Favipiravir (T-705)

For research use only.

Catalog No.S7975

13 publications

Favipiravir (T-705) Chemical Structure

CAS No. 259793-96-9

Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.

Selleck's Favipiravir (T-705) has been cited by 13 publications

2 Customer Reviews

  • (A) BoDV-1 infection was measured by IFA. BoDV-1 P40 was detected with a primary monoclonal antibody (red), nuclei were stained with DAPI (blue), merged image (scale bars: 50 μm). Favipiravir: T-705

    Cell Physiol Biochem, 2018, 49(1):381-394. Favipiravir (T-705) purchased from Selleck.

  • (B) IFA of Vero-rBoDV-1-Gluc cells treated with T-705. Vero-rBoDV-1-Gluc cells were treated as indicated and the cells were stained with an anti-P antibody (shown in green) and DAPI (shown in blue). Bars, 50 μm.

    Antiviral Res, 2017, 143:237-245. Favipiravir (T-705) purchased from Selleck.

Purity & Quality Control

Choose Selective DNA/RNA Synthesis Inhibitors

Biological Activity

Description Favipiravir (T-705) is a potent and selective RNA-dependent RNA polymerase inhibitor, used to treat influenza virus infections.
Targets
RNA-dependent RNA polymerase [1]
In vitro

Favipiravir shows anti-influenza virus activities with IC50 ranged from 0.013 to 0.48 μg/ml for the influenza A viruses, from 0.039 to 0.089 μg/ml for the influenza B viruses, and from 0.030 to 0.057 μg/ml for the influenza C viruses. In mammalian cell lines (MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells), Favipiravir shows no cytotoxicity at concentrations up to 1,000 μg/ml. [1] In MDCK cells inoculated with seasonal influenza A (H1N1) viruses, Favipiravir induces lethal mutagenesis. [2]

