DNA alkylator

Choose Selective DNA alkylator Inhibitors
Isoform-selective Inhibitors

DNA alkylator Products

  • All (16)
  • DNA alkylator Inhibitors (3)
  • DNA alkylator Activator (1)
  • DNA alkylator Modulators (2)
  • New DNA alkylator Products
Catalog No. Product Name Information Product Use Citations Product Validations
S1215 Carboplatin (NSC 241240) Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.
Cancer Cell, 2021, S1535-6108(21)00659-0
Nat Commun, 2021, 12(1):3636
Cell Rep, 2021, 34(10):108814
S3658 O6-Benzylguanine O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Neuro Oncol, 2021, 23(6):920-931
S8056 Lomeguatrib Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Pharmaceuticals (Basel), 2021, 14(2)107
Cancer Sci, 2020, 112(1):133-143
Cancer Res, 2018, 78(20):5731-5740
S1302 Ifosfamide (NSC109724) Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.
Cancer Cell Int, 2021, 21(1):646
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S4447New Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958 Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

S1224 Oxaliplatin (NSC 266046) Oxaliplatin (NSC 266046, L-OHP, Eloxatin) is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.
J Exp Clin Cancer Res, 2022, 41(1):5
Cell, 2021, 184(25):6119-6137.e26
Cancer Cell, 2021, S1535-6108(21)00659-0
S1278 Altretamine Altretamine (Hexamethylmelamine, NSC13875, ENT50852) is an anti-neoplastic agent.
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00579-z
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S1312 Streptozotocin (STZ) Streptozotocin (STZ, NSC-85998, Streptozocin, U 9889) is a glucosamine-nitrosourea derivative, which is a DNA-methylating, carcinogenic, antibiotic and diabetes inducing agent. Streptozotocin induces autophagy and apoptosis. Solutions are best fresh-prepared.
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00639-4
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S1692 Busulfan (NSC-750) Busulfan (NSC-750) is a cell cycle non-specific alkylating antineoplastic agent. Busulfan induces apoptosis.
Breast Cancer Res, 2021, 23(1):100
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00579-z
S2057 Cyclophosphamide (NSC-26271) Monohydrate Cyclophosphamide (NSC-26271, Cytoxan) Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.
Transl Oncol, 2022, 15(1):101287
Nat Immunol, 2021, 22(9):1107-1117
Biomaterials, 2021, 272:120770
S5840 Palifosfamide Palifosfamide (ZIO-201, Isophosphamide mustard) is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.
S6984New Dianhydrogalactitol (VAL-083) Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.
S7829 CB1954 CB1954 (Tretazicar, NSC 115829) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.
S8266 Melphalan Melphalan (Alkeran, Sarcolysin, L-PAM) is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.
Mol Cancer Ther, 2021, 20(2):367-378
Hemasphere, 2021, 5(7):e602
Blood Adv, 2021, 5(9):2391-2402
S8880 Lobaplatin (D-19466) Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.
Biochem Pharmacol, 2020, 12:114023
S1215 Carboplatin (NSC 241240) Carboplatin (NSC 241240, JM-8, CBDCA) is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.
Cancer Cell, 2021, S1535-6108(21)00659-0
Nat Commun, 2021, 12(1):3636
Cell Rep, 2021, 34(10):108814
S3658 O6-Benzylguanine O6-Benzylguanine (O6-BG) is a potent O6-alkylguanine DNA alkyltransferase (AGT) inactivator.
Neuro Oncol, 2021, 23(6):920-931
S8056 Lomeguatrib Lomeguatrib (PaTrin-2) is a potent inhibitor of O6-alkylguanine-DNA-alkyltransferase with IC50 of 5 nM.
Pharmaceuticals (Basel), 2021, 14(2)107
Cancer Sci, 2020, 112(1):133-143
Cancer Res, 2018, 78(20):5731-5740
S1302 Ifosfamide (NSC109724) Ifosfamide (NSC109724, Isophosphamide) is a nitrogen mustard alkylating agent used in the treatment of cancer.
Cancer Cell Int, 2021, 21(1):646
Hum Cell, 2021, 34(6):1911-1918
Hum Cell, 2021, 10.1007/s13577-021-00639-4
S4447New Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6958 Treosulfan

Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.

S4447New Pipobroman Pipobroman (PB, Vercyte), a neutral amide of piperazine, acts as an alkylating agent with antiproliferative activity.
S6984New Dianhydrogalactitol (VAL-083) Dianhydrogalactitol (VAL-083, Dianhydrodulcitol, Dulcitol Diepoxide) is a bi-functional alkylating agent that readily crosses the blood-brain barrier and creates N7 methylation on DNA. Dianhydrogalactitol shows antitumor activity.