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Alkylating Agent

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP WRN Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group
Cat.No. Product Name Information Product Use Citations Product Validations
S1692 Busulfan Busulfan is a cell cycle non-specific alkylating antineoplastic agent. It causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase activity. It also induces apoptosis. It is an immunosuppressive and myeloablative chemotherapeutic agent.Busulfan (NSC-750) can be used to induce animal models of Anemia.
Biomolecules, 2025, 15(2)297
J Immunother Cancer, 2024, 12(11)e009805
iScience, 2024, 27(10):110862
S1237 TMZ(Temozolomide) Temozolomide (TMZ) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. It is a DNA damage inducer in L-1210 and L-1210/BCNU cells. This compound induces apoptosis and exhibits antitumor activity.
Cancer Cell, 2025, S1535-6108(25)00223-5
Cancer Cell, 2025, 43(4):776-796.e14
Nat Commun, 2025, 16(1):5676
Verified customer review of TMZ(Temozolomide)
S1217 Cyclophosphamide Cyclophosphamide(NSC 26271,Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane) is a nitrogen mustard alkylating agent from the oxazophorines group.
Neurotherapeutics, 2025, 22(1):e00480
Sci Rep, 2025, 15(1):2893
Front Biosci (Landmark Ed), 2025, 30(11):45744
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S2057 Cyclophosphamide Monohydrate Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.Cyclophosphamide (NSC-26271) Monohydrate can be used to induce animal models of Anemia.
Cell Rep Med, 2025, S2666-3791(25)00102-8
Cell Mol Life Sci, 2025, 82(1):164
Int J Mol Sci, 2025, 26(17)8494
Verified customer review of Cyclophosphamide Monohydrate
S1302 Ifosfamide Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
iScience, 2024, 27(10):110862
Cancers (Basel), 2024, 16(21)3565
Cancer Res, 2023, 83(16):2750-2762
Verified customer review of Ifosfamide
E0157 MNNG (1-Methyl-3-nitro-1-nitrosoguanidine) 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) is an orally active alkylating agent with toxic and mutagenic effects. It acts as a carcinogen and mutagen among 3 human diploid lymphoblast lines, MIT-2, WI-L2, and GM 130.The product is a solid-liquid mixture.1-Methyl-3-nitro-1-nitrosoguanidine can be used to induce animal models of Gastric Carcinoma. Solutions are unstable and should be fresh-prepared.
Nature, 2025, 10.1038/s41586-025-09694-5
bioRxiv, 2025, 2025.05.14.654090
Am J Hum Genet, 2024, 111(6):1165-1183
S7758 Trabectedin Trabectedin (Ecteinascidin 743, ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata with antitumour activity. Trabectedin binds to the N2 of guanine in the minor groove, causing DNA damage and affecting transcription regulation in a promoter- and gene-specific manner.
EMBO Molecular Medicine, 2023, e16863
EMBO Mol Med, 2023, e16863.
Chem Biol Interact, 2022, 369:110262
E0158 N-Nitroso-N-methylurea (NMU)

N-Nitroso-N-methylurea (NMU, MNU, NMH, 1-Methyl-1-nitrosourea, N-Methyl-Nnitrosourea, Methylnitrosourea) is a highly reliable carcinogen, mutagen, and teratogen.

N-Nitroso-N-methylurea can be used to induce animal models of Breast Carcinoma.
Phytomedicine, 2025, 141:156701
bioRxiv, 2025, Preprint
S9046 Berberine (Umbellatine) Berberine (Umbellatine), an alkaloid isolated from Rhizoma coptidis, has broad applications, particularly as an antibacterial agent in the clinic.
J Inflamm Res, 2025, 18:10919-10937
BMC Biol, 2024, 22(1):280
Chin Med, 2024, 19(1):128.