Cell Data
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID
MDCK NH\PWHFCdnSrdnnyZYwh[XO|YYm= MlvCN{Bl[Xm| NHPLNG5CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL17le{B[d3KtL{O0M|IxODhqSEHONUkqKGijcnLvdolv\yCPMjDMNlZKKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2luIFXDOVAhRSByLkG5JO69VS5? M2m4WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NV7ZO5BQSW62aY\pdoFtKGG|c3H5 NGTCUlE{KGSjeYO= NFrVRmRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNSxib4PlcJRidWm4aYKtMEB7[W6jbXn2bZIue3W|Y3XweIljdGViSX7mcJVmdnqjIFGgeolzfXNiKFGvRY5vKEG{Yn;yM|YwOTl4MDjINm4zMSliaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{B2e2mwZzDjdpl{fGGuII\pc4xmfCC|dHHpckwhTUN3MDC9JFAvOzhizszNMi=> NGfjZ|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M{jrXGFvfGm4aYLhcEBie3OjeR?= NU\2Snp{OyCmYYnz NVjLVGE6SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;GcI9zcWSjL{CxM|IxODlqSEPONkkqKGijcnLvdolv\yCPMjDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KG2rY4Lvd4NweGmlIHHuZYx6e2m|LDDFR|UxKD1iMD60OUDPxE1w M{n3eVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MVfBcpRqfmm{YXygZZN{[Xl? NGXHc5A{KGSjeYO= NX\DN5hYSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhd3OnbIThcYl3cXJvc4XzZ4VxfGmkbHWgfoFv[W2rdnnyMUwh[WSjbXHueIFv\S2{ZYPpd5RidnRiSX7mcJVmdnqjIFKgeolzfXNiQj;N[Y1xcGm|L{KwM|E6QTZiaHHyZo9zcW6pIH7leZJidWmwaXThd4UhWjF3MlugcZV1[W62IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgcYlkem:|Y3;wbYMh[W6jLDDFR|UxKD1iMD61O{DPxE1w NWrEfnpWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MYfBcpRqfmm{YXygZZN{[Xl? MYOzJIRigXN? NVn0TnNESW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM3N4cW6nL2PveZRpKESja3;0ZU8xOy9{MEC4LGgyVjFrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{KHW|aX7nJINzgXO2YXygeolwdGW2LDDFR|UxKD1iMD64N{DPxE1w NF:0Opg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK MUPBcpRqfmm{YXygZZN{[Xl? NWXvPWVJOyCmYYnz MV3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZN2e2OncITpZoxmKHqjbnHtbZZqei1uIH;z[Yx1[W2rdnnyMZJme2m|dHHueEBKdm[udXXufoEhSSC4aYL1d{ApSS:EcnH6bYwwOTZ|Mz:yNFA5MEhzTkGpLUBp[XKkb4LpcochdmW3cnHtbY5q\GG|ZTDRNVM3UyCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5MtKEWFNUCgQUAxNjh|IN88UU4> MVm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK MU\BcpRqfmm{YXygZZN{[Xl? Mmj4N{Bl[Xm| M4rM[WFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM2NidGmob4LubYEwODVxMkCwPUApUDGQMTmpJIhiemKxcnnu[{BOOiCYMkjJMEBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5JweyxiRVO1NEA:KDBwOEOg{txONg>? M{L6WFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NITBZpFCdnSrdnnyZYwh[XO|YYm= MkHkN{Bl[Xm| M{njXGFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM25mfyC\b4LrM|E5NzJyMEmgLGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5NkdyxiRVO1NEA:KDBwOEmg{txONg>? NVuzd5NxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NXnhTmdmSW62aY\pdoFtKGG|c3H5 NGTRNZk{KGSjeYO= M1W0VmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCC8YX7hcYl3cXJvc4XzZ4VxfGmkbHWgc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL4T1dotmgS:PaX7u[ZNwfGFxOEOzM|E6QDBqSETONkkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGUyOTmJIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KCxiRVO1NEA:KDBwOEmg{txONg>? NGDqeWc9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M1;ZeGFvfGm4aYLhcEBie3OjeR?= NIqxT5g{KGSjeYO= NV\VcVhQSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM5R2emuneT;NbY5v\XOxdHGvPFM{NzF7OECoTFRPOilrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBi\nSncjCzJIRigXNiYomgcYlkem:|Y3;wbYMh[W6jbInzbZMhfXOrbnegZ5J6e3SjbDD2bY9t\XRiLDDFR|UxKD1iMD65OkDPxE1w NXvuZWV1RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MlHPRY51cX[rcnHsJIF{e2G7 Mle4RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sgc5NmdHSjbXn2bZIue3W|Y3XweIljdGVienHuZY1qfmm{LTygZYRidWGwdHHu[U1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxQnX0bIV{\GFxOUW2M|IxODZqSEPONkkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJHIzQTKNIH31eIFvfCCjbnSgUVIhWzNzTjDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnNCCHQ{WwJF0hOS5{MTFOwG0v M3zSc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NXW2PHJwSW62aY\pdoFtKGG|c3H5 NIT4fWM{KGSjeYO= NGfOV3JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4DkcU9O\XirY3:vOFYxPC9{MEC5JEhJOU5zKTmgbIFz[m:{aX7nJG0zKFZ{OFmsJHM{OU5ibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[29uIFXDOVAhRSBzLkKxJO69VS5? NFnoZ5M9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NFLTXFNCdnSrdnnyZYwh[XO|YYm= MmfLN{Bl[Xm| NHHQfolCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCEII\pdpV{KEJxTXXtdIhqey9{MD:xPVk3KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[2:yaXOgZY5idHm|aYOgeZNqdmdiY4L5d5RidCC4aX;s[ZQhe3SjaX6sJGVEPTBiPTCxMlIyKM7:TT6= NXvzO2JYRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NEXucJNCdnSrdnnyZYwh[XO|YYm= NXnZRZhNSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM4NpcWOtZX6vWolmfG6jbT;OR3ZFOTB|L{KwNFch[2yjZHWgNk4{NjRiKFi1UlEqMSCqYYLic5JqdmdibnX1doFucW6rZHHz[UBKOjJ{VDDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{LDDFR|UxKD1iMT6yO{DPxE1w NEnHPJg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NX7aOFNUSW62aY\pdoFtKGG|c3H5 M4HxTWlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25ib3[gbY5ndHWnborhJGEhfmm{dYOgLGEwUG:wZzDLc45oNzJzMz:wN{hJPU5zKTmgZY5lKGmwZnz1[Y57[SCDII\pdpV{KCiDL1HuckBCemKxcj:2M|YxMEh{TkKpLUBpgWK{aXSgeolzfXNiaX6gUWREUyClZXzsd{BjgSC4aYL1d{B6cWWuZDDy[YR2[3Srb36gZZN{[XluIFXDPVAhRSBzLkOg{txONg>? M33nc|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUm0PFMzLz5zN{G5OFg{OjxxYU6=
MDCK MVrBcpRqfmm{YXygZZN{[Xl? M{DIPFEhcHJ? M4X3b2FvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBDKH[rcoXzJEhDN0K{aYPiZY5mNzZyL{KwNFgqKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKGO7dH;wZZRpd2enbnnjbZR6KGG2IEGgbJIheG:|dD3pcoZm[3Srb36gcYVie3W{ZXSgZYZ1\XJiMzDkZZl{KGK7IH\seY9z\XOlZXnuMYRq[WOndHH0[UBj[XOnZDDmcJVwemmvZYTybYMh[W6jbInzbZMtKEWFNUCgQUAyNjN{IN88UU4> NHHkR5c9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{M{SxPVc{QCd-MkO0NVk4Ozh:L3G+
