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Catalog No. Product Name Information Product Use Citations Product Validations
S0706 ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Cell Death Dis, 2022, 13(2):111
Nat Commun, 2021, 12(1):4651
Nat Commun, 2021, 12(1):5507
S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Nat Commun, 2021, 12(1):1589
Cell Mol Life Sci, 2021, 10.1007/s00018-021-03970-z
Cell Death Dis, 2021, 12(9):834
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S7369 4EGI-1 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.
FASEB J, 2021, 35(5):e21445
Mol Pharmacol, 2021, 99(1):1-16
J Cell Mol Med, 2021, 10.1111/jcmm.16307
S7370 4E1RCat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
Cell Chem Biol, 2021, S2451-9456(21)00213-0
J Cell Mol Med, 2021, 10.1111/jcmm.16307
Int J Ophthalmol, 2020, 13(1):7-10
S7428 Rocaglamide Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S8181 SBI-0640756 SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
Sci Rep, 2021, 11(1):21689
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
J Med Chem, 2022, 10.1021/acs.jmedchem.1c01941
J Clin Invest, 2021, 140752
Elife, 2020, 9e60151
S9668 PKR-IN-C16 PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.
Cell Chem Biol, 2021, S2451-9456(21)00303-2
Pulm Circ, 2021, 11(4):20458940211046156
S0706 ISRIB ISRIB is an integrated stress response (ISR) inhibitor that potently reverses the effects of eukaryotic initiation factor 2α (eIF2α) phosphorylation with IC50 of 5 nM.
Cell Death Dis, 2022, 13(2):111
Nat Commun, 2021, 12(1):4651
Nat Commun, 2021, 12(1):5507
S2923 Salubrinal Salubrinal is a selective inhibitor of eIF2α dephosphorylation and inhibits ER stress-mediated apoptosis with EC50 of ~15 μM in a cell-free assay.
Nat Commun, 2021, 12(1):1589
Cell Mol Life Sci, 2021, 10.1007/s00018-021-03970-z
Cell Death Dis, 2021, 12(9):834
S2961 GC7 Sulfate GC7 (N1-guanyl-1,7-diaminoheptane) Sulfate is an inhibitor of deoxyhypusine synthase (DHPS). GC7 inhibits Neuroblastoma (NB) cell proliferation in a dose-dependent manner, through induction of the cell cycle inhibitor p21 and reduction of total and phosphorylated Rb proteins.
S6533 Briciclib Briciclib (ON-014185) is a water soluble derivative of ON-013100, a small molecule that binds to and inhibits eukaryotic translation initiation factor 4E (eIF4E).
S7369 4EGI-1 4EGI-1 is a competitive eIF4E/eIF4G interaction inhibitor by binding to eIF4E with KD of 25 μM. 4EGI-1 specifically inhibits the function of mTOR by blocking the activation of 4E-BP1. 4EGI-1 induces apoptosis.
FASEB J, 2021, 35(5):e21445
Mol Pharmacol, 2021, 99(1):1-16
J Cell Mol Med, 2021, 10.1111/jcmm.16307
S7370 4E1RCat 4E1RCat is a dual inhibitor of eIF4E:eIF4G and eIF4E:4E-BP1 interaction, and inhibits the binding of eIF4G to eIF4E with IC50 of 3.2 μM.
Cell Chem Biol, 2021, S2451-9456(21)00213-0
J Cell Mol Med, 2021, 10.1111/jcmm.16307
Int J Ophthalmol, 2020, 13(1):7-10
S7428 Rocaglamide Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of heat shock factor 1 (HSF1) activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor eIF4A. Rocaglamide also inhibits NF-κB activity. Rocaglamide exhibits anti-tumor activity.
S7437 Sal003 Sal003 is a potent and cell-permeable eIF-2α phosphatase inhibitor.
S8181 SBI-0640756 SBI-0640756 is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex. It can also suppress AKT and NF-kB signaling.
Sci Rep, 2021, 11(1):21689
S8275 Tomivosertib (eFT-508) Tomivosertib (eFT-508) is a potent and selective MNK1/2 inhibitor with IC50s of 2.4 nM and 1 nM, respectively. It potentially results in decreased tumor cell proliferation and tumor growth. Tomivosertib (eFT-508) inhibits eIF4E phosphorylation and dramatically downregulates PD-L1 protein abundance.
J Med Chem, 2022, 10.1021/acs.jmedchem.1c01941
J Clin Invest, 2021, 140752
Elife, 2020, 9e60151
S9668 PKR-IN-C16 PKR-IN-C16 (imoxin, C16, Imidazolo-oxindole PKR inhibitor C16) is a specific inhibitor of RNA-dependent protein kinase (PKR, Protein Kinase R, EIF2AK2). PKR-IN-C16 prevents apoptosis and IL-1β production in an acute excitotoxic rat model with a neuroinflammatory component.
Cell Chem Biol, 2021, S2451-9456(21)00303-2
Pulm Circ, 2021, 11(4):20458940211046156