Signaling Pathway Map

Research Area

  • Inhibitory Selectivity
  • Solubility
Catalog No. Product Name Solubility(25°C)
Water DMSO Alcohol
S1541 Selisistat (EX 527) <1 mg/mL 49 mg/mL 18 mg/mL
S2804 Sirtinol <1 mg/mL 23 mg/mL <1 mg/mL
S1899 Nicotinamide (Vitamin B3) 24 mg/mL 24 mg/mL 24 mg/mL
S7845 SirReal2 <1 mg/mL 84 mg/mL <1 mg/mL
S8627 OSS_128167 <1 mg/mL 73 mg/mL <1 mg/mL
S4900 Tenovin-6 98 mg/mL 98 mg/mL <1 mg/mL
S7577 AGK2 <1 mg/mL 10 mg/mL <1 mg/mL
S8245 Thiomyristoyl <1 mg/mL 100 mg/mL 100 mg/mL
S8460 Salermide <1 mg/mL 78 mg/mL 7 mg/mL
S8628 3-TYP 5 mg/mL 29 mg/mL 29 mg/mL
S1129 SRT1720 HCl <1 mg/mL 38 mg/mL <1 mg/mL
S4735 Salvianolic acid B 100 mg/mL 100 mg/mL 100 mg/mL
S8270 SRT2183 <1 mg/mL 93 mg/mL 3 mg/mL
S7792 SRT2104 (GSK2245840) <1 mg/mL 16 mg/mL <1 mg/mL
S2391 Quercetin <1 mg/mL 61 mg/mL 10 mg/mL
S2298 Fisetin <1 mg/mL 57 mg/mL 3 mg/mL
S8481 SRT3025 HCl <1 mg/mL 100 mg/mL 5 mg/mL

Isoform-specific Inhibitors

Catalog No. Information Product Use Citations Product Validations

Selisistat (EX 527)

Selisistat (EX 527) is a potent and selective SIRT1 inhibitor with IC50 of 38 nM in a cell-free assay, exhibits >200-fold selectivity against SIRT2 and SIRT3. Phase 2.



Sirtinol is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.


Nicotinamide (Vitamin B3)

Nicotinamide (Vitamin B3), a water-soluble vitamin, is an active component of coenzymes NAD and NADP, and also act as an inhibitor of sirtuins.



SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.



OSS_128167 is a specific SIRT6 inhibitor with IC50 values of 89, 1578 and 751 μM for SIRT6, SIRT1 and SIRT2, respectively.



Tenovin-6 is a small molecule activator of p53 transcriptional activity.



AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.



Thiomyristoyl is a potent and specific SIRT2 inhibitor with an IC50 of 28 nM. It inhibits SIRT1 with an IC50 value of 98 μM and does not inhibit SIRT3 even at 200 μM.



Salermide is a reverse amide with a strong in vitro inhibitory effect on Sirt1 and Sirt2. Compared with Sirt1, Salermide is even more efficient at inhibiting Sirt2.



3-TYP is a selective SIRT3 inhibitor which is selective for Sirt3 over Sirt1 and Sirt2. The IC50 values for SITR1, SIRT2, SIRT3 are 88 nM, 92 nM, 16 nM respectively.


SRT1720 HCl

SRT1720 HCl is a selective SIRT1 activator with EC50 of 0.16 μM in a cell-free assay, but is >230-fold less potent for SIRT2 and SIRT3.


Salvianolic acid B

Salvianolic acid B (Sal B), an antioxidant and free radical scavenging compound, is the most abundant bioactive compound extracted from the root of Salvia miltiorrhiza Bunge.



SRT2183 is a small-molecule activator of the sirtuin subtype SIRT1, currently being developed by Sirtris Pharmaceuticals.


SRT2104 (GSK2245840)

SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.



Quercetin, a natural flavonoid present in vegetables, fruit and wine, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4-5.4 μM. Phase 4.



Fisetin (Fustel) is a potent sirtuin activating compound (STAC) and an agent that modulates sirtuins.


SRT3025 HCl

SRT3025 is an orally available small molecule activator of the SIRT1 enzyme.

Tags: Sirtuin activation | SIRT1 inhibition | SIRT1 activation | SIRT1 protein | SIRT1 cancer | SIRT1 activity | SIRT1 pathway | SIRT1 assay | Sirtuin protein | Sirtuin activity | SIRT activation | SIRT assay | Sirtuin cancer | Sirtuin pathway | SIRT1 phosphorylation | Sirtuin assay | SIRT2 cancer | SIRT pathway | SIRT2 protein | SIRT2 assay | SIRT1 inhibitor review