MDCK NUixZXBUSW62aY\pdoFtKGG|c3H5 M3m0VWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxVnnleI5idS:KTkOwOFA5NzJyMEWgUlI6PFNiY3zh[IUhOSBqSEXONUkqKGijcnLvdolv\yCPMjDMNlZKNCCVM{HOJI12fGGwdDDhcoQhdmW3cnHtbY5q\GG|ZTDONlk1WyCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKCxiRVO1NEA:KDFwM{SxJO69VS5? NETZXFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M{j1bGFvfGm4aYLhcEBie3OjeR?= M2O5dFMh\GG7cx?= NFHUSXBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4DkcU9E[WyrZn;ycoliNzB5L{KwNFkhMEhzTkGpLUBp[XKkb4LpcochVTJiVkK4TUwhWzNzTjDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYNzd3NuIFXDOVAhRSBzLkSg{txONg>? NYLUWoI{RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NIDCXWhCdnSrdnnyZYwh[XO|YYm= NF\NOI4{KGSjeYO= NXXGOJd1SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S2{ZYPpd5RidnRienHuZY1qfmm{LTzvd4VtfGGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQjD2bZJ2eyBqQj;Sc4Np\XO2ZYKvNFEwOjByMTmgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyC3c3nu[{Bkenm|dHHsJJZqd2yndDDzeIFqdixiRVO1NEA:KDFwNDFOwG0v M1rwcVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MWPBcpRqfmm{YXygZZN{[Xl? MoOyN{Bl[Xm| MmnKRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKG:|ZXz0ZY1qfmm{LTygfoFv[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL1flc5JocWFxMUevNlAxPiiKMV6xLUkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5Nkd3CrYzDhcoFtgXOrczD1d4lv\yClconzeIFtKH[rb3zleEB{fGGrbjygSWM2OCB;IEGuOFYh|ryPLh?= NUWxWGxTRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NXyzW41TSW62aY\pdoFtKGG|c3H5 MYmzJIRigXN? M{[wVmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;0eZJs\XlxVlGvOFUzQS9{MECyJEhJP05{KTmgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyC3c3nu[{Bkenm|dHHsJJZqd2yndDDzeIFqdixiRVO1NEA:KDFwNUOg{txONg>? MVy8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK MlrlRY51cX[rcnHsJIF{e2G7 NHLOV4g{KGSjeYO= NIrsVGRCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNSxienHuZY1qfmm{LYP1d4NmeHSrYnzlJI9{\Wy2YX3peolzNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;GcI9zcWSjL{KxM|IxODhqSEHONUkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGgzPzS\IH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2NuIFXDOVAhRSBzLkW5JO69VS5? Mnr3QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NIfFNotCdnSrdnnyZYwh[XO|YYm= MVizJIRigXN? M1r3XWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;keYNsN1[rZYTuZY0wVkOYREmzM|IxODdiY3zh[IUhOi5|LkSgLGg2VjFrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{KHW|aX7nJINzgSxiRVO1NEA:KDFwNUmg{txONg>? NFTWUpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NYe3bodRSW62aY\pdoFtKGG|c3H5 M4G5RVMh\GG7cx?= MlzBRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sgc5NmdHSjbXn2bZIue3W|Y3XweIljdGVienHuZY1qfmm{LTygZYRidWGwdHHu[U1z\XOrc4ThcpQhUW6obIXlcppiKEJidnnyeZMhMEJxUn;jbIV{fGW{L{CxM|IxODFrIHjhdoJwemmwZzDu[ZVz[W2rbnnkZZNmKERzOUjOJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkNCCHQ{WwJF0hOS55MjFOwG0v MoL6QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NV\BZ4Z6SW62aY\pdoFtKGG|c3H5 MknRN{Bl[Xm| M3HzeWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;CdoF7cWxxMUC2O{8zODB6KFixUlEqMSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KHO2YXnuMEBGSzVyIE2gNU45PSEQvF2u MoPlQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MV7BcpRqfmm{YXygZZN{[Xl? NXHN[3RNOSCqch?= MmfIRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJGIhfmm{dYOgLGIwVGWnL{SwLUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBifCBzIHjyJJBwe3RvaX7m[YN1cW:wIH3lZZN2emWmIHHmeIVzKDNiZHH5d{BjgSCobIXvdoV{[2Wrbj3kbYFk\XSjdHWgZoF{\WRiZnz1c5JqdWW2cnnjJIFv[Wy7c3nzMEBGSzVyIE2gNU46OyEQvF2u NX76cnNrRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVk4OzhpPkKzOFE6PzN6PD;hQi=>
MDCK M4jRZWFvfGm4aYLhcEBie3OjeR?= NFjBU5YyKGi{ NGnkeXlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSiC4aYL1d{ApSi:SYX7hcYEwPDVxMUm5NEkhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdpV{NWmwZIXj[YQh[3m2b4DheIhw\2WwaXPpeJkh[XRiMTDodkBxd3O2LXnu[oVkfGmxbjDt[YF{fXKnZDDh[pRmeiB|IHThfZMh[nliZnz1c5Jme2OnaX6t[Ili[2W2YYTlJIJie2WmIH\seY9zcW2ndILpZ{BidmGueYPpd{whTUN3MDC9JFEvQTRizszNMi=> M2P0WlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ|NEG5O|M5Lz5{M{SxPVc{QDxxYU6=
MDCK MXLBcpRqfmm{YXygZZN{[Xl? M3XxblMh\GG7cx?= MXrBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN3CmbT;DZYxq\m:{bnnhM|A1NzJyMEmgLGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIHHmeIVzKDNiZHH5d{BjgSCvaXPyc5MtKEWFNUCgQUAyNjl5IN88UU4> MnTUQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MnPqRY51cX[rcnHsJIF{e2G7 Mn[yN{Bl[Xm| NWHVd4dxSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM5N4cW6nL13pZ4hq\2GwL{C5M|IxODdiKFixUlIqMSCqYYLic5JqdmdiTUKgWlI4USxiVkK4SEBufXSjboSgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCjLDDFR|UxKD1iMj6yN{DPxE1w MWq8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK MUDBcpRqfmm{YXygZZN{[Xl? MWWzJIRigXN? M3ezdWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1{fXOlZYD0bYJt\SCLbn\seYVvgmFiQTD2bZJ2eyBqQT;FZ5Vi\G:{L{WxO|kwOjByODjINW4yMSliaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGueYPpd{B2e2mwZzDjdpl{fGGuII\pc4xmfCC|dHHpckwhTUN3MDC9JFIvPDhizszNMi=> M2rsdFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MoK1RY51cX[rcnHsJIF{e2G7 MoLFN{Bl[Xm| M2PESWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCC8YX7hcYl3cXJvc4XzZ4VxfGmkbHWgc5NmdHSjbXn2bZIuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL1flc5JocWFxMkCvNlAxPiiKMV6xLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgTFI4PFlibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{[yxiRVO1NEA:KDJwNUWg{txONg>? NW\BSJc3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MX\BcpRqfmm{YXygZZN{[Xl? MWHJcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IDjBM2hwdmdiS3;u[{8zOTNxMEOoTFVPOSlrIHHu[EBqdm[udXXufoEhSSC4aYL1d{ApSS:Dbn6gRZJjd3JxNj:2NEhJOk5{KTmgbJljemmmII\pdpV{KGmwIF3ER2sh[2WubIOgZpkhdmW3dILhcEBz\WRidYD0ZYtmKGG|c3H5MEBGSzVyIE2gNk43KM7:TT6= MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7NEizNkc,OTdzOUS4N|I9N2F-
MDCK NFfXe2JCdnSrdnnyZYwh[XO|YYm= Ml\LTY5pcWKrdHnvckBw\iCrbn\seYVvgmFiQTD2bZJ2eyBqQT;keYNsN02rbn7ld491[S9zNUK1M|E6QDFiKFi1UlEqMSC{ZYDsbYNifGmxbjDpckBOTEONIHPlcIx{KGK7II\pdpV{KHmrZXzkJJJm\HWldHnvckBie3OjeTygSWM6OCB;IEKuOkDPxE1w MUi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7NEizNkc,OTdzOUS4N|I9N2F-
