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Sirtuin Signaling Pathway Map

Sirtuin Signaling Pathways

Sirtuin Products

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  • Sirtuin Inhibitors (17)
  • Sirtuin Antibodies (2)
  • Sirtuin Activators (13)
  • Sirtuin Modulator (1)
  • New Sirtuin Products
Catalog No. Product Name Information Product Use Citations Product Validations
E1150New SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
S1396 Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Int Immunopharmacol, 2022, 103:108489
Eur J Neurosci, 2022, 10.1111/ejn.15596
Adv Sci (Weinh), 2021, e2103360
S1541 Selisistat (EX 527) Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
Dev Cell, 2022, 57(2):260-276.e9
Front Pharmacol, 2022, 13:797469
J Transl Med, 2022, 20(1):44
S1899 Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
Cell Rep, 2022, 38(3):110250
Cell Death Dis, 2022, 13(1):43
Cell Metab, 2021, 33(1):110-127.e5
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S2804 Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
J Cell Sci, 2022, jcs.259207
Front Pharmacol, 2022, 13:797469
Hepatology, 2021, 10.1002/hep.32245
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.
Front Immunol, 2021, 12:685523
Biomed Pharmacother, 2020, 125:109948
J Cell Sci, 2019, 132(6)
S5914 AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S6744 Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.
Cancer Lett, 2020, 501:20-30
S7577 AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
Dev Cell, 2022, 57(2):260-276.e9
Front Pharmacol, 2022, 13:797469
Cell Rep, 2021, 34(13):108921
S7845 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Basic Res Cardiol, 2021, 116(1):48
Cancer Lett, 2020, 501:20-30
J Cell Physiol, 2020, 10.1002
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
J Pharm Biomed Anal, 2021, 201:114121
J Transl Med, 2019, 17(1):76
Sci Rep, 2019, 9(1):1897
S8245 Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Cell Metab, 2020, 32(3):420-436.e12
Cancer Lett, 2020, 501:20-30
J Cell Physiol, 2020, 10.1002
S8460 Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
Cancer Lett, 2020, 501:20-30
Am J Transl Res, 2019, 11(8):4789-4799
J Proteome Res, 2018, 17(4):1436-1451
S8627 OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Biochem Pharmacol, 2022, 199:115022
Front Cell Dev Biol, 2021, 9:625540
Front Cell Dev Biol, 2021, 9:648627
S8628 3-TYP 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
Dev Cell, 2022, 57(2):260-276.e9
Exp Mol Med, 2022, 10.1038/s12276-022-00745-9
Toxicol Lett, 2022, 354:14-23
S9903New NRD167

NRD167 is a potent and selective SIRT5 inhibitor.

A5039 SIRT6 Rabbit Recombinant mAb

SIRT6 Antibody detects endogenous levels of SIRT6.

A5049 SIRT1 Rabbit Recombinant mAb

SIRT1 Antibody detects endogenous levels of total SIRT1.

