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Favipiravir (T-705)

Catalog No.S7975

For research use only.

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

Favipiravir (T-705) Chemical Structure

CAS No. 259793-96-9

Selleck's Favipiravir (T-705) has been cited by 17 publications

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DNA/RNA Synthesis Signaling Pathways

DNA/RNA Synthesis Signaling Pathway Map

Biological Activity

Description Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
Targets
RNA-dependent RNA polymerase [1]
In vitro

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]
Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK M4\vfGFvfGm4aYLhcEBie3OjeR?= M2HSZ|Mh\GG7cx?= M2LnTGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxTnX3JHlwemtxM{SvNlAxQCiKMV6xLUkhcGG{Yn;ybY5oKE1{IFyyOmkhdXW2YX70JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cSxiRVO1NEA:KDBwMUmg{txONg>? NGOxb3E9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK MXLBcpRqfmm{YXygZZN{[Xl? NGTDd5A{KGSjeYO= MmDCRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKG:|ZXz0ZY1qfmm{LTygfoFv[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL1HuckBCemKxcj:2M|E6PjBqSELONkkqKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOgeZNqdmdiY4L5d5RidCC4aX;s[ZQhe3SjaX6sJGVEPTBiPTCwMlM5KM7:TT6= NVnwOYkyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MlnPRY51cX[rcnHsJIF{e2G7 NF\z[3A{KGSjeYO= NYrTVZk5SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;GcI9zcWSjL{CxM|IxODlqSEPONkkqKGijcnLvdolv\yCPMjDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxKD1iMD60OUDPxE1w MUC8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NG[0cllCdnSrdnnyZYwh[XO|YYm= M4TRbFMh\GG7cx?= MnS5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sgc5NmdHSjbXn2bZIue3W|Y3XweIljdGVienHuZY1qfmm{LTygZYRidWGwdHHu[U1z\XOrc4ThcpQhUW6obIXlcppiKEJidnnyeZMhSi:PZX3wbIl{NzJyL{G5PVYhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgVlE2OktibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgZY5iNCCHQ{WwJF0hOC53NzFOwG0v Mni1QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MUfBcpRqfmm{YXygZZN{[Xl? M4D5[|Mh\GG7cx?= NV;4T5RoSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM3N4cW6nL2PveZRpKESja3;0ZU8xOy9{MEC4LGgyVjFrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{KHW|aX7nJINzgXO2YXygeolwdGW2LDDFR|UxKD1iMD64N{DPxE1w M3T1bFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NUewPHp[SW62aY\pdoFtKGG|c3H5 M4nCdlMh\GG7cx?= MoPKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1{fXOlZYD0bYJt\SC8YX7hcYl3cXJvLDDvd4VtfGGvaY\pdk1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxQoLhfoltNzF4M{OvNlAxQCiKMV6xLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgVVE{PktibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{NCCHQ{WwJF0hOC56MzFOwG0v NXnoPHM2RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK Mk[1RY51cX[rcnHsJIF{e2G7 MX2zJIRigXN? NWD2VVF1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wS2GuaX\vdo5q[S9yNT:yNFA6KCiKMV6xLUkhcGG{Yn;ybY5oKE1{IG[yPGktKFN|MV6gcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgcYlkem:|LDDFR|UxKD1iMD64N{DPxE1w M1\GRVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NWXF[XBGSW62aY\pdoFtKGG|c3H5 NE\2OXk{KGSjeYO= NXLxTldySW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wVmW5IGnvdoswOThxMkCwPUApUDGQMTmpJIhiemKxcnnu[{BOOiCYMkjJMEBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxLDDFR|UxKD1iMD64PUDPxE1w MVK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NIXBPVNCdnSrdnnyZYwh[XO|YYm= MX:zJIRigXN? M{m4e2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCC8YX7hcYl3cXJvc4XzZ4VxfGmkbHWgc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL4T1dotmgS:PaX7u[ZNwfGFxOEOzM|E6QDBqSETONkkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGUyOTmJIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KCxiRVO1NEA:KDBwOEmg{txONg>? MUK8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NFm0ZVhCdnSrdnnyZYwh[XO|YYm= Mlv2N{Bl[Xm| M3XHdWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;0eZJs\XlxTXnucoV{d3SjL{izN{8yQThyKFi0UlIqMSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KCxiRVO1NEA:KDBwOU[g{txONg>? Mnv0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NFnqd4pCdnSrdnnyZYwh[XO|YYm= NGq5[WRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBwe2WudHHtbZZqei2|dYPj[ZB1cWKuZTD6ZY5idWm4aYKtMEBi\GGvYX70ZY5mNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;C[ZRp\XOmYT:5OVYwOjByNjjIN24zMSliaHHyZo9zcW6pIH7leZJidWmwaXThd4UhWjJ7MlugcZV1[W62IHHu[EBOOiCVM{HOJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[WZuIFXDOVAhRSBzLkKxJO69VS5? MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK MUPBcpRqfmm{YXygZZN{[Xl? MnjNN{Bl[Xm| NVqzbYNlSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;w[I0wVWW6aXPvM|Q3ODRxMkCwPUApUDGQMTmpJIhiemKxcnnu[{BOOiCYMkjJMEBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxLDDFR|UxKD1iMT6yNUDPxE1w MXu8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NHrSZYlCdnSrdnnyZYwh[XO|YYm= MV:zJIRigXN? M3fNR2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEJidnnyeZMhSi:PZX3wbIl{NzJyL{G5PVYhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczD1d4lv\yClconzeIFtKH[rb3zleEB{fGGrbjygSWM2OCB;IEGuNlEh|ryPLh?= MmDtQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MVrBcpRqfmm{YXygZZN{[Xl? MmHtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKG:|ZXz0ZY1qfmm{LTygfoFv[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL3PobYNs\W5xVnnleI5idS:QQ2\ENVA{NzJyMEegZ4xi\GViMj6zMlQhMEh3TkGpLUBp[XKkb4LpcochdmW3cnHtbY5q\GG|ZTDJNlIzXCCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzNCCHQ{WwJF0hOS5{NzFOwG0v NGPuSoc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M{T5eWFvfGm4aYLhcEBie3OjeR?= NE\YVW1KdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIH;mJIlv\my3ZX76ZUBCKH[rcoXzJEhCN0ixbnegT49v\y9{MUOvNFMpUDWQMTmpJIFv\CCrbn\seYVvgmFiQTD2bZJ2eyBqQT;Bco4hSXKkb4KvOk83OCiKMl6yLUkhcHmkcnnkJJZqenW|IHnuJG1FS0tiY3XscJMh[nlidnnyeZMhgWmnbHSgdoVlfWO2aX;uJIF{e2G7LDDFR|kxKD1iMT6zJO69VS5? MV28ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7NEizNkc,OTdzOUS4N|I9N2F-
MDCK M{XtTWFvfGm4aYLhcEBie3OjeR?= M3rNdFEhcHJ? NH;DeGtCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSiC4aYL1d{ApSi:EcnnzZoFv\S94MD:yNFA5MSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolzfXNvaX7keYNm\CCleYTvdIF1cG:pZX7pZ4l1gSCjdDCxJIhzKHCxc4StbY5n\WO2aX;uJI1m[XO3cnXkJIFnfGW{IEOg[IF6eyCkeTDmcJVwemW|Y3Xpck1lcWGlZYTheIUh[mG|ZXSg[ox2d3KrbXX0dolkKGGwYXz5d4l{NCCHQ{WwJF0hOS5|MjFOwG0v NUTNPFJbRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVk4OzhpPkKzOFE6PzN6PD;hQi=>
MDCK MmT6RY51cX[rcnHsJIF{e2G7 NYHpe4t2SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;WbYV1dmGvL1jON|A1ODhxMkCwOUBPOjl2UzDjcIFl\SBzIDjIOW4yMSliaHHyZo9zcW6pIF2yJGwzPkluIGOzNW4hdXW2YX70JIFv\CCwZYXyZY1qdmmmYYPlJG4zQTSVIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxiLDDFR|UxKD1iMT6zOFEh|ryPLh?= NEDWSY89[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
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MDCK NHTrO4lCdnSrdnnyZYwh[XO|YYm= MoK4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgNE4xODFiTV;JJIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM21mgGmlbz:0OlA1NzJyMEmoTFFPOSlrIHjhdoJwemmwZzDNNkBXOjiLLDDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIRmfGW{bXnuZZRqd25ib3[geolz[WxidHn0[ZIhcW5iY3XscEBkfWy2dYLlJIF1NCCQVVzMJF0hVlWOTDFOwG0v NGfMSZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M3LPZ2FvfGm4aYLhcEBie3OjeR?= NVfrOHlrSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhOC5yMEGgUW9KKGGmYX3hcpRidmVvcnXzbZN1[W62IIrhcoFucX[rcj2sc5NmdHSjbXn2bZIue3W|Y3XweIljdGViSX7mcJVmdnqjIFGgeolzfXNiKFGvdIRuN0OjbHnmc5JvcWFxMESvNlAxQSiKMV6xLUkhcGG{Yn;ybY5oKE1{IG[yPGktKFN|MV6gcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiZHX0[ZJucW6jdHnvckBw\iC4aYLhcEB1cXSncjDpckBk\WyuIHP1cJR2emViLDDOWWxNKD1iTmXMUEDPxE1w Mm\mQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MWnBcpRqfmm{YXygZZN{[Xl? M3y4WFEzQCC3TR?= MV7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN3CmbT;N[Zhq[29xNE[wOE8zODB7KFixUlEqMSCqYYLic5JqdmdiTUKgWlI5USxiU{OxUkBufXSjboSgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDk[ZRmem2rbnH0bY9vKG:oII\pdoFtKHSrdHXyJIlvKGOnbHygZ5VtfHW{ZTDheEAyOjhidV2gZYYtKE6XTFygQUBPXUyOIN88UU4> NFnxXnU9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK Mn71RY51cX[rcnHsJIF{e2G7 MkC0NVI5KHWP MnjzRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:yZH2vR4FtcW[xcn7pZU8xPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UBifCBzMkigeW0hNCCQVVzMJF0hVlWOTDFOwG0v NFrwcnM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
Vero NX7qc3U3SW62aY\pdoFtKGG|c3H5 NYWxZ3hyPjRyMDD1US=> MUj1dEB1dyBzMjDodpM> Moj5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgXYVtdG:5IH\leoVzKH[rcoXzJFE4TCCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxIHPlcIx{KGG|c3Xzd4VlKGG|IITpcYUhemWzdXny[YQh\m:{IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[XRiNkSwNEB2VSC3cDD0c{AyOiCqcoOgdI9{fC24aYLhcEBqdm[nY4Tpc44tKE6XTFygQUBPXUyOIN88UU4> MlfMQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUW1N|YoRjF6OUW1OVM3RC:jPh?=
MDCK M3zES2FvfGm4aYLhcEBie3OjeR?= NIP1[|ExKHSxIEKgbJJ{ MX3Jcohq[mm2aX;uJI9nKGmwZnz1[Y57[SCDII\pdpV{KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCCub3HkJJRz\WG2ZXSge4l1cCClb33wc5Vv\CCjdDCwJJRwKDJiaILzJJBwe3RvaX7m[YN1cW:wIHL5JHJVNXGSQ2KgcYV1cG:mIHLhd4VlKHSrbXWgc4Yh[WSmaYTpc44h[XO|YYmsJG5WVExiPTDOWWxNKM7:TT6= M1fUbFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK MoqwRY51cX[rcnHsJIF{e2G7 MmDmOUB1dyB6IHjydy=> NEf6d|hKdmirYnn0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDsc4FlKHS{ZXH0[YQhf2m2aDDjc41xd3WwZDDheEA2KHSxIEigbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KFKWLYHQR3IhdWW2aH;kJIJie2WmIITpcYUhd2ZiYXTkbZRqd25iYYPzZZktKE6XTFygQUBPXUyOIN88UU4> NYjoepJsRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxPVI2PDRpPkOwNVkzPTR2PD;hQi=>
MDCK MWfBcpRqfmm{YXygZZN{[Xl? NVrNdGhbOCC2bzCxNEBpenN? NU\GR2VyUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygcI9i\CC2cnXheIVlKHerdHigZ49ueG:3bnSgZZQhOCC2bzCxNEBpenNicH;zeE1qdm[nY4Tpc44h[nliUmStdXBEWiCvZYToc4Qh[mG|ZXSgeIlu\SCxZjDh[IRqfGmxbjDhd5NigSxiTmXMUEA:KE6XTFyg{txONg>? M1z5OlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK M4PFUWFvfGm4aYLhcEBie3OjeR?= MXiyJJRwKDViaILz MkfhTY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxibH;h[EB1emWjdHXkJJdqfGhiY3;tdI92dmRiYYSgNkB1dyB3IHjyd{Bxd3O2LXnu[oVkfGmxbjDifUBTXC2zUFPSJI1mfGixZDDiZZNm\CC2aX3lJI9nKGGmZHn0bY9vKGG|c3H5MEBPXUyOIE2gUnVNVCEQvF2u NHj2R2Y9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG5NlU1PCd-M{CxPVI2PDR:L3G+
MDCK NYXEVndCSW62aY\pdoFtKGG|c3H5 NXPtOGh2OTBidV2= NVLPOolofXBidH:gPEBpenN? MoLkRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJGEhfmm{dYOgLGEw[2irY3vlck9JfWKnaT:zNlcwOjByNDjIOW4yMSliaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJIViemy7IIP0ZYdmeyCxZjD2bZJidCC{ZYDsbYNifGmxbjDheEAyOCC3TTD1dEB1dyB6IHjyd{BjgSClconzeIFtKH[rb3zleEB{fGGrbnnu[{Bj[XOnZDDwcIFyfWVicnXkeYN1cW:wIHHzd4F6KGSncHXu[IVvfCC2aX3lMY9nNCCQVVzMJF0hVlWOTDFOwG0v NYr3R2F7RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPVI5QTdpPkOwNlkzQDl5PD;hQi=>
MDCK NVHLdo9xSW62aY\pdoFtKGG|c3H5 M3W3UVExOCC3TR?= M1nV[FEzKGi{cx?= MWjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgeolzfXNiQT;YMVMyKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjDvcoUh[3mlbHWgeolz[WxiUl7BJJN6dnSqZYPpd{BifCBzMECgeW0heHKnaX7jeYJifGWmIIfpeIgh[2WubIOg[o9zKDF{IHjyd{Bnd2yub4fl[EBjgSC4aYLhcEBqdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgNVAhcHK|IIDvd5QhcW6oZXP0bY9vKGK7IGLUMZFRS1JibXX0bI8tKE6XTFygQUBPXUyOIN88UU4> MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyNkO5Nkc,Ojl7ME[zPVI9N2F-
MDCK NH:0UGVCdnSrdnnyZYwh[XO|YYm= NWLiTZB3OjVyIIXN NEKxTZIyOCCqcoO= NH;TSlNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhfmm{dYOgRU9ZNTNzIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBwdmViY4njcIUhfmm{YXygVm5CKHO7dHjlbZMh[XRiMkWwJJVOKGGmZHXkJJRw\2W2aHXyJJdqfGhidnnyeZMh[W6mIH3lZZN2emWmIHH0JFExKGi{czDwc5N1KGmwZnXjeIlwdiCkeTDSWE1yWEOUIH3leIhw\CxiTmXMUEA:KE6XTFyg{txONg>? M{nZdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
Click to View More Cell Line Experimental Data
Assay
Methods Test Index PMID
Growth inhibition assay Survival ; Cell viability 26711718 28848019
IHC H&E Staining ; NiV nucleoprotein ; LASV antigen ; H&E stain 29765101 26456301 33037151
Immunofluorescence rNiV-Gluc 29765101
In vivo In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]

Protocol (from reference)

Cell Research:[1]
  • Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
  • Concentrations: 1000 μg/mL
  • Incubation Time: 3 days
  • Method: The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).
Animal Research:[1]
  • Animal Models: Mice infected with influenza virus A/PR/8/34
  • Dosages: 200 mg/kg/day
  • Administration: p.o.

Solubility (25°C)

In vitro

Chemical Information

Molecular Weight 157.1
Formula

C5H4FN3O2
CAS No. 259793-96-9
Storage 3 years -20°C powder
2 years -80°C in solvent
Smiles C1=C(N=C(C(=O)N1)C(=O)N)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such
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Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment Interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907682 Recruiting Drug: Ribavirin iv|Drug: Favipiravir Lassa Fever Bernhard Nocht Institute for Tropical Medicine|University of Hamburg-Eppendorf|Alliance for International Medical Action|Institut National de la Santé Et de la Recherche Médicale France|University of Bordeaux|Federal Medical Centre Owo|Irrua Specialist Teaching Hospital July 30 2021 Phase 2
NCT04464408 Completed Drug: Favipiravir|Drug: Placebo COVID-19 King Abdullah International Medical Research Center|Ministry of Health Saudi Arabia July 23 2020 Phase 2|Phase 3

(data from https://clinicaltrials.gov, updated on 2022-08-01)

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

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