MDCK MmHCRY51cX[rcnHsJIF{e2G7 M1zOR|I1KGi{cx?= NGPnW|JCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSSC4aYL1d{BCN1eVTj:zN{hJOU5zKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4YhdmW3cnHtbY5q\GG|ZTDhZ5Rqfmm2eTD1d4lv\yB{Jz2oOE1u\XSqeXz1cYJmdGyrZnXyfYwqNWGucHjhMWQuVi2jY3X0fYxv\XW{YX3pcolkKGGlaXSgd5Vje3S{YYTlJJBz\XS{ZXH0[YQhf2m2aDDj[YxteyCob4KgNlQhcHK|IH\vcIxwf2WmIHL5JJZqemFuIFXDOVAhRSB{Lkeg{txONg>? MorwQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjdzMkC1PFMoRjJ5MUKwOVg{RC:jPh?=
MDCK MmDXRY51cX[rcnHsJIF{e2G7 MkLmNUBpeg>? NWXSRldtSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKEJidnnyeZMhMEJxVHHpe4FvNzJxNkKpJIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYL1d{1qdmS3Y3XkJIN6fG:yYYToc4dmdmmlaYT5JIF1KDFiaIKgdI9{fC2rbn\lZ5Rqd25ibXXhd5Vz\WRiYX\0[ZIhOyCmYYnzJIJ6KG[udX;y[ZNk\WmwLXTpZYNmfGG2ZTDiZZNm\CCobIXvdolu\XS{aXOgZY5idHm|aYOsJGVEPTBiPTCyMlg1KM7:TT6= NWDwXllWRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkO0NVk4OzhpPkKzOFE6PzN6PD;hQi=>
MDCK MWDBcpRqfmm{YXygZZN{[Xl? MYSzJIRigXN? MlzjRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:ZaYPjc45{cW5xMU[vNlAxQCiKMV6xLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgTFI4PFlibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDh[pRmeiB|IHThfZMh[nlibXnjdo9{NCCHQ{WwJF0hOi56NzFOwG0v NETUfnk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M17YNWFvfGm4aYLhcEBie3OjeR?= NYPERnB1OyCmYYnz M1vMPWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuNCCxc3XseIFucX[rcj2sJJpidmGvaY\pdk1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxSXThbI8wODFxMkCwPUhJOU5zKTmgbIFz[m:{aX7nJI5mfXKjbXnubYRie2ViSEK3OHkhdXW2YX70JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJl{cSxiRVO1NEA:KDJwOUOg{txONg>? MlrWQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NYTBcJBsSW62aY\pdoFtKGG|c3H5 M3LUbWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JI9{\Wy2YX3peolzNXO3c3PldJRq[mynIIrhcoFucX[rcj2sJIFl[W2jboThcoUuemW|aYP0ZY51KEmwZnz1[Y57[SCDII\pdpV{KCiDL1z1bIFve2txMUivNlAxQCiKMV6xLUkhcGG{Yn;ybY5oKG6ndYLhcYlvcWSjc3WgTFI4PFlibYX0ZY51KGGwZDDNNkBIOzSHIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\SxiRVO1NEA:KDJwOUOg{txONg>? NXz0[oVnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M1XyV2FvfGm4aYLhcEBie3OjeR?= MkTlN{Bl[Xm| MV;BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMUwhd3OnbIThcYl3cXJvLDD6ZY5idWm4aYKtdoV{cXO2YX70JGlv\my3ZX76ZUBDKH[rcoXzJEhDN0mubHnuc4l{NzB|L{KwNFgqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGUyOTmDIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJUtKEWFNUCgQUA{KM7:TT6= M3HOSFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MnLCRY51cX[rcnHsJIF{e2G7 MXezJIRigXN? NHf4OZZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNSxienHuZY1qfmm{LYP1d4NmeHSrYnzlJI9{\Wy2YX3peolzNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;XZZNpcW6pdH;uM|ExNzJyMEioTFFPOSlrIHjhdoJwemmwZzDNNkBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[WxuIFXDOVAhRSB|LkK1JO69VS5? M4XuVVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NGPuRVRCdnSrdnnyZYwh[XO|YYm= NH[w[WVCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXO3c3PldJRq[mynIIrhcoFucX[rcj2sJI9{\Wy2YX3peolzNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;keYNsN1[rZYTuZY0wVkOYREm0M|IxODdiY3zh[IUhOi5|LkSgLGg2VjFrKTDoZZJjd3KrbnegcoV2emGvaX7p[IF{\SCLMUG3WkBufXSjboSgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGFuIFXDOVAhRSB|LkO4JO69VS5? MnewQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MknqRY51cX[rcnHsJIF{e2G7 Mlf1N{Bl[Xm| NX;wWG84SW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM2NidGmob4LubYEwOjdxMkCwO{hJOU5zKTmgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrY3H0bY9vKGGodHXyJFMh\GG7czDifUBucWO{b4Pjc5Bq[yCjbnHsfZNqeyC3c3nu[{Bkenm|dHHsJJZqd2yndDDzeIFqdixiRVO1NEA:KDNwNkOg{txONg>? MXm8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK M2CzdWFvfGm4aYLhcEBie3OjeR?= NIXBNXZKdmirYnn0bY9vKG:oII\pdoFtKHKncHzpZ4F1cW:wIH;mJIlv\my3ZX76ZUBCKH[rcoXzJEhCN1[rZYTuZY0wOTJyMz:yNFA1KCiKNV6xLUkh[W6mIHnu[ox2\W68YTDBJJZqenW|IDjBM2FvdiCDcnLvdk83NzZyKFiyUlIqMSCqeXLybYQhfmm{dYOgbY4hVUSFSzDj[YxteyCkeTD2bZJ2eyC7aXXs[EBz\WS3Y4Tpc44h[XO|YYmsJGVEQTBiPTCzMlgh|ryPLh?= M2f2PFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5MUm0PFMzLz5zN{G5OFg{OjxxYU6=
MDCK Ml62RY51cX[rcnHsJIF{e2G7 Ml\KRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4Sgc5NmdHSjbXn2bZIue3W|Y3XweIljdGVienHuZY1qfmm{LTygZYRidWGwdHHu[U1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxVHX4ZZMwOTJxMkCwO{Ap[2yxbnWpLGg{VjJrKTDoZZJjd3KrbnegcoV2emGvaX7p[IF{\SCHMUG5TUBufXSjboSgZY5lKGijcnLvdolv\yCPMjDTN|FPKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhNCCHQ{WwJF0hOy57NTFOwG0v NHK3dpY9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK MVrBcpRqfmm{YXygZZN{[Xl? NFu1Tm0{KGSjeYO= MorIRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSiC4aYL1d{ApSi:LbHzpco9qey92Nz:yNFA2MSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KHO2YXnuMEBGSzVyIE2gOE4xOSEQvF2u NGLQVpM9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK MUTBcpRqfmm{YXygZZN{[Xl? MlnCN{Bl[Xm| MkXqRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:QZYegTIFueHOqaYLlM|AyNzJyMEmoTFNPOilrIHjhdoJwemmwZzDNNkBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFvNCCHQ{WwJF0hPC5yODFOwG0v MkT2QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK NYTiXWp1SW62aY\pdoFtKGG|c3H5 NILKbIlCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBwe2WudHHtbZZqei2|dYPj[ZB1cWKuZTD6ZY5idWm4aYKtMEBi\GGvYX70ZY5mNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;WbYV1dmGvL1jON|A1ODhxMkCwOUBJOjd2WTDjcIFl\SBzIDjIOW4yMSliaHHyZo9zcW6pIF2yJGwzPkluIGOzNW4hdXW2YX70JIFv\CCwZYXyZY1qdmmmYYPlJGgzPzS\IH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25uIFXDOVAhRSB2LkG0JO69VS5? NIfveVE9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M1\hVmFvfGm4aYLhcEBie3OjeR?= M1nqflMh\GG7cx?= Mn\VRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:PYYPzZYNpfXOndITzM|A{NzJyMEmoTFNPOilrIHjhdoJwemmwZzDNNkBUOzGQIH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFvNCCHQ{WwJF0hPC5{IN88UU4> M4DqUVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MUfBcpRqfmm{YXygZZN{[Xl? M1zRVlMh\GG7cx?= MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN1ejc3jpcod1d25xMEGvNlAxPyiKM16yLUkhcGG{Yn;ybY5oKE1{IGOzNW4hdXW2YX70JIlv\mWldHXkJIlvKE2GQ1ugZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcEBz\XCuaXPheIlwdiCjZoTldkA{KGSjeYOgZpkhdWmlcn;zZ49xcWNiYX7hcJktKEWFNUCgQUA1NjR4IN88UU4> M13rWlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK MXjBcpRqfmm{YXygZZN{[Xl? NUfmdpdDUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czCoRU9lfWOtL13pco5me2:2YT:xOVI2NzF7OEGgLGg2VjFrKTDy[ZBtcWOjdHnvckBqdiCPRFPLJINmdGy|IHL5JI5mfXS{YXygdoVlKHWydHHr[UBie3OjeTygSWM2OCB;IESuOUDPxE1w NWTk[XRtRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMUexPVQ5OzJpPkG3NVk1QDN{PD;hQi=>