S1129 SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.
FEBS J, 2022, 10.1111/febs.16353
J Diabetes Res, 2022, 2022:1755563
bioRxiv, 2022, 2022.01.04.474979
S2298 Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Cancer Lett, 2022, S0304-3835(22)00021-0
Front Immunol, 2021, 12:692321
S2391 Quercetin (NSC 9221) Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Mol Neurobiol, 2022, 10.1007/s12035-021-02712-3
Nucleic Acids Res, 2021, gkab538
S2935 Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
PLoS One, 2021, 16(6):e0252554
Nat Metab, 2021, 3(8):1109-1124
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
S3262 Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
S4735 Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
Stem Cell Res Ther, 2021, 12(1):507
Research Square, 2021, 10.21203/rs.3.rs-372611/v1
J Cell Mol Med, 2020, 29
S5918 CAY10602 CAY10602 is a potent SIRT1 activator.
J Med Chem, 2020, 31
S6880 SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
S7792 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
Neuro Oncol, 2021, 23(1):53-62
Front Pharmacol, 2021, 12:653233
Hepatology, 2020, 10.1002/hep.31222
S8270 SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
Neuro Oncol, 2021, 23(1):53-62
Cell Death Differ, 2021, 10.1038/s41418-021-00841-9
Life Sci, 2020, S0024-3205(20)31542-3
S8481 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
Neuro Oncol, 2021, 23(1):53-62
Aging Cell, 2020, e13164
Acta Haematol, 2019, 142(3):142-148
S8909 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Cell Death Discov, 2022, 8(1):96
S2347 Quercetin Dihydrate Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Nucleic Acids Res, 2021, gkab538
Front Immunol, 2021, 12:649285
E1150New SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
S1396 Resveratrol (SRT501) Resveratrol (SRT501, trans-Resveratrol) has a wide spectrum of targets including cyclooxygenases(i.e. COX, IC50=1.1 μM), lipooxygenases(LOX, IC50=2.7 μM), kinases, sirtuins and other proteins. It has anti-cancer, anti-inflammatory, blood-sugar-lowering and other beneficial cardiovascular effects. Resveratrol induces mitophagy/autophagy and autophagy-dependent apoptosis.
Int Immunopharmacol, 2022, 103:108489
Eur J Neurosci, 2022, 10.1111/ejn.15596
Adv Sci (Weinh), 2021, e2103360
S1541 Selisistat (EX 527) Selisistat (EX 527, SEN0014196) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.
Dev Cell, 2022, 57(2):260-276.e9
Front Pharmacol, 2022, 13:797469
J Transl Med, 2022, 20(1):44
S1899 Nicotinamide (NSC 13128) Nicotinamide (NSC 13128, Niacinamide, Vitamin PP, Nicotinic acid amide, Vitamin B3, NSC 27452), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.
Cell Rep, 2022, 38(3):110250
Cell Death Dis, 2022, 13(1):43
Cell Metab, 2021, 33(1):110-127.e5
S2176 Tenovin-3 Tenovin-3 is an inhibitor of SIRT2. Tenovin-3 is able to increase p53 levels in MCF-7 cells.
S2804 Sirtinol Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.
J Cell Sci, 2022, jcs.259207
Front Pharmacol, 2022, 13:797469
Hepatology, 2021, 10.1002/hep.32245
S4900 Tenovin-6 Tenovin-6 is a small molecule activator of p53 transcriptional activity and inhibits dihydroorotate dehydrogenase (DHODH). Tenovin-6 is also an inhibitor of SirT1 and SirT2.
Front Immunol, 2021, 12:685523
Biomed Pharmacother, 2020, 125:109948
J Cell Sci, 2019, 132(6)
S5914 AK 7 AK 7 is a brain-permeable selective SIRT2 inhibitor with an IC50 of 15.5 μM.
S6744 Inauhzin Inauhzin is a cell-permeable SIRT1 inhibitor with an IC50 of 0.7-2 μM and reactivates p53 by inhibiting SIRT1 deacetylation activity.
Cancer Lett, 2020, 501:20-30
S7577 AGK2 AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
Dev Cell, 2022, 57(2):260-276.e9
Front Pharmacol, 2022, 13:797469
Cell Rep, 2021, 34(13):108921
S7845 SirReal2 SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
Basic Res Cardiol, 2021, 116(1):48
Cancer Lett, 2020, 501:20-30
J Cell Physiol, 2020, 10.1002
S8000 Tenovin-1 Tenovin-1 protects against MDM2-mediated p53 degradation, which involves ubiquitination, and acts through inhibition of protein-deacetylating activities of SirT1 and SirT2. Tenovin-1 is also an inhibitor of dihydroorotate dehydrogenase (DHODH).
J Pharm Biomed Anal, 2021, 201:114121
J Transl Med, 2019, 17(1):76
Sci Rep, 2019, 9(1):1897
S8245 Thiomyristoyl Thiomyristoyl (TM) is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.
Cell Metab, 2020, 32(3):420-436.e12
Cancer Lett, 2020, 501:20-30
J Cell Physiol, 2020, 10.1002
S8460 Salermide Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.
Cancer Lett, 2020, 501:20-30
Am J Transl Res, 2019, 11(8):4789-4799
J Proteome Res, 2018, 17(4):1436-1451
S8627 OSS_128167 OSS_128167 (SIRT6-IN-1) is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively. OSS_128167 has anti-viral effect in HBV transcription and replication.
Biochem Pharmacol, 2022, 199:115022
Front Cell Dev Biol, 2021, 9:625540
Front Cell Dev Biol, 2021, 9:648627
S8628 3-TYP 3-TYP (3-(1H-1,2,3-triazol-4-yl) pyridine) is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.
Dev Cell, 2022, 57(2):260-276.e9
Exp Mol Med, 2022, 10.1038/s12276-022-00745-9
Toxicol Lett, 2022, 354:14-23
S9903New NRD167

NRD167 is a potent and selective SIRT5 inhibitor.

A5039 SIRT6 Rabbit Recombinant mAb

SIRT6 Antibody detects endogenous levels of SIRT6.

