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eIF
eIF Products
- All (28)
- eIF Inhibitors (13)
- New eIF Products
| Catalog No. | Product Name | Information | Product Use Citations | Product Validations |
|---|---|---|---|---|
| S2923 | Salubrinal | Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay. |
|
|
| S7369 | 4EGI-1 | 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis. |
|
|
| S0706 | ISRIB | ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation. | ||
| S8275 | Tomivosertib (eFT-508) | Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. | ||
| S7370 | 4E1RCat | 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E. |
|
|
| S7437 | Sal003 | Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. | ||
| S7428 | Rocaglamide | Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity. | ||
| S9668 | PKR-IN-C16 | PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. | ||
| S8181 | SBI-0640756 | SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling. | ||
| F0316New | eIF2α Rabbit mAb | EIF2S1,eIF2α | ||
| F0257New | Phospho-eIF2α (Ser51) Rabbit mAb | EIF2S1 (phospho S51),Phospho-eIF2α (Ser51) | ||
| F0128New | 4E-BP1 Rabbit mAb | 4EBP1,4E-BP1,eIF4EBP1 |
|
|
| F0562New | eIF4E Rabbit mAb | eIF4E,eIF-4E | ||
| F0851New | Phospho-4E-BP1 (Thr70) Rabbit mAb | |||
| F0614New | eIF4G Rabbit mAb | |||
| F1674New | Phospho-eIF4E (Ser 209) Rabbit mAb | eIF4E (phospho S209),Phospho-eIF4E (Ser209) | ||
| F3063New | eIF4A Rabbit mAb | eIF4A | ||
| F0666New | eIF3A Rabbit mAb | |||
| F0919New | eIF4GI Rabbit mAb | EIF4G1,eIF4GI | ||
| F1432New | eIF4G2/p97 Rabbit mAb | |||
| F0585New | Non-phospho 4E-BP1 (Thr 46) Rabbit mAb | Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1, Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, eIF4E-binding protein 2, EIF4EBP2, Eukaryotic translation initiation factor 4E-binding protein 3, 4E-BP3, eIF4E-binding protein 3, EIF4EBP3 | ||
| F1305New | Phospho-eIF4B (Ser406) Rabbit mAb | |||
| F1420New | eIF3H Rabbit mAb | |||
| F1481New | eIF4H Rabbit mAb | |||
| E4888New | Guanabenz hydrochloride | Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease. | ||
| S6533 | Briciclib | Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). | ||
| S8994New | Zotatifin | Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity. | ||
| S2961 | GC7 Sulfate | GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins. | ||
| S2923 | Salubrinal | Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay. |
|
|
| S7369 | 4EGI-1 | 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis. |
|
|
| S0706 | ISRIB | ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation. | ||
| S8275 | Tomivosertib (eFT-508) | Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance. | ||
| S7370 | 4E1RCat | 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E. |
|
|
| S7437 | Sal003 | Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor. | ||
| S7428 | Rocaglamide | Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity. | ||
| S9668 | PKR-IN-C16 | PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component. | ||
| S8181 | SBI-0640756 | SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling. | ||
| E4888New | Guanabenz hydrochloride | Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease. | ||
| S6533 | Briciclib | Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E). | ||
| S8994New | Zotatifin | Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity. | ||
| S2961 | GC7 Sulfate | GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins. | ||
| F0316New | eIF2α Rabbit mAb | EIF2S1,eIF2α | ||
| F0257New | Phospho-eIF2α (Ser51) Rabbit mAb | EIF2S1 (phospho S51),Phospho-eIF2α (Ser51) | ||
| F0128New | 4E-BP1 Rabbit mAb | 4EBP1,4E-BP1,eIF4EBP1 |
|
|
| F0562New | eIF4E Rabbit mAb | eIF4E,eIF-4E | ||
| F0851New | Phospho-4E-BP1 (Thr70) Rabbit mAb | |||
| F0614New | eIF4G Rabbit mAb | |||
| F1674New | Phospho-eIF4E (Ser 209) Rabbit mAb | eIF4E (phospho S209),Phospho-eIF4E (Ser209) | ||
| F3063New | eIF4A Rabbit mAb | eIF4A | ||
| F0666New | eIF3A Rabbit mAb | |||
| F0919New | eIF4GI Rabbit mAb | EIF4G1,eIF4GI | ||
| F1432New | eIF4G2/p97 Rabbit mAb | |||
| F0585New | Non-phospho 4E-BP1 (Thr 46) Rabbit mAb | Eukaryotic translation initiation factor 4E-binding protein 1, 4E-BP1, eIF4E-binding protein 1, Phosphorylated heat- and acid-stable protein regulated by insulin 1, PHAS-I, EIF4EBP1, Eukaryotic translation initiation factor 4E-binding protein 2, 4E-BP2, eIF4E-binding protein 2, EIF4EBP2, Eukaryotic translation initiation factor 4E-binding protein 3, 4E-BP3, eIF4E-binding protein 3, EIF4EBP3 | ||
| F1305New | Phospho-eIF4B (Ser406) Rabbit mAb | |||
| F1420New | eIF3H Rabbit mAb | |||
| F1481New | eIF4H Rabbit mAb | |||
| E4888New | Guanabenz hydrochloride | Guanabenz hydrochloride(NE56490) is a small molecule, antihypertensive agonist of α2-adrenoceptor. It also inhibits eIF2α and GADD34, showing potential for treating cardiac hypertrophy, heart failure, atherosclerosis, and ischemic heart disease. | ||
| S8994New | Zotatifin | Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity. |
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Tags: eIF inhibitor|eIF agonist|eIF activator|eIF inducer|eIF antagonist|eIF signaling pathway|eIF assay kit
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