MDCK MoXJRY51cX[rcnHsJIF{e2G7 M4DufVMh\GG7cx?= NWrTellMSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qh[WSjbXHueIFv\S1uIH;z[Yx1[W2rdnnyMUwhgmGwYX3peolzNXO3c3PldJRq[mynIFnu[ox2\W68YTDBJJZqenW|IDjBM3N4cW6nL2TlfIF{NzF2L{KwNFghMEhzTkGpLUBp[XKkb4LpcochVTJiVkK3WEwhXjJ6RDDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYNzd3Olb4DpZ{BidmGuLDDFR|UxKD1iND61NkDPxE1w MW[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK M13Td2FvfGm4aYLhcEBie3OjeR?= MUKzJIRigXN? NHLt[nBCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXO3c3PldJRq[mynIIrhcoFucX[rcj2sJI9{\Wy2YX3peolzNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;TZY51cWGpbz:1NlQ5NzJyMEioTFFPOSlrIHjhdoJwemmwZzDu[ZVz[W2rbnnkZZNmKERzOUjFJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3JuIFXDOVAhRSB2Lkeg{txONg>? MoPEQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOjB|NUC5OFkoRjJyM{WwPVQ6RC:jPh?=
MDCK MnW5RY51cX[rcnHsJIF{e2G7 M{mxOlEhcHJ? NIDtTGNCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhSSC4aYL1d{ApSS:Kb37nJItwdmdxOD:xPVY5MEh{TkOpLUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyeZMucW6mdXPl[EBkgXSxcHH0bI9o\W6rY3n0fUBifCBzIHjyJJBwe3RvaX7m[YN1cW:wIH3lZZN2emWmIHHmeIVzKDNiZHH5d{BjgSCobIXvdoV{[2Wrbj3kbYFk\XSjdHWgZoF{\WRiZnz1c5JqdWW2cnnjJIFv[Wy7c3nzMEBGSzVyIE2gOE44OSEQvF2u MWO8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOUezPEc,OjN2MUm3N|g9N2F-
MDCK M{HaPGFvfGm4aYLhcEBie3OjeR?= NYD4SWlzOyCmYYnz MUnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMUwhgmGwYX3peolzNXO3c3PldJRq[mynIH;z[Yx1[W2rdnnyMZJme2m|dHHueEBKdm[udXXufoEhSSC4aYL1d{ApSS:QZYegToVze2W7L{G1M|IxODdqSEHONUkqKGijcnLvdolv\yCwZYXyZY1qdmmmYYPlJGgzPzS\IH31eIFvfCCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5ItKEWFNUCgQUA1NjlizszNMi=> NUHhZYV6RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
Vero NGe4TYZCdnSrdnnyZYwh[XO|YYm= M2fwOVchfG9iODDkZZl{ M4X2emFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGp2dmmwII\pdpV{KEOjbnTp[E0yKGmwIG\ldo8h[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJ2ey2rbnT1Z4VlKH[rc4XhcEBkgXSxcHH0bIlkKGWoZnXjeEBi\nSncjC3JJRwKDhiZHH5d{whTUN3MDC9JFUh|ryPLh?= MlLHQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTd4ME[2PVEoRjF5NkC2OlkyRC:jPh?=
MDCK NWDDRphpSW62aY\pdoFtKGG|c3H5 MYCzJIRigXN? MmXtRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U0tKHqjbnHtbZZqei2|dYPj[ZB1cWKuZTDvd4VtfGGvaY\pdk1z\XOrc4ThcpQhUW6obIXlcppiKEFidnnyeZMhMEFxTn;yeIghS2G{b3zpcoEwODJxIEKwNFkpUDGQMTmpJIhiemKxcnnu[{BOOiCVM{HOJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkNCCHQ{WwJF0hPS5yMzFOwG0v NWTkZYtVRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK MU\BcpRqfmm{YXygZZN{[Xl? MYizJIRigXN? M1S5SWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JI9{\Wy2YX3peolzNXO3c3PldJRq[mynIIrhcoFucX[rcj2sJIFl[W2jboThcoUuemW|aYP0ZY51KEmwZnz1[Y57[SCEII\pdpV{KCiEL13pZ4hq\2GwL{KwM|IxODVrIHjhdoJwemmwZzDu[ZVz[W2rbnnkZZNmKEh{N{TZJI12fGGwdDDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKCxiRVO1NEA:KDVwMEOg{txONg>? M{TtdVxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK M2\sTGFvfGm4aYLhcEBie3OjeR?= M{[wXFMh\GG7cx?= MXPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN1[rZYTuZY0wOTJyMz:yNFA1KGOuYXTlJFEhMEh3TkGpLUBp[XKkb4LpcochVTJiTEK2TUwhWzNzTjDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYMtKEWFNUCgQUA2NjJ{IN88UU4> NXO5dnVoRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NFXiPYVCdnSrdnnyZYwh[XO|YYm= NH;1TYZCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBwe2WudHHtbZZqei2|dYPj[ZB1cWKuZTD6ZY5idWm4aYKtMEBi\GGvYX70ZY5mNXKnc3nzeIFvfCCLbn\seYVvgmFiQTD2bZJ2eyBqQT;U[Zhiey9zMj:yNFA4KCilbH;u[UkpUDOQMjmpJIhiemKxcnnu[{Bv\XW{YX3pcoll[XOnIFWxNVlXKG23dHHueEBidmRiaHHyZo9zcW6pIF2yJHM{OU5ibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhcW6qaXLpeIlwdiCxZjD2bZJidCBuIFXDOVAhRSB3LkKyJO69VS5? MYe8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK M3;IcmFvfGm4aYLhcEBie3OjeR?= MlfYN{Bl[Xm| MnPERY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSiC4aYL1d{ApSi:QZYegXY9zcy9{Mj:yNFA5MSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[geolz[WxicnXwcIlk[XSrb36gZYZ1\XJiMzDkZZl{KGK7IH3pZ5Jwe2OxcHnjJIFv[Wy7c3nzJJV{cW6pIHPyfZN1[WxidnnvcIV1KHO2YXnuMEBGSzVyIE2gOU4{KM7:TT6= NYDiO2hPRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M3zGbWFvfGm4aYLhcEBie3OjeR?= MmHYN{Bl[Xm| NXT6PIhoSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhd3OnbIThcYl3cXJvc4XzZ4VxfGmkbHWgfoFv[W2rdnnyMUwh[WSjbXHueIFv\S2{ZYPpd5RidnRiSX7mcJVmdnqjIFGgeolzfXNiKFGvW5Vp[W5xM{m1M|E6QTVvbHnr[UApUDOQMjmpJIhiemKxcnnu[{Bv\XW{YX3pcoll[XOnIFWxNVlXKG23dHHueEBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJIlvcGmkaYTpc44hd2ZidnnyZYwhemWybHnjZZRqd25iYX\0[ZIhOyCmYYnzJIJ6KG2rLDDFR|UxKD1iNT60NUDPxE1w NEW1TZk9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NI\zR|ZCdnSrdnnyZYwh[XO|YYm= MUSzJIRigXN? NFnRN29CdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL2f1bIFvNzN7NT:xPVk2NWyra3WgLGg{VjJrKTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygdoVxdGmlYYTpc44h[W[2ZYKgN{Bl[Xm|IHL5JI1q[3Kxc3PvdIlkKGGwYXz5d4l{KHW|aX7nJINzgXO2YXygeolwdGVuIFXDOVAhRSB3Lkm5JO69VS5? NGnmb5Q9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
Vero MmC5RY51cX[rcnHsJIF{e2G7 NFGwSmM4KHSxIEig[IF6ew>? NHvKcJJCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBRcWOqaX7k[UB3cXK3czDBckA1PzZ|IHnuJHZmem9iY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmII\pd5VidCCleYTvdIF1cGmlIHXm[oVkfCCjZoTldkA4KHSxIEig[IF6eyxiRVO1NEA:KDZizszNMi=> NImxd|I9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9zN{[wOlY6OSd-MUe2NFY3QTF:L3G+