A5049 SIRT1 Rabbit Recombinant mAb

SIRT1 Antibody detects endogenous levels of total SIRT1.

S1129 SRT1720 HCl SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3. SRT1720 induces autophagy.
FEBS J, 2022, 10.1111/febs.16353
J Diabetes Res, 2022, 2022:1755563
bioRxiv, 2022, 2022.01.04.474979
S2298 Fisetin Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Cancer Lett, 2022, S0304-3835(22)00021-0
Front Immunol, 2021, 12:692321
S2391 Quercetin (NSC 9221) Quercetin (NSC 9221, Sophoretin, C.I. 75720), a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Quercetin induces mitophagy, apoptosis and protective autophagy. Phase 4.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Mol Neurobiol, 2022, 10.1007/s12035-021-02712-3
Nucleic Acids Res, 2021, gkab538
S2935 Nicotinamide Riboside Chloride Nicotinamide Riboside Chloride is the chloride salt form of nicotinamide riboside(NR).NR is a new form pyridine-nucleoside of vitamin B3 that functions as a precursor to nicotinamide adenine dinucleotide(NAD) or NAD+ . Nicotinamide riboside chloride is a crystal form of Nicotinamide riboside (NR) chloride. Nicotinamide riboside chloride increases NAD[+] levels and activates SIRT1 and SIRT3, culminating in enhanced oxidative metabolism and protection against high fat diet-induced metabolic abnormalities. Nicotinamide riboside chloride is used in dietary supplements.
PLoS One, 2021, 16(6):e0252554
Nat Metab, 2021, 3(8):1109-1124
S3168 cis-Resveratrol cis-Resveratrol (cis-RESV, cRes, (Z)-Resveratrol) is the Cis isomer of Resveratrol. Resveratrol is a natural phenolic compound with anti-oxidant, anti-inflammatory, cardioprotective, and anti-cancer properties. Resveratrol is an inhibitor of pregnane X receptor (PXR) and an activator of Nrf2 and SIRT1 and may induce apoptosis. Resveratrol also inhibits a wide spectrum of targets including 5-lipoxygenase (LOX), cyclooxygenase (COX), IKKβ, DNA polymerases α and δ with IC50 of 2.7 μM, <1 μM, 1 μM, 3.3 μM and 5 μM, respectively.
S3262 Scopolin Scopolin, a coumarin isolated from Arabidopsis thaliana (Arabidopsis), attenuates hepatic steatosis through activation of SIRT1-mediated signaling cascades, a potent regulator of lipid homeostasis.
S4735 Salvianolic acid B Salvianolic acid B (Sal B, Lithospermate B, Lithospermic acid B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.
Stem Cell Res Ther, 2021, 12(1):507
Research Square, 2021, 10.21203/rs.3.rs-372611/v1
J Cell Mol Med, 2020, 29
S5918 CAY10602 CAY10602 is a potent SIRT1 activator.
J Med Chem, 2020, 31
S6880 SRT-1460 SRT-1460 is a potent and selective activator of Sirtuin 1 (SIRT1) with EC1.5 of 2.9 μM. SRT-1460 reduces cell viability and growth of pancreatic cancer cells and induces apoptosis.
S7792 SRT2104 (GSK2245840) SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
Neuro Oncol, 2021, 23(1):53-62
Front Pharmacol, 2021, 12:653233
Hepatology, 2020, 10.1002/hep.31222
S8270 SRT2183 SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.
Neuro Oncol, 2021, 23(1):53-62
Cell Death Differ, 2021, 10.1038/s41418-021-00841-9
Life Sci, 2020, S0024-3205(20)31542-3
S8481 SRT3025 HCl SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.
Neuro Oncol, 2021, 23(1):53-62
Aging Cell, 2020, e13164
Acta Haematol, 2019, 142(3):142-148
S8909 UBCS039 UBCS039 is the first synthetic SIRT6 activator with EC50 of 38 μM,induces a time-dependent activation of autophagy in several human tumor cell lines.
Cell Death Discov, 2022, 8(1):96
S2347 Quercetin Dihydrate Quercetin (Sophoretin), a polyphenolic flavonoid found in a wide variety of plant-based foods, such as apples, onions, berries, and red wine, is utilized in many different cultures for their nervous system and anticancer effects. Quercetin (dihydrate), a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively.
ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138
Nucleic Acids Res, 2021, gkab538
Front Immunol, 2021, 12:649285
E1150New SIRT7 inhibitor 97491 SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
S9903New NRD167

NRD167 is a potent and selective SIRT5 inhibitor.

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