NUDIX

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PI3K mTOR Akt GSK-3 DNA-PK ATM/ATR PDK AMPK PTEN MELK

Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
E1274 TH1760 TH1760 (Compound 18) is a first-in-class, potent, selective and cell-active NUDT15 (MTH2) inhibitor with an IC50 value of 25 nM.
E2849 TH5427 TH5427 is a potent and cell-active NUDT5 (also called NUDIX5) inhibitor that can be used to further understand the role of NUDT5 in biological systems.
S7505 (S)-crizotinib (S)-crizotinib, the (S)-enantiomer of crizotinib, is a potent MTH1 (NUDT1) inhibitor with IC50 of 72 nM in a cell-free assay.
SLAS Discovery, 2026 Feb, 100291
SLAS Discovery, 2025, 100291
iScience, 2024, 27(10):110862
Verified customer review of (S)-crizotinib
S7631 TH287 TH287 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 0.8 nM.
Nucleic Acids Research, May 13, 2024, 6532–6542
Nat Commun, 2024, 15(1):2377
Nucleic Acids Research, 2024, 6532-6542
S7632 TH588 TH588 is a potent and selective MTH1 (NUDT1) inhibitor with IC50 of 5 nM. It has no relevant inhibition of any of the other tested proteins at 100 μM, although this compound showed reasonable selectivity when tested on a much larger panel of 87 enzymes, GPCRs, kinases, ion channels and transporters at 10 μM.
Oncology Letters, December 29, 2017, 3240-3244
Adv Healthc Mater, 2024, e2402349.
Advanced Healthcare Materials, 2024, e2402349
Verified customer review of TH588