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DNA alkylator

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Isoform-selective Products

Cat.No. Product Name Information Product Use Citations Product Validations
S1224 Oxaliplatin Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells.Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nature, 2025, 10.1038/s41586-025-08974-4
Cancer Cell, 2025, S1535-6108(25)00223-5
Signal Transduct Target Ther, 2025, 10(1):341
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S1215 Carboplatin Carboplatin, a derivative of CDDP, is a DNA synthesis inhibitor which binds to DNA, inhibits replication and transcription and induces cell death and interfers with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks. Solutions are unstable and should be fresh-prepared.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
Nat Commun, 2025, 16(1):8932
Cell Rep Med, 2025, 6(6):102160
Cancer Res, 2025, 10.1158/0008-5472.CAN-24-2360
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S8266 Melphalan Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.This product is a hazardous chemical (acute toxicity/flammable/skin corrosive). Please use it while wearing a protective face mask, gloves, and clothing.
Cell, 2025, S0092-8674(25)00572-0
J Exp Clin Cancer Res, 2025, 44(1):125
J Transl Med, 2025, 23(1):917
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S1278 Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.
iScience, 2024, 27(10):110862
J Pers Med, 2022, 12(2)258
Hum Cell, 2022, 10.1007/s13577-022-00671-y
S8056 Lomeguatrib Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Sci Rep, 2024, 14(1):12363
Neurooncol Adv, 2024, 6(1):vdad165
Int J Mol Sci, 2023, 24(20)15179
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S3658 O6-Benzylguanine O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Nat Commun, 2024, 15(1):10089
Nat Commun, 2023, 14(1):5913
Nat Commun, 2023, 14(1):5913
E0609 Methyl methanesulfonate Methyl methanesulfonate (MMS), a DNA alkylating agent, modifies both guanine (to 7-methylguanine) and adenine (to 3-methlyladenine) to cause base mispairing and replication blocks, respectively.
J Adv Res, 2025, S2090-1232(25)00934-8
Int J Biol Sci, 2024, 20(11):4513-4531
Cell Death Dis, 2024, 15(12):898
S8880 Lobaplatin (D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
United Eur Gastroent, 2025, 13(7):1328-1342
Int J Nanomedicine, 2024, 19:9503-9547
Biochem Pharmacol, 2020, 12:114023
S6984 Dianhydrogalactitol (VAL-083) Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. It shows antitumor activity.
S4447 Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.