6-Thio-dG

Catalog No.S7757

6-Thio-dG Chemical Structure

Molecular Weight(MW): 283.31

6-thio-dG is a nucleoside analog and telomerase substrate.

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Biological Activity

Description 6-thio-dG is a nucleoside analog and telomerase substrate.
In vitro

6-Thio-dG induces telomere dysfunction and results in progressive telomere shortening in telomerase-positive human cancer cells and hTERT-expressing human fibroblasts. In tested cancer cells, 6-thio-dG inhibits cell viability with IC50 values between 0.7 and 2.9 μM. [1]

In vivo In mice bearing A549 lung cancer xenografts, 6-Thio-dG (2 mg/kg, i.p.) decreases the tumorigenicity of A549 Cells by inducing telomere dysfunction. [1]

Protocol

Cell Research:[1]
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  • Cell lines: HCT11, A549, H2882, HCC2429, HCC827, HCC15, H2087, HCC4017, HCC515, H2009, BJ and HCEC1 cells
  • Concentrations: ~10 μM
  • Incubation Time: 7 d
  • Method: Cells are plated in growth media in 96-well plates. Cells are incubated for 1 week and treated with varying concentrations of 6-thio-dG and 6-thioguanine or DMSO every 3 days. The 96-well plates are analyzed according the manufacturer’s directions for the CellTiterGlo luminescent cell viability assay to obtain IC50 values. The IC50 is defined as the concentration of drug at which 50% of the cells are inhibited by the drug. Sigmoidal dose–response curves are used to calculate IC50 values. All samples are analyzed in triplicate, and SDs are from two independent experiments.
    (Only for Reference)
Animal Research:[1]
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  • Animal Models: Mice bearing A549 lung cancer xenografts
  • Formulation: 5% DMSO solution
  • Dosages: ~2 mg/kg
  • Administration: i.p.
    (Only for Reference)

Solubility (25°C)

In vitro DMSO 56 mg/mL (197.66 mM)
Water Insoluble
Ethanol Insoluble

* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Chemical Information

Molecular Weight 283.31
Formula

C10H13N5O3S

CAS No. 789-61-7
Storage powder
in solvent
Synonyms N/A

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Cell Lines Assay Type Concentration Incubation Time Formulation Activity Description PMID