DNA alkylator

Inhibitory Selectivity

DNA alkylator Products

Catalog No. Information Product Use Citations Product Validations
S1215

Carboplatin

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

S1224

Oxaliplatin

Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S1312

Streptozotocin (STZ)

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent.

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

S8880New

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

S1278

Altretamine

Altretamine is an anti-neoplastic agent.

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.

Catalog No. Information Product Use Citations Product Validations
S1215

Carboplatin

Carboplatin is a DNA synthesis inhibitor by binding to DNA and interfering with the cell's repair mechanism in A2780, SKOV-3, IGROV-1, and HX62 cells. Solutions are best fresh-prepared.

Catalog No. Information Product Use Citations Product Validations
S1224

Oxaliplatin

Oxaliplatin is a DNA alkylating agent that activates autophagy. Oxaliplatin inhibits DNA synthesis by conforming DNA adducts in RT4, TCCSUP, A2780, HT-29, U-373MG, U-87MG, SK-MEL-2, and HT-144 cells. DMF is recommended for dissolution. Solutions are best fresh-prepared.

S1312

Streptozotocin (STZ)

Streptozotocin is a glucosamine-nitrosourea derivative, which is a methylating, carcinogenic, antibiotic and diabetes inducing agent.

S1692

Busulfan

Busulfan is a cell cycle non-specific alkylating antineoplastic agent.

S2057

Cyclophosphamide Monohydrate

Cyclophosphamide Monohydrate is a nitrogen mustard alkylating agent, it attaches the alkyl group to the guanine base of DNA, shown to crosslink DNA, causing strand breakage and inducing mutations.

S8880New

Lobaplatin ( D-19466)

Lobaplatin (D-19466) is a third-generation platinum anti-neoplastic agent. It is a platinum complex with DNA alkylating activity.

S1278

Altretamine

Altretamine is an anti-neoplastic agent.

S7829

CB1954

CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2.

S5840

Palifosfamide

Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide with potential antineoplastic activity.

S8266

Melphalan

Melphalan is a phenylalanine derivative of nitrogen mustard with antineoplastic activity.