Vero MV;BcpRqfmm{YXygZZN{[Xl? M1S5R|chfG9iODDkZZl{ MU\BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDUZYNiemmkZTD2bZJ2eyCWUm\MNVE2PzNiaX6gWoVzdyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqenW|LXnu[JVk\WRidnnzeYFtKGO7dH;wZZRpcWNiZX\m[YN1KGGodHXyJFchfG9iODDkZZl{NCCHQ{WwJF0hPiEQvF2u M{DncFxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzF5NkC2OlkyLz5zN{[wOlY6OTxxYU6=
MDCK NFHPdXFCdnSrdnnyZYwh[XO|YYm= NWLlcHdMSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhd3OnbIThcYl3cXJvc4XzZ4VxfGmkbHWgfoFv[W2rdnnyMUwh[WSjbXHueIFv\S2{ZYPpd5RidnRiSX7mcJVmdnqjIFGgeolzfXNiKFGvdIRuN1ejc3jpcod1d25xMkmvNlAxQSBqSEHONUkqKGijcnLvdolv\yCPMjDWNlhKNCCVM{HOJI12fGGwdDDhcoQhdmW3cnHtbY5q\GG|ZTDINlc1YSCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{BqdmirYnn0bY9vKG:oII\pdoFtKHKnLDDFR|UxKD1iNj62NkDPxE1w MXG8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
MDCK NEXOXXlCdnSrdnnyZYwh[XO|YYm= NVjKWY8xOSCqch?= Mn;QN{Bl[Xm| M1ftUmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUBCKH[rcoXzJEhCN1SjaYfhck8yNzF7OE[oTFFPOSlrIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXK3cz3pcoR2[2WmIHP5eI9x[XSqb3flcolkcXS7IHH0JFEhcHJicH;zeE1qdm[nY4Tpc44hdWWjc4Xy[YQh[W[2ZYKgN{Bl[Xm|IHL5JIZtfW:{ZYPj[YlvNWSrYXPleIF1\SCkYYPl[EBndHWxcnnt[ZRzcWNiYX7hcJl{cXNuIFXDOVAhRSB4Lkm1JO69VS5? MV:8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zOzRzOUezPEc,OjN2MUm3N|g9N2F-
MDCK MoOxRY51cX[rcnHsJIF{e2G7 M3vBSmlvcGmkaYTpc44hd2ZiSX7mcJVmdnqjIFGgeolzfXNiKFGv[5VtdC:SZX7ud5ltfmGwaXGvOFE4PS96MzCoTFVPOSlrIILldIxq[2G2aX;uJIlvKE2GQ1ugZ4VtdHNiYomgeolzfXNieXnlcIQhemWmdXP0bY9vKGG|c3H5MEBGSzlyIE2gO{44KM7:TT6= Moq0QIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOUS4N|IoRjF5MUm0PFMzRC:jPh?=
MDCK M{O4O2FvfGm4aYLhcEBie3OjeR?= NFnseW8{KGSjeYO= M3fmRWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGlv\my3ZX76ZUB3cXK3czDCM25m\C93M{evNFUhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bz\WS3Y4Tpc44hcW5idnnyZYwhemWybHnjZZRqd25iYYSgN{Bl[Xm|IIDvd5QhcW6oZXP0bY9vKGK7IH\vdo1igmGwLXLhd4VlKE2WUzDhd5NigSxiRVO1NEA:KDhwMzFOwG0v M3TCb|xiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
MDCK NF7WUpBCdnSrdnnyZYwh[XO|YYm= NWfqO415OyCmYYnz Ml3jRY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFKvUoVlNzV|Nz:wOUBqdm[nY4Tl[EBqdiCPRFPLJINmdGy|IHHzd4V{e2WmIHHzJJJm\HWldHnvckBqdiC4aYLhcEBz\XCuaXPheIlwdiCjdDCzJIRigXNicH;zeEBqdm[nY4Tpc44h[nlibXnjdo9{[2:yaXOgZY5idHm|aYOsJGVEPTBiPTC5JO69VS5? NVnXcJFxRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFY{QTJpPkK5PVA3Ozl{PD;hQi=>
MDCK MWDBcpRqfmm{YXygZZN{[Xl? MV[zJIRigXN? MXnBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN06ndzDZc5JsNzFyNz:yNFA{MEh5TkKpLUBp[XKkb4LpcochVTJiVkK4RUwhWzNzTjDteZRidnRiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIILldIxq[2G2aX;uJIFnfGW{IEOg[IF6eyCkeTDtbYNzd3Olb4DpZ{AtKEWFNUCgQUAyOC5{IN88UU4> NIjOd5A9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK M1vPW2FvfGm4aYLhcEBie3OjeR?= M135RmlvcGmkaYTpc44hd2ZiSX7mcJVmdnqjIFGgeolzfXNiKFGv[5VtdC:SZX7ud5ltfmGwaXGvOFE4PS96MzCoTFVPOSlrIILldIxq[2G2aX;uJIlvKE2GQ1ugZ4VtdHNiYomgcoV2fHKjbDDy[YQhfXC2YXvlJIF{e2G7LDDFR|UxKD1iMUGuOUDPxE1w MmGyQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTdzOUS4N|IoRjF5MUm0PFMzRC:jPh?=
MDCK M1q2emFvfGm4aYLhcEBie3OjeR?= NYjXUmlJUW6qaXLpeIlwdiCxZjD2bZJidCC{ZYDsbYNifGmxbjDv[kBqdm[udXXufoEhSSC4aYL1d{ApSS:YaXX0coFuNzF{MEOvNlAxPCBqSEXONUkqKGGwZDDpcoZtfWWwenGgRUB3cXK3czCoRU9Cdm5iQYLic5IwPi94MDjINm4zMSliaInidollKH[rcoXzJIlvKE2GQ1ugZ4VtdHNiYomgcoV2fHKjbDDy[YQhfXC2YXvlJIF{e2G7LDDFR|UxKD1iMUKuNUDPxE1w MXi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8yPzF7NEizNkc,OTdzOUS4N|I9N2F-
Vero-A MnXQRY51cX[rcnHsJIF{e2G7 M1HufmFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JGNpcWu3bnf1cpliKH[rcoXzJJZmdnS3cnnubUBqe2:uYYTlJEhKfGGueTCyNFA5MSCrbn\lZ5Rm\CCrbjDB[pJq[2GwIHfy[YVvKG2xbnvlfUBX\XKxLVGgZ4VtdHNiYYPz[ZN{\WRiYYOgbY5pcWKrdHnvckBw\iC4aYLhcE1qdmS3Y3XkJIN6fG:yYYTobYMh\W[oZXP0JI1m[XO3cnXkJI9vKGSjeTC3JJBwe3RiaX7m[YN1cW:wIHL5JG1VWy:STWOgZZN{[XluIFXDOVAhRSBzNjFOwG0v MU[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQDZ6OUm3OUc,Ojh4OEm5O|U9N2F-
MDCK NV3ZTYFMSW62aY\pdoFtKGG|c3H5 NVrQemFkSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5Qhd3OnbIThcYl3cXJvc4XzZ4VxfGmkbHWgfoFv[W2rdnnyMUwh[WSjbXHueIFv\S2{ZYPpd5RidnRiSX7mcJVmdnqjIFGgeolzfXNiKFGvdIRuN0mubHnuc4l{NzFyL{KwNFkpUDGQMTmpJIhiemKxcnnu[{BOOiCYMkjJMEBUOzGQIH31eIFvfCCjbnSgcoV2emGvaX7p[IF{\SCKMke0XUBufXSjboSgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDpcohq[mm2aX;uJI9nKH[rcnHsJJJmeGyrLDDFR|UxKD1iMkKuOFgh|ryPLh?= NVXhRWNyRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK M1rEN2FvfGm4aYLhcEBie3OjeR?= MoHsN{Bl[Xm| MmD0RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgTY5ndHWnborhJJZqenW|IFGvXE0{OSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KHKnZIXjeIlwdiCrbjD2bZJidCC{ZYDsbYNifGmxbjDheEA{KGSjeYOgdI9{fCCrbn\lZ5Rqd25iYomgcYlkem:|Y3;wbYMh[W6jbInzbZMtKEWFNUCgQUAzPCEQvF2u NV7QT|dwRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkm5NFY{QTJpPkK5PVA3Ozl{PD;hQi=>
Vero-A MVnBcpRqfmm{YXygZZN{[Xl? MX3BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDDbIlsfW6pdX75ZUB3cXK3czC4PVkhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdy2DIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXytbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDvckBl[XliNzDwc5N1KGmwZnXjeIlwdiCkeTDNWHMwWE2VIHHzd4F6NCCHQ{WwJF0hOjVizszNMi=> NYL4bI5URGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFk6PzVpPkK4Olg6QTd3PD;hQi=>
Vero-A NYnSWphbSW62aY\pdoFtKGG|c3H5 MoC5RY51cX[rcnHsJIFkfGm4aYT5JIFo[Wmwc4SgR4hqc3WwZ4XufYEhfmm{dYOgUHIzODB4LV;QXVEhcW6oZXP0[YQhcW5iQX\ybYNidiCpcnXlckBud26tZYmgWoVzdy2DIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXytbY5lfWOnZDDjfZRweGG2aHnjJIVn\mWldDDt[YF{fXKnZDDvckBl[XliNzDwc5N1KGmwZnXjeIlwdiCkeTDNWHMwWE2VIHHzd4F6NCCHQ{WwJF0hOjVizszNMi=> NVXHe|hqRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMki2PFk6PzVpPkK4Olg6QTd3PD;hQi=>
MDCK NV61bIl3SW62aY\pdoFtKGG|c3H5 NEXEb|A{KGSjeYO= MUHBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgeolzfXNiQT;YMVMyKGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMhemWmdXP0bY9vKGmwII\pdoFtKHKncHzpZ4F1cW:wIHH0JFMh\GG7czDwc5N1KGmwZnXjeIlwdiCkeTDmc5Ju[Xqjbj3iZZNm\CCPVGOgZZN{[XluIFXDOVAhRSB{NjFOwG0v MY[8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zQTlyNkO5Nkc,Ojl7ME[zPVI9N2F-
MDCK MlfuRY51cX[rcnHsJIF{e2G7 M2LWNWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JFAvODBzIF3PTUBi\GGvYX70ZY5mNXKnc3nzeIFvfCC8YX7hcYl3cXJvLH;z[Yx1[W2rdnnyMZN2e2OncITpZoxmKEmwZnz1[Y57[SCDII\pdpV{KCiDL4DkcU9O\XirY3:vOFYxPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UBifCxiTmXMUEA:KE6XTFyg{txONg>? M1uxclxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJyM{WwPVQ6Lz5{MEO1NFk1QTxxYU6=
MDCK NUnxOXRwSW62aY\pdoFtKGG|c3H5 MX7BcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDCwMlAxOSCPT1mgZYRidWGwdHHu[U1z\XOrc4ThcpQhgmGwYX3peolzNSyxc3XseIFucX[rcj3zeZNk\XC2aXLs[UBKdm[udXXufoEhSSC4aYL1d{ApSS:yZH2vR4FtcW[xcn7pZU8xPC9{MEC5LGgyVjFrKTDoZZJjd3KrbnegUVIhXjJ6STygV|MyViCvdYThcpQhcW6oZXP0[YQhcW5iTVTDT{Bk\WyuczDhd5Nme3OnZDDhd{Bl\XSncn3pcoF1cW:wIH;mJJZqemGuIITpeIVzKGmwIHPlcIwh[3WudIXy[UAtKE6XTFygQUBPXUyOIN88UU4> NVLpd2Y5RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxMkCzOVA6PDlpPkKwN|UxQTR7PD;hQi=>
MDCK NHrnVmpCdnSrdnnyZYwh[XO|YYm= NFm3SVMyOjhidV2= MVjBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDh[IFu[W62YX7lMZJme2m|dHHueEB7[W6jbXn2bZIuNG:|ZXz0ZY1qfmm{LYP1d4NmeHSrYnzlJGlv\my3ZX76ZUBCKH[rcoXzJEhCN3CmbT;N[Zhq[29xNE[wOE8zODB7KFixUlEqMSCqYYLic5JqdmdiTUKgWlI5USxiU{OxUkBufXSjboSgbY5n\WO2ZXSgbY4hVUSFSzDj[YxteyCjc4Pld5Nm\CCjczDk[ZRmem2rbnH0bY9vKG:oII\pdoFtKHSrdHXyJIlvKGOnbHygZ5VtfHW{ZTDheEAyOjhidV2gZYYtKE6XTFygQUBPXUyOIN88UU4> NETTelg9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{MEO1NFk1QSd-MkCzOVA6PDl:L3G+
MDCK NW\LSWs6SW62aY\pdoFtKGG|c3H5 Mk[2NVI5KHWP M4n3OWFvfGm4aYLhcEBi[3Srdnn0fUBi\2GrboP0JIFl[W2jboThcoUuemW|aYP0ZY51KHqjbnHtbZZqei1ub4PlcJRidWm4aYKtd5V{[2WydHnicIUhUW6obIXlcppiKEFidnnyeZMhMEFxcHTtM2NidGmob4LubYEwODRxMkCwPUhJOU5zKTmgbIFz[m:{aX7nJG0zKFZ{OFmsJHM{OU5ibYX0ZY51KGmwZnXjeIVlKGmwIF3ER2sh[2WubIOgZZN{\XO|ZXSgZZMh\GW2ZYLtbY5ifGmxbjDv[kB3cXKjbDD0bZRmeiCrbjDj[YxtKGO3bIT1doUh[XRiMUK4JJVOKCxiTmXMUEA:KE6XTFyg{txONg>? MWi8ZUB1[XKpZYS9K39jdGGwazegbJJm\j1paIT0dJM7Ny:ydXLt[YQvdmOkaT7ucI0vdmmqLnfvek8zODN3MEm0PUc,OjB|NUC5OFk9N2F-
Vero MlPpRY51cX[rcnHsJIF{e2G7 M4XWfFY1ODBidV2= MX;1dEB1dyBzMjDodpM> MVTBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDZ[Yxtd3diZnX2[ZIhfmm{dYOgNVdFKGmwZnXjeIVlKGmwIFHmdolk[W5iZ4Ll[Y4hdW:wa3X5JHZmem9iY3XscJMh[XO|ZYPz[YQh[XNidHnt[UBz\XG3aYLl[EBnd3JiaX7obYJqfGmxbjDv[kB3cXKjbDDy[ZBtcWOjdHnvckBifCB4NECwJJVOKHWyIITvJFEzKGi{czDwc5N1NX[rcnHsJIlv\mWldHnvckwhVlWOTDC9JG5WVExizszNMi=> MkPhQIEhfGG{Z3X0QUdg[myjbnunJIhz\WZ;J3j0eJB{Qi9xcIXicYVlNm6lYnmucoxuNm6raD7nc5YwOTh7NUW1N|YoRjF6OUW1OVM3RC:jPh?=
MDCK MkTORY51cX[rcnHsJIF{e2G7 M4PtW|AhfG9iMjDodpM> NWjOSXNSUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygcI9i\CC2cnXheIVlKHerdHigZ49ueG:3bnSgZZQhOCC2bzCyJIhzeyCyb4P0MYlv\mWldHnvckBjgSCUVD3xVGNTKG2ndHjv[EBj[XOnZDD0bY1mKG:oIHHk[Il1cW:wIHHzd4F6NCCQVVzMJF0hVlWOTDFOwG0v NWPxfFI3RGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CxPVI2PDRpPkOwNVkzPTR2PD;hQi=>
MDCK NE\3fHhCdnSrdnnyZYwh[XO|YYm= MVy1JJRwKDhiaILz M3K2WGlvcGmkaYTpc44hd2ZiaX7mcJVmdnqjIFGgeolzfXNiaX7m[YN1\WRiaX6gUWREUyClZXzsd{Bie3Onc4Pl[EBieyCrbnjpZol1cW:wIH;mJJZqemGuIHzvZYQhfHKnYYTl[EB4cXSqIHPvcZBwfW6mIHH0JFUhfG9iODDodpMheG:|dD3pcoZm[3Srb36gZpkhWlRvcWDDVkBu\XSqb3SgZoF{\WRidHnt[UBw\iCjZHTpeIlwdiCjc4PhfUwhVlWOTDC9JG5WVExizszNMi=> NIDtNFQ9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG5NlU1PCd-M{CxPVI2PDR:L3G+
MDCK M3TxcGFvfGm4aYLhcEBie3OjeR?= NEm5PJkxKHSxIEGwJIhzew>? NXTJfo5MUW6qaXLpeIlwdiCxZjDpcoZtfWWwenGgRUB3cXK3czDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhfmm{YXygcI9i\CC2cnXheIVlKHerdHigZ49ueG:3bnSgZZQhOCC2bzCxNEBpenNicH;zeE1qdm[nY4Tpc44h[nliUmStdXBEWiCvZYToc4Qh[mG|ZXSgeIlu\SCxZjDh[IRqfGmxbjDhd5NigSxiTmXMUEA:KE6XTFyg{txONg>? NFeyOJA9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9|MEG5NlU1PCd-M{CxPVI2PDR:L3G+
MDCK M3TMN2FvfGm4aYLhcEBie3OjeR?= M4\xVlIhfG9iNTDodpM> NFnRXpJKdmirYnn0bY9vKG:oIHnu[ox2\W68YTDBJJZqenW|IHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kB3cXKjbDDsc4FlKHS{ZXH0[YQhf2m2aDDjc41xd3WwZDDheEAzKHSxIEWgbJJ{KHCxc4StbY5n\WO2aX;uJIJ6KFKWLYHQR3IhdWW2aH;kJIJie2WmIITpcYUhd2ZiYXTkbZRqd25iYYPzZZktKE6XTFygQUBPXUyOIN88UU4> M3O2ZlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzNyMUmyOVQ1Lz5|MEG5NlU1PDxxYU6=
MDCK Mnm5RY51cX[rcnHsJIF{e2G7 MnG0NVAhfU1? MUH1dEB1dyB6IHjydy=> MVPBcpRqfmm{YXygZYN1cX[rdImgZYdicW6|dDDJcoZtfWWwenGgRUB3cXK3czCoRU9kcGmla3XuM2h2[mWrL{OyO{8zODB2KFi1UlEqMSCrbn\lZ5Rm\CCrbjDNSGNMKGOnbHzzJIF{e2W|c3XkJIF{KGmwaHnibZRqd25ib3[g[YFzdHlic4Th[4V{KG:oII\pdoFtKHKncHzpZ4F1cW:wIHH0JFExKHWPIIXwJJRwKDhiaILzJIJ6KGO{eYP0ZYwhfmmxbHX0JJN1[WmwaX7nJIJie2WmIIDsZZF2\SC{ZXT1Z5Rqd25iYYPzZZkh\GWyZX7k[Y51KHSrbXWtc4YtKE6XTFygQUBPXUyOIN88UU4> NUDZOYdnRGFidHHy[4V1RSehYnzhcosoKGi{ZX[9K4h1fHC|Oj:vdJVjdWWmLn7jZokvdmyvLn7pbE5od3ZxM{CyPVI5QTdpPkOwNlkzQDl5PD;hQi=>
MDCK MmLyRY51cX[rcnHsJIF{e2G7 NYnN[3JFOTByIIXN M1riNFEzKGi{cx?= NEPWdlFCdnSrdnnyZYwh[WO2aY\peJkh[WejaX7zeEBKdm[udXXufoEhfmm{dYOgRU9ZNTNzIHnu[oVkfGWmIHnuJG1FS0tiY3XscJMh[XO|ZYPz[YQh[XNiaX7obYJqfGmxbjDv[kBwdmViY4njcIUhfmm{YXygVm5CKHO7boTo[ZNqeyCjdDCxNFAhfU1icILlbY5kfWKjdHXkJJdqfGhiY3XscJMh\m:{IEGyJIhzeyCob3zsc5dm\CCkeTD2bZJidCCrbn\lZ5Rqd25ibXXhd5Vz\WRiYX\0[ZIhOTBiaILzJJBwe3RiaX7m[YN1cW:wIHL5JHJVNXGSQ2KgcYV1cG9uIF7VUGwhRSCQVVzMJO69VS5? M{TodlxiKHSjcnfleF0oZ2KuYX7rK{BpemWoPTfoeJRxezpxL4D1Zo1m\C6wY3LpMo5tdS6waXiu[493NzJ7OUC2N|kzLz5{OUmwOlM6OjxxYU6=
MDCK NF;YN3RCdnSrdnnyZYwh[XO|YYm= MXuyOVAhfU1? NID6[IUyOCCqcoO= NXfxNJlDSW62aY\pdoFtKGGldHn2bZR6KGGpYXnud5QhUW6obIXlcppiKH[rcoXzJGEwYC1|MTDpcoZm[3SnZDDpckBOTEONIHPlcIx{KGG|c3Xzd4VlKGG|IHnubIljcXSrb36gc4Yhd26nIHP5Z4xmKH[rcnHsJHJPSSC|eYTo[Yl{KGG2IEK1NEB2VSCjZHTl[EB1d2endHjldkB4cXSqII\pdpV{KGGwZDDt[YF{fXKnZDDheEAyOCCqcoOgdI9{fCCrbn\lZ5Rqd25iYomgVnQueVCFUjDt[ZRpd2RuIF7VUGwhRSCQVVzMJO69VS5? NF7wOWw9[SC2YYLn[ZQ:L1:kbHHub{chcHKnZk2nbJR1eHN8Lz;weYJu\WRwbnPibU5vdG1wbnnoModwfi9{OUmwOlM6Oid-Mkm5NFY{QTJ:L3G+

... Click to View More Cell Line Experimental Data

Assay
Methods Test Index PMID
Growth inhibition assay
Survival; 

PubMed: 26711718     


Initial dose-ranging study of ribavirin/favipiravir treatment of JUNV-infected guinea pigs. Animals in each group (n=6) were infected with 100 PFU of JUNV and treated i.p. with the indicated doses of favipiravir, ribavirin, a combination of both compounds, or placebo twice daily for 2 weeks starting 3 days p.i. Kaplan-Meier survival curves are shown. **P < 0.01, ***P < 0.001, compared to placebo-treated animals. Tx, treatment; p.i., postinfection.

Cell viability; 

PubMed: 28848019     


Reduction of WNV yield and cytotoxicity of favipiravir. (B) Percentage of viable Vero cells after favipiravir treatment. The 50% cytotoxic concentration was determined by measuring the cellular ATP content at 48 h posttreatment. Data are presented as the mean ± standard deviation (SD) from three independent determinations of both IC50 and CC50.

26711718 28848019
IHC
H&E Staining; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (a) Formalin fixed tissues were embedded in paraffin and H&E stained. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c.

NiV nucleoprotein; 

PubMed: 29765101     


Histopathology and immunohistochemistry. (b) Formalin fixed tissues were embedded in paraffin and stained with anti-NiV nucleoprotein antibodies. Images represent brains, lungs, and spleens of vehicle control animals, favipiravir p.o. and favipiravir s.c. V, blood vessels; Br, bronchioles; Fo, follicles; Arrows, NiV nucleoprotein antigens.

LASV antigen; 

PubMed: 26456301     


Immunohistochemical analysis of tissues from animals infected with GPA-LASV and treated daily with favipiravir, ribavirin or placebo. Tissue samples from infected guinea pigs treated daily with favipiravir (150 or 300 mg/kg/d), ribavirin (50 mg/kg/d) or placebo were collected at 12 days post-infection and examined for the presence of LASV antigen (glycoprotein, GP) using a GP-specific monoclonal antibody according to standard immunohistochemistry techniques.

H&E stain; 

PubMed: 33037151     


(F) Representative H&E images of lungs at day 4 pi of SARS-CoV-2−infected hamsters and treated with favipiravir. At day 4, lungs of untreated hamsters show significant inflammation in bronchial wall (blue arrows) with apoptotic bodies in respiratory epithelium and extension into adjacent alveoli (orange arrow) and inflammatory cells in arterial wall (red arrow). Lungs of infected hamsters treated with 600 mg⋅kg−1⋅d−1 favipiravir still show a few inflammatory cells in the bronchial wall (blue arrows) and a few focal perivascular lymphocytes (red arrow), whereas lungs of hamsters treated with 1,000 mg⋅kg−1⋅d−1 favipiravir contain even less inflammatory cells in the bronchial wall, but no perivascular inflammation. Apoptotic bodies (black circles) were present in bronchial walls of hamsters from all three groups (Scale bars, 100 µm.)

29765101 26456301 33037151
Immunofluorescence
rNiV-Gluc; 

PubMed: 29765101     


Delayed treatment in vitro efficacy of favipiravir against NiV infection. (a) Microscopic analysis of Vero cells infected with rNiV-Gluc-eGFP (MOI 0.01). Favipiravir (250 μM) was added at 1, 12, and 24 HPI; eGFP expression, development of syncytia, and cytopathic effect were monitored by microscopy at 24, 48 and 72 HPI.

29765101
In vivo In influenza virus-infected mice, Favipiravir (200 mg/kg/day, p.o.) protects the mice from death from influenza virus infection. [1] In mice experimentally infected with Ebola virus, Favipiravir efficiently blocks viral production, reaching an antiviral effectiveness of 95% and 99.6% at 2 and 6days after initiation of treatment, respectively. [3]

Protocol

Cell Research:[1]
- Collapse
  • Cell lines: MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells
  • Concentrations: 1000 μg/mL
  • Incubation Time: 3 days
  • Method: The cytotoxicity of T-705 is evaluated by an assay with XTT. XTT is converted to aqueous formazan by an enzyme in MDCK cells, Vero cells, HEL cells, A549 cells, HeLa cells, and HEp-2 cells. The compounds are diluted to the appropriate concentrations (volume, 100 μl) with test medium (EMEM containing 10% FCS) in 96-well culture plates in which each well contains a concentration of 2 × 103 cells/100 μL. The test plates are incubated for 3 days at 37°C in 100% humidity and 5% CO2. After 3 days, 50 μl of the XTT reagent (1 mg/ml in FCS-free EMEM containing 5 mM phenazine methosulfate) is added, and the reaction product is assayed by measurement of the absorbance at 450 nm with a microplate reader. Cytotoxicity is expressed as the 50% cell-inhibitory concentration (CC50).
    (Only for Reference)
Animal Research:[1]
- Collapse
  • Animal Models: Mice infected with influenza virus A/PR/8/34
  • Dosages: 200 mg/kg/day
  • Administration: p.o.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 31 mg/mL (197.32 mM)
Water 5 mg/mL warmed (31.82 mM)
Ethanol ''22 mg/mL warmed

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 157.1
Formula

C5H4FN3O2

CAS No. 259793-96-9
Storage powder
in solvent
Synonyms N/A
Smiles C1=C(N=C(C(=O)N1)C(=O)N)F

In vivo Formulation Calculator (Clear solution)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Dosage mg/kg Average weight of animals g Dosing volume per animal ul Number of animals
Step 2: Enter the in vivo formulation ()
% DMSO % % Tween 80 % ddH2O
CalculateReset

Bio Calculators

Molarity Calculator

Molarity Calculator

Calculate the mass, volume or concentration required for a solution. The Selleck molarity calculator is based on the following equation:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass
    Concentration
    Volume
    Molecular Weight

*When preparing stock solutions, please always use the batch-specific molecular weight of the product found on the via label and SDS / COA (available on product pages).

Dilution Calculator

Dilution Calculator

Calculate the dilution required to prepare a stock solution. The Selleck dilution calculator is based on the following equation:

Concentration (start) x Volume (start) = Concentration (final) x Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2 ( Input Output )

  • C1
    V1
    C2
    V2

* When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / COA (available online).

The Serial Dilution Calculator Equation

  • Serial Dilutions

  • Computed Result

  • C1=C0/X C1: LOG(C1):
    C2=C1/X C2: LOG(C2):
    C3=C2/X C3: LOG(C3):
    C4=C3/X C4: LOG(C4):
    C5=C4/X C5: LOG(C5):
    C6=C5/X C6: LOG(C6):
    C7=C6/X C7: LOG(C7):
    C8=C7/X C8: LOG(C8):
Molecular Weight Calculator

Molecular Weight Calculator

Enter the chemical formula of a compound to calculate its molar mass and elemental composition:

Total Molecular Weight: g/mol

Tip: Chemical formula is case sensitive. C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:

To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.

Definitions of molecular mass, molecular weight, molar mass and molar weight:

Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed in the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

Molarity Calculator

Mass Concentration Volume Molecular Weight

Clinical Trial Information

NCT Number Recruitment interventions Conditions Sponsor/Collaborators Start Date Phases
NCT04907682 Recruiting Drug: Ribavirin iv|Drug: Favipiravir Lassa Fever Bernhard Nocht Institute for Tropical Medicine|University of Hamburg-Eppendorf|Alliance for International Medical Action|Institut National de la Santé Et de la Recherche Médicale France|University of Bordeaux|Federal Medical Centre Owo|Irrua Specialist Teaching Hospital July 30 2021 Phase 2
NCT04464408 Recruiting Drug: Favipiravir|Drug: Placebo COVID-19 King Abdullah International Medical Research Center|Ministry of Health Saudi Arabia July 23 2020 Phase 2|Phase 3

Tech Support

Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

Handling Instructions

Tel: +1-832-582-8158 Ext:3

If you have any other enquiries, please leave a message.

  • * Indicates a Required Field

DNA/RNA Synthesis Signaling Pathway Map

Related DNA/RNA Synthesis Products

Tags: buy Favipiravir (T-705) | Favipiravir (T-705) supplier | purchase Favipiravir (T-705) | Favipiravir (T-705) cost | Favipiravir (T-705) manufacturer | order Favipiravir (T-705) | Favipiravir (T-705) distributor
×
Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID