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Cat.No. Product Name Information Product Use Citations Product Validations
S0706 ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation.
EMBO J, 2025, 44(4):1107-1130
Cell Death Dis, 2025, 16(1):190
Cancer Cell Int, 2025, 25(1):245
S8994 Zotatifin (eFT226) Zotatifin (eFT226) is a highly effective and sequence-selective inhibitor of the RNA helicase eIF4A. It promotes eIF4A binding to specific mRNA sequences with recognition motifs in the 5'-UTRs, with an IC50 of 2 nM, and disrupts the assembly of the eIF4F initiation complex. By enhancing the interaction between eIF4A and polypurine RNA sequence or structural motifs, zotatifin converts eIF4A into a sequence-specific translation repressor, thereby regulating the translation of certain target genes. It also exhibits anti-tumor activity.
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. This compound inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
Nat Commun, 2025, 16(1):7853
Nat Commun, 2024, 15(1):9755
Nat Commun, 2024, 15(1):9755
S7369 4EGI-1 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. This compound specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. It induces apoptosis.
Nat Commun, 2024, 15(1):4083
Nat Commun, 2024, 15(1):4083
Nucleic Acids Res, 2024, gkae849
Verified customer review of 4EGI-1
S7370 4E1RCat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E.
Cancer Res Commun, 2024, 10.1158/2767-9764.CRC-24-0221
Cell Chem Biol, 2021, S2451-9456(21)00213-0
J Cell Mol Med, 2021, 10.1111/jcmm.16307
Verified customer review of 4E1RCat
S8181 SBI-0640756 SBI-0640756(SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-κB signaling.
Neoplasia, 2024, 60:101109
Sci Rep, 2021, 11(1):21689
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Cell Discov, 2025, 11(1):80
Cell Metab, 2025, 37(8):1715-1731.e11
EMBO J, 2025, 44(4):1107-1130
Verified customer review of Salubrinal
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
Front Pharmacol, 2023, 14:1095307
bioRxiv, 2023, 2023.05.19.540602
bioRxiv, 2023, 2023.05.19.540602
S7428 Rocaglamide Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. This compound inhibits the function of the translation initiation factor eIF4A. It also inhibits NF-κB activity. This chemical exhibits anti-tumor activity.
Life Sci Alliance, 2024, 7(9)e202302396
Elife, 2023, 12e69521
Blood Adv, 2023, 7(12):2926-2937