WRN

Other DNA Damage/DNA Repair Related Inhibitors

HDAC PARP Sirtuin Topoisomerase Telomerase DNA/RNA Synthesis MTH1 DNA alkylator High-mobility Group CRISPR/Cas9

Cat.No.	Product Name	Information	Product Use Citations	Product Validations
E1908	HRO761	HRO761 is a potent, selective, allosteric inhibitor of Werner syndrome RecQ helicase (WRN). It binds at the interface of the D1 and D2 helicase domains, locking WRN in an inactive conformation, and demonstrates anti-proliferative effects specifically in microsatellite instability (MSI) cancer cells.
E1966	VVD-214 (VVD-133214, RO7589831)	VVD-214 (RO7589831, VVD-133214) is a synthetic allosteric inhibitor of WRN helicase. VVD-214 binds irreversibly to cysteine 727 on WRN, suppressing ATP hydrolysis and helicase activity. VVD-214 exhibits potent efficacy in inducing double-stranded DNA breaks, nuclear enlargement, and cellular apoptosis in cancers with high microsatellite instability (MSI).