Favipiravir (T-705)

For research use only.

Catalog No.S7975

9 publications

Favipiravir (T-705) Chemical Structure

CAS No. 259793-96-9

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

Size Price Stock Quantity  
10mM (1mL in DMSO) USD 97 In stock
USD 107 In stock
USD 397 In stock
USD 997 In stock
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Selleck's Favipiravir (T-705) has been cited by 9 publications

2 Customer Reviews

  • (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705

    Cell Physiol Biochem, 2018, 49(1):381-394. Favipiravir (T-705) purchased from Selleck.

    (B) IFA of Vero-rBoDV-1-Gluc cells treated with T-705. Vero-rBoDV-1-Gluc cells were treated as indicated and the cells were stained with an anti-P antibody (shown in green) and DAPI (shown in blue). Bars, 50 μm.

    Antiviral Res, 2017, 143:237-245. Favipiravir (T-705) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
RNA-dependent RNA polymerase [1]
In vitro

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK cells M2r3RWZ2dmO2aX;uJIF{e2G7 MlzETY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czCoRU9Jd26pIFvvcocwOjF|L{CzLGg2VjFrKTDhcoQhcW6obIXlcppiKEFidnnyeZMhMEFxQX7uJGFz[m:{L{[vOlApUDKQMjmpJIh6[nKrZDD2bZJ2eyCrbjDNSGNMKGOnbHzzJIJ6KG6ndYTyZYwhemWmIIXweIFs\SCjc4PhfS=> M1TKRlE4OTl2OEOy
Vero cells MmPsSpVv[3Srb36gZZN{[Xl? NH7mNnE4NThiZHH5dy=> MkWwRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTpVvcW5idnnyeZMhS2GwZHnkMVEhcW5iVnXyc{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQhfmm|dXHsJIN6fG:yYYTobYMh\W[oZXP0JIFnfGW{IEegeI8hQCCmYYnz NV70U45ROTd4ME[2PVE>
MDCK cells MlLsSpVv[3Srb36gZZN{[Xl? MkHaTY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyBqQT;keYNsN02rbn7ld491[S9zNUK1M|E6QDFiKFi1UlEqMSC{ZYDsbYNifGmxbjDpckBOTEONIHPlcIx{KGK7IH7leZRz[WxicnXkJJVxfGGtZTDhd5NigQ>? Mn\nNVcyQTR6M{K=

... Click to View More Cell Line Experimental Data

In vivo In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]


Cell Research:[1]
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  • Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
  • Concentrations: 1000 μg/mL
  • Incubation Time: 3 days
  • Method: The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mice infected with influenza virus A/PR/8/34
  • Dosages: 200 mg/kg/day
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 31 mg/mL (197.32 mM)
Ethanol 22 mg/mL warmed (140.03 mM)
Water 5 mg/mL warmed (31.82 mM)

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 157.1


CAS No. 259793-96-9
Storage powder
in solvent
Synonyms N/A
Smiles C1=C(N=C(C(=O)N1)C(=O)N)F

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Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04444986 Completed Drug: FAVIR 200 MG FT|Drug: AVIGAN 200 mg FT Bioequivalence Kocak Farma|Novagenix Bioanalytical Drug R&D Center|Farmagen Ar-Ge Biyot. Ltd. Sti June 5 2020 Phase 1

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DNA/RNA Synthesis Signaling Pathway